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Articles 181 - 210 of 213
Full-Text Articles in Medical Sciences
The Study Of The Effect Of Drugs Of Abuse On Protein Kinase A Activity In Mouse Brain And Spinal Cord, George D. Dalton
The Study Of The Effect Of Drugs Of Abuse On Protein Kinase A Activity In Mouse Brain And Spinal Cord, George D. Dalton
Theses and Dissertations
Morphine and Δ9-THC are drugs that produce analgesia and rewarding effects. However, chronic treatment with morphine and Δ9-THC produces problematic side-effects including tolerance and physical dependence. The cellular mechanisms underlying opioid and cannabinoid antinociceptive tolerance have been studied for years. Research has demonstrated that the expression of morphine and Δ9-THC antinociceptive tolerance may be mediated through intracellular signaling pathways, such as the adenylyl cyclase /Protein Kinase A (PKA) cascade. The present study investigated the role of PKA in the expression of morphine and Δ9-THC antinociceptive tolerance. Male Swiss Webster mice were treated chronically with morphine or Δ9-THC and the warm-water …
The Effect Of Antioxidant Supplementation On Human Sperm Cryopreservation, Katrina E. Taylor
The Effect Of Antioxidant Supplementation On Human Sperm Cryopreservation, Katrina E. Taylor
Theses : Honours
Semen cryopreservation has an important role in assisted reproductive technology however, the cooling, freezing and thawing processes often result in a significant loss of sperm motility, viability and nuclear integrity. The destructive effects of cryopreservation are significantly exacerbated in samples exhibiting low sperm number and poor morphological characteristics. Recent research into infertility has focused on the correlation between excessive oxidation and subfertility, in particular radical induced lipid peroxidation within the phospholipid bilayer of the spermatozoon plasma membrane and the promotion of cellular damage as a result of antioxidant insufficiency. The aim of this study was to evaluate the effect of …
The Effects Of Footshock On The Reinforcing Efficacy Of Cocaine In Male Long-Evans Rats, Elizabeth S. Hendrick
The Effects Of Footshock On The Reinforcing Efficacy Of Cocaine In Male Long-Evans Rats, Elizabeth S. Hendrick
Theses and Dissertations
Many links exist between cocaine abuse and stress. The literature and laboratory studies in rats suggest that this could be because stress increases the reinforcing efficacy of cocaine. Using male Long-Evans rats, experiments in this thesis tested effects of footshock on the reinforcing efficacy of cocaine using a progressive ratio schedule of reinforcement. They also examined effects of footshock on the reinforcing efficacy of a half-maximal dose of cocaine. Finally, they tested the effects of footshock on cocaine self-administration in rats initially resistant to acquisition of cocaine self-administration. Footshock did not increase reinforcing efficacy of cocaine on a PR schedule …
Mechanism Of Cancer Selective Apoptosis By Par-4, Sushma Gurumurthy
Mechanism Of Cancer Selective Apoptosis By Par-4, Sushma Gurumurthy
University of Kentucky Doctoral Dissertations
Despite distinct dissimilarities, diverse cancers express several common pro-tumorigenic traits. We present here evidence that the pro-apoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated PKA activity noted in cancer cells activated the apoptotic function of ectopic Par-4 or its SAC domain, which induces apoptosis selectively in cancer cells and not in normal or immortalized cells. PKA preferentially phosphorylated Par-4 at the T155 residue within the SAC domain in cancer cells. Moreover, pharmacological-, peptide- or siRNA-mediated inhibition of PKA activity in cancer cells resulted in abrogation of both T155 …
The Evaluation Of Rectal Bleeding In Adults, Elizabeth Allen, Christina Nicolaidis, Mark Helfand
