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2020

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Articles 1261 - 1290 of 1778

Full-Text Articles in Medical Sciences

An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik Jan 2020

An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik

Turkish Journal of Medical Sciences

Background/aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper (ABS) are considered to contribute to wound healing. The purpose of this study was to investigate the effect of ABS and CAPE on secondary wound healing of oral mucosal tissue. Materials and methods: In total, 63 male Sprague-Dawley rats were used in this study. The animals were randomly divided into three groups and anaesthetized with ketamine (8 mg/100 g, intraperitoneally): a control group, CAPE group, and ABS group. A full-thickness excisional wound was created using a 4 mm punch biopsy tool. Topical ABS and CAPE were then applied in each …

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Characterization Of Silk Sutures Coated With Propolis And Biogenic Silver Nanoparticles (Agnps); An Eco-Friendly Solution With Wound Healing Potential Against Surgical Site Infections (Ssis), Tuba Baygar Jan 2020

Characterization Of Silk Sutures Coated With Propolis And Biogenic Silver Nanoparticles (Agnps); An Eco-Friendly Solution With Wound Healing Potential Against Surgical Site Infections (Ssis), Tuba Baygar

Turkish Journal of Medical Sciences

Background/aim: Bacterial adherence to a suture material is one of the main causes of surgical site infections. An antibacterial suture material with enhanced wound healing function may protect the surgical site from infections. Thus, the present study aimed to investigate the synergistic effect of propolis and biogenic metallic nanoparticles when combined with silk sutures for biomedical use.Materials and methods: Silver nanoparticle (AgNP) synthesis was carried out via a microbial-mediated biological route and impregnated on propolis-loaded silk sutures using an in situ process. Silk sutures fabricated with propolis and biosynthesized AgNPs (bioAgNP-propolis-coated sutures) were intensively characterized using scanning electron microscopy (SEM), …

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St534: The New Sequence Type Of Corynebacterium Diphtheriae Causing Diphtheria In Jakarta And Surrounding Areas, Indonesia, Sunarno Sunarno, Yuni Rukminiati, Ratih Dian Saraswati Jan 2020

St534: The New Sequence Type Of Corynebacterium Diphtheriae Causing Diphtheria In Jakarta And Surrounding Areas, Indonesia, Sunarno Sunarno, Yuni Rukminiati, Ratih Dian Saraswati

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to find out characteristics and patterns of the spread of Corynebacterium diphtheriaeisolated from Jakarta and the surrounding areas, using the whole genome sequencing (WGS) technique and multilocus sequence typing (MLST) approach.Materials and methods: The study samples consisted of 86 C. diphtheriae isolates, which were isolated from diphtheria patients and close contacts of patients. The DNA sequencing was carried out using the WGS technique. Data conversion applied the U-gene software. Molecular typing was conducted through the MLST approach, then followed by online data analysis. Results: The results showed that as many as 43 (50%) …

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Carvacrol Alters Soluble Factors In Hct-116 And Ht-29 Cell Lines, Ahu Pakdemi̇rli̇, Caner Karaca, Tolga Sever, Ezgi̇ Daşkin, Asim Leblebi̇ci̇, Türkan Yi̇ği̇tbaşi, Yasemi̇n Başbinar Jan 2020

Carvacrol Alters Soluble Factors In Hct-116 And Ht-29 Cell Lines, Ahu Pakdemi̇rli̇, Caner Karaca, Tolga Sever, Ezgi̇ Daşkin, Asim Leblebi̇ci̇, Türkan Yi̇ği̇tbaşi, Yasemi̇n Başbinar

Turkish Journal of Medical Sciences

Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanism of action is yet to be discovered. Materials and methods: The investigation aims to illuminate a new perceptive in the role of this substance on colorectal cancer treatment, by the means of differences in a well-defined range of soluble factors. Carvacrol effect on both HT-29 and HCT-116 cell lines was …

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Does Selection Of Nostrils Really Affect Performance Of Nasotracheal Intubation With Nasotracheal Airtraq®?, Liu-Jia-Zi Shao, Shaohua Liu, Fushan Xue Jan 2020

Does Selection Of Nostrils Really Affect Performance Of Nasotracheal Intubation With Nasotracheal Airtraq®?, Liu-Jia-Zi Shao, Shaohua Liu, Fushan Xue

Turkish Journal of Medical Sciences

No abstract provided.

