Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (2)
- Anatomy (2)
- Biomedical Engineering and Bioengineering (2)
- Cardiovascular System (2)
- Chemicals and Drugs (2)
-
- Diseases (2)
- Engineering (2)
- Medical Specialties (2)
- Biological Engineering (1)
- Biomaterials (1)
- Biomedical (1)
- Biomedical Devices and Instrumentation (1)
- Cardiology (1)
- Cardiovascular Diseases (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Computer Engineering (1)
- Diagnosis (1)
- Electrical and Computer Engineering (1)
- Electrical and Electronics (1)
- Enzymes and Coenzymes (1)
- Equipment and Supplies (1)
- Genetic Phenomena (1)
- Hardware Systems (1)
- Hemic and Immune Systems (1)
- Hemic and Lymphatic Diseases (1)
- Hepatology (1)
- Institution
- Keyword
-
- AS1949490 (1)
- Acetylcholinesterase inhibition (1)
- Angiogenesis (1)
- Anti tumor immune mediated effects (1)
- Breast cancer (1)
-
- Cancer (1)
- Cancer Survivorship (1)
- Complication (1)
- Drug delivery (1)
- Endothelial Cell Biology (1)
- Goblet cells (1)
- Horseradish peroxidase (1)
- Hydrogel (1)
- Hydrogel ejector (1)
- Hydrogen peroxide (1)
- INPPL1 (1)
- Intestine (1)
- Intratumoral electroporation (1)
- Live cell entrapment (1)
- Liver model (1)
- Liver on a chip (1)
- Liver sinusoid (1)
- Long-term co-culture (1)
- Lymphangiogenesis (1)
- Lymphatic System (1)
- Lymphedema (1)
- MAPK/ERK (1)
- Malignant melanoma (1)
- MiRNAs (1)
- Microfluidic platform (1)
- Publication
- Publication Type
Articles 1 - 7 of 7
Full-Text Articles in Medical Biotechnology
Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy, Paloma Del C. Monroig
Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy, Paloma Del C. Monroig
Dissertations and Theses (Open Access)
The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule inhibitors represent an attractive approach to pursue this. However, the absence of molecular structures for most of the miRNAs makes it very difficult to predict which inhibitors can bind to them. Herein we designed a strategy to screen for small molecules by assesing whether they could directly bind/ interact with miR-10b/miR-21. As part of our …
Subclavian Vein Stenosis/Occlusion Following Transvenous Cardiac Pacemaker And Defibrillator Implantation: Incidence, Pathophysiology And Current Management, Brian O'Leary, Suhail Allaqaband
Subclavian Vein Stenosis/Occlusion Following Transvenous Cardiac Pacemaker And Defibrillator Implantation: Incidence, Pathophysiology And Current Management, Brian O'Leary, Suhail Allaqaband
Journal of Patient-Centered Research and Reviews
Subclavian vein stenosis is a common, but usually asymptomatic, complication following cardiac device placement. In addition to reviewing the literature on incidence, pathogenesis and management options for this important clinical problem, we describe two cases of symptomatic subclavian vein occlusion following pacemaker/defibrillator placement and successful treatment with venoplasty and stenting.
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Honors Scholar Theses
Hydrogels are useful in wound healing, drug delivery, and tissue engineering applications, but the available methods of injecting them quickly and noninvasively are limited. The medical industry does not yet have access to an all-purpose device that can quickly synthesize hydrogels of different shapes and sizes. Many synthesis procedures that have been developed result in the formation of amorphous hydrogels. While generally useful, amorphous hydrogels exhibit limited capability in tissue engineering applications, especially due to their viscous properties. This endeavor aims to modulate the appropriate gelation parameters, optimize the injection process, and create a prototype that allows for the extrusion …
Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector Of Lymphatic Dysfunction, Germaine D. Agollah
Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector Of Lymphatic Dysfunction, Germaine D. Agollah
Dissertations and Theses (Open Access)
The lymphatic system is essential for the transport of excess fluid, protein, and foreign materials from interstitial tissues to lymph nodes; for immune surveillance, and to maintain fluid homeostasis. Dysregulated lymphatics can be attributed to pathological conditions including tumor metastasis, inflammation, chronic wounds, obesity, blood vascular disorders, and lymphedema. Of these, lymphedema is the most extreme of lymphatic disorders and is represented by a spectrum of symptoms ranging from mild, subtle presentation to severe, disfiguring, overt presentation. Lymphedema is more manageable in the early stages of disease but severely reduces quality of life with progression. Due to lack of molecular …
Mechanisms Underlying Control Of Anti-Microbial Immunity By Acetylcholinesterase Inhibition, Ray M. Esam Al-Barazie
Mechanisms Underlying Control Of Anti-Microbial Immunity By Acetylcholinesterase Inhibition, Ray M. Esam Al-Barazie
Dissertations
Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tightly regulated through immunological and neural pathways. Previously, we demonstrated that cholinergic stimulation confers enhanced protection in experimental animals orally infected with a lethal dose of Salmonella typhymurium. In this study, we investigated the mechanism by which this enhanced protection takes place. We showed that cholinergic stimulation enhanced host survival following oral-route infection, which correlated with significantly reduced …
Liver Sinusoid On A Chip: Long-Term Layered Co-Culture Of Primary Rat Hepatocytes And Endothelial Cells In Microfluidic Platforms, Young Bok (Abraham) Kang, Temitope R. Sodunke, Jason Lamontagne, Joseph Cirillo, Caroline Rajiv, Michael J. Bouchard, Moses Noh
Liver Sinusoid On A Chip: Long-Term Layered Co-Culture Of Primary Rat Hepatocytes And Endothelial Cells In Microfluidic Platforms, Young Bok (Abraham) Kang, Temitope R. Sodunke, Jason Lamontagne, Joseph Cirillo, Caroline Rajiv, Michael J. Bouchard, Moses Noh
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
We describe the generation of microfluidic platforms for the co-culture of primary hepatocytes and endothelial cells; these platforms mimic the architecture of a liver sinusoid. This paper describes a progressional study of creating such a liver sinusoid on a chip system. Primary rat hepatocytes (PRHs) were co-cultured with primary or established endothelial cells in layers in single and dual microchannel configurations with or without continuous perfusion. Cell viability and maintenance of hepatocyte functions were monitored and compared for diverse experimental conditions. When primary rat hepatocytes were co-cultured with immortalized bovine aortic endothelial cells (BAECs) in a dual microchannel with continuous …
Long-Term Overall Survival From A Phase 1 Trial Using Intratumoral Plasmid Interleukin-12 With Electroporation In Patients With Melanoma, Adil Daud, Kathryn T. Takamura, Tu Diep, Richard Heller, Robert H. Pierce
Long-Term Overall Survival From A Phase 1 Trial Using Intratumoral Plasmid Interleukin-12 With Electroporation In Patients With Melanoma, Adil Daud, Kathryn T. Takamura, Tu Diep, Richard Heller, Robert H. Pierce
Bioelectrics Publications
No abstract provided.