The Evaluation Of Rectal Bleeding In Adults, Elizabeth Allen, Christina Nicolaidis, Mark Helfand
School of Social Work Faculty Publications and Presentations
Colon cancer is the third leading cause of cancer-related death in this country.5 The majority of medical societies recommend some form of colon cancer screening for asymptomatic adult patients over age 50. The evaluation of rectal bleeding is different from screening because the risk of serious disease is higher and it is unclear whether early diagnosis and treatment of serious disease results in improved mortality once gross bleeding has occurred. The optimal evaluation strategy for rectal bleeding is unknown. Neither historical information nor the presence or absence of hemorrhoids has been shown to reliably differentiate benign from serious disease.6–11 Fecal …
Global Gene Expression Profiling Of Cells Overexpressing Smc3., Giancarlo Ghiselli, Chang-Gong Liu
Global Gene Expression Profiling Of Cells Overexpressing Smc3., Giancarlo Ghiselli, Chang-Gong Liu
Department of Microbiology and Immunology Faculty Papers
BACKGROUND: The Structural Maintenance of Chromosome 3 protein (SMC3) plays an essential role during the sister chromatid separation, is involved in DNA repair and recombination and participates in microtubule-mediated intracellular transport. SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms murine NIH3T3 fibroblasts. In order to gain insight into the mechanism of SMC3-mediated tumorigenesis a gene expression profiling was performed on human 293 cells line stably overexpressing SMC3. RESULTS: Biotinylated complementary RNA (cRNA) was used for hybridization of a cDNAmicroarray chip harboring 18,861 65-mer oligos derived from the published dEST sequences. After filtering, the hybridization …
Association Between Coinfection Of Porphyromonas Gingivalis, Actinobacillus Actinomycetemcomitans And Treponema Denticola And Periodontal Tissue Destruction In Chronic Periodontitis, L. L. Chen, Y. M. Wu, J. Yan, W. L. Sun, Y. Z. Sun, David M. Ojcius
Association Between Coinfection Of Porphyromonas Gingivalis, Actinobacillus Actinomycetemcomitans And Treponema Denticola And Periodontal Tissue Destruction In Chronic Periodontitis, L. L. Chen, Y. M. Wu, J. Yan, W. L. Sun, Y. Z. Sun, David M. Ojcius
All Dugoni School of Dentistry Faculty Articles
No abstract provided.
Periplasm Organization In Treponema Denticola As Studied By Cryo-Electron Tomography, Jacques Izard, C.-E. Hsieh, C. A. Mannella, Ronald J. Limberger, M. Marko
Periplasm Organization In Treponema Denticola As Studied By Cryo-Electron Tomography, Jacques Izard, C.-E. Hsieh, C. A. Mannella, Ronald J. Limberger, M. Marko
Department of Food Science and Technology: Faculty Publications
As a spirochete, the genus Treponema is one of the few major bacterial groups whose natural phylogenic relationships are evident at the level of gross phenotypic characteristics such as their morphology. Treponema spp. are highly invasive due to their unique motility in dense media, and their ability to penetrate cell layers. This feature is associated with the helical cell body and the presence of flagellar filaments in the periplasm. Treponema denticola is an oral pathogen involved in endodontic infections and periodontal diseases. The presence and quantity of T. denticola in the subgingival biofilm is correlated with the severity of periodontal …
Mitochondrial Dna Mutations, Apoptosis, And The Misfolded Protein Response., Justin L. Mott, Dekui Zhang, Hans Peter Zassenhaus
Mitochondrial Dna Mutations, Apoptosis, And The Misfolded Protein Response., Justin L. Mott, Dekui Zhang, Hans Peter Zassenhaus
Journal Articles: Biochemistry & Molecular Biology
