Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Chemicals and Drugs (4)
- Medical Specialties (4)
- Public Health (3)
- Biochemical Phenomena, Metabolism, and Nutrition (2)
- Diseases (2)
-
- Enzymes and Coenzymes (2)
- Optometry (2)
- Pharmacy and Pharmaceutical Sciences (2)
- Alternative and Complementary Medicine (1)
- Amino Acids, Peptides, and Proteins (1)
- Anatomy (1)
- Behavior and Behavior Mechanisms (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Chemical and Pharmacologic Phenomena (1)
- Chemistry (1)
- Circulatory and Respiratory Physiology (1)
- Cognitive Neuroscience (1)
- Community Health and Preventive Medicine (1)
- Digestive, Oral, and Skin Physiology (1)
- Endocrinology, Diabetes, and Metabolism (1)
- Gastroenterology (1)
- Life Sciences (1)
- Medical Anatomy (1)
- Keyword
-
- 2-AG (1)
- AEA (1)
- Age related macular degeneration (1)
- Alcohol consumption (1)
- Alcohol metabolism and toxic byproducts (1)
-
- Alzheimer's (1)
- Amyloid Beta (1)
- Aneurysm (1)
- Antioxidants (1)
- Atherosclerosis (1)
- Blue light (1)
- Blue light lenses (1)
- Calcium (1)
- Cardiomyopathy (1)
- Cardiovascular (1)
- Cell Signaling (1)
- Cell Signalling (1)
- Circadian rhythm (1)
- Curcumin (1)
- Dementia (1)
- Drug exposure (1)
- Dual Enzyme Inhibitor (1)
- Endocannabinoid System (1)
- FAAH (1)
- Glucocorticoid signaling (1)
- Glutamate (1)
- Gut dysbiosis (1)
- Gut microbiota (1)
- Influences on drinking (1)
- Insulin resistance (1)
Articles 1 - 7 of 7
Full-Text Articles in Medical Biochemistry
Titanium Dioxide: An Inquiry Into The Mechanisms And Implications Of Exposure In Gut Dysbiosis And Metabolic Disorders, Meghan Gardiner
Titanium Dioxide: An Inquiry Into The Mechanisms And Implications Of Exposure In Gut Dysbiosis And Metabolic Disorders, Meghan Gardiner
Senior Honors Theses
Titanium dioxide (TiO2) is one of the most prevalent food additives utilized in commercial products in the United States. While TiO2 was originally hailed as a nontoxic and cost-effective additive, studies are beginning to reveal that TiO2 is not as safe as it once seemed. TiO2 may contribute to the development of insulin resistance and metabolic disorders through direct and indirect mechanisms. The compound induces gut dysbiosis, leading to alterations in bacterial metabolites and pro-inflammatory cytokines, which results in the selective resistance of glucocorticoid receptors. Additionally, TiO2 itself can translocate from the gut to …
Influence And Excess: A Study Of Alcohol’S Governmental, Societal, Biochemical, And Enzymatic Impact In The U.S And Other Countries Around The World, Thomas W. Snider
Influence And Excess: A Study Of Alcohol’S Governmental, Societal, Biochemical, And Enzymatic Impact In The U.S And Other Countries Around The World, Thomas W. Snider
Senior Honors Theses
The conduct of the thesis is to explore the intricacies of alcohol consumption. The thesis will outline the history of alcohol and the societal pressures and conduct of drinking with relation to the government. After the history of alcohol has been defined, the thesis will move into the chemistry portion, delineating the absorption, digestion, metabolism, and excretion of alcohol. This is the portion of the thesis that will contain the quantitative data and source material as much research has already been conducted regarding these components of alcohol consumption. The condition of the research is that the data will be collected …
Design And Synthesis Of Peripherally Selective Endocannabinoid Enzyme Inhibitors For Ocular Indications, Kezia Reji Thomas
Design And Synthesis Of Peripherally Selective Endocannabinoid Enzyme Inhibitors For Ocular Indications, Kezia Reji Thomas
Senior Honors Theses
