Medical Sciences Commons^™

Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …

A Sensitive Indicator For The Severity Of Covid-19: Thiol, Özcan Erel, Sali̇m Neşeli̇oğlu, Merve Ergi̇n Tunçay, Esra Firat Oğuz, Funda Eren, Meryem Sena Akkuş, Hati̇ce Rahmet Güner, İhsan Ateş

Turkish Journal of Medical Sciences

Background/aim: Thiol status is a good reflector of the cellular redox and have vital roles in various cellular signaling pathways. The purpose of the study was to investigate thiol status in patients with SARS-CoV-2 infection. Materials and methods: A total of 587 subjects (517 patients/70 healthy controls) were enrolled in the study.The patients were categorized into the groups regarding to the severity of disease (mild, moderate, severe, and critical).Thiol status of all groups were compared. Results: The patients had significantly diminished thiol levels compared to controls. Thiol levels were gradually decreased as the severity of the disease increased. Logistic regression …

Evaluation Of Systemic Involvement Of Coronavirus Disease 2019 Through Spleen; Size Andtexture Analysis, Abdussamet Batur, Abi̇di̇n Kilinçer, Fati̇h Ateş, Nazlim Aktuğ Demi̇r, Recai̇ Ergün

Turkish Journal of Medical Sciences

Background/aim: To investigate the changes in the spleen size, parenchymal heterogeneity, and computed tomography (CT) texture analysis features of patients diagnosed with Coronavirus disease 2019 (COVID-19) Materials and methods: The size and parenchymal structure of the spleen in 91 patients who underwent thoracic CT examination due to COVID-19 were evaluated. For the evaluation of parenchymal heterogeneity, CT texture analysis was performed using dedicated software (Olea Medical, France). The texture analysis of each case consisted of 15 first-order intensity-based features, 17 gray level cooccurrence matrix-based features, and 9 gray level run length matrix-based features. Results: A total of 91 patients (45 …

How Safe Are Children With Covid-19 From Cardiac Risks? Pediatric Risk Assesment;Insights From Echoc, Berna Şaylan Çevi̇k, Şule Arici, Zeynep Ergenç, Eda Kepenekli̇ Kadayi̇fci̇, Özge Günal, Nurhayat Yakut

Turkish Journal of Medical Sciences

Background/aim: Approximately 40 million individuals worldwide have been infected with SARS-CoV-2, the virus responsible for the novel coronavirus disease-2019 (COVID-19). Despite the current literature about the cardiac effects of COVID-19 in children, more information is required. We aimed to determine both cardiovascular and arrhythmia assessment via electrocardiographic and echocardiographic parameters. Materials and methods: We evaluated seventy children who were hospitalized with COVID-19 infections and seventy children as normal control group through laboratory findings, electrocardiography (ECG), and transthoracic echocardiography (TTE). Results: We observed significantly increased levels of Tp-Te, Tp-Te/QT, and Tp-Te/QTc compared with the control group. Twenty-five of 70 (35.7%) patients …

Evaluation Of The Chest Computed Tomography And Hemogram Data In Patients Withcovid-19: The Importance Of Thymus, Vefa Çakmak, Atakan Yilmaz, Tuğba Sari, Pinar Çakmak, Mert Özen, Duygu Herek, Alten Oskay

Turkish Journal of Medical Sciences

Background/aim: To investigate the relationship between imaging findings and peripheral blood cell counts of COVID-19 patients and the degree of thymus fat involution of these patients. Materials and methods: Computed tomography (CT) images of 87 patients with COVID-19 positive through RT-PCR testing were evaluated retrospectively by two radiologists. Ground glass densities and other signs of viral pneumonia were recorded, lung involvement was scored quantitatively. The patients thymus fat involution was graded on CT. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratios (PLR), lymphocyte and platelet counts were calculated. Imaging findings and degrees of thymus fat involution were compared with laboratory data. Results: Quantitative …