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Reply To Letter To The Editor, Zehra İpek Arslan Aydin Jan 2020

Reply To Letter To The Editor, Zehra İpek Arslan Aydin

Turkish Journal of Medical Sciences

No abstract provided.

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Geoepidemiology And Clinical Characteristics Of Neonatal Lupus Erythematosus: Asystematic Literature Review Of Individual Patients' Data, Abdulsamet Erden, Antonis Fanouri̇aki̇s, Levent Kiliç, Alper Sari, Berkan Armağan, Emre Bi̇lgi̇n, Yusuf Zi̇ya Şener, Benazi̇r Hymabaccus, Fati̇h Gürler, Serdar Ceylan, Sedat Ki̇raz, Ömer Karadağ, Dimitrious Boumpas Jan 2020

Geoepidemiology And Clinical Characteristics Of Neonatal Lupus Erythematosus: Asystematic Literature Review Of Individual Patients' Data, Abdulsamet Erden, Antonis Fanouri̇aki̇s, Levent Kiliç, Alper Sari, Berkan Armağan, Emre Bi̇lgi̇n, Yusuf Zi̇ya Şener, Benazi̇r Hymabaccus, Fati̇h Gürler, Serdar Ceylan, Sedat Ki̇raz, Ömer Karadağ, Dimitrious Boumpas

Turkish Journal of Medical Sciences

Background/aim: Neonatal lupus erythematosus (NLE) is an autoimmune syndrome caused by transplacental transmission of maternal autoantibodies, often with devastating consequences. The objective of this systematic literature review was to analyze the demographic data, geoepidemiology, clinical, and serological characteristics associated with NLE. Materials and methods: We performed a systematic literature search of the Pubmed database covering the period from 1976 to August 2015, using the MeSH terms "neonatal lupus" or "congenital heart block". To be included in the study, articles of any type (original articles, case series, and case reports) had to report on infants with NLE on an individualized (i.e. …

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Smokeless Tobacco Use And Risk Of Oral Cavity Cancer, Shah Zeb Khan, Ahmed Farooq, Misbah Masood, Abubaker Shahid, Irfan Ullah Khan, Hasan Nisar, Ismat Fatima Jan 2020

Smokeless Tobacco Use And Risk Of Oral Cavity Cancer, Shah Zeb Khan, Ahmed Farooq, Misbah Masood, Abubaker Shahid, Irfan Ullah Khan, Hasan Nisar, Ismat Fatima

Turkish Journal of Medical Sciences

Background/aim: Smokeless tobacco has been associated with oral cavity cancer for several decades. The incidence of oral cavity cancer is higher in some parts of the world especially South and South-East Asia including Pakistan. The aim of current study was to evaluate the risk of oral cavity cancer among smokeless tobacco users in our country. Materials and methods: A case-control study was conducted between November 2016 and September 2017. Patients diagnosed with oral cavity cancer receiving treatment were included as cases and the attendants of various cancer patients visiting the hospital during the study period were included in the study …

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25-Hydroxy Vitamin D Level Is Associated With Sleep Disturbances In Patients With Chronickidney Disease On Hemodialysis: A Cross-Sectional Study, Demet Yavuz, Rahman Yavuz, Mehmet Derya Demi̇rağ, Düri̇ye Sila Karagöz Özen, Zeynep Banu Ramazanoğlu Jan 2020

25-Hydroxy Vitamin D Level Is Associated With Sleep Disturbances In Patients With Chronickidney Disease On Hemodialysis: A Cross-Sectional Study, Demet Yavuz, Rahman Yavuz, Mehmet Derya Demi̇rağ, Düri̇ye Sila Karagöz Özen, Zeynep Banu Ramazanoğlu

