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Articles 1 - 12 of 12
Full-Text Articles in Medical Pharmacology
Impact Of Multifactorial Interventions With Medication And Lifestyle Optimization On Patients With Type 2 Diabetes: A Randomised Controlled Trial, Marwan M. El Deyarbi
Impact Of Multifactorial Interventions With Medication And Lifestyle Optimization On Patients With Type 2 Diabetes: A Randomised Controlled Trial, Marwan M. El Deyarbi
Thesis/ Dissertation Defenses
The incidence of diabetes is increasing worldwide, consequently increasing mortality rates due to complications such as diabetic kidney disease. Clinical evidence on the protective effect of balanced diet, exercise and medication adherence with glucose-lowering intensification therapies on the progression of diabetes is insufficient, and interventions that are most effective in slowing cardiorenal metabolic complications in patients with type 2 diabetes mellitus (T2DM), especially in the UAE population diabetes remain to be elucidated. Several studies have shown that patient-related factors and limited medication adherence in patients with chronic diseases, are associated with poor clinical outcomes, long-term complications, and increased overall disease …
Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism, Mohammad Moutaz Nakhal
Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism, Mohammad Moutaz Nakhal
Thesis/ Dissertation Defenses
Autism spectrum disorder (ASD) is a neurodevelopmental disease with a substantially increasing incidence rate. It is mainly characterized by repetitive behavior, intellectual difficulties, social communication and interactions deficits. Many medications, dietary supplements, and behavioral treatments have been recommended for ASD management, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory and antioxidant effects. The main objective of this study is to assess the ability of canagliflozin in improving the behavioural characteristics of autistic rats and investigate the efficacy of canagliflozin in …
Intrinsic Programmed Death Ligand 1 (Pd-L1) Role In Promoting Triple Negative Breast Cancer (Tnbc) Progression, Duaa Salem Alkaabi
Intrinsic Programmed Death Ligand 1 (Pd-L1) Role In Promoting Triple Negative Breast Cancer (Tnbc) Progression, Duaa Salem Alkaabi
Theses
This thesis is concerned with Triple Negative Breast Cancer (TNBC), which is characterized by lack of estrogen, progesterone, and HER2 receptors expression, making targeted drugs ineffective. TNBC has a high proliferative rate, which results in a poor prognosis. Chemotherapy, the primary treatment for metastatic breast cancer, is not an ideal choice due to its toxicity towards normal cells. Therefore, Cancer-targeted therapy has been developed to improve the specificity and strength of the immune system against cancer cells. PD-L1 is an immunosuppressive protein that inactivates T cells by binding to the inhibitory receptor PD-1. The clinical use of PD-L1 blockade agents …
Effects Of St713 With Simultaneous Histamine H3 And Dopamine D2/D3 Receptor Antagonist Properties On Cognitive Impairments And Autism-Like Behaviors In Btbr T+Tf/J Mice, Mohammed Mustafa Alawad
Effects Of St713 With Simultaneous Histamine H3 And Dopamine D2/D3 Receptor Antagonist Properties On Cognitive Impairments And Autism-Like Behaviors In Btbr T+Tf/J Mice, Mohammed Mustafa Alawad
Theses
Autism spectrum disorders (ASD) is a multifactorial neurodevelopmental disorder characterized by two core symptoms which are impairments in social interaction and communication, repetitive and restricted behaviors. Dopamine (DA) and histamine (HA) are two neurotransmitters that are proposed to be involved in several brain disorders including schizophrenia, depression, anxiety, and narcolepsy, all of those disorders are comorbid with ASD. Thus, the palliative effects of the novel multiple-active histamine H3 receptor (H3R) antagonist and dopamine D2/D3 receptor (D2/D3R) antagonist ST-713 with its high H3R antagonist affinity and balanced inhibitory effects on both dopaminergic receptor subtypes D2R and D3R on ASD-like behaviors in …
Role Of Limonene In An Experimental Model Of Rotenone Induced Parkinson’S Disease, Lujain Mohamad Bader Eddin
Role Of Limonene In An Experimental Model Of Rotenone Induced Parkinson’S Disease, Lujain Mohamad Bader Eddin
Theses
Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases in elderly population. The symptoms of PD often begin with motor and cognitive impairment that are attributed to the dopaminergic neurons degeneration. Rotenone (ROT) is a naturally derived pesticide that is used in agriculture to control pests. It is a neurotoxin well-established for use in resembling PD symptoms in research. Limonene (LMN) is a plant derived monoterpene extracted from citrus peel with a wide range of therapeutic effects. Due to the shortage in available therapeutic agents that can cure or halt the progressive degeneration of PD, the main aim of …
Novel Insights Into The Anti-Diabetic Mechanism(S) Of Withania Coagulans And Its Active Constituent, Coagulansin-A, Mariyam Khalid Naeem
Novel Insights Into The Anti-Diabetic Mechanism(S) Of Withania Coagulans And Its Active Constituent, Coagulansin-A, Mariyam Khalid Naeem
Dissertations
Type 2 diabetes mellitus has become a serious medical challenge of the 21st century with a dramatic surge in diabetes cases since the last decade. It accounts for 90-95% of all cases of diabetes mellitus. The interplay between insulin resistance and beta cells dysfunction plays a crucial role in the pathophysiology of diabetes mellitus. Type 2 diabetes mellitus is characterized by peripheral insulin resistance in skeletal muscles that leads to a constellation of metabolic disorders, and exhaustion of pancreatic beta cells to maintain euglycemia. The inability of pancreatic beta cells to compensate insulin demand in an insulin-resistant state, result in …