Current Community Transmission And Future Perspectives On The Covid-19 Process, Seyhan Türk, Can Türk, Ümi̇t Yavuz Malkan, Eli̇f Sena Temi̇rci̇, Mustafa Çağri Peker, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: COVID-19 syndrome due to the SARS-CoV-2 virus is a currently challenging situation ongoing worldwide. Since the current pandemic of the SARS-CoV-2 virus is a great concern for everybody in the World, the frequently asked question is how and when the COVID-19 process will be concluded. The aim of this paper is to propose hypotheses in order to answer this essential question. As recently demonstrated, SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome. Our main hypothesis is that the ultimate aim of the SARS-CoV-2 virus is the incorporation to human genome and being an element of the …

Treatment Approaches For Managing Patients With Hematological Malignancies In Thetime Of Covid-19 Pandemic, Güldane Cengi̇z Seval, Pervi̇n Topçuoğlu, Taner Demi̇rer

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 pandemic is a unique challenge to the care of patients with hematological malignancies. We aim to provide supportive guidance to clinicians making individual patients decisions during the COVID-19 pandemic, in particular during periods that access to healthcare resources may be limited. Conclusion: This review also provides recommendations, which are convenient in evaluating indications for therapy, reducing therapy-associated immunosuppression, and reducing healthcare utilization in patients with specific hematological malignancies in the COVID-19 era. Specific decisions regarding treatment of hematological malignancies will need to be individualized, based on disease risk, risk of immunosuppression, rates of community transmission of SARS-CoV-2, …

Which Hematological Markers Have Predictive Value As Early Indicators Of Severecovid-19 Cases In The Emergency Department?, İshak Şan, Emi̇n Gemci̇oğlu, Mehmet Davutoğlu, Rami̇s Çatalbaş, Berkan Karabuğa, Enes Kaptan, Abdulsamet Erden, Orhan Küçükşahi̇n, İhsan Ateş, Selma Karaahmetoğlu, İmran Hasanoğlu, Osman İnan, Büşra Nur Ünal, Ecem Erdemi̇r, Fati̇h Ahmet Kahraman

Turkish Journal of Medical Sciences

Background/aim: Coronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. As a result of high mortality rate among the severe COVID-19 patients, the early detection of the disease stage and early effective interventions are very important in reducing mortality. Hence, it is important to differentiate severe and nonsevere cases from each other. To date, there are no proven diagnostic or prognostic parameters that can be used in this manner. Due to the expensive and not easily accessible tests that are performed for COVID-19, researchers are investigating …

The Analysis Of Pleural Complications Of Covid-19 Pneumonia, Merve Şatir Türk, Irmak Akarsu, İsmai̇l Tombul, Aykut Kankoç, Nur Di̇lvi̇n Özkan, Elgun Valiyev, Muhammet Sayan, Ali̇ Çeli̇k, İsmai̇l Cüneyt Kurul, Olgun Kadi̇r Aribaş, Abdullah İrfan Taştepe

Turkish Journal of Medical Sciences

Background/aim: As the number of case reports related to the new type of coronavirus (COVID-19) increases, knowledge of and experience with the virus and its complications also increase. Pleural complications are one relevant issue. We aimed in this study to analyze pleural complications, such as pneumothorax, pneumomediastinum, and empyema, in patients hospitalized with the diagnosis of COVID-19 pneumonia. Materials and methods: The files of patients who have pleural complications of COVID-19 pneumonia and were consulted about thoracic surgery between March 2020 and December 2020 were retrospectively reviewed. The data of the patients were analyzed according to age, sex, length of …

Correlation Of Neuroimaging And Thorax Ct Findings In Patients With Covid-19:A Large Single-Center Experience, Hedi̇ye Pinar Günbey, Günay Rona, Özge Adigüzel Karaoysal, Ayşe Batirel, Banu Özen Barut

Turkish Journal of Medical Sciences

Background/aim: The aim of this current study was to describe the neuroimaging findings among patients with COVID-19 and to compare them with thorax CT imaging findings and clinicobiological profiles. Materials and methods: Between the period March 11 and December 31, 2020, we evaluated brain computed tomography (CT) and magnetic resonance (MR) images of patients with COVID-19. A total of 354 patients (mean age 65.2 ± 16.6, 52% female, 42% male) who had brain imaging were included in the study. Of this total sample, 218 had thorax CT scanning (65.5%). Neuroimaging and thorax CT findings, clinical course, neurologic findings, and laboratory …