Studies of transgenic mice with accelerated accumulation of mtDNA mutations specifically in the heart lead us to propose that apoptotic signaling and cell death is central to the pathogenesis of mtDNA mutations in aging. It is the cellular response to that apoptotic signaling and the organ?s compensatory response to a loss of cells that specify the phenotype of an accumulation of mtDNA mutations. In the heart, cardiomyocytes induce a vigorous anti-apoptotic, pro-survival response to counteract mitochondrial apoptotic signaling. The heart up-regulates contractility of remaining myocytes in order to maintain cardiac output. We hypothesize that mutant mitochondrial proteins originate apoptotic signaling …
The Use Of Time-Resolved Fluorescence Imaging In The Study Of Protein Kinase C Localisation In Cells., Christopher D Stubbs, Stanley W Botchway, Simon J Slater, Anthony W Parker
The Use Of Time-Resolved Fluorescence Imaging In The Study Of Protein Kinase C Localisation In Cells., Christopher D Stubbs, Stanley W Botchway, Simon J Slater, Anthony W Parker
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
BACKGROUND: Two-photon-excitation fluorescence lifetime imaging (2P-FLIM) was used to investigate the association of protein kinase C alpha (PKCalpha) with caveolin in CHO cells. PKCalpha is found widely in the cytoplasm and nucleus in most cells. Upon activation, as a result of increased intracellular Ca2+ and production of DAG, through G-protein coupled-phospholipase C signalling, PKC translocates to a variety of regions in the cell where it phosphorylates and interacts with many signalling pathways. Due to its wide distribution, discerning a particular interaction from others within the cell is extremely difficult. RESULTS: Fluorescence energy transfer (FRET), between GFP-PKCalpha and DsRed-caveolin, was used …
Biomarkers For Placental Abnormality, Cathal Mccarthy
Biomarkers For Placental Abnormality, Cathal Mccarthy
Doctoral
Obstetrical complications including recurrent miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR) affect 1%-5% of pregnant women (Younis and Samueloff 2003). Dysfunctional trophoblasts, impaired development of spiral arteries, imbalance in systems controlling the dilation and contraction of spiral arteries, placental fibrin clots and intervillous thrombosis are all possible factors that can result in an insufficient placental circulation. The combination of the hypercoagulable state of pregnancy and presence of genetic thrombophilic markets has the potential to induce placental thrombosis and cause placental insufficiency with subsequent obstetrical complications. The initial part of the research work involved examining the relationship between four common genetic …
Multidisciplinary Treatment Approach For The Localized Gingival Recession: A Case Report, Işil Saygun, Şeni̇z Karaçay, Ati̇lla Özdemi̇r, Deni̇z Sağdiç
Multidisciplinary Treatment Approach For The Localized Gingival Recession: A Case Report, Işil Saygun, Şeni̇z Karaçay, Ati̇lla Özdemi̇r, Deni̇z Sağdiç
Turkish Journal of Medical Sciences
GUN^1, Şeniz KARAÇAY^2, Atilla ÖZDEMİR^1, Deniz SAĞDIÇ^2 ^1Department of Periodontology, Gülhane Military Medical Academy, Ankara - Turkey ^2Department of Orthodontics, Gülhane Military Medical Academy, Ankara - Turkey
A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay
A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay
Turkish Journal of Medical Sciences
Bioluminescent imaging (BLI) is particularly well suited for imaging small animals, and it can be readily used by scientists who are already routinely using the luciferase gene as a reporter in cell-based assays. This strategy relies on ATP and an O_2 dependent photochemical reaction between luciferin and luciferase, resulting in the release of photons from only live cells. In BLI, the intensity of the light detected by the device is proportional to the intensity of light emitted and the relationship is quantitative. This study was performed to determine the sensitivity of BLI for the imaging of lung metastasis and breast …