Turkish Journal of Medical Sciences

Background/aim: Deficient levels of vitamin D are an important factor in the pathogenesis of some neurodegenerative diseases. The aim of this study is to determine the relationship between vitamin D deficiency and depression status and sleep disorders of patients on dialysis. Materials and methods: In this cross-sectional study, 121 hemodialysis patients were enrolled. All patients had been on hemodialysis for at least six months at the time of the study. Sleep quality and depression status were measured by using specific inventories. All the patients filled out Pittsburg Sleep Quality Index (PSQI) and Beck Depression Inventory (BDI), and gave blood samples. …

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Adiponectin Levels Decrease Independently Of Body Mass Index And Diabetes Type Afterthe Normalization Of Hyperglycemia, Nalan Meti̇n Aksu, Duygu Yazgan Aksoy, Meltem Akkaş, Neşe Çinar, Fatma Uçar, Okan Bülent Yildiz, Aydan Usman Jan 2020

Adiponectin Levels Decrease Independently Of Body Mass Index And Diabetes Type Afterthe Normalization Of Hyperglycemia, Nalan Meti̇n Aksu, Duygu Yazgan Aksoy, Meltem Akkaş, Neşe Çinar, Fatma Uçar, Okan Bülent Yildiz, Aydan Usman

Turkish Journal of Medical Sciences

Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), because it is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acute hyperglycemic states and after normalization of blood glucose with insulin treatment. Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia were included in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose with insulin treatment, and adiponectin levels were measured …

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Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t Jan 2020

Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t

Turkish Journal of Medical Sciences

Background/aim: Crohn's disease (CD) is a kind of inflammatory bowel disease. Midkine (MDK) is an endogenous inflammatory marker. We aimed to investigate the relationship between MDK levels and inflammation and hence determine whether MDK can be used as a noninvasive biomarker in active CD. Materials and methods: Sixty-five consecutive patients over the age of 18 with CD and 36 healthy controls were included in this study. CD patients' venous blood samples were taken before treatment. Serum MDK levels were determined in human plasma samples by enzyme-linked immunosorbent assay (ELISA) method. Results: The mean age of the study patients was 44.8 …

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Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker Jan 2020

Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker

Turkish Journal of Medical Sciences

Background/aim: Allergic rhinitis (AR) and asthma are the most common allergic disorders worldwide. Aeroallergens are critical causative factors in the pathogenesis of these disorders and sensitization to aeroallergens differs in various countries and regions. Identification of the most common aeroallergen sensitization is crucial in the diagnosis and management of AR and asthma. We examined the distribution of aeroallergen sensitizations detected by skin prick tests (SPTs) in adult patients with AR and/or asthma in the city of Bursa. Materials and methods: Five hundred forty-five patients who underwent a SPT and were diagnosed with rhinitis and/or asthma in the Uludağ University Faculty …

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Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi Jan 2020

Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi

Turkish Journal of Medical Sciences

Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …

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Effect Of Sevoflurane Anaesthesia On Nasal Mask In Endoscopic Retrogradecholangiopancreatography: Is It A Preferred Alternative?, Bülent Baltaci, Hülya Başar, Murat Keki̇lli̇, Mert Naki̇p, Fati̇h Karaahmet, Mehmet Çakirca, Meli̇s Engi̇n, Meltem Bektaş Jan 2020

Effect Of Sevoflurane Anaesthesia On Nasal Mask In Endoscopic Retrogradecholangiopancreatography: Is It A Preferred Alternative?, Bülent Baltaci, Hülya Başar, Murat Keki̇lli̇, Mert Naki̇p, Fati̇h Karaahmet, Mehmet Çakirca, Meli̇s Engi̇n, Meltem Bektaş

