Medical Biophysics Commons^™

Injury Prevention Programs: Factors That Effect If A Coach Uses Injury Prevention Programs, A Deguzman, Jc Martinez

Clinical Practice in Athletic Training

Context: The purpose of this study was to determine how coaches view injury prevention programs (IPP) and how this affects their decision to implement an IPP with their team. The more information gained on a coach’s influence to implement an injury prevention program for their team, the more athletic trainers can understand and educate on the importance of injury prevention programs. Methods: Design: Cross-sectional Setting: Web-based survey Target Population: Youth Sport Coaches Dependent Variable: Coaches beliefs on IPPs Independent Variable: Willingness to implement an IPP. Youth sport coaches were surveyed on their attitudes and beliefs about injury prevention programs. All …

Interdisciplinary Approach To Management Of An L4/L5 Disc Herniation In A Collegiate Football Player: A Type 3 Case Study, Cc Janush, A Meriwether, M Tillman

Clinical Practice in Athletic Training

Background: The rate for low back injuries in collegiate football players has been reported as 2.70 per 10,000 athlete exposures with lumbar disc herniations (LDH) accounting for roughly 8% of these injuries. In athletic populations, the decision of surgical versus conservative management for LDH can present a unique challenge to the clinician and patient given an patient’s concern for return to play with minimal time loss. This type 3 CASE study will discuss the non-operative management of an L4/L5 disc herniation in a collegiate football player and highlight the interdisciplinary team approach that allowed the athlete to play an entire …

Measuring Psychological Readiness With The Shoulder Instability-Return To Sport After Injury Scale In Athletes With Traumatic Shoulder Dislocations: A Critically Appraised Topic, Ha Arnett, K Moore, Zk Winkelmann, H Miller

Clinical Practice in Athletic Training

Focused Clinical Question: How can using the Shoulder Return to Sport after Injury (SI-RSI) scale to measure mental readiness in athletes after a shoulder injury improve return-to-play protocol? Data Sources: In September 2023, a computerized search of PubMed for evidence was completed. The search terms were fear of reinjury or psychological readiness, kinesiophobia, confidence, and return to play or return to sport, or RTP. The search was limited to studies published between 2018 and 2023. Study Selection: The inclusion criteria consisted of studies that used the SI-RSI to measure fear during return to play and shoulder injuries that required surgery. …

Mole Or Melanoma: Knowing Your Abcde’S May Save Your Life!, Jh Knaul

Clinical Practice in Athletic Training

Background: Skin cancer is the most common type of cancer in the United States. One in five Americans will be diagnosed with skin cancer in their lifetime, or about 9500/day. Research indicates that nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), affects more than 3 million Americans a year. More than 1 million Americans are living with Melanoma, nearly 200,000 cases of melanoma were diagnosed in 2022 with about 98,000 being invasive and 100,000 being non-invasive (in situ). The average age of diagnosis is 65. Melanoma rates in the US have been rising rapidly …

Myositis Ossificans In A Female Sprinter With The Sickle Cell Trait, Rl Quintana, M Menjivar

Clinical Practice in Athletic Training

Background: Sickle cell trait (SCT) is associated with an increase in muscle breakdown after strenuous exercise due to improper blood flow to active muscles. Evidence suggests that individuals with SCT can increase muscle breakdown during exercise by as much as 54%. This case outlines a 21-year-old African collegiate sprinter with SCT who reported feeling a “pop” in her right hamstring that caused her to stop running mid-race. She reported that no pain was associated with the “pop” but was scared by the sensation. Evaluations of strength and range of motion were all unremarkable and there were no palpable deformities. She …

Non-Operative Management Of Distal And Proximal Interphalangeal Fractures Without Excessive Sport Removal, Og Newhouse, J Johnson

Clinical Practice in Athletic Training

Background: Intra-articular fracturs of the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints occur primarily from impacted shear force. With continued participation, fractures have a high possibility of nonunion or malunion. While accounting for patients’ requests may not always be possible, extreme modification of activity may permit their requests. Patient: The patient is a college-aged female volleyball athlete who plays in the front row. The initial report showed a fracture of the right fifth phalange from incomplete range of motion (ROM), swelling, and bruising after an impacted shear force was placed on her finger from a block. She was referred …

