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Articles 4831 - 4860 of 4871
Full-Text Articles in Medical Sciences
An Investigation On Adherence Of Cryptococcusneoformans Serotypes (A, B, C And D) In Ratlung Cell Culture, Şinasi Taner Yildiran, Hüseyin Gün
An Investigation On Adherence Of Cryptococcusneoformans Serotypes (A, B, C And D) In Ratlung Cell Culture, Şinasi Taner Yildiran, Hüseyin Gün
Turkish Journal of Medical Sciences
Cryptococcus neoformans causes an opportunistic infection known as cryptococcosis principally in immunocompromised individuals. It is not clearly known whether the serotype of the infecting strain of Cryptococcus neoformans has its own properties related to its adherence to host tissues in disease process. Here, the adherence of each serotype (A, B, C, and D) was investigated using primary rat lung cell culture in a timedependent manner. After the confluent monolayer of primary rat lung cell culture was obtained, the adherence assay was performed. The mean binding index (Bl) value of serotype D was statistically significant(p0.05). These findings suggest that the adherence …
How Hyperosmolar Solutions (Glucose 30%) Mayprevent Stress Induced Ulcers In Rats, Mustafa Yandi, Nazim Ağaoğlu, Tevhide Sel, Nihat Mansur
How Hyperosmolar Solutions (Glucose 30%) Mayprevent Stress Induced Ulcers In Rats, Mustafa Yandi, Nazim Ağaoğlu, Tevhide Sel, Nihat Mansur
Turkish Journal of Medical Sciences
It is accepted that administration of hyperosmolar solutions (glucose 30%) prevent stress-induced ulcers in the rats; but their mechanisms of action are not elucidated. In this study, we have investigated whether glucose is absorbed or not through the gastric wall. C14 labelled glucose solution of 30% was given to groups A (n=6), and B (n=8) and physiologic serum to group C(n=7). Restriction of movement with cold application was performed in group B and C. Ulcer indexes were 0.56±0.12 in group A, 0.83±0.27 in group B and 1.63±0.43 in group C. Net absorption rates were 12.2±4.8 %, 23.01±8.3 % and 53.1±4.65 …
The Role Of Vasopressin In Reduced Renalmass-Saline Hypertension, Besim Özaykan, Ayşe Doğan
The Role Of Vasopressin In Reduced Renalmass-Saline Hypertension, Besim Özaykan, Ayşe Doğan
Turkish Journal of Medical Sciences
The cause of reduced renal mass (RRM)-saline hypertension is not clear. In our study, it was aimed to investigate the role of vasopressin (AVP) in this type of hypertension by using selective V 1 antagonist of AVP. RRM was performed in 32 normotensive male Wistar rats under anesthesia in which we used a mixture of ketamine (130 mg/kg, i.m.) and chlorpromazine (1.3 mg/kg, i.m.). After a one-week of recovery period, all of the rats were given a low sodium diet and either distilled water (group 1) or 1% NaCl (group 2) as drinking water for 4 weeks. Five weeks after …
The Effects Of Phenoxybenzamine On Tyrosinehydroxylase (Th) And Th Mrna Level In Adrenalmedulla Of Sprague Dawley Rats, Muhittin Yürekli̇
The Effects Of Phenoxybenzamine On Tyrosinehydroxylase (Th) And Th Mrna Level In Adrenalmedulla Of Sprague Dawley Rats, Muhittin Yürekli̇
Turkish Journal of Medical Sciences
The effects of anti-hipertensive phenoxybenzamine were in-vestigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were used. Phenoxybenzamine was injected i.p as 20 mg/kg which prepared in the 0.9 % NaCl and 5% ethanole. TH activity was measured by detecting of formation of 3 H 2 O as a formation of dopa from 3 H-tyrosine by radioisotope technique total adrenal RNA was isolated and hybridized wit 32 P labeled cDNA. TH mRNA was assayed by densitometric scanning of the autoradiograms using a densitometer. TH activity and TH …
Laminar Distribution Of The Sources Ofascending Spino-Supraspinal Pathways Involvedin Nociceptive Transmission And Pain Modulation, Figen Gövsa, Gülgün Kayalioğlu, Berrin Erdem, Vladimir A. Maisky, Nuran Hariri
Laminar Distribution Of The Sources Ofascending Spino-Supraspinal Pathways Involvedin Nociceptive Transmission And Pain Modulation, Figen Gövsa, Gülgün Kayalioğlu, Berrin Erdem, Vladimir A. Maisky, Nuran Hariri