Decrease Of Left Ventricular Ejection Fraction In Severe Illness Patients Due To Covid-19may Improve As The Disease Resolves, Aykut Demi̇rkiran, Lütfi̇ Çağatay Onar, Mustafa Doğan

Turkish Journal of Medical Sciences

Background/aim: Increase in publications supporting myocardial involvement in the COVID-19 disease has led to need to gain insight into the the global burden of heart failure after pandemic. We examined the course of myocardial systolic function in patients without elevated troponin levels. Materials and methods: We performed a prospective study. Patients with high troponin levels were excluded from the study in order to definitively exclude complications known to cause permanent left ventricular systolic dysfunction, such as acute coronary syndromes. Two echocardiographic examinations were performed. The first evaluation was performed within the days of hospitalization, if possible, on the day when …

Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez

Turkish Journal of Medical Sciences

Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of …

The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya

Turkish Journal of Medical Sciences

Background/aim: SARS-CoV-2, a ribonucleic acid coronavirus, rapidly spread worldwide within a short timeframe. Although different antiviral, antiinflammatory, and immunomodulatory drugs are used, current evidence is insufficient as to which drug is more efficient. Our study compared favipiravir and lopinavir/ritonavir (LPV/RTV) therapies in inpatient care for coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Demographic data, test results, treatments, and latest status of patients receiving inpatient COVID-19 pneumonia therapy were recorded. The initial favipiravir and LPV/RTV receiving groups were compared regarding the need for intensive care units (ICU) and mortality. Logistic regression analysis was performed by including variables showing significant differences …

Impact Of Covid-19 On Serum Melatonin Levels And Sleep Parameters In Children, Özlem Yayici Köken, Pembe Gültutan, Merve Si̇bel Güngören, Gülsüm İclal Bayhan, Deni̇z Yilmaz, Esra Gürkaş, Hami̇t Özyürek, Ayşegül Neşe Çitak Kurt

Turkish Journal of Medical Sciences

Background/aim: This study aimed to analyze the serum melatonin levels and changes in sleep patterns in pediatric patients with coronavirus disease 2019 (COVID-19). Materials and methods: This study was designed as a descriptive, cross-sectional study. Serum melatonin levels and sleep parameters of children with the diagnosis of COVID-19 who had mild and moderate disease (i.e., COVID-19 group) were compared with those of children admitted with non-COVID-19 nonspecific upper respiratory tract infection (i.e., control group). The sleep disturbance scale for children (SDSC) questionnaire was applied to the participants' primary caregivers to analyze their sleep patterns at present and six months before …

The Clinical Course Of Covid-19 In Hematopoietic Stem Cell Transplantation (Hsct)Recipients, Ayşe Karataş, Ümi̇t Yavuz Malkan, Mustafa Velet, Haluk Demi̇roğlu, Yahya Büyükaşik, Gülçi̇n Telli̇ Di̇zman, Ahmet Çağkan İnkaya, Batuhan Erdoğdu, Olgu Erki̇n Çinar, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Ni̇lgün Sayinalp, Hakan Göker

Turkish Journal of Medical Sciences

Background/aim: The disease caused by SARS-CoV-2 was named as COVID-19. There is as yet insufficient information about the effects of HSCT on the clinical course of COVID-19. In the present study, we aimed to investigate the clinical course of COVID-19 in patients who had undergone HSCT. Materials and methods: We analyzed baseline characteristics, clinical course and findings of COVID-19, hospitalization and death rates, overall survival, and case fatality rates of HSCT recipients diagnosed with COVID-19 retrospectively. Results: 57.6% of the patients underwent AHSCT, and 42.4% underwent allo-HSCT. 60.6%, 27.3%, and 12.1% of the patients had mild, moderate, and severe COVID-19 …

Allergic Reactions Against Covıd-19 Vaccines, Hi̇lal Ünsal, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner

Turkish Journal of Medical Sciences

Coronavirus Disease 2019 (COVID-19) affected the whole world in a short time. One of the most influential public health initiatives modern medicine has to offer, the vaccine has become even more important as the COVID-19 pandemic continues to worsen worldwide. Many vaccine trials were launched during the COVID-19 pandemic, and these vaccines were widely used around the world, offering realistic hope for ending the pandemic. Allergic reactions to vaccines were reported shortly after their approval. These reactions, in general, are rare, but, in some circumstances, they can be serious. Allergy to vaccines can occur because of either the active vaccine …

A Single Center Survey Study Of Systemic Vasculitis And Covid-19 During The First Months Of Pandemic, Burak İnce, Murat Bektaş, Nevzat Koca, Besi̇m Fazil Ağargün, Si̇bel Zarali, Damla Yenersu Güzey, Ayşe İnce, Mehmet Sali̇h Sevdi̇, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç

Turkish Journal of Medical Sciences

Backgroun/aim: COVID-19 pandemic created concerns among patients receiving immunosuppressive therapy. Frequency of COVID-19 and impact of lockdown on treatment compliance in patients with vasculitis are largely unknown. Materials Method: Patients with ANCA-associated and large vessel vasculitis that have been followed-up in our clinic were contacted by phone and a questionnaire containing home isolation status, treatment adherence and history of COVID-19 between March 1st and June 30th, 2020 was applied. Results: The survey was applied to 103 patients (F/M: 59/44, mean age: 53.2±12.5). Thirty-three (32%) patients didn't attend at least one appointment; 98(95.1%) noted that they spent 3 months in home …

Interleukin-21: A Potential Biomarker For Diagnosis And Predicting Prognosis In Covid-19 Patients, Ni̇lüfer Ayli̇n Acet Öztürk, Ahmet Ursavaş, Asli Görek Di̇lektaşli, Ezgi̇ Demi̇rdöğen, Necmi̇ye Funda Coşkun, Dane Edi̇ger, Ayşe Esra Uzaslan, Di̇ğdem Yöyen Ermi̇ş, Mert Karaca, Orkun Eray Terzi̇, Merve Bayram, Di̇lara Ömer Topçu, Büşra Yi̇ği̇tli̇ler, Ahmet Yurttaş, Shahri̇yar Maharramov

Turkish Journal of Medical Sciences

Background/aim: COVID-19 patients have a wide spectrum of disease severity. Several biomarkers were evaluated as predictors for progression towards severe disease. IL-21 is a member of common γ-chain cytokine family and creates some specific effects during programming and maintenance of antiviral immunity. We aimed to assess IL-21 as a biomarker for diagnosis and outcome prediction in patients hospitalized with COVID-19. Materials and methods: Patients with a preliminary diagnosis of COVID-19 and pneumonia other than COVID-19 admitted to a tertiary care hospital were included consecutively in this comparative study. Results: The study population consisted of 51 patients with COVID-19 and 11 …

Clinical Characteristics And Risk Factors For 28-Day Mortality In Critically Ill Patients With Covid-19: A Retrospective Cohort Study, Mehmet Nuri̇ Yakar, Begüm Ergan, Bi̇şar Ergün, Murat Küçük, Ali̇ Cantürk, Mahmut Cem Ergon, Naci̇ye Si̇nem Gezer, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen

Turkish Journal of Medical Sciences

Background: To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality. Materials and Methods: In this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study. Results: A total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = …

Assessment Of Olfactory And Gustatory Functions In Covid-19 Patients, Muammer Meli̇h Şahi̇n, Eray Uzunoğlu, Mücahi̇t Yalçin, Gökçen Cesur, Mehmet Yildiz, Pinar Aysert Yildiz, Hasan Selçuk Özger, Süleyman Cebeci̇, Recep Karamert, Mehmet Düzlü, Hakan Tutar, Murat Di̇zbay, Alper Ceylan

Turkish Journal of Medical Sciences

Background/aim: This study aims to evaluate of olfactory and gustatory functions of COVID-19 patients and possible risk factors for olfactory and gustatory dysfunctions. Materials and methods: The cross-sectional study included adult patients who were diagnosed with COVID-19 in Gazi University Hospital between April 2020 and June 2020. Volunteered patients participated in a survey in which olfactory and gustatory functions and various clinical information were questioned. Sinonasal Outcome Test-22 was also administrated to all patients. Results: A hundred and seventy-one patients participated in this study. Olfactory and gustatory dysfunctions rates were 10.5% (n: 18) and 10.5% (n: 18), respectively. Patients without …

