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Articles 1 - 4 of 4
Full-Text Articles in Medical Biophysics
A Nano-Scale Approach To Controlled Apoptosis In Brain Cancer Through Magneto-Mechanical Actuation, Sakura Rieck
A Nano-Scale Approach To Controlled Apoptosis In Brain Cancer Through Magneto-Mechanical Actuation, Sakura Rieck
Biological Sciences Undergraduate Honors Theses
In this study, we investigate the effects of cell therapy and magneto-mechanical actuation (MMA) to treat glioblastoma (U87). MMA approach employs super low-frequency alternating magnetic fields (AMF) to actuate intracellular PEGylated superparamagnetic iron oxide nanoparticles (PEG-SPIONs). Magnetic forces are translated into mechanical agitation on PEG-SPIONs, which can disrupt key cellular components. We explored two ways in which the MMA approach can be used to combat cancer growth. First, we investigated MMA directly in U87 cells. Preliminary observations indicate that PEG-SPIONs are intracellularly taken up by the U87 cells via micropinocytosis. Cell-counting kit-8 toxicity assays revealed a cytotoxic effect of MMA …
Quantitative Study Of The Antimicrobial Effects Of Silver On The Motility Of Escherichia Coli, Benjamin Russell
Quantitative Study Of The Antimicrobial Effects Of Silver On The Motility Of Escherichia Coli, Benjamin Russell
Graduate Theses and Dissertations
In recent decades, the number of antibiotic-resistant bacterial infections has grown to become a serious global threat. This rise can be attributed to the widespread misuse of antibiotics and the lack of newly developed drugs to fight resistant organisms. Novel bactericidal substances have, therefore, garnered significant research interest. Silver, due to its powerful antimicrobial effects, is one such substance. Silver is typically most effective in cationic form; however, advancements in nanotechnology have paved the way for the controlled fabrication of nano-silver. Silver nanoparticles have been shown to have increased antibacterial potency for a variety of reasons, including the release of …
Behavior Coding Strategies: Population Coupling And The Functional Role Of Excitatory/Inhibitory Balance In Primary Motor Cortex, Patrick Aaron Kells
Behavior Coding Strategies: Population Coupling And The Functional Role Of Excitatory/Inhibitory Balance In Primary Motor Cortex, Patrick Aaron Kells
Graduate Theses and Dissertations
The complexities of an organism’s experience of- and interaction with the world are emergent phenomena produced by large populations of neurons within the cerebral cortex and other brain regions. The network dynamics of these populations have been shown to be sometimes synchronous, with many neurons firing together, and sometimes asynchronous, with neurons firing more independently, leading to a decades-old debate within the neuroscience community. This discrepancy comes from viewing the system at two different scales; at the single cell level, the spiking activity of two neurons within cortex tend to be rather independent, but when the average activity of a …
Measuring Pain Withdrawal Threshold Using A Novel Device In "Pseudo-Continuous" Mode, A. H. Walker, S. Thurman, N. Martinez, S. Burns, M. Dobretsov
Measuring Pain Withdrawal Threshold Using A Novel Device In "Pseudo-Continuous" Mode, A. H. Walker, S. Thurman, N. Martinez, S. Burns, M. Dobretsov
Journal of the Arkansas Academy of Science
The study of pain and analgesia is an important area of biomedical research that has led to a significant number of advances in the treatment of acute and chronic pain. This study introduces a novel approach to mechanical testing of pain withdrawal of a rat hind paw to a stimulus. This systematic method involves a modified electronic esthesiometer controlled by an IDEA drive that allows for consistency in experiments. The device gives the experimenter computer control of the step size and velocity of approach of the probe stimulus. We discuss here some of the limitations in the current techniques used …