Orientation Using Standardized Patients Increases Athletic Training Student Communication Effectiveness When Transitioning To Clinical Education Experiences, Jl Frye, Ma Belbey, Kj Armstrong

Clinical Practice in Athletic Training

Context: Transitioning from didactic to clinical education is overwhelming for novice athletic training students. The change in the learning environment often causes anxiousness as students get acquainted with the clinical site, preceptor expectations, and demonstrating clinical skills during patient care. Learning to communicate provides additional challenges as students must convey information to their patients, practice active listening, relay patient information to their preceptor, and possibly navigate conflict management. Simulation-based orientations have been effective in other healthcare professions to ease this transition; however, it has not been examined in professional athletic training students. Methods: The study used a convenience sample of …

Platelet-Rich-Plasma Injections Vs. Corticosteroid Injections In The Reduction Of Pain For Patients With Frozen Shoulder: A Critically Appraised Topic, Al Pendleton, Mr Dombrowski, Rj Bonser, Jg Coots

Clinical Practice in Athletic Training

Focused Clinical Question: Is a platelet-rich plasma or a corticosteroid injection better for relieving pain for patients with frozen shoulder pathologies? Data Sources: To identify relevant research papers, Boolean searches were conducted on Google Scholar, CINAHL Ultimate, MEDLINE Ultimate, and SPORTDiscus databases from September 14th through September 25th, 2023. Key terms used were corticosteroid (CS) injection, platelet-rich-plasma (PRP) injection, frozen shoulder, and adhesive capsulitis. Study Selection: The inclusion criteria were: articles published from 2018-2023, Randomized Control Trials comparing PRP and CS injections, and studies that used visual analog scale (VAS). Additionally, each article selected summarized outcome measures in a table. …

Presentation Of Bilateral Acetabular Labral Tears In A Collegiate Women’S Lacrosse Player: A Level 3 Clinical Case Study, W Giannelli, K Herraiz, A Mercer

Clinical Practice in Athletic Training

Background: The hip and groin injury rate in female collegiate lacrosse players has been reported to be 35.06 per 100,000 athlete exposures yet the frequency of acetabular labral tears (ATL) remains unclear. Sports which involve repeated bouts of running in combination with frequent twisting and pivoting motions, have been suggested to have a higher prevalence rate of ALT. This level 3 case study will discuss the unique presentation of bilateral ALTs in a female collegiate lacrosse player. Patient: Patient is a 19-year-old Division I collegiate women’s lacrosse player who first presented with pain in her left hip while at home …

Reliability And Validity Of The Iphone To Measure Hip Internal And External Rotation, Jl Blatz, Nm Cattano

Clinical Practice in Athletic Training

Context: Clinicians use a traditional goniometer or a quick visual estimate to measure range of motion (ROM) in patients, these methods can be time consuming or inaccurate. The purpose of this study is to assess the reliability and validity of the iPhone Measure app to measure hip internal rotation (IR) and external rotation (ER). Methods: 20 participants were recruited; they were physically active and aged 18-28 years old. Hip IR and ER was measured prone with the subject on a table. The measures were taken three times and bilaterally for each, then recorded. The ROM was measured by 2 student …

Single Limb Postural Control Throughout A Collegiate Football Season, L Custer, S Tomasi, J Lima, A Rieland

Clinical Practice in Athletic Training

Context: It is estimated that college football players sustain an average of 3 subconcussive blows to the head per game. Limited research has demonstrated that collegiate football players present with decreased static postural control, as measured using the Balance Error Scoring System, at the end of season compared to baseline. Interestingly, neurocognitive test scores in collegiate football players were not found to differ preseason, midseason and postseason. Authors hypothesized that using neurocognitive tests may not have been sensitive enough to detect the effects of the subconcussive impacts. Force plate data provides valid information of postural control. The purpose of this …

Specific Barriers To Athletic Trainers’ Familiarity With And Attitudes Toward Concussion Biomarkers: A Phenomenological Qualitative Study, Te Mccormick, Jm Allen, Kgs Swindell, Tr Campbell

