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Full-Text Articles in Medical Biotechnology

The Single Mitochondrion Of The Kinetoplastid Parasite Crithidia Fasciculata Is A Dynamic Network., John Dimaio, Gordon Ruthel, Joshua J. Cannon, Madeline F. Malfara, Megan L. Povelones Dec 2018

The Single Mitochondrion Of The Kinetoplastid Parasite Crithidia Fasciculata Is A Dynamic Network., John Dimaio, Gordon Ruthel, Joshua J. Cannon, Madeline F. Malfara, Megan L. Povelones

Department of Medical Laboratory Sciences & Biotechnology Faculty Papers

Mitochondria are central organelles in cellular metabolism. Their structure is highly dynamic, allowing them to adapt to different energy requirements, to be partitioned during cell division, and to maintain functionality. Mitochondrial dynamics, including membrane fusion and fission reactions, are well studied in yeast and mammals but it is not known if these processes are conserved throughout eukaryotic evolution. Kinetoplastid parasites are some of the earliest-diverging eukaryotes to retain a mitochondrion. Each cell has only a single mitochondrial organelle, making them an interesting model for the role of dynamics in controlling mitochondrial architecture. We have investigated the mitochondrial division cycle in …


A Plausible Mechanism, Based Upon Short-Root Movement, For Regulating The Number Of Cortex Cell Layers In Roots., Shuang Wu, Chin-Mei Lee, Tomomi Hayashi, Simara Price, Fanchon Divol, Sophia Henry, Germain Pauluzzi, Christophe Perin, Kimberly L Gallagher Nov 2014

A Plausible Mechanism, Based Upon Short-Root Movement, For Regulating The Number Of Cortex Cell Layers In Roots., Shuang Wu, Chin-Mei Lee, Tomomi Hayashi, Simara Price, Fanchon Divol, Sophia Henry, Germain Pauluzzi, Christophe Perin, Kimberly L Gallagher

Department of Medical Laboratory Sciences & Biotechnology Faculty Papers

Formation of specialized cells and tissues at defined times and in specific positions is essential for the development of multicellular organisms. Often this developmental precision is achieved through intercellular signaling networks, which establish patterns of differential gene expression and ultimately the specification of distinct cell fates. Here we address the question of how the SHORT-ROOT (SHR) proteins from Arabidopsis thaliana (AtSHR), Brachypodium distachyon (BdSHR), and Oryza sativa (OsSHR1 and OsSHR2) function in patterning the root ground tissue. We find that all of the SHR proteins function as mobile signals in A. thaliana and all of the SHR homologs physically interact …