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Articles 1 - 6 of 6
Full-Text Articles in Medical Biochemistry
Factors Affecting Production Of Scopulariopsis Brevicaulis Spores For Use In Self-Healing Concrete, Lu-Kwang Ju, Ahsanul Kabir Sumon
Factors Affecting Production Of Scopulariopsis Brevicaulis Spores For Use In Self-Healing Concrete, Lu-Kwang Ju, Ahsanul Kabir Sumon
University Research
Concrete durability is compromised by its susceptibility to cracking, necessitating innovative solutions like self-healing concrete (SHC). Scopulariopsis brevicaulis is capable of biomineralization and its spores were found to hold high potential for use in SHC. Realizing this potential requires clean and effective production of S. brevicaulis spores, which remains unexplored. Here the factors and processes conducive to high productivity of S. brevicaulis spores were investigated. Suitability of cheap, renewable soy-based substrates: soy molasses (SM), soy hull (SH), and soy flour (SF) were first evaluated, and SH was found suitable. The comparison of SH-based solid-state fermentation (SSF) with submerged fermentation (SmF) …
Extracellular Matrix Repair And Organization Of Chronic Infected Diabetic Wounds Treated With Methacrylated Chitosan-Based Hydrogels, Nic D. Leipzig, Shahrzad Abri, Hannah A. Durr, Samuel D. Salinas
Extracellular Matrix Repair And Organization Of Chronic Infected Diabetic Wounds Treated With Methacrylated Chitosan-Based Hydrogels, Nic D. Leipzig, Shahrzad Abri, Hannah A. Durr, Samuel D. Salinas
University Research
Diabetic foot ulcers (DFUs) are a multifactorial medical problem that require multifaceted approaches for effective healing. Most research on DFU healing has concentrated on promoting wound closure, with less emphasis on the quality of repaired tissue. This is problematic, however, since quality of the repaired tissues can have potential to improve wound healing outcomes and limit re-ulceration. If more functionally active dermis replaces the lost tissue, this can effectively maximize strength, organization, and overall structure of the plantar surface. Additionally, DFUs commonly show multi-strain infection, which further exacerbates the non-healing status of these wounds. Treatment of chronic wounds can be …
Antifreezing Hydrogels From Mechanisms, Strategies, To Applications, Jie Zheng, Dong Zhang, Hong Cheng, Yanxian Zhang
Antifreezing Hydrogels From Mechanisms, Strategies, To Applications, Jie Zheng, Dong Zhang, Hong Cheng, Yanxian Zhang
University Research
Antifreezing hydrogels have emerged as an innovative solution for maintaining functional performance and mechanical integrity in subzero environments, offering a robust alternative to traditional water-free antifreezing materials that often fail under wet and cold conditions. These water-rich hydrogels leverage their porous, crosslinked, polymeric networks, which serve as the structural basis for implementing two parallel strategies: the incorporation of antifreezing additives (peptides/proteins, salts, ionic liquids, and organics) and the meticulous engineering of polymer systems and network structures for manipulating the water–ice phase equilibrium to significantly enhance antifreezing properties. This review synthesizes recent findings to provide a fundamental overview of the important …
Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley
Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley
Williams Honors College, Honors Research Projects
Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes. In this proposal, we further examine the chemical and toxicological properties of cuprizone. Immunofluorescence imaging and microarray data on MO3.13 cells treated with cuprizone revealed the possibility of alterations in lysosomal function, as well as mitochondrial disruption via mTOR and Electron Transport Chain (ETC) related pathways. Cell viability assays conducted suggest that addition of Branched-Chain Amino Acids, most commonly used from literature, leucine, can increase …
The Potential Role Of Oxidative Stress In Reduced Uterine Perfusion Pressure Vascular Reactivity, Abigail J. Gindlesberger
The Potential Role Of Oxidative Stress In Reduced Uterine Perfusion Pressure Vascular Reactivity, Abigail J. Gindlesberger
Williams Honors College, Honors Research Projects
Preeclampsia is a hypertensive disease of pregnant women that is known to cause detrimental physiological complications to both the mother and fetus. The hypertension hypothesized to result from endothelial dysfunction may be improved therapeutically by increasing Vascular Endothelial Growth Factor ligand concentration and it’s Vascular Endothelial Growth Factor Receptor 2 (VEGF and VEGFR2). Together, this receptor pathway may help overall vasodilation of key blood vessels linking the mother and fetal placental unit, allowing for increased clinical pathologies of both. Previous studies have also linked increased reactive oxygen species (ROS) production in preeclamptic pregnancies to the damaged endothelial tissues of the …
Drug Interactions With Glutaredoxin Orthologues, Kahlilah R. Napper, Thomas C. Leeper, Ram Khattri, Daniel Morris, Caroline Davis
Drug Interactions With Glutaredoxin Orthologues, Kahlilah R. Napper, Thomas C. Leeper, Ram Khattri, Daniel Morris, Caroline Davis
Williams Honors College, Honors Research Projects
Glutaredoxin, an enzymatic protein, is an important component of cell viability and function. It catalyzes reactions involved in DNA synthesis and innate immunity [1,4]. Glutaredoxin is also essential in antibiotic resistance in pathogenic bacterial species. Pseudomonas aeruginosa in particular is responsible for infecting the lung tissue of its human hosts, resulting in the development of pneumonia and cystic fibrosis [3]. Because glutaredoxin is pertinent in cell proliferation of eukaryotic and bacterial cells alike, medicinal fragments that take advantage of the subtle differences in protein structure of the orthologous proteins can be synthesized and enhanced to bind bacterial glutaredoxins, without inhibiting …