Turkish Journal of Medical Sciences

Background/aim: Endoscopic retrograde cholangiopancreatography (ERCP) often requires deep sedation. Propofol provides adequate sedation and amnesia at subhypnotic doses, but safe guarding the patient's airway is important for preventing respiratory depression or hypoxic events. This study compared sedation levels, operator satisfaction, intraoperative and recovery characteristics using sevoflurane with nasal mask and propofol in ERCP. Material and methods: Sixty-one patients underwent ERCP (Group I: propofol, n = 31; Group II, sevoflurane, n = 30), with sedation controlled by the Ramsay sedation scale (RSS). The patients' demographic data, procedure length, overall drug dose, hemodynamic changes, duration of recovery and Aldrete scores during recovery …

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Efficacy Of Hijamat (Wet Cupping Therapy) In Iranian Patients With Nonalcoholic Fattyliver Disease: A Controlled Clinical Trial, Homayoon Bashiri, Arezoo Bozorgomid, Vahid Shojaeimotlagh Jan 2020

Efficacy Of Hijamat (Wet Cupping Therapy) In Iranian Patients With Nonalcoholic Fattyliver Disease: A Controlled Clinical Trial, Homayoon Bashiri, Arezoo Bozorgomid, Vahid Shojaeimotlagh

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver disease (NAFLD) is known to be the most prevalent chronic liver disease all over the world. The incidence of this disease has dramatically increased during the last decade. Studies have shown a strong relationship between the level of ferritin and the severity of NAFLD. The objective of the present study was to assess the effect of adding Hijamat, as an iron reducing procedure, to standard lifestyle modification on the improvement of insulin resistance and liver enzymes in patients with NAFLD. Materials and methods: One hundred and twenty NAFLD patients participated in a randomized, controlled, single-blind trial …

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Tumour Budding In Preoperative Biopsy Specimens Is A Useful Prognostic Index Foridentifying High-Risk Patients In Early-Stage (Pn0) Colon Cancer, Mehmet Zengi̇n, Aydin Çi̇fci̇ Jan 2020

Tumour Budding In Preoperative Biopsy Specimens Is A Useful Prognostic Index Foridentifying High-Risk Patients In Early-Stage (Pn0) Colon Cancer, Mehmet Zengi̇n, Aydin Çi̇fci̇

Turkish Journal of Medical Sciences

Background/aim: Tumour budding (BD) is considered a valuable prognostic factor in colon cancer (CC), but its use in daily practice is uncertain. We investigated the prognostic effect of BD using preoperative biopsy specimens in a fairly homogeneous population. Materials and methods: Eighty-two (pN0) CC patients who underwent surgery after preoperative biopsy between 1997 and 2013 were included in the study. Model A (using the `deeply invasive blocks & hot-spot area & invasive margin) and method 1 (using the `20× objective & immunohistochemistry staining & quantitive counting') were used as standard methods. Results: High BD was significantly associated with poor prognostic …

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The Use Of Prealbumin As A Predictor Of Malnutrition In Cirrhotic Patients And The Effectof Nutritional Support In Patients With Low Prealbumin Levels, Zuhal Dağ, Hüseyi̇n Köseoğlu, Murat Keki̇lli̇ Jan 2020

The Use Of Prealbumin As A Predictor Of Malnutrition In Cirrhotic Patients And The Effectof Nutritional Support In Patients With Low Prealbumin Levels, Zuhal Dağ, Hüseyi̇n Köseoğlu, Murat Keki̇lli̇

Turkish Journal of Medical Sciences

Background/aim: Malnutrition is an important and commonly seen prognostic factor in patients with cirrhosis. The diagnosis of malnutrition in cirrhosis patients may be challenging, and an easily measured and widely usable marker is lacking. Prealbumin, however, is an easily measured marker. In the current study we measured prealbumin levels in cirrhotic patients with no clinically apparent malnutrition and used it as a malnutrition marker. Another aim of this study was to evaluate the effect of nutritional support on patient with low prealbumin levels. Materials and methods: Fifty-two patients with Child A and Child B cirrhosis were selected for the study. …