Turkish Journal of Medical Sciences
In the present study, we made an attempt to detect more exactly the laminar distribution of spinomesencephalic, spinothalamic and spinotelencephalic tract neurons and to estimate the character of axonal collateralization in these spinosupraspinal pathways in the rat by means of retrograde double-labelling of cells with Fluoro-Gold (FG) and Primuline O (Pr). We found that sources of spino-supraspinal pathways to the upper centers of the brain stem, nucleus accumbens and septal nuclei were mixed together in the marginal zone, deep dorsal horn, reticulated area, lamina X and the lateral spinal nucleus, but have as a rule their own discrete projection fields. …
The Effect Of Pre-And Postnatal Cd Exposure Onconduction Velocity In Sciatic Nerve, Piraye Yargiçoğlu, Aysel Ağar, Ümit Kemal Şentürk, Nimet İzgüt Uysal, Derya Kiliç
The Effect Of Pre-And Postnatal Cd Exposure Onconduction Velocity In Sciatic Nerve, Piraye Yargiçoğlu, Aysel Ağar, Ümit Kemal Şentürk, Nimet İzgüt Uysal, Derya Kiliç
Turkish Journal of Medical Sciences
The purpose of the study has been to investigate the effect of preand postnatal Cd exposure on conduction velocity of sciatic nerve. Pregnant Swiss albino rats were divided into three groups as control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water while rats in Cd group received Cd as CdCl 2 in their drinking water during the experimental period. The mothers of the NCd group were given Cd during their pregnancy but given tap water after birth. Twenty-two days after birth (postnatal day 22) the rats were separated from the mothers. The present study was performed …
The Validity Of Mahmood Scoring System Inmeningiomas, Sülen Sarioglu, M Serefettin Canda, Tülay Canda, Fulya Çakalağaoğlu, Nagihan Yalçin
The Validity Of Mahmood Scoring System Inmeningiomas, Sülen Sarioglu, M Serefettin Canda, Tülay Canda, Fulya Çakalağaoğlu, Nagihan Yalçin
Turkish Journal of Medical Sciences
Meningiomas are well known for their diverse histological apperance. Although generally considered benign, their behaviour is unpredictable and characterized by frequent recurrences. Histopathological features associated with aggressive behaviour have been described, but even the World Health Organization (WHO) grading system provides broad criteria for malignancy. Mahmood et al. described a scoring system, based on 6 histopathological features, establishing objective criteria. In this study, 73 specimens from 61 cases which were diagnosed as meningioma have been reviewed and scored by the criteria described by Mahmood et al. in order to search for the availability of the application of the system. Out …
Blood Lactate/Pyruvate As A Predictor Of Shockdevelopment In Acute Myocardial Infarction, Arzu Seven, Sabiha Ci̇velek, Figen Kocaman, Lale Koldaş, Gülden Candan
Blood Lactate/Pyruvate As A Predictor Of Shockdevelopment In Acute Myocardial Infarction, Arzu Seven, Sabiha Ci̇velek, Figen Kocaman, Lale Koldaş, Gülden Candan
Turkish Journal of Medical Sciences
This study, designed to investigate the blood lactate and pyruvate levels in AMI, was carried out on 41 patients. Based upon the localization of AMI, the patients were studied under anterior AMI (n=17), anteroseptal AMI (n=9) and inferior AMI (n=15) groups. Left ventricular failure developed in five patients with anterior AMI and in one patient with anteroseptal AMI. Cardiogenic shock developed in two patients with anterior AMI. Lactate and pyruvate were analysed in the blood samples drawn 24-48 hours after AMI. CPK, CPK-MB, AST and LDH activities were determined in the sera of blood samples drawn within 6-24 hours of …
Hepatoerythropoietic Porphyria And Cerebralabnormalities, Mehmet Helvaci, Buket Özkaya, Işın Yaprak, Üstün Ezer
Hepatoerythropoietic Porphyria And Cerebralabnormalities, Mehmet Helvaci, Buket Özkaya, Işın Yaprak, Üstün Ezer
Turkish Journal of Medical Sciences
No abstract provided.
