Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Microbiology (88)
- Medical Specialties (45)
- Oncology (20)
- Medical Genetics (19)
- Medical Cell Biology (12)
-
- Neurology (12)
- Diseases (6)
- Infectious Disease (5)
- Medical Biochemistry (4)
- Medical Neurobiology (4)
- Pathology (4)
- Life Sciences (3)
- Medical Molecular Biology (3)
- Medical Pathology (3)
- Biological Phenomena, Cell Phenomena, and Immunity (2)
- Chemicals and Drugs (2)
- Immune System Diseases (2)
- Medical Pharmacology (2)
- Organisms (2)
- Pharmacy and Pharmaceutical Sciences (2)
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Animal Sciences (1)
- Dermatology (1)
- Fungi (1)
- Genetics and Genomics (1)
- Hemic and Lymphatic Diseases (1)
- Keyword
-
- Humans (46)
- Animals (43)
- Mice (36)
- Thomas Jefferson University (34)
- Department of Microbiology and Immunology (18)
-
- Female (16)
- Antibodies (10)
- Inbred C57BL (10)
- Male (10)
- Mice, Inbred C57BL (10)
- COVID-19 (9)
- Kimmel Cancer Center (9)
- Receptors (8)
- T-Lymphocytes (8)
- Adult (7)
- Apoptosis (7)
- Cells (7)
- Cells, Cultured (7)
- Cultured (7)
- Department of Medical Oncology (7)
- Lymphocyte Activation (7)
- Phenotype (7)
- SARS-CoV-2 (7)
- Vaccines (7)
- Antigens (6)
- Article (6)
- CD8-Positive T-Lymphocytes (6)
- Immunotherapy (6)
- Macrophages (6)
- Signal Transduction (6)
- Publication Year
- Publication
-
- Department of Microbiology and Immunology Faculty Papers (110)
- Department of Medical Oncology Faculty Papers (17)
- Department of Neurology Faculty Papers (13)
- Department of Medicine Faculty Papers (10)
- Kimmel Cancer Center Faculty Papers (5)
-
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (4)
- Department of Biochemistry and Molecular Biology Faculty Papers (3)
- Department of Cancer Biology Faculty Papers (3)
- Summer Training Program in Cancer Immunotherapy (2)
- Center for Translational Medicine Faculty Papers (1)
- College of Life Sciences Faculty Papers (1)
- Computational Medicine Center Faculty Papers (1)
- Department of Dermatology and Cutaneous Biology Faculty Papers (1)
- Department of Pathology, Anatomy, and Cell Biology Posters (1)
- Department of Pediatrics Faculty Papers (1)
- Department of Pharmacology and Experimental Therapeutics Faculty Papers (1)
- Department of Rehabilitation Medicine Faculty Papers (1)
- Jefferson Institute of Molecular Medicine Papers and Presentations (1)
- Kimmel Cancer Center Papers, Presentations, and Grand Rounds (1)
- Phase 1 (1)
- Population Health Matters (Formerly Health Policy Newsletter) (1)
- Rothman Institute Papers (1)
- Student Papers, Posters & Projects (1)
- The Medicine Forum (1)
- Publication Type
Articles 181 - 182 of 182
Full-Text Articles in Medical Immunology
Signal Transducer And Activator Of Transcription (Stat)5 Activation By Bcr/Abl Is Dependent On Intact Src Homology (Sh)3 And Sh2 Domains Of Bcr/Abl And Is Required For Leukemogenesis., M Nieborowska-Skorska, M A Wasik, A Slupianek, P Salomoni, T Kitamura, B Calabretta, T Skorski
Signal Transducer And Activator Of Transcription (Stat)5 Activation By Bcr/Abl Is Dependent On Intact Src Homology (Sh)3 And Sh2 Domains Of Bcr/Abl And Is Required For Leukemogenesis., M Nieborowska-Skorska, M A Wasik, A Slupianek, P Salomoni, T Kitamura, B Calabretta, T Skorski
Department of Microbiology and Immunology Faculty Papers
Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain. Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 3 and/or serum and did not induce leukemia in severe combined …
Expression Of Constitutively Active Raf-1 In The Mitochondria Restores Antiapoptotic And Leukemogenic Potential Of A Transformation-Deficient Bcr/Abl Mutant., P Salomoni, M A Wasik, R F Riedel, K Reiss, J K Choi, T Skorski, B Calabretta
Expression Of Constitutively Active Raf-1 In The Mitochondria Restores Antiapoptotic And Leukemogenic Potential Of A Transformation-Deficient Bcr/Abl Mutant., P Salomoni, M A Wasik, R F Riedel, K Reiss, J K Choi, T Skorski, B Calabretta
Department of Microbiology and Immunology Faculty Papers
The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176-426 in the BCR domain (p185DeltaBCR) failed to protect interleukin 3-deprived 32Dcl3 myeloid precursor cells from apoptosis, although it possessed tyrosine kinase activity and was capable of activating the Ras-Raf-MAP kinase pathway. Compared to p185 wild-type transfectants, p185DeltaBCR-transfected cells showed markedly reduced levels of Bcl-2 and expressed the hypophosphorylated, proapoptotic form of BAD. Bcl-2 expression in the mitochondrial fraction of p185DeltaBCR cells was also markedly diminished and mitochondrial RAF was undetectable. In p185DeltaBCR …