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Somatic Regional Oxygen Saturation As An Early Marker Of Intra-Abdominal Hypertensionin Critically Ill Children: A Pilot Study, Özden Özgür Horoz, Vahi̇de Nagehan Aslan, Riza Di̇nçer Yildizdaş, Yasemi̇n Çoban, Yaşar Sertdemi̇r, Awni Al-Subu Jan 2020

Somatic Regional Oxygen Saturation As An Early Marker Of Intra-Abdominal Hypertensionin Critically Ill Children: A Pilot Study, Özden Özgür Horoz, Vahi̇de Nagehan Aslan, Riza Di̇nçer Yildizdaş, Yasemi̇n Çoban, Yaşar Sertdemi̇r, Awni Al-Subu

Turkish Journal of Medical Sciences

Background/aim: Intraabdominal hypertension is a common clinical condition with high mortality and morbidity in pediatric intensive care units. The aim of this study was to test the feasibility of regional tissue oxygenation (rSO2 ) measurement using nearinfrared spectroscopy and to assess the correlation between rSO2 and perfusion markers of intraabdominal hypertension in high-risk pediatric patients. Materials and methods: In this prospective observational cohort study in a tertiary pediatric intensive care unit in Çukurova University Faculty of Medicine, a total of 31 patients who were admitted between May 2017 and May 2018 with a risk of intraabdominal hypertension were included. Mesenteric …

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What Is The Effect Of The Early Follicular Phase Fsh/Lh Ratio On The Number Of Matureoocytes And Embryo Development?, Özgür Arat, Şükri̇ye Derya Deveci̇, Zehra Sema Özkan, Sevi̇m Tuncer Can Jan 2020

What Is The Effect Of The Early Follicular Phase Fsh/Lh Ratio On The Number Of Matureoocytes And Embryo Development?, Özgür Arat, Şükri̇ye Derya Deveci̇, Zehra Sema Özkan, Sevi̇m Tuncer Can

Turkish Journal of Medical Sciences

Background/aim: Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes. Materials and methods: This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ∠ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme. Results: TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups. Conclusion: In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.

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Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal Jan 2020

Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate the role of Shearwave Elastography (SWE) in the evaluation of response to uterine artery embolization (UAE) in patients with uterine leiomyomas. Materials and methods: SWE images of the dominant uterin leiomyomas were obtained before and 1.5 months after performing UAE in 33 women suffering from symptoms due to leiomyomas (menometrorrhagia, bulk related symptoms, pelvic pain). Leiomyomas were also evaluated by 2 observers for location and longest diameter in axial plane. Interobserver agreement in the quantitative SWE analysis was calculated using intraclass correlation coefficients. Results: Thirty-three women (mean age, 39.7 years; range, 31-48 years) were examined …

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Efficacy Of Mepolizumab Treatment In Oral Corticosteroid-Dependent Severe Eosinophilicasthma Patients With Chronic Rhinosinusitis With Nasal Polyps: Single Center, Real Life Study, İnsu Yilmaz, Murat Türk, Saki̇ne Nazi̇k Bahçeci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez Jan 2020

Efficacy Of Mepolizumab Treatment In Oral Corticosteroid-Dependent Severe Eosinophilicasthma Patients With Chronic Rhinosinusitis With Nasal Polyps: Single Center, Real Life Study, İnsu Yilmaz, Murat Türk, Saki̇ne Nazi̇k Bahçeci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez

Turkish Journal of Medical Sciences

Background/aim: Oral corticosteroid (OCS)-dependent severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps (SEACRSwNP) would be a suitable phenotype for mepolizumab treatment. This study evaluated the short-term efficacy of mepolizumab treatment in OCS-dependent SEA-CRSwNP. Materials and methods: Baseline and 24th week results [daily OCS doses, asthma exacerbation frequency, asthma control test (ACT) scores, blood eosinophil levels, FEV1 values, and numerical analog scale (NAS) of CRSwNP symptoms] of patients who were treated for at least 24 weeks with mepolizumab were retrospectively evaluated and compared. Results: A total of 16 patients were enrolled in the study. Mepolizumab was discontinued in one patient …