Do Initial Hematologic Indices Predict The Severity Of Covid-19 Patients?, Ali̇ Asan, Yasemi̇n Üstündağ, Ni̇zameddi̇n Koca, Abdullah Şi̇mşek, Hali̇l Erkan Sayan, Hülya Parildar, Burcu Dalyan Ci̇lo, Kağan Huysal

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to evaluate the initial hematological findings analyzed on admission in confirmed COVID-19 patients who were transferred to the intensive care unit (ICU), to predict possible hematological indices. Materials and methods: Initial neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), red cell distribution width to platelet ratio (RPR), mean platelet volume to platelet ratio, and lymphocyte multiplied by platelet count (LYM × PLT), of 695 patients with laboratory-confirmed COVID-19 were investigated and comparisons were made between the mild/moderate and severe groups. Results: The proportion of COVID-19 cases admitted …

Efficacy Of Convalescent Plasma According To Blood Groups In Covid-19 Patients, Tuba Hacibeki̇roğlu, Yasi̇n Kalpakçi, Ahmed Ci̇had Genç, İlhan Hacibeki̇roğlu, Cenk Sunu, Adem Saricaoğlu, Yakup Tomak, Oğuz Karabay, Mehmet Köroğlu

Turkish Journal of Medical Sciences

Background/aim: In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. Materials and methods: Twenty-eight critically ill and laboratory-confirmed COVID-19 patients who were admitted to the intensive care unit (ICU) of Sakarya University, Medical Faculty were included in the study. Patients were divided into 2 groups: patients who received anti-A antibody (Ab) containing CP (BG O and B) and those who did not receive CP containing anti-A Ab (BG A and AB). Results: Among the 28 patients, 13 patients received anti-A Ab …

Hepatitis A Susceptibility Parallels High Covid-19 Mortality, Fai̇k Sariali̇oğlu, Fatma Burcu Belen, Kadi̇r Mutlu Hayran

Turkish Journal of Medical Sciences

Background/aim:COVID-19 has become the biggest health problem of this century. It has been hypothesized that immunity against hepatitis A virus (HAV) may provide protection from COVID- 19. Materials and methods: As of 10June 2020, the infection had spread to 213 countries, with 7.3 million people infected and 413,733 dead. This data was combined with the World Health Organization susceptibility classification on the worldwide prevalence of HAV, and the relationship between HAV susceptibility and COVID-19 mortality were analyzed. Results: When the data from 213 countries were analyzed, it was found that there was a significant increasing trend in COVID-19 mortality rates …

Profile Of Immunoglobulin G N-Glycome In Covid-19 Patients: A Case-Control Study, Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang

Research outputs 2014 to 2021

Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in …

Thyroid Storm In A Patient With Covid-19, Angela N Rao, Ruaa Y Al-Ward, Ruchi Gaba

Faculty, Staff and Students Publications

OBJECTIVE: A thyroid storm is a severe exacerbation of thyrotoxicosis that can cause significant morbidity and mortality. The emergence of the novel coronavirus (SARS-CoV-2) that originated in Wuhan, China, has become a worldwide pandemic. We present the first documented case of thyroid storm (as defined by the Burch-Wartofsky criteria) in a patient with COVID-19.

METHODS: Laboratory and diagnostic studies, including thyroid function tests, thyroid antibody testing, SARS-CoV-2 nasopharyngeal polymerase chain reaction testing, and thyroid ultrasound were performed.

RESULTS: A 25-year-old woman presented to the hospital with dry cough, dyspnea, palpitations, weight loss, diarrhea, and anxiety. Physical examination revealed exophthalmos with …

Characteristics And Outcomes Of In-Hospital Cardiac Arrest In Covid-19 A Systematic Review And Meta-Analysis, Lukasz Szarpak, Magdalena Borkowska, Frank W Peacock, Zubaid Rafique, Aleksandra Gasecka, Jacek Smereka, Katarzyna Pytkowska, Marta Jachowicz, Lukasz Iskrzycki, Natasza Gilis-Malinowska, Milosz J Jaguszewski

Faculty, Staff and Students Publications

BACKGROUND: The purpose herein, was to perform a systematic review of interventional outcome studies in patients with in-hospital cardiac arrest before and during the coronavirus disease 2019 (COVID-19) pandemic period.