Peripherally selective compounds have been found to stimulate endocannabinoid receptor activity, which has been observed to have positive physiological effects such as ocular wound healing and inflammation control. The activation of the cannabinoid 1 receptor via binding of the endogenous ligands, anandamide and 2-arachidonoylglycerol, has been indicated to elicit these effects. Both ligands are controlled by two hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), which can be targeted for therapeutic inhibition. Sulfonamide derivatives of JZL195 containing carbamate functionalities in the southern region of the inhibitor compounds were produced using novel carbamate exchange reactions. Polar functionalities were …
Jnk And Nf-Κb Cell Signaling Pathways In Cardiovascular Disease Present Potential Targets For Curcumin Therapy, Mary Richfield
Jnk And Nf-Κb Cell Signaling Pathways In Cardiovascular Disease Present Potential Targets For Curcumin Therapy, Mary Richfield
Senior Honors Theses
Curcumin (diferuloylmethane) is a compound derived from the rhizomes of Curcumin longa that has been long used for medicinal purposes. Curcumin alleviates the pathology of cardiovascular diseases, including atherosclerosis, aneurysm, and cardiomyopathy. The mechanism of curcumin therapy is under active research. The NF-κB and JNK pathways are two that curcumin interacts with to block inflammatory processes, apoptosis, and fibrotic tissue remodeling to prevent the pathologies of cardiovascular disease. While curcumin has demonstrated powerful mediation of cardiovascular disease, its bioavailability in body tissues is limited due to the instability and hydrophobicity of its structure. Further work is underway to stabilize …
Prenatal Drug Exposure And Its Effects On Fetal Development: Clinical And Health Education Implications, Johanna Marie Olo Tapangan
Prenatal Drug Exposure And Its Effects On Fetal Development: Clinical And Health Education Implications, Johanna Marie Olo Tapangan
Senior Honors Theses
Prenatal drug exposure is a common clinical phenomenon in pregnancy cases. Pregnancy is a fragile period of time for both the mother and the fetus. Therefore, strict drug regulation is important to ensure the safety and wellbeing of the developing fetus. Certain drugs, once thought to be safe, have been found to have detrimental effects on the normal development of functioning organ systems in the fetus. Current research has identified drugs that when taken during pregnancy can result in the onset of fetal physical abnormalities, impaired brain development, and disrupted organogenesis and organ function. Thalidomide, losartan, opioids, alcohol, and caffeine …
Understanding Blue Light Retinal Damages And The Methods Of Prevention, Amelia Lee
Understanding Blue Light Retinal Damages And The Methods Of Prevention, Amelia Lee
Senior Honors Theses
Light emitting diode (LED) lights that comprise television screens, phone displays, laptops, and tablets have been studied by scientists in order to understand the implications of blue light radiation and the effects that it has on the human body—especially the retina of the eye. The retina is comprised of highly metabolic cells, and when those cells are placed under oxidative stress, death occurs causing ocular disease. Additionally, excess blue light exposure causes shifts in biological rhythms that govern patterns of alertness and sleep. Recently scientists began studying the methods of blue light prevention. Some studies show that blue light radiation …
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Senior Honors Theses
This paper reviews functions of Amyloid-β (Aβ) in healthy individuals compared to the consequences of aberrant Aβ in Alzheimer’s disease (AD). As extraneuronal Aβ accumulation and plaque formation are characteristics of AD, it is reasonable to infer a pivotal role for Aβ in AD pathogenesis. Establishing progress of the disease as well as the mechanism of neurodegeneration from AD have proven difficult (Selkoe, 1994). This thesis provides evidence suggesting the pathogenesis of AD is due to dysfunctional neuronal processes involving Aβ’s synaptic malfunction, abnormal interaction with tau, and disruption of neuronal homeostasis. Significant evidence demonstrates that AD symptoms are partially …