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The In Vitro Cytotoxic, Genotoxic, And Oxidative Damage Potentials Of The Oral Artificialsweetener Aspartame On Cultured Human Blood Cells, Kenan Çadirci, Özlem Özdemi̇r Tozlu, Hasan Türkez, Adi̇l Mardi̇noğlu Jan 2020

The In Vitro Cytotoxic, Genotoxic, And Oxidative Damage Potentials Of The Oral Artificialsweetener Aspartame On Cultured Human Blood Cells, Kenan Çadirci, Özlem Özdemi̇r Tozlu, Hasan Türkez, Adi̇l Mardi̇noğlu

Turkish Journal of Medical Sciences

Background/aim: Aspartame (APM, L-aspartyl-L-phenylalanine methylester) is a low-calorie, nonsaccharide artificial sweetener widely used in foods and beverages. When metabolized by the body, APM is broken down into aspartic acid, phenylalanine amino acids, and a third substance, methanol. Since the amino acid phenylalanine serves as a neurotransmitter building block affecting the brain, and methanol is converted into toxic formaldehyde, APM has deleterious effects on the body and brain. Thus, its safety and, toxicity have been the subjects of concern ever since it was first discovered. Although many studies have been performed on it, due to the presence of conflicting data in …

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Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar Jan 2020

Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar

Turkish Journal of Medical Sciences

Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The …

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Reliability And Validity Of The Turkish Version Of The Diabetes Distress Scale For Type 2diabetes And Distress Levels Of The Participants, Özge Telci̇ Çaklili, Güneş Feyi̇zoğlu, Selcan Tülü Çolak, Nazli Di̇zman, Sidika İrem Bozkurt Çakir, Ayteki̇n Oğuz Jan 2020

Reliability And Validity Of The Turkish Version Of The Diabetes Distress Scale For Type 2diabetes And Distress Levels Of The Participants, Özge Telci̇ Çaklili, Güneş Feyi̇zoğlu, Selcan Tülü Çolak, Nazli Di̇zman, Sidika İrem Bozkurt Çakir, Ayteki̇n Oğuz

Turkish Journal of Medical Sciences

Background/aim: Studies have shown an increased depression rate in patients with type 2 diabetes mellitus (T2DM) compared to the normal population. It is now acknowledged that patients suffer from distress rather than depression. Our aim was to validate the Turkish version of the Diabetes Distress Scale (DDS) and to show distress levels of the participants. Materials and methods: The scale was translated from English to Turkish by the authors and translated back to English. Between August 2015 and January 2016 all the patients who were referred to the T2DM Clinic of İstanbul Medeniyet University were screened, and eligible patients were …

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The Validity And Reliability Of The Turkish Version Of The Body Esteem Scale Foradolescents And Adults (Besaa) For Children, Umut Ece Arslan, Lütfi̇ye Hi̇lal Özcebe, Hande Konşuk Ünlü, Sarp Üner, Mahmut Saadi̇ Yardim, Ozgur Araz, Terry T-K Huang Jan 2020

The Validity And Reliability Of The Turkish Version Of The Body Esteem Scale Foradolescents And Adults (Besaa) For Children, Umut Ece Arslan, Lütfi̇ye Hi̇lal Özcebe, Hande Konşuk Ünlü, Sarp Üner, Mahmut Saadi̇ Yardim, Ozgur Araz, Terry T-K Huang

Turkish Journal of Medical Sciences

Background/aim: Body esteem (BE) is defined as the self-evaluation of one's own body or appearance. The Body Esteem Scale for Adolescents and Adults (BESAA) consists of three subscales: BE-appearance, BE-weight, and BE-attribution. Though initially developed for adolescents and adults, the use of the scale has recently increased in health-related research on children. This study aimed to assess the validity and reliability of the Turkish version of the BESAA for children. Materials and methods: The participants in the study were 4th grade children (aged 9-10 years) in Ankara, Turkey. The validity of the scale was evaluated through exploratory and confirmatory factor …

