Open Access. Powered by Scholars. Published by Universities.®
Biological Phenomena, Cell Phenomena, and Immunity Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Biological Phenomena, Cell Phenomena, and Immunity
Cellular Senescence Is Induced By The Environmental Neurotoxin Paraquat And Contributes To Neuropathology Linked To Parkinson’S Disease, Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda Mcquade, David T. Madden
Cellular Senescence Is Induced By The Environmental Neurotoxin Paraquat And Contributes To Neuropathology Linked To Parkinson’S Disease, Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda Mcquade, David T. Madden
Faculty Publications & Research of the TUC College of Pharmacy
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence is an anticancer mechanism that arrests proliferation of replication-competent cells and results in a pro-inflammatory senescence-associated secretory phenotype (SASP) capable of damaging neighboring tissues. Here, we demonstrate that senescent cell markers are preferentially present within astrocytes in PD brain tissues. Additionally, PQ was found to induce astrocytic senescence and an SASP in vitro and in vivo, and senescent cell depletion in the latter protects against …
Visualizing Morphogenesis With The Processing Programming Language, Avik Patel, Amar Bains, Richard Millet, Tamira Elul
Visualizing Morphogenesis With The Processing Programming Language, Avik Patel, Amar Bains, Richard Millet, Tamira Elul
Faculty Publications & Research of the TUC College of Osteopathic Medicine
We used Processing, a visual artists’ programming language developed at MIT Media Lab, to simulate cellular mechanisms of morphogenesis – the generation of form and shape in embryonic tissues. Based on observations of in vivo time-lapse image sequences, we created animations of neural cell motility responsible for elongating the spinal cord, and of optic axon branching dynamics that establish primary visual connectivity. These visual models underscore the significance of the computational decomposition of cellular dynamics underlying morphogenesis.
Human Stem Cells: Is It Possible To Limit Pluripotent Human Stem Cells To Differentiate Into Specific Tissue Or Organ?, Chaya Korf
The Science Journal of the Lander College of Arts and Sciences
It would seem that differentiation of stem cells is the remedy of modern times. Yet stem cell research is more complex that the public may recognize and is still in the developmental stage. Recent breakthroughs show promise; various guidelines provide structure to this growing field but it is not ready for gross public application. The objective of this paper is to research various different methods of stem cell production and application. Methods included reviewing articles and studies to evaluate the process in production of affective stem cells. There are many therapies that illustrate this research. Upon completing and explaining this …
Neural Plasticity Following Ischemia, Shira Brickman
Neural Plasticity Following Ischemia, Shira Brickman
The Science Journal of the Lander College of Arts and Sciences
Neural plasticity refers to the ability of one’s brain to change its structure and/or function in response to changes in behavior, environment, and neural processes. When a person suffers an ischemic brain injury, it often leads to hemisyndrome with motor and sensory deficits in the arm, leg, and face of one side. This article discusses the various ways that the existing network can be restructured and neuronal connections can be remodeled after the injury to enable partial or complete recovery of motor function. Spontaneous functional recovery after stroke develops through the overlapping sequence of events including a phase of axonal …