Clinical Practice in Athletic Training

Context: The diagnosis of concussions is largely reliant on subjective information in conjunction with objective measures that might not be the most valid and/or reliable. There is now new research being performed evaluating the use of biological indicators, or biomarkers in the diagnosis and management of concussion. However, the amount of knowledge about biomarkers among athletic trainers is unknown. Additionally, the barriers preventing ATs from using such biomarkers has yet to be studied. Therefore, the purpose of this study is to examine athletic trainers’ familiarity with and their attitude towards concussion biomarkers, while evaluating specific barriers preventing their use in …

The Analysis Of Ground Kinematics In Tie-Down Ropers, M Watts, A Chelette, J Sandford, K Mata

Clinical Practice in Athletic Training

Context: Tie-down roping, an event in rodeo, occurs when the athlete ropes a calf while on horseback, quickly dismounts from the horse and ties three legs of the calf together. Injuries to the knee and lower body have occurred with athletes in the tie-down roping event. Previous research with college rodeo athletes has shown the knee to be the most frequently injured area of the body. The athlete’s lower body movements during the dismount from the horse may increase the risk of injury to the knee. However, these movements have not been previously studied in the tie-down roping event. The …

The Food Environment Of Female Athletes Attending Historically Black Colleges And Universities: A Qualitative Study On The Dimensions Of Food Access And Nutrition, Na Uriegas, Zk Winkelmann, Dm Emerson

Clinical Practice in Athletic Training

Context: Student-athletes are a subset of college students who face additional stressors related to the demands of their sport and academic workload. The food choices of student-athletes may be influenced by the unique food environment they are in. Further challenges may present for Historically Black Colleges and Universities (HBCUs) student-athletes as their institutions tend to be in low food access areas. We aimed to assess food security and explore the lived experiences of HBCU female student-athletes surrounding their food environment and ability to access food based on the five dimensions of food access: availability, accessibility, affordability, accommodation, and acceptability. Methods: …

Use Of An External Dynamic Arm Stabilizer In A Collegiate Baseball Player With Valgus Extension Overload: A Case Report., Jp Goza, Ap Jacobsen

Clinical Practice in Athletic Training

Background: A 21-year-old, male, collegiate baseball player reported to the athletic training staff complaining of pain along the posteromedial aspect of the right elbow. The patient reported a previous history of a grade I ulnar collateral ligament sprain that had been rehabilitated until he was able to return to full pain free activities. The patient could not recall a specific mechanism of injury. Physical examination revealed a loss of terminal elbow extension, and pain along the posteromedial aspect of the elbow. The patient reported no neurological symptoms during or after throwing. Valgus Stress, Milking, and Posterolateral Rotary Drawer tests were …

Weighted Ball Programs And Medial Elbow Injury In Youth Baseball Pitchers, M Sobolewski, K Pritchard

Clinical Practice in Athletic Training

Introduction: Weighted ball programs have been proven to increase pitching velocity, however a combination of poor musculature and body mechanics with increased elbow valgus can heighten the incidence of medial elbow overuse injuries in the youth population. Clinical Question: Can youth baseball pitchers who use weighted ball programs increase their pitching velocity without causing an increased risk of medial elbow injury? Methods: The literature was explored to discover studies that investigated medial elbow injuries using weighted ball programs in youth baseball pitchers. Articles included weighted ball programs as an intervention, kinetics/injury mechanics, youth elbow injuries, and prevention of overuse injuries. …

Identification Of Immune-Associated Biomarkers Of Diabetes Nephropathy Tubulointerstitial Injury Based On Machine Learning: A Bioinformatics Multi-Chip Integrated Analysis, Lin Wang, Jiaming Su, Zhongjie Liu, Shaowei Ding, Yaotan Li, Baoluo Hou, Yuxin Hu, Zhaoxi Dong, Jingyi Tang, Hongfang Liu, Weijing Liu

Faculty, Staff and Student Publications

BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irreversible end-stage renal disease progression due to the inability to diagnose the disease early. Therefore, reliable biomarkers that are helpful for early diagnosis and treatment are identified. The migration of immune cells to the kidney is considered to be a key step in the progression of DN-related vascular injury. Therefore, finding markers in this process may be more helpful for the early diagnosis and progression prediction of DN.