METHODS: A meta-analysis was performed of publications meeting the following PICOS criteria: (1) participants, patients > 18 years of age with cardiac arrest due to any causes; (2) intervention, cardiac arrest in COVID-19 period; (3) comparison, cardiac arrest in pre-COVID-19 period; (4) outcomes, detailed information for survival; (5) study design, randomized controlled trials, quasi-randomized or observational studies comparing cardiac arrest in COVID-19 and pre-COVID-19 period for their effects in patients with …

Secretion Of Von Willebrand Factor And Suppression Of Adamts-13 Activity By Markedly High Concentration Of Ferritin, Dalia A Bashir, Qi Da, Subhashree Pradhan, Nitin Sekhar, Christian Valladolid, Fong Lam, Danielle Guffey, Jordana Goldman, Moreshwar S Desai, Miguel A Cruz, Carl Allen, Trung C Nguyen, K Vinod Vijayan

Faculty, Staff and Students Publications

Hyperferritinemia is associated with poor outcomes in critically ill patients with sepsis, hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndromes (MAS) and coronavirus disease 19 (COVID-19). Autopsies of hyperferritinemic patients that succumbed to either sepsis, HLH, MAS or COVID-19 have revealed disseminated microvascular thromboses with von Willebrand factor (VWF)-, platelets-, and/or fibrin-rich microthrombi. It is unknown whether high plasma ferritin concentration actively promotes microvascular thrombosis, or merely serves as a prognostic biomarker in these patients. Here, we show that secretion of VWF from human umbilical vein endothelial cells (HUVEC) is significantly enhanced by 100,000 ng/ml of recombinant ferritin heavy chain protein (FHC). …

Effects Of Hydroxychloroquine And Favipiravir On Clinical Course In Outpatients Withcovid-19, Seyda Kayhan Ömeroğlu, Fehmi̇naz Temel, Di̇lek Altun, Mehmet Burak Öztop

Turkish Journal of Medical Sciences

Background/aim: Due to the importance of early outpatient treatment to prevent hospitalization and disease progression, we examined the effects of hydroxychloroquine and favipiravir, which were initiated in early period, on the clinical course of COVID-19 outpatients. Materials and methods: Data of confirmed COVID-19 outpatients over a 4-month period were analyzed retrospectively. Public Health Management System (HSYS) was used for the case-based follow-up. Patients on antiviral therapy for at least five days, including hydroxychloroquine and / or favipiravir and patients who were followed-up for 30 days were included in this analysis. Results: We enrolled 1489 patients in this study. Overall, 775 …

Retrospective Evaluation Of Seven Different Treatment Protocols In Hospitalizedcovid-19 Patients, Kübra Demi̇r Önder, Ayşegül Seremet Keski̇n, Hande Berk Cam, Derya Seyman, Nefi̇se Öztoprak Çuvalci

Turkish Journal of Medical Sciences

Background/aim: As the experience has increased regarding SARS-CoV-2 in time, treatment trends have changed since the beginning of the pandemic. This study aimed to compare the outcomes of different treatment modalities for inpatients in a tertiary pandemic hospital in Antalya, Turkey. Materials and methods: Individuals aged 18 years and above who tested positive for SARS-CoV-2 in PCR with presenting COVIDrelated radiological findings, hospitalized for at least 3 days, and completed follow-up between March 15, 2020 and November 30, 2020 were included in the study. Patients' data were reviewed retrospectively. Seven treatment groups based on the single or combined use of …

Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: The SARS-CoV-2 infection was declared as a pandemic by the World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already surpassed that of many previous epidemics. A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. This study aims to explain the background of convalescent plasma (CP) treatment and its relations with COVID-19 immunity, to define ideal treatment procedures, and to reveal present and future perspectives in the light of the rapidly growing data. Immunological basis …