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Caspase-12, Rheumatoid Arthritis, And The Dog That Didn’T Bark, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

CASPASE-12 (CASP12) has an anti-inflammatory function during infection. To determine and if CASP12 could protect against inflammatory disease, we investigated the distribution of CASP12 alleles in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 homozygous patients had lower baseline joint narrowing and total disease scores. However, there was no significant difference for distribution of CASP12 genotypes between AA controls and patients with RA, or any other clinical criteria for this disease. CASP12 homozygosity appears to be, at best a subtle protective factor for some aspects of RA in AA patients. This raises an intriguing issue as to how this protein would …

Caspase-12 And Lupus: The Curious Case Of The Dog That Didn’T Bark, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

CASPASE-12 (CASP12) has an anti-inflammatory function during infection, and is a risk factor for sepsis in African-Americans (AA). To determine if CASP12 could be protective for systemic lupus erythematosus (SLE) in AA, we genotyped AA SLE patients and controls. We found that, at best, there was a weak association between CASP12 genotype with the absence of anti-dsDNA autoantibodies in SLE patients. No effect was seen upon serum interleukin-1 beta levels, nor was any other protective effect noted for the CASP12 genotype, whether upon association with SLE, or any of the 11 American College of Rheumatology classification criteria. We concluded that …

The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

No abstract provided.

Week Of December 14, 2015, New York Medical College

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• Summer Fellowship Pays Off in the Form of Published Research
• Department of Surgery Hosts Twelfth Annual Louis R.M. Del Guercio, M.D., Distinguished Visiting Professorship and Research Day
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Week Of December 7, 2015, New York Medical College

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Week Of November 16, 2015, New York Medical College

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Week Of November 9, 2015, New York Medical College

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• Penghua Wang, Ph.D., Identifies Protein that Fights Intestinal Bugs
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Week Of November 2, 2015, New York Medical College

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• NYMC Supporters Gather at Founder's Dinner
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• Medical Student, Adrian Romero, is the Recipient of 2015 AMA Foundation
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Week Of October 26, 2015, New York Medical College

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• William Campbell, Ph.D., Longtime, Celebrated NYMC Adjunct Professor, Wins Nobel
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Week Of October 19, 2015, New York Medical College

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• NYMC Set to Honor Three at 2015 Founder's Dinner
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Week Of October 5, 2015, New York Medical College

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Week Of September 28, 2015, New York Medical College

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Week Of September 14, 2015, New York Medical College

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• Dean Miller Hosts School of Medicine Retreat
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Week Of September 8, 2015, New York Medical College

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Week Of August 31, 2015, New York Medical College

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• NYMC Achieves Top ACCME Accreditation
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Week Of August 24, 2015, New York Medical College

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• School of Medicine Class of 2019 Embarks on their Journey to Medicine at the White Coat Ceremony
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Week Of July 27, 2015, New York Medical College

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• Public Health Program Passes the Test... with Flying Colors
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• NYMC Hosts 16th Pediatric Cancer Research Foundation Memorial Lectureship
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• Lawrence Shapiro, M.D., Is Named Professor Emeritus of Pediatrics

Week Of June 29, 2015, New York Medical College

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• New Campus Walkway is Now Open
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Week Of June 1, 2015, New York Medical College

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• NYMC Bids Farewell to the Class of 2015
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Week Of May 18, 2015, New York Medical College

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• Dr. Jan K. Richardson Will Address the Class of 2015
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Week Of May 11, 2015, New York Medical College

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• Office of the Registrar Rolls Out Self-Service Portal for Students
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Week Of April 27, 2015, New York Medical College

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• NYMC Receives the Business Council of Westchester Corporate Citizenship Award
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• Doctoral Projects Demonstrate Breadth and Depth of Physical Therapy
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Week Of April 20, 2015, New York Medical College

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• NYMC Welcomes New BioInc Client
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Human Stem Cells: Is It Possible To Limit Pluripotent Human Stem Cells To Differentiate Into Specific Tissue Or Organ?, Chaya Korf

The Science Journal of the Lander College of Arts and Sciences

It would seem that differentiation of stem cells is the remedy of modern times. Yet stem cell research is more complex that the public may recognize and is still in the developmental stage. Recent breakthroughs show promise; various guidelines provide structure to this growing field but it is not ready for gross public application. The objective of this paper is to research various different methods of stem cell production and application. Methods included reviewing articles and studies to evaluate the process in production of affective stem cells. There are many therapies that illustrate this research. Upon completing and explaining this …

Pancreas: Do All Roads Lead To Mitochondria?, Amit Mukherji, Omobola Onikoyi, Vasudeva G. Kamath

Touro College of Osteopathic Medicine (Middletown) Publications and Research

Over several millions of years of evolution, mitochondria have transformed into specialized organelles. Today, they cannot live outside the cell nor can the host cell live without them, resulting in a symbiotic relationship. Richard Altmann, in 1894, documented them as cell organelles and called them “bioblasts”. Later, the term “mitochondria” itself was coined by Carl Benda in 1898. Ever since these findings, we in the field of medicine have learned a lot about this tiny organelle, but numerous aspects continue to be discovered. In this article, we will review the significance of this organelle in terms of pancreatic dysfunctions.

Mechanisms, Potential Therapies, And The Role Of Tgf-Β In The Formation Of Scars, Isaac Traube

The Science Journal of the Lander College of Arts and Sciences

Scarring is the inevitable outcome of wound healing. This review looks at some of the underlying mechanisms of this complex process with the aim of identifying targets for therapeutic manipulation that could result in reduced scarring or even scarless wound repair. Fetal wounds are shown to heal without scars primarily due to low levels of TGF-β1 and TGF-β2 and high levels of TGF-β3 as compared to adult wounds which heal with scars. Abnormal excessive scarring in keloid and hypertrophic scars are also attributed to TGF-β. Clinical manipulation of TGF-β ratios showed promise as a therapeutic means of controlling scar formation. …

Transposon Based Gene Therapy As A Treatment For Cancer, Jacob Stauber

The Science Journal of the Lander College of Arts and Sciences

Gene therapy is the use of genes to treat or prevent diseases. Diseases such as cancer, which are difficult to treat using conventional methods, can be treated using gene therapy. The transport of the therapeutic transgene can be accomplished using viral or non-viral methods. However, widespread use of viral vectors is limited due to its high cost of manufacture and safety concern. Non-viral vectors are limited in their effectiveness. The use of transposons such as the Sleeping Beauty transposon system can effectively deliver the transgene with less concern than viral vectors. This review discusses the various vectors and treatment strategies …

Viability Of Sirna As A Clinical Treatment, Zev Blumenkranz

The Science Journal of the Lander College of Arts and Sciences

The purpose of this paper is to better understand the methods problems and some solutions for siRNA treatments. The benefits of this novel medical treatment are explored and its benefits are expounded on by comparing it to other more complex and futuristic treatments. The exact process of siRNA silencing and down regulation is unknown. Some hypotheses of how it may work are discussed giving precedence to the most widely accepted hypothesis. Although siRNA treatments are not yet used on a major scale for many diseases, different possible treatment options are compared and explained. Particular care was taken to give a …

Epigenetics As A Cure For Cancer, Sara Rivka Margolis

The Science Journal of the Lander College of Arts and Sciences

Epigenetics is an emerging research topic that is being tested as a potential cure for cancer. Epigenetics is a non-genetic influence that shapes the phenotype. Epigenetics effects gene expression, but does not cause any changes in the DNA. DNA methylation patterns is one such epigenetic change in the cell that has huge potential for cancer treatment. Scientists have observed that many cancerous genes express signs of either hypermethylation or hypomethylation. The key for the treatment is that epigenetic changes are reversible, which opens the door to potential drugs to cure cancer and other diseases.

Similarities Between Corticosteroids, M. Einhorn

The Science Journal of the Lander College of Arts and Sciences

Corticosteroids are a class of potent drugs with important physiological effects on the body. Regular use is linked with common and serious side effects. This paper uses studies to analyze the similarities between various corticosteroids. All drugs in this class are molecules that contain the same steroid backbone and are therefore associated with the same cellular receptor. This results in a comparable mechanism and parallel overall effect in the body. Side effects of corticosteroids are analogous as well. Using the knowledge of physiological changes in the body due to corticosteroids will allow healthcare providers to determine the most effective corticosteroid …