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Validation Of The Turkish Version Of The Sunnybrook Facial Grading System, Erdem Mengi̇, Cüneyt Orhan Kara, Fazil Necdet Ardiç, Funda Tümkaya, Fevzi̇ Barlay, Taylan Çi̇l, Hande Şenol Jan 2020

Validation Of The Turkish Version Of The Sunnybrook Facial Grading System, Erdem Mengi̇, Cüneyt Orhan Kara, Fazil Necdet Ardiç, Funda Tümkaya, Fevzi̇ Barlay, Taylan Çi̇l, Hande Şenol

Turkish Journal of Medical Sciences

Background/aim: To adapt the Sunnybrook facial grading system (SFGS) into Turkish and perform validation and reliability studies on the Turkish version. Materials and Methods: The original English version of the SFGS was translated into Turkish by performing a linguistic validity study based on international standards. The evaluators comprised 6 physicians. Evaluations were performed twice independently using the video recordings of 65 facial palsy patients. Synchronously, the House-Brackman facial grading system (HBFGS) was filled out to display concurrent validity. The intraclass correlation coefficient (ICC) and Cronbach's alpha was used for the examination of the inter- and intra-rater reliability. As another indication …

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Gynecological Laparoscopic Surgery In The Shade Of Covid-19 Pandemic, Şadiman Kiykaç Altinbaş, Ömer Lütfi̇ Tapisiz, Yaprak Üstün Jan 2020

Gynecological Laparoscopic Surgery In The Shade Of Covid-19 Pandemic, Şadiman Kiykaç Altinbaş, Ömer Lütfi̇ Tapisiz, Yaprak Üstün

Turkish Journal of Medical Sciences

A global public health problem with a high rate spread and transmission, Coronavirus outbreak has become the most talkedabout matter throughout the world. We are severely affected by the nations with vast numbers of deaths; it was hard to predict such a colossal pandemic with terrifying consequences. Elective surgeries are limited, but situations requiring an urgent gynaecological or obstetric surgical approach must still be performed during the COVID-19 pandemic. Concerns regarding surgical safety and the risk of viral transmission during surgery are of great importance. In this review, we aimed to summarize the concepts related to laparoscopic gynecological surgery during …

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Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş Jan 2020

Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş

Turkish Journal of Medical Sciences

A new type of coronavirus (2019-nCoV) is rapidly spreading worldwide and causes pneumonia, respiratory distress, thromboembolic events, and death. Chest computed tomography (CT) plays an essential role in the diagnosis of viral pneumonia, monitoring disease progression, determination of disease severity, and evaluating therapeutic efficacy. Chest CT can show important clues of 2019-nCoV disease (also known as COVID-19) in patients with an appropriate clinic. Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provides close clinical observation of patients with clinically severe disease. Therefore, radiologists and clinicians should be familiar with the CT imaging findings of COVID-19 pneumonia. Herein, …

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The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal Jan 2020

The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal

Turkish Journal of Medical Sciences

Background/aim: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in …

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The Usual Course Of Thorax Ct Findings Of Covid-19 Infection Andwhen To Perform Control Thorax Ct Scan, Yasemi̇n Gündüz, Mehmet Hali̇l Öztürk, Yakup Tomak Jan 2020

The Usual Course Of Thorax Ct Findings Of Covid-19 Infection Andwhen To Perform Control Thorax Ct Scan, Yasemi̇n Gündüz, Mehmet Hali̇l Öztürk, Yakup Tomak

Turkish Journal of Medical Sciences

: COVID-19 infection, a highly contagious disease caused by the SARS-CoV virus, and the World Health Organization declared this increasingly spreading disease as a global public health emergency (pandemic). In the diagnosis of COVID-19, the polymerase chain reaction (RT-PCR) is considered as the reference standard test. In the early stages, thorax CT findings could be present even before the onset of symptoms, thorax CT has quite high sensitivity in COVID-19 patients with false negative RT-PCR results, and it has a great importance not only in diagnosis but also in follow up. We think that it might be beneficial for our …

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