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Articles 1 - 3 of 3
Full-Text Articles in Medical Molecular Biology
Niche Cadherins Control The Quiescence-To-Activation Transition In Muscle Stem Cells., Aviva J. Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L. Radice, Robert S. Krauss
Niche Cadherins Control The Quiescence-To-Activation Transition In Muscle Stem Cells., Aviva J. Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L. Radice, Robert S. Krauss
Department of Medicine Faculty Papers
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool. These SCs have an incomplete disruption of the myofiber-SC adhesive junction and …
A Concise Review On The Current Understanding Of Pancreatic Cancer Stem Cells., Arokia P. Vaz, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
A Concise Review On The Current Understanding Of Pancreatic Cancer Stem Cells., Arokia P. Vaz, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Journal Articles: Biochemistry & Molecular Biology
No abstract provided.
Enhanced Pancreatic Beta-Cells Proliferation And Functionality, Hanan Abdulaziz Alismail
Enhanced Pancreatic Beta-Cells Proliferation And Functionality, Hanan Abdulaziz Alismail
Graduate Theses and Dissertations
Biologically functional beta-cells proliferate at an extremely low rate with limited turnover capacity. This cellular property hinders cell-based therapy for clinical applications. Many attempts have been made to develop techniques that allow large quantities of production of clinically relevant islet β-cells in vitro. A line of studies demonstrates that functional beta-cells can proliferate under certain circumstances, providing hope for generating and expanding these cells in vitro and transplanting them into the recipient. In this study, we showed that a membrane substrate offers a better niche for beta cell proliferation and insulin secretion. Mouse beta cells were grown on a tissue …