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- Keyword
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- Actin dynamics; Gelsolin function; Macromolecular crowding; TIRF microscopy; Cytoskeletal regulation (1)
- Calorie restriction; MiR-34a; Lipid metabolism; Ames dwarf mice; Nonalcoholic fatty liver disease (1)
- DNA profiling; Single sperm analysis; Forensic techniques; Sperm cell recovery; Sexual assault evidence (1)
- Nanocomposite; Antimicrobial; Synthesis; Characterization; Bioavailability (1)
Articles 1 - 4 of 4
Full-Text Articles in Medical Biotechnology
Downregulation Of Mir-34a Via Calorie Restriction Regulates Lipid Metabolism In The Liver Of Long-Living Ames Dwarf Mice, Sarah Ashiqueali
Downregulation Of Mir-34a Via Calorie Restriction Regulates Lipid Metabolism In The Liver Of Long-Living Ames Dwarf Mice, Sarah Ashiqueali
Electronic Theses and Dissertations, 2020-2023
Ames dwarf mice (df/df) display delayed aging relative to their normal siblings, living approximately 40-60% longer. As such, investigating the mechanisms that enable these organisms to have superior life expectancies may prove useful in developing therapies to slow aging and deter age-related disease. Nonalcoholic fatty liver disease (NAFLD) is a condition that is characterized by the accumulation of excess adipose tissue in the liver. Interestingly, its prevalence tends to increase with age with an incidence rate of greater than 40% in individuals over the age of 60. Previous studies highlight the potential of calorie restriction (CR) in promoting longevity, but …
Gelsolin-Mediated Actin Filament Severing In Crowded Environments, James Heidings
Gelsolin-Mediated Actin Filament Severing In Crowded Environments, James Heidings
Electronic Theses and Dissertations, 2020-2023
Actin is an essential cytoskeletal protein that plays key roles in several cellular functions such as phagocytosis and cell motility with the help of actin binding proteins (ABPs). Gelsolin is a calcium regulated ABP that severs and caps actin filaments. Gelsolin helps control actin filament assembly dynamics that are required for cell survival. Cleavage products of gelsolin lead to Familial Amyloidosis, Finnish type, and conformational changes to gelsolin are implicated in disease progression. The majority of in vitro studies of gelsolin and actin have been performed in dilute buffer conditions which do not simulate the molecular interactions occurring in the …
Single Cell Forensic Genomics - Dna Profiling Of Micromanipulated Single Spermatozoa, Haley Hardin
Single Cell Forensic Genomics - Dna Profiling Of Micromanipulated Single Spermatozoa, Haley Hardin
Electronic Theses and Dissertations, 2020-2023
Current U.S. National guidelines allow for the collection of sexual assault evidence up to 5 days after the incidence occurs. In these cases, the ability to obtain an autosomal STR (aSTR) profile of the male donor in these cases diminishes as the time interval increases. This inability to recover an aSTR profile from the semen donor is not due to a complete lack of sperm cells, as studies have frequently shown that sperm persists in the vaginal canal or cervix up to 10 days post coitus. Thus, the inability to recover an aSTR profile of the sperm donor is likely …
Copper/N-Acetylcysteine Coated Iron Oxide Nanoparticles Synthesis, Characterization, And Antimicrobial Activities, Danya Belnour
Copper/N-Acetylcysteine Coated Iron Oxide Nanoparticles Synthesis, Characterization, And Antimicrobial Activities, Danya Belnour
Electronic Theses and Dissertations, 2020-2023
In recent years, there is a growing interest in developing metal based antimicrobial nanomaterials suitable for agricultural and biomedical applications. For centuries, Copper (Cu) biocide has been used for protecting a wide variety of crops from devastating bacterial and fungal diseases. However, prolonged and aggressive use of Cu led to the development of resistance and accumulation in soil. The latter has been linked to aquatic toxicity due to soil Cu leaching. Furthermore, copper build up in soil causes phytotoxicity and reduces uptake of micronutrient Zn through the root system. In biomedical field, Cu has been historically used as an antimicrobial …