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Full-Text Articles in Medical Biophysics
A Nano-Scale Approach To Controlled Apoptosis In Brain Cancer Through Magneto-Mechanical Actuation, Sakura Rieck
A Nano-Scale Approach To Controlled Apoptosis In Brain Cancer Through Magneto-Mechanical Actuation, Sakura Rieck
Biological Sciences Undergraduate Honors Theses
In this study, we investigate the effects of cell therapy and magneto-mechanical actuation (MMA) to treat glioblastoma (U87). MMA approach employs super low-frequency alternating magnetic fields (AMF) to actuate intracellular PEGylated superparamagnetic iron oxide nanoparticles (PEG-SPIONs). Magnetic forces are translated into mechanical agitation on PEG-SPIONs, which can disrupt key cellular components. We explored two ways in which the MMA approach can be used to combat cancer growth. First, we investigated MMA directly in U87 cells. Preliminary observations indicate that PEG-SPIONs are intracellularly taken up by the U87 cells via micropinocytosis. Cell-counting kit-8 toxicity assays revealed a cytotoxic effect of MMA …