Effects Of The N-Ras Oncogene On The Expression Of Other Cellular Genes In Co25 Myoblast Cells, Hülya Zeyti̇noğlu, Ian Gibson
Effects Of The N-Ras Oncogene On The Expression Of Other Cellular Genes In Co25 Myoblast Cells, Hülya Zeyti̇noğlu, Ian Gibson
Turkish Journal of Medical Sciences
The effects of the N- ras oncogene on the transcription levels of c- myc, p53, c-K-ras and b-actin genes have been investigated by Northern blotting in a cell line which normally differentiates into myotubes. Treatment of cells with dexamethasone activates N- ras gene, then cells proliferate and form foci. The transcription level of c- myc gene was generally high during transformation whereas c-K- ras mRNAs levels were high during differentiation. Following induction of the N- ras oncogene, the level of c-myc mRNA first decreased in two days and then increased in three and four days. During differentiation, c-K- ras mRNA …
Effects Of Acute Hypothyroidism On Brainstemauditory Evoked Potentials (Baeps), Metin Özata, Abdullah Özkardeş, M. Ali Gündoğan
Effects Of Acute Hypothyroidism On Brainstemauditory Evoked Potentials (Baeps), Metin Özata, Abdullah Özkardeş, M. Ali Gündoğan
Turkish Journal of Medical Sciences
Although functional alterations in the central nervous system (CNS) and peripheral nerves are well documented in overt hypothyroidism, little is known about alterations of CNS in acute hypothyroidism. Sixteen patients with differentiated thyroid carcinoma were studied when prepared for radioiodine scanning after stopping levothyroxine (LT 4 ) therapy for 6 weeks to determine whether acute hypothyroidism leads to alteration in brainstem auditory evoked potentials (BAEPs). Repeat BAEPs were performed on the same patients at 6 months of the following L-T 4 therapy when patients were eu-thyroid. Neurophysiological findings were compared with a group of 20 normal controls with no hystory …
Alterations Of Erythrocyte And Plasma Lipid Peroxides As Well As Antioxidant Mechanism In Patients With Type Ii Diabetes Mellitus (Niddm), Yıldız Atamer, Yüksel Koçyi̇ği̇t, Aytaç Atamer, Nuriye Mete, Naime Canoruç, Gülten Toprak
Alterations Of Erythrocyte And Plasma Lipid Peroxides As Well As Antioxidant Mechanism In Patients With Type Ii Diabetes Mellitus (Niddm), Yıldız Atamer, Yüksel Koçyi̇ği̇t, Aytaç Atamer, Nuriye Mete, Naime Canoruç, Gülten Toprak
Turkish Journal of Medical Sciences
It has been maintained that free oxygen radicals (FOR) that occur in cell have important roles in the ethiopathogenesis of diabet, and that cell damage progressing as a result of their accumulation is responsible for the development of diabetic complications. In recent years, along with free oxygen radicals, antioxidant mechanisms and the substances influencing as free radical cleaner have been investigated in connection with diabet. With this respect, in a total of 30 patients with type II Diabetes Mellitus (NIDDM), 15 with diabetic retinopathy and 15 without diabetic retinopathy, and in 20 healthy subjects, we measured glutathione (GSH), catalase and …
Histologic Evaluation In Patients With Benign Prostatic Hyperplasia Treated With Finasteride And Surgery Alone, Özkan Polat, Osman Gül, İsa Özbey, Cemal Gündoğdu, Yılmaz Bayraktar
Histologic Evaluation In Patients With Benign Prostatic Hyperplasia Treated With Finasteride And Surgery Alone, Özkan Polat, Osman Gül, İsa Özbey, Cemal Gündoğdu, Yılmaz Bayraktar
Turkish Journal of Medical Sciences
In this study, we compared stroma, epithelium, glandular lumen, smooth muscle hyperplasia, inflammation and fibrous components in benign prostatic hyperplasia (BPH) tissue between the group undergone surgery only and the group who had taken finasteride (5 alpha-reductase inhibitor) prior to surgical treatment. Prostate adenomas were obtained from both 12 patients administered finasteride for six months prior to surgical treatment and those of 11 patients undergone only surgical treatment. The histological evaluation were performed quantitatively by planimetry. The mean epithelium ratio in the group administered 5 alpha-reductase inhibitor prior to surgery lessened approximately twofold compared to the other group's. In conclusion, …