Differential Effect Of Glutathione Depletion On Glycogenolysis In Isolated Rat Hepatocytes Mediated By A-Adrenoceptor Agonists And Glucagon, Mukadder Atmaca, Jeffrey R. Fry
Differential Effect Of Glutathione Depletion On Glycogenolysis In Isolated Rat Hepatocytes Mediated By A-Adrenoceptor Agonists And Glucagon, Mukadder Atmaca, Jeffrey R. Fry
Turkish Journal of Medical Sciences
Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity …
The Quality Of Collaboration Among Medical Research Centers, Universities, Health Executives And The Community In İran, Saeed Asefzadeh
The Quality Of Collaboration Among Medical Research Centers, Universities, Health Executives And The Community In İran, Saeed Asefzadeh
Turkish Journal of Medical Sciences
A health research system is defined as a system for planning, coordinating, monitoring and managing health research resources and activities, and for promoting research aimed at effective and equitable national health development. This study was conducted to describe the quality of mutual collaboration among medical research centers, universities, executive organizations and the community. In this situation analysis qualitative methods were applied. In-depth interviews were held with the heads of 20 research centers (RCs), 6 senior executive health administrators at national level, 10 vice chancellors at universities and 3 directors of private medical research firms. In addition to the interviews, records …
Most Common Infections And Antibiotic Prescribing Habits Of Residents: Experience Of Three University Hospitals, Serpi̇l Aydin, Füsun Yariş, Ali̇s Özçakir, Canan Ağalar
Most Common Infections And Antibiotic Prescribing Habits Of Residents: Experience Of Three University Hospitals, Serpi̇l Aydin, Füsun Yariş, Ali̇s Özçakir, Canan Ağalar
Turkish Journal of Medical Sciences
As the common use of antibiotics is a very important factor in antibiotic resistance, their rational use has to be promoted world. We planned this study in order to define the habits and approach of Turkish residents when prescribing antibiotics, including their selection criteria, and to discover if the availability of laboratory tests affected their approach. In this descriptive study, the residents in the authors' hospitals were visited once during October and November 2001. Anonymous, volunteer-based questionnaires were used, which required the following information: demographic features of resident, the most common types of infections and groups of antibiotics prescribed, any …
Prenatal Diagnosis Of A Trisomy 13 Case Associated With Holoprosencephaly By Ultrasonography And Quantitative Fluorescent Pcr, N. Lale Şatiroğlu Tufan, A. Çevi̇k Tufan, Başak Yildirim, Babür Kaleli̇, C. Nur Semerci̇, Ferda Bi̇r, Füsun Düzcan, Hüseyi̇n Bağci
Prenatal Diagnosis Of A Trisomy 13 Case Associated With Holoprosencephaly By Ultrasonography And Quantitative Fluorescent Pcr, N. Lale Şatiroğlu Tufan, A. Çevi̇k Tufan, Başak Yildirim, Babür Kaleli̇, C. Nur Semerci̇, Ferda Bi̇r, Füsun Düzcan, Hüseyi̇n Bağci
Turkish Journal of Medical Sciences
ŞATIROĞLU TUFAN^{1,2}, A. Çevik TUFAN^{2,3}, Başak YILDIRIM^4, Babür KALELİ^4, C. Nur SEMERCİ^1, Ferda BİR^5, Füsun DÜZCAN^1, Hüseyin BAĞCI^{1,2} ^1Department of Medical Biology, Center for Genetic Diagnosis, Molecular Genetics Laboratory, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^2Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli - Turkey ^3Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^4Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, Denizli - Turkey ^5Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli - Turkey
Wolfram Syndrome (Ws), Neither An Autosomal Nor A Sex Linked Disorder, Şi̇nasi̇ Özsoylu
Wolfram Syndrome (Ws), Neither An Autosomal Nor A Sex Linked Disorder, Şi̇nasi̇ Özsoylu
Turkish Journal of Medical Sciences
No abstract provided.
