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Articles 1 - 6 of 6
Full-Text Articles in Medical Molecular Biology
Machine Learning Prediction Of Glioblastoma Patient One-Year Survival, Andrew Du '20, Warren Mcgee, Jane Y. Wu
Machine Learning Prediction Of Glioblastoma Patient One-Year Survival, Andrew Du '20, Warren Mcgee, Jane Y. Wu
Student Publications & Research
Glioblastoma (GBM) is a grade IV astrocytoma formed primarily from cancerous astrocytes and sustained by intense angiogenesis. GBM often causes non-specific symptoms, creating difficulty for diagnosis. This study aimed to utilize machine learning techniques to provide an accurate one-year survival prognosis for GBM patients using clinical and genomic data from the Chinese Glioma Genome Atlas. Logistic regression (LR), support vector machines (SVM), random forest (RF), and ensemble models were used to identify and select predictors for GBM survival and to classify patients into those with an overall survival (OS) of less than one year and one year or greater. With …
Cloning Of An Overexpression Vector For The Rare And Uncharacterized Kras Mutant R164l, Julliane Jeanne Negre
Cloning Of An Overexpression Vector For The Rare And Uncharacterized Kras Mutant R164l, Julliane Jeanne Negre
The International Student Science Fair 2018
Mutations in the coding DNA of KRAS, which encodes for an active protein in the Ras signaling pathway regulating cell proliferation and growth, may be critical in the development of lung and colorectal cancer in humans. Clinical tests and therapies for cancer specifically target mutations, some of which may cause erroneous prognosis and prescription of cancer therapy posing more danger for patients with unique mutations. Therefore, characterization of non-hotspot mutations is becoming more important, where, KRAS R164L is an existing uncharacterized mutation identified through the Catalogue of Somatic Mutations in Cancer (COSMIC). The project aimed to clone a pTarget overexpression …
A Humanized Hypertrophic Cardiomyopathy Model To Elucidate Molecular Mechanism In Disease Pathology, Ragavi Vijayakumar, Maxine Hong
A Humanized Hypertrophic Cardiomyopathy Model To Elucidate Molecular Mechanism In Disease Pathology, Ragavi Vijayakumar, Maxine Hong
The International Student Science Fair 2018
Hypertrophic cardiomyopathy (HCM), that clinically manifests as an enlarged heart is a highly prevalent cardiac disorder with propensity towards arrhythmia-induced sudden cardiac death. The mechanism of HCM remains poorly defined, necessitating further understanding of the disease for improved therapeutic strategies. As it is challenging to obtain cardiac biopsies from human subjects, using induced pluripotent stem cells technology, we generated cardiomyocytes (CMs) in a dish from HCM patients. These HCM-CMs presented the clinical manifestation in that they were significantly larger in size in comparison to control (healthy)-CMs. Furthermore, gene expression profiling of cardiac ion channels revealed increased transcripts encoding for calcium …
Cloning Of An Overexpression Vector For The Rare And Uncharacterized Kras Mutant R164l, Julliane Jeanne Negre
Cloning Of An Overexpression Vector For The Rare And Uncharacterized Kras Mutant R164l, Julliane Jeanne Negre
The International Student Science Fair 2018
Mutations in the coding DNA of KRAS, which encodes for an active protein in the Ras signaling pathway regulating cell proliferation and growth, may be critical in the development of lung and colorectal cancer in humans. Clinical tests and therapies for cancer specifically target mutations, some of which may cause erroneous prognosis and prescription of cancer therapy posing more danger for patients with unique mutations. Therefore, characterization of non-hotspot mutations is becoming more important, where, KRAS R164L is an existing uncharacterized mutation identified through the Catalogue of Somatic Mutations in Cancer (COSMIC). The project aimed to clone a pTarget overexpression …
A Humanized Hypertrophic Cardiomyopathy Model To Elucidate Molecular Mechanism In Disease Pathology, Ragavi Vijayakumar, Maxine Hong
A Humanized Hypertrophic Cardiomyopathy Model To Elucidate Molecular Mechanism In Disease Pathology, Ragavi Vijayakumar, Maxine Hong
The International Student Science Fair 2018
Hypertrophic cardiomyopathy (HCM), that clinically manifests as an enlarged heart is a highly prevalent cardiac disorder with propensity towards arrhythmia-induced sudden cardiac death. The mechanism of HCM remains poorly defined, necessitating further understanding of the disease for improved therapeutic strategies. As it is challenging to obtain cardiac biopsies from human subjects, using induced pluripotent stem cells technology, we generated cardiomyocytes (CMs) in a dish from HCM patients. These HCM-CMs presented the clinical manifestation in that they were significantly larger in size in comparison to control (healthy)-CMs. Furthermore, gene expression profiling of cardiac ion channels revealed increased transcripts encoding for calcium …
Early Events In Herpes Simplex Virus Lifecycle With Implications For An Infection Of Lifetime, Sarah Salameh '12, Urmi Sheth '12, Deepak Shukla
Early Events In Herpes Simplex Virus Lifecycle With Implications For An Infection Of Lifetime, Sarah Salameh '12, Urmi Sheth '12, Deepak Shukla
Student Publications & Research
Affecting a large percentage of human population herpes simplex virus (HSV) types -1 and -2 mainly cause oral, ocular, and genital diseases. Infection begins with viral entry into a host cell, which may be preceded by viral “surfing” along filopodia. Viral glycoproteins then bind to one or more of several cell surface receptors, such as herpesvirus entry mediator (HVEM), nectin-1, 3-O sulfated heparan sulfate (3-OS HS), paired immunoglobulin-like receptor, and non-muscle myosin-IIA. At least five viral envelope glycoproteins participate in entry and these include gB, gC, gD and gH-gL. Post-entry, these glycoproteins may also facilitate cell-to-cell spread of the virus, …