The Effect Of Β-Caryophyllene On Isoproterenol-Induced Myocardial Infarction, Farah M. Jamal Laham
The Effect Of Β-Caryophyllene On Isoproterenol-Induced Myocardial Infarction, Farah M. Jamal Laham
Theses
Cannabinoid type 2 receptors (CB2), a key member of the endocannabinoid system have recently emerged as a crucial therapeutic target for cardiovascular diseases (CVDs). Downregulation of CB2 receptors has been witnessed in various cancers, neurological and cardiovascular disorders. Thus, the activation of CB2 receptors may protect against ISO-induced myocardial infarction (MI) in rats. The present study investigates the cardioprotective effect of a selective cannabinoid type 2 receptor agonist β-caryophyllene (BCP), a dietary phytocannabinoid, and a natural bicyclic sesquiterpene against isoproterenol (ISO)-induced MI in rats. Male albino Wistar rats were pre-and co-treated with β-caryophyllene (50 mg/kg, orally) twice daily for 10 …
Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa
Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa
Theses
Several studies showed the effects of glucocorticoid hormones on the hippocampus. It has been reported that the chronic administration of high dose glucocorticoids (GC) results in the degeneration of pyramidal neurons. However, bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively, there are few publications on the effects of short-term bilateral adrenalectomy (ADX). We aimed to investigate the effects of ADX on levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interkeukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); levels of growth factors, response of microglia and astrocytes to neuronal death, and oxidative …
Effect Of Genipin On Cisplatin- Induced Nephrotoxicity, Eglal Orner Mahgoub
Effect Of Genipin On Cisplatin- Induced Nephrotoxicity, Eglal Orner Mahgoub
Theses
Cisplatin (CSP) is a potent and widely used chemotherapeutic agent. However, clinical efficacy of CSP is compromised due to the elicitation of nephrotoxicity and ototoxicity. In this study, I have investigated the nephroprotective effects of a phytochemical – genipin (GP) isolated from gardenia flower (Gardenia jasminoides), on a murine model of cisplatin-induced nephropathy. CSP-induced renal tissue injury was characterized by elevated levels of serum blood urea nitrogen (BUN), creatinine (Cr) and cystatin-C. In addition, levels of kidney injury molecule-1 (KIM-1) were increased in the renal tissues of CSP administered animals. CSP also induced renal oxidative stress, evidenced by increased NADPH …
The Effects Of Thujone On The Function Of Nicotinic Acetylcholine Receptors, Ahmed Salaheldin Mustafa Ali Sultan
The Effects Of Thujone On The Function Of Nicotinic Acetylcholine Receptors, Ahmed Salaheldin Mustafa Ali Sultan
Theses
Thujone is a natural compound found in plants such as “wormwood” and “sage” and it’s also found in the alcoholic drink “Absinthe”. Thujone has been suggested as a neurotoxic compound and reported to modulate GABAA receptors. In this study, we investigated the pharmacology of Thujone on nicotinic receptors expressed in Xenopus oocytes using the two electrode voltage clamp method. Thujone (100μM) caused an 80% inhibition of Acetylcholine (ACh) induced currents in human α7-nAChRs expressed in frog oocytes while only 30% inhibition currents in α4β2 expressed oocytes and no effect on α3β4, α3β2 and α4β4 nAChRs. The mechanisms of Thujone effect …
Development And Application Of Novel Conformation-Specific Monoclonal Antibodies For Parkinson’S Disease Pathology., Nour Khaled Majbour
Development And Application Of Novel Conformation-Specific Monoclonal Antibodies For Parkinson’S Disease Pathology., Nour Khaled Majbour
Accounting Dissertations
An abundance of genetic, biochemical and histopathological evidence suggests that the formartion of α-synuclein (α-syn) protein deposits is an important, and likely seminal, step in the development of several important neurodegenerative diseases, the so-called synucleinopathies, including Parkinson’s Disease (PD), intensive research, to date, the only accepted diagnosis for PD is based on clinical criteria. α-syn conversion from soluble monomers into oligomers or fibrils represents a crucial step in synucleinopathies pathogenesis; however, the exact mechanism underlying the cellular aggregation has not been fully elucidated. A growing body of evidence suggests that α-syn soluble oligomers, rather than mature fibrils, are the neurotoxic …
Ventricular Myocyte Contraction, Calcium Transport And Expression Of Genes Encoding Cardiac Muscle Proteins In Type 2 Diabetic Rats Fed A Sucrose-Enriched Diet, Eslam Mohamed Gaber El Nebrisi
Ventricular Myocyte Contraction, Calcium Transport And Expression Of Genes Encoding Cardiac Muscle Proteins In Type 2 Diabetic Rats Fed A Sucrose-Enriched Diet, Eslam Mohamed Gaber El Nebrisi
Theses
Diabetes Mellitus (DM) is currently the fastest growing disease in the world. The prevalence of DM has increased worldwide and is expected to double within 20 years. The UAE is ranked 15th worldwide, with 18.98% of the UAE population living with diabetes. Six Middle East North Africa (MENA) region countries – Bahrain, Egypt, Kuwait, Oman, Saudi Arabia, and United Arab Emirates (UAE) - are among the world’s 10 highest for prevalence of diabetes and impaired glucose tolerance. This represents a huge cost to society in terms of morbidity and mortality, and economically through lost productivity and cost burden on …