Lipid Profile And Lipid Peroxidation Pattern Pre And Post Exercise In Coronary Artery Disease, Hedef D. El-Yassin, Nabil M. A. Hasso, Hassan A. Al-Rubayi
Lipid Profile And Lipid Peroxidation Pattern Pre And Post Exercise In Coronary Artery Disease, Hedef D. El-Yassin, Nabil M. A. Hasso, Hassan A. Al-Rubayi
Turkish Journal of Medical Sciences
Increased aerobic metabolism during exercise is a potential source of oxidative stress, which plays an important role in the development of atherosclerotic disease, while antioxidants delay or prevent various steps in atherosclerosis. The aim of this study was to identify the effect of oxidative stress induced by the TMT (Treadmill exercise Test) and the lipid peroxidation level as and lipid profile in blood, which may help in confirming the diagnosis of CAD (Coronary Artery Disease) in borderline cases of TMT results. This may help in future for early detection and possible prevention of atherosclerosis especially in people with a family …
Lymphocyte Subpopulations In Patients With Acute Brucellosis, İlhami̇ Çeli̇k, H. Handan Akbulut
Lymphocyte Subpopulations In Patients With Acute Brucellosis, İlhami̇ Çeli̇k, H. Handan Akbulut
Turkish Journal of Medical Sciences
The aim of this work was to evaluate changes in lymphocyte subpopulations, especially helper and cytotoxic T cells, in acute brucellosis patients undergoing treatment. Forty-three acute brucellosis patients were included in the study. Twenty healthy subjects served as controls. Total lymphocytes and the CD3^+, CD4^+, CD8^+, CD19^+ and CD (16+56)^+ subpopulations were counted by two-color flow cytometric analysis. The CD4+ counts in patients before and after treatment were not statistically different (p = 0.7), but healthy subjects had significantly more of these cells (p = 0.001 and p = 0.001 compared to pre- and post-treatment patients, respectively). The CD8^+ counts …
Juvenile Dermatomyositis Resistant To Steroids, Muzaffer Polat, İpek Akil, Tarkan İki̇zoğlu, Seli̇m Serter, Mi̇ne Özkol, Özge Yilmaz İki̇zoğlu, Şenol Coşkun
Juvenile Dermatomyositis Resistant To Steroids, Muzaffer Polat, İpek Akil, Tarkan İki̇zoğlu, Seli̇m Serter, Mi̇ne Özkol, Özge Yilmaz İki̇zoğlu, Şenol Coşkun
Turkish Journal of Medical Sciences
POLAT^1, İpek AKIL^1, Tarkan İKİZOĞLU^1, Selim SERTER^2, Mine ÖZKOL^2, Özge YILMAZ İKİZOĞLU^1, Şenol COŞKUN^1 ^1Department of Pediatrics, Faculty of Medicine Celal Bayar University, Manisa - Turkey ^2Department of Radiology, Faculty of Medicine Celal Bayar University, Manisa - Turkey
National Tuberculosis Reference Laboratory Experience In Multi Center Quality Control Programs For Molecular Diagnostics Of Tuberculosis, Gülnur Tarhan, İsmai̇l Ceyhan, Sali̇h Cesur
National Tuberculosis Reference Laboratory Experience In Multi Center Quality Control Programs For Molecular Diagnostics Of Tuberculosis, Gülnur Tarhan, İsmai̇l Ceyhan, Sali̇h Cesur
Turkish Journal of Medical Sciences
Nucleic acid amplification methods to detect Mycobacterium tuberculosis complex (MTBC) in clinical specimens are increasingly used to diagnose tuberculosis. A number of nucleic acids amplification assays have been developed to detect MTBC DNA in clinical material. These assays differ in their requirements for sample volume and sample preparation, methods of amplification, and methods of detection. There are advantages and disadvantages of all assays; thus, there is probably no assay which is best suited to all situations. Quality control programs for molecular diagnostics (QCMD) based on nucleic acid amplification have not been widely implemented in clinical laboratories and remain limited to …
Evaluation Of Plasma Protein C Antigen, Protein C Activity And Thrombomodulin Levels In Type 2 Diabetic Patients, Berna Aslan, Nezaket Eren, Şebnem Ci̇ğerli̇, Fatma Müldür, Ni̇hal Yücel
Evaluation Of Plasma Protein C Antigen, Protein C Activity And Thrombomodulin Levels In Type 2 Diabetic Patients, Berna Aslan, Nezaket Eren, Şebnem Ci̇ğerli̇, Fatma Müldür, Ni̇hal Yücel
Turkish Journal of Medical Sciences
The imbalance between coagulation and fibrinolysis leads to vascular complications in diabetics. In our study, we have investigated the effects of the protein C-thrombomodulin system as a cause of diabetic vascular complications. Whereas PC-Ag levels were lower, thrombomodulin (TM) levels of diabetics were higher than that of the controls (P < 0.001, P < 0.001 respectively). Furthermore, patients were divided into three groups according to their urinary albumin excretion (UAE). Group 1, 2 and 3 consisted of 27 patients with UAC £ 30 µg/ml, 16 patients with UAC in range 30-140 µg/ml, 3 patients with UAC >140 µg/ml, respectively. Plasma PC-Ag levels were significantly decreased in group 1 and 2 with respect to controls (P < 0.01, P < 0.01). Plasma TM concentrations were significantly increased in group 1, 2 and 3 compared with the control group (P < 0.001, P < 0.01, P < 0.01). Patients were also divided into two groups according to the duration of their illness; patients whose diabetic age < 10 years (Group A) and whose diabetic age > 10 years (Group B). In both groups, PC-Ag levels were lower and TM levels higher than that of the control group (P < 0.01, P < 0.01; P < 0.001, P < 0.001 respectively). There was no significant difference between group A and B in PC-Ag levels (P > 0.50) but a significant difference in TM levels (P < 0.001).
The Prevalence And Resistance Patterns Of Pseudomonas Aeruginosa In Intensive Care Units In A University Hospital, Lütfü Savaş, Ni̇zami̇ Duran, Nazan Savaş, Yusuf Önlen, Sabahatti̇n Ocak
The Prevalence And Resistance Patterns Of Pseudomonas Aeruginosa In Intensive Care Units In A University Hospital, Lütfü Savaş, Ni̇zami̇ Duran, Nazan Savaş, Yusuf Önlen, Sabahatti̇n Ocak
Turkish Journal of Medical Sciences
The intensive care units (ICUs) are burdened with a high frequency of nosocomial infections often caused by multiresistant nosocomial pathogens. Pseudomonas aeruginosa has emerged as one of the most problematic Gram-negative pathogens. The objective of this study was to identify frequency of Pseudomonas aeruginosa from the various clinical samples in ICUs, and to investigate resistance patterns against various antibiotics widely used for treatment. This study was carried out between September 2000-September 2002. Antimicrobial susceptibility testing was performed by the disc diffusion method according to NCCLS (National Commitee for Clinical and Laboratory Standards) guidelines. The following antibiotics were tested: imipenem, meropenem, …
Prospective Analysis Of Antibiotic Susceptibility Patterns Of Mrsa In A Turkish University Hospital, Lütfü Savaş, Ni̇zami̇ Duran, Yusuf Önlen, Nazan Savaş, Mustafa Erayman
Prospective Analysis Of Antibiotic Susceptibility Patterns Of Mrsa In A Turkish University Hospital, Lütfü Savaş, Ni̇zami̇ Duran, Yusuf Önlen, Nazan Savaş, Mustafa Erayman
Turkish Journal of Medical Sciences
Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. The prevalence of MRSA in many countries is increasing and, in some hospitals, more than half of all S. aureus disease isolates are MRSA. MRSA strains are becoming increasingly multiresistant, and have recently developed resistance to vancomycin, which has been used successfully to treat MRSA for more than 30 years. In-vitro determination of resistance patterns of S. aureus is critical in terms of administering suitable antimicrobial treatments. The objective of this study was to identify the frequency of MRSA from various clinical samples and resistance patterns against various antibiotics used broadly …
Analysis Of The Cytotoxicity Of Four Dentin Bonding Agents On Gingival Fibroblasts, Jüli̇de Özen, Arzu Atay, Fulya Toksoy Topçu, Ali̇ Uğur Ural, Mehmet Dalkiz, Yaşar Meri̇ç Tunca
Analysis Of The Cytotoxicity Of Four Dentin Bonding Agents On Gingival Fibroblasts, Jüli̇de Özen, Arzu Atay, Fulya Toksoy Topçu, Ali̇ Uğur Ural, Mehmet Dalkiz, Yaşar Meri̇ç Tunca
Turkish Journal of Medical Sciences
The objective of this study is to evaluate effects of four dentin bonding agents PromptL-Pop, Syntac, Pekabond, Scotchbond-1 on cell proliferation in human gingival fibroblast cultures. Under aseptic conditions, test specimens were placed in the centre of 24-well tissue culture trays. Each well was covered at a concentration of 104 cells/cm2. The cultures were incubated at 37 ºC and cell proliferation was determined by the MTT method 24 h and 72 h after exposure. Statistical analysis was performed applying the Student t test. Statistical analysis of data showed that all materials caused noncytotoxic effects for 24 hours and cytoxic effects …
Faculty Publications 2004, Lsu Health Sciences Center New Orleans
Faculty Publications 2004, Lsu Health Sciences Center New Orleans
Historical Faculty Publications
This Faculty bibliography contains 1027 publications.
Ccl20/Macrophage Inflammatory Protein 3Α And Tumor Necrosis Factor Alpha Production By Primary Uterine Epithelial Cells In Response To Treatment With Lipopolysaccharide Or Pam3cys, M. A. Crane-Godreau, C. R. Wira
Ccl20/Macrophage Inflammatory Protein 3Α And Tumor Necrosis Factor Alpha Production By Primary Uterine Epithelial Cells In Response To Treatment With Lipopolysaccharide Or Pam3cys, M. A. Crane-Godreau, C. R. Wira
Dartmouth Scholarship
Having previously shown that CCL20/macrophage inflammatory protein 3 and tumor necrosis factor alpha (TNF-alpha) are released by polarized primary rat uterine epithelial cells (UEC) in response to Escherichia coli but not to Lactobacillus rhamnosus , we sought to determine if epithelial cells are responsive to pathogen-associated molecular patterns (PAMP), including lipopolysaccharide (LPS), lipoteichoic acid (LTA), and Pam 3 Cys, a bacterial lipoprotein analog. Epithelial cells were grown to confluence on Nunc cell culture inserts prior to apical treatment with PAMPs. In response to LPS, LTA, and Pam 3 Cys (EMC Microcollection GmbH, Tu ̈- bingen, Germany), CCL20 levels increased (4- …
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important For Generation Of An Optimal Polymorphonuclear Response Against Toxoplasma Gondii Infection, Michelle N. Kelly, Jay K. Kolls, Kyle Happel, Joseph D. Schwartzman
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important For Generation Of An Optimal Polymorphonuclear Response Against Toxoplasma Gondii Infection, Michelle N. Kelly, Jay K. Kolls, Kyle Happel, Joseph D. Schwartzman
Dartmouth Scholarship
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
Identification Of Fatty Acid Oxidation Disorder Patients With Lowered Acyl-Coa Thioesterase Activity In Human Skin Fibroblasts, Mary Hunt, Jos Ruiter, Petra Mooyer, Carlo W T Van Roermond, Rob Ofman, Lodewig Ijlst, Ronald J A Wanders
Identification Of Fatty Acid Oxidation Disorder Patients With Lowered Acyl-Coa Thioesterase Activity In Human Skin Fibroblasts, Mary Hunt, Jos Ruiter, Petra Mooyer, Carlo W T Van Roermond, Rob Ofman, Lodewig Ijlst, Ronald J A Wanders
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Background: Acyl-CoA thioesterases are enzymes that hydrolyze acyl-CoAs to the free fatty acid and coenzyme A (CoASH). These enzymes have been identified in several cellular compartments and are thought to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. However, to date no patients deficient in acyl-CoA thioesterases have been identified. Design: Acyl-CoA thioesterase activity was measured in human skin fibroblasts. Western blot analysis was used to determine Type-II acyl-CoA thioesterase protein levels in patients. Results: Activity was found in human fibroblasts with all saturated acyl-CoAs from C4:0- to C18:0-CoA, with highest activity detected with lauroyl-CoA and myristoyl-CoA (C12:0 …