Comparison Of Two Catheterizable Continence Mechanisms For Urinary Diversion, Ahmet Ersay, Şükrü Boylu, Hayrettin Şahi̇n, Nedim Aban, Yılmaz Akgün, İbrahim Taçyildiz
Comparison Of Two Catheterizable Continence Mechanisms For Urinary Diversion, Ahmet Ersay, Şükrü Boylu, Hayrettin Şahi̇n, Nedim Aban, Yılmaz Akgün, İbrahim Taçyildiz
Turkish Journal of Medical Sciences
Benchekroun hydraulic ileal valve and hipple valve techniques are widely used continent valve systems in recontructive urology, We compared continence, catheterizability and complications of the nipple and Benchekroun hydraulic ileal valve ruling out the inherent error of comparing different reservoirs under different conditions. A pouch was constructed with two methods present side by side. Comparable data from each valve were statistically evaluated through Mann-Whitney U test. Although the rate of complications such as dessusception and difficult catheterization for each valve are close, leakage of the Benchekroun hydraulic ileal valve was observed at significantly higher pouch volumes than in the nipple …
Needle Localization For Nonpalpable Breast Cancers, Murat Kapkaç, Sinan Ersi̇n, Servet Yetgi̇n, Ahmet Eldem Orhan Özbal, Emin Özdedeli̇, Rasih Yilmaz
Needle Localization For Nonpalpable Breast Cancers, Murat Kapkaç, Sinan Ersi̇n, Servet Yetgi̇n, Ahmet Eldem Orhan Özbal, Emin Özdedeli̇, Rasih Yilmaz
Turkish Journal of Medical Sciences
Nonpalpable breast lesions are being detected with the advent of improved mammographic techniques. Although only 20-30 % of these lesions are malignant, definitive diagnosis has usually required a needle- localization breast biopsy during a 6 year period were reviewed to determine the effect of this procedure on the diagnosis and treatment of early breast cancer. Calcifications were the most common mammographic abnormality for biopsy. Of the 62(27%) patients diagnosed with malignancy, 38 (61%) had invasive carcinoma and 24 (39%) had noninvasive carcinoma. Breast conservation was the most common form (53%) of surgical treatment in this study. Metastatic disease involving the …
Juvenile Dermatomyositis Associated With Acute Lymphocytic Leukemia, F. Ferda Özki̇nay, Sevgi̇ Mi̇r, Nuretti̇n Onur Kutlu, Caner Kabasakal, Eren Demi̇rtaş, Kaan Kavakli, Güngör Ni̇şli̇
Juvenile Dermatomyositis Associated With Acute Lymphocytic Leukemia, F. Ferda Özki̇nay, Sevgi̇ Mi̇r, Nuretti̇n Onur Kutlu, Caner Kabasakal, Eren Demi̇rtaş, Kaan Kavakli, Güngör Ni̇şli̇
Turkish Journal of Medical Sciences
No abstract provided.
Specific Binding And Epitope Recognition In Lectin Subtypes, Ayşegül Ayyildiz
Specific Binding And Epitope Recognition In Lectin Subtypes, Ayşegül Ayyildiz
Turkish Journal of Medical Sciences
No abstract provided.
Lymphangitic Carcinomatosa And Bronchorrea In A Patient With Mucoepidermoid Tumor Of The Lung, F. Sema Oymak, Olcay Belenli, Murat Alper
Lymphangitic Carcinomatosa And Bronchorrea In A Patient With Mucoepidermoid Tumor Of The Lung, F. Sema Oymak, Olcay Belenli, Murat Alper
Turkish Journal of Medical Sciences
No abstract provided.
Adenoid Cystic Carcinoma Of The Breast, Mustafa Şahi̇n, Mustafa Erbi̇len, Adnan Hasanoğlu, Ertan Bülbüloğlu, Nasuhi E. Aydin
Adenoid Cystic Carcinoma Of The Breast, Mustafa Şahi̇n, Mustafa Erbi̇len, Adnan Hasanoğlu, Ertan Bülbüloğlu, Nasuhi E. Aydin
Turkish Journal of Medical Sciences
No abstract provided.
Controversy On Prophylactic Oophorectomy, Utku Özcan, Didem Akyol, Selma Oransay, Murat Ekin, Tayfun Güngör, Oya Gökmen
Controversy On Prophylactic Oophorectomy, Utku Özcan, Didem Akyol, Selma Oransay, Murat Ekin, Tayