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Articles 481 - 510 of 565

Full-Text Articles in Medical Sciences

Week Of September 6, 2016, New York Medical College Sep 2016

Week Of September 6, 2016, New York Medical College

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Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension And Heart Failure In Female But Not Male Mice, Sachindra R. Joshi, Anand Lakhkar, Vidhi Dhagia, Ariadne Zias, Vasiliki Soldatos, Kaori Oshima, Houli Jiang, Katherine Gotlinger, Jorge H Capdevila, Michal L. Schwartzman, Ivan F. Mcmurtry, Sachin A. Gupte Sep 2016

Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension And Heart Failure In Female But Not Male Mice, Sachindra R. Joshi, Anand Lakhkar, Vidhi Dhagia, Ariadne Zias, Vasiliki Soldatos, Kaori Oshima, Houli Jiang, Katherine Gotlinger, Jorge H Capdevila, Michal L. Schwartzman, Ivan F. Mcmurtry, Sachin A. Gupte

NYMC Faculty Publications

Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertension (PH). A recent study showed that deficiency of Cyp2j did not protect male and female mice from hypoxia-induced PH. Since CYP2C44 is a functionally important epoxygenase, we hypothesized that knockout of the Cyp2c44 gene would protect both sexes of mice from hypoxia-induced PH. We tested this hypothesis in wild-type (WT) and Cyp2c44 knockout (Cyp2c44 (-/-)) mice exposed to normoxia (room air) and …


Week Of August 29, 2016, New York Medical College Aug 2016

Week Of August 22, 2016, New York Medical College Aug 2016

Week Of August 8, 2016, New York Medical College Aug 2016

Week Of July 18, 2016, New York Medical College Jul 2016

Sexually Dimorphic Adaptation Of Cardiac Function: Roles Of Epoxyeicosatrienoic Acid And Peroxisome Proliferator-Activated Receptors, Jun Qin, Yicong Le, Ghezal Froogh, Sharath Kandhi, Houli Jiang, Dong Sun, An Huang Jun 2016

Sexually Dimorphic Adaptation Of Cardiac Function: Roles Of Epoxyeicosatrienoic Acid And Peroxisome Proliferator-Activated Receptors, Jun Qin, Yicong Le, Ghezal Froogh, Sharath Kandhi, Houli Jiang, Dong Sun, An Huang

NYMC Faculty Publications

Epoxyeicosatrienoic acids (EETs) are cardioprotective mediators metabolized by soluble epoxide hydrolase (sEH) to form corresponding diols (DHETs). As a sex-susceptible target, sEH is involved in the sexually dimorphic regulation of cardiovascular function. Thus, we hypothesized that the female sex favors EET-mediated potentiation of cardiac function via downregulation of sEH expression, followed by upregulation of peroxisome proliferator-activated receptors (PPARs). Hearts were isolated from male (M) and female (F) wild-type (WT) and sEH-KO mice, and perfused with constant flow at different preloads. Basal coronary flow required to maintain the perfusion pressure at 100 mmHg was significantly greater in females than males, and …


Week Of June 20, 2016, New York Medical College Jun 2016

Week Of May 31, 2016, New York Medical College May 2016

Week Of May 16, 2016, New York Medical College May 2016

Week Of May 9, 2016, New York Medical College May 2016

Week Of May 2, 2016, New York Medical College May 2016

Spinal Cord Compression Secondary To Extramedullary Hematopoiesis: Case Report And Review Of The Literature, Arthur Wang, Nathan Carberry, Elena Solli, John Gillick, Humayun Islam, Virany Hillard May 2016

Spinal Cord Compression Secondary To Extramedullary Hematopoiesis: Case Report And Review Of The Literature, Arthur Wang, Nathan Carberry, Elena Solli, John Gillick, Humayun Islam, Virany Hillard

NYMC Faculty Publications

Extramedullary hematopoiesis (EMH) is a rare cause of spinal cord compression (SCC). EMH represents the growth of blood cells outside of the bone marrow and occurs in a variety of hematologic illnesses, including various types of anemia and myeloproliferative disorders. Although EMH usually occurs in the liver, spleen, and lymph nodes, it may also occur within the spinal canal. When this occurs, the mass effect can compress the spinal cord, potentially leading to the development of neurological deficits. We present a case of SCC secondary to EMH. This report illustrates the importance of considering EMH in the differential diagnosis of …


Week Of April 25, 2016, New York Medical College Apr 2016

Week Of April 18, 2016, New York Medical College Apr 2016

Week Of April 11, 2016, New York Medical College Apr 2016

Week Of April 4, 2016, New York Medical College Apr 2016

Week Of March 21, 2016, New York Medical College Mar 2016

Week Of March 14, 2016, New York Medical College Mar 2016

Week Of March 7, 2016, New York Medical College Mar 2016

Week Of March 7, 2016, New York Medical College

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Week Of February 29, 2016, New York Medical College Feb 2016

Week Of February 22, 2016, New York Medical College Feb 2016

Week Of February 16, 2016, New York Medical College Feb 2016

Week Of February 8, 2016, New York Medical College Feb 2016

Week Of February 1, 2016, New York Medical College Feb 2016

Week Of January 19, 2016, New York Medical College Jan 2016

Week Of January 4, 2016, New York Medical College Jan 2016

Stability Of Metabolic Factor Before And After Bariatric Surgery, Brandon Davis, Joseph Indelicato Jan 2016

Stability Of Metabolic Factor Before And After Bariatric Surgery, Brandon Davis, Joseph Indelicato

The School of Health Sciences Publications and Research

No abstract provided.


Crispr/Cas9 As A Therapeutic Approach To Duchenne Muscular Dystrophy, Abraham Daniel Levitman Jan 2016

Crispr/Cas9 As A Therapeutic Approach To Duchenne Muscular Dystrophy, Abraham Daniel Levitman

The Science Journal of the Lander College of Arts and Sciences

Transhumanism, designer babies, gene therapy, and super-soldiers are founded upon the same concept—genetic engineering. Clustered Regularly-Interspersed Short Palindromic Repeats (CRISPR) is a natural bacterial immune response method that takes advantage of gene manipulation to prevent an infection from mobile genetic elements. Since Mojica et al. (2005) first suggested the relationship between the CRISPR/Cas system and prokaryotic immunity, significant advancements have been made in understanding the mechanism and subsequent applications of CRISPR. CRISPR, has three main subtypes based on unique proteins and interference pathways and serves as an accurate and effective method for gene editing. Its mechanism consists of spacer acquisition, …


Is The High Frequency Of Postoperative Atrial Fibrillation After Cardiac And Lung Surgeries Related To Hypomagnesemia And Releases Of Ceramides And Platelet-Activating Factor?, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Aimin Zhang, Wenyan Li, Bella T. Altura Jan 2016

Is The High Frequency Of Postoperative Atrial Fibrillation After Cardiac And Lung Surgeries Related To Hypomagnesemia And Releases Of Ceramides And Platelet-Activating Factor?, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Aimin Zhang, Wenyan Li, Bella T. Altura

Touro College of Osteopathic Medicine (Middletown) Publications and Research

The authors discuss the possible role of hypomagnesemia, ceramides and platelet-activating factor in the incidence of postoperative atrial fibrillation after cardiac and lung surgeries.