METHODS: The …

Evaluation Of An End-To-End Radiotherapy Treatment Planning Pipeline For Prostate Cancer, Mohammad Daniel El Basha, Court Laurence, Carlos Eduardo Cardenas, Julianne Pollard-Larkin, Steven Frank, David T. Fuentes, Falk Poenisch, Zhiqian H. Yu

Dissertations and Theses (Open Access)

Radiation treatment planning is a crucial and time-intensive process in radiation therapy. This planning involves carefully designing a treatment regimen tailored to a patient’s specific condition, including the type, location, and size of the tumor with reference to surrounding healthy tissues. For prostate cancer, this tumor may be either local, locally advanced with extracapsular involvement, or extend into the pelvic lymph node chain. Automating essential parts of this process would allow for the rapid development of effective treatment plans and better plan optimization to enhance tumor control for better outcomes.

The first objective of this work, to automate the treatment …

Methods For The Prediction Of Osteoradionecrosis Resulting From Head And Neck Cancer Radiation Therapy, Brandon Reber

Dissertations and Theses (Open Access)

Head and neck cancer (HNC) is the sixth most diagnosed cancer worldwide with over 600,000 patients diagnosed every year. One of the primary methods to treat HNC is through radiation therapy (RT). While RT is effective at treating HNC, late toxicities resulting from treatment can occur months to years post-treatment and can cause debilitating quality of life changes for HNC survivors. One of these late toxicities is osteoradionecrosis (ORN), which is the death of bone due to radiation. For HNC, the mandible is commonly affected and can cause challenges chewing, swallowing, and physical appearance changes. Several factors indicate the pressing …

Inter-Individual Variations In Circadian Misalignment-Induced Nafld Pathophysiology In Mice, Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, Akira Sugimoto, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita

Faculty, Staff and Student Publications

Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL). We observed that CJL markedly increased the prevalence of hepatic steatosis with pronounced inter-individual differences. Stratification of individual mice based on CJL-induced hepatic transcriptomic signature, validated by histopathological analysis, pinpoints dysregulation of lipid metabolism. Moreover, the period and power of …

The Development Of Artificial Intelligence-Based To Ols For Expert Peer Review Of Radiotherapy Treatment Plans, Mary Gronberg

Dissertations and Theses (Open Access)

Creating a patient-specific radiation treatment plan is a time-consuming and operator-dependent manual process. The treatment planner adjusts the planning parameters in a trial-and-error fashion in an effort to balance the competing clinical objectives of tumor coverage and normal tissue sparing. Often, a plan is selected because it meets basic organ at risk dose thresholds for severe toxicity; however, it is evident that a plan with a decreased risk of normal tissue complication probability could be achieved. This discrepancy between “acceptable” and “best possible” plan is magnified if either the physician or treatment planner lacks focal expertise in the disease site. …

Machine Learning For Ecg Diagnosis And Risk Stratification Of Occlusion Myocardial Infarction, Salah S Al-Zaiti, Christian Martin-Gill, Jessica K Zègre-Hemsey, Zeineb Bouzid, Ziad Faramand, Mohammad O Alrawashdeh, Richard E Gregg, Stephanie Helman, Nathan T Riek, Karina Kraevsky-Phillips, Gilles Clermont, Murat Akcakaya, Susan M Sereika, Peter Van Dam, Stephen W Smith, Yochai Birnbaum, Samir Saba, Ervin Sejdic, Clifton W Callaway

Faculty, Staff and Students Publications

Patients with occlusion myocardial infarction (OMI) and no ST-elevation on presenting electrocardiogram (ECG) are increasing in numbers. These patients have a poor prognosis and would benefit from immediate reperfusion therapy, but, currently, there are no accurate tools to identify them during initial triage. Here we report, to our knowledge, the first observational cohort study to develop machine learning models for the ECG diagnosis of OMI. Using 7,313 consecutive patients from multiple clinical sites, we derived and externally validated an intelligent model that outperformed practicing clinicians and other widely used commercial interpretation systems, substantially boosting both precision and sensitivity. Our derived …

The Role Of Native Cysteine Residues In The Oligomerization Of Kcnq1 Channels, Alison Bates, Rebecca B Stowe, Elizabeth M Travis, Lauryn E Cook, Carole Dabney-Smith, Gary A Lorigan

Faculty, Staff and Student Publications

KCNQ1, the major component of the slow-delayed rectifier potassium channel, is responsible for repolarization of cardiac action potential. Mutations in this channel can lead to a variety of diseases, most notably long QT syndrome. It is currently unknown how many of these mutations change channel function and structure on a molecular level. Since tetramerization is key to proper function and structure of the channel, it is likely that mutations modify the stability of KCNQ1 oligomers. Presently, the C-terminal domain of KCNQ1 has been noted as the driving force for oligomer formation. However, truncated versions of this protein lacking the C-terminal …

Automating The Radiation Therapy Treatment Planning Process For Pediatric Patients With Medulloblastoma, Soleil Hernandez

Dissertations and Theses (Open Access)

Over the past 50 years, pediatric cancer 5-year survival rates increased from 20% to 80% in high-income countries, however, these trends have not been mirrored in low-and-middle-income countries (LMICs). This is due in part to delayed diagnosis, higher rates of advanced disease at presentation and a growing lack of access to high quality medical personnel and technology necessary to deliver complex treatments.

The long-term goal of this study was to alleviate demanding workflows and increase global access to high-quality pediatric radiation therapy by harnessing the power of artificial intelligence to automate the radiation therapy treatment planning process for pediatric patients …

Sexual Dimorphism Of Glomerular Capillary Morphology In Rats, Zackarias Coker

Undergraduate Honors Theses

Chronic kidney disease (CKD) progresses faster in males than females; however, the underlying mechanisms remain poorly understood. Sex differences in glomerular capillary morphology has been hypothesized to contribute, in part, to the increased susceptibility to hypertension-induced renal injury and CKD progression in males, but this has not been investigated. The goal of the present study was to assess glomerular capillary morphology in male vs. female rats with intact kidneys and after uninephrectomy (UNX). We hypothesized that glomerular capillary radii (R_CAP) and length (L_CAP) would be greater in male rats.

Male (n=4) and female (n=4) with intact …

Mechanosensitive Membrane Proteins: Usual And Unusual Suspects In Mediating Mechanotransduction, Miriam B Goodman, Elizabeth S Haswell, Valeria Vásquez

Faculty, Staff and Student Publications

This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. Though researchers' attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of …

Contribution Of Metabolic Cell Swelling On Microcirculatory Perfusion In Septic Shock, Charles E. Payne

Theses and Dissertations

Sepsis, a systemic immunological response that leads to organ-dysfunction, the development of septic shock, and death has mortality rate of 15-25%. A subset of sepsis, septic shock, has an in-hospital mortality rate of 30-50%. Sepsis and its treatment are the most expensive healthcare problem in the United States with the US Agency for Healthcare Research and Quality estimating annual costs over $20 billion. Hypoxia experienced in septic shock induces metabolic cell and tissue swelling leading to further microcirculatory dysfunction and poor tissue perfusion. Reversing metabolic cell swelling corrects these perfusion defects. Two models were used in rats to induce septic …

Characterization And Investigation Of Cold Atmospheric Plasma And Its Effects On Cancer Cell Biology, Thomas M. Ritrosky

Theses and Dissertations

Modern cancer treatment uses radiation therapy in over 50% of patient cases. It is an e↵ective way of treating tumors because the mechanisms of cell killing are well known through the damage that ionizing radiation does to DNA. The amount of radiation can be tracked through measuring the dose of the clinical photon or electron beam used. However, there are limitations in the usage of radiation therapy, for example, a tumor can create hypoxic areas that become radioresistant leading to complete ine↵ectiveness of further radiation treatment. This project looks into the application of cold atmospheric plasma as an adjuvant therapy …

A Learning Health System For Radiation Oncology, Rishabh Kapoor

Theses and Dissertations

The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes.

The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes …

Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol In A Cardiolipin-Lacking Yeast Respiratory Supercomplex, Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

Faculty, Staff and Student Publications

Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K+ from Na+ without the conventional K+ selectivity filter found in classical K+ channels. The genome of H. catenoides also encodes a third paralog that is more permeable for Na+ than for K+. To identify structural motifs responsible for the unusual K+ selectivity of KCRs, we systematically analyzed a series of chimeras and mutants of this protein. We found that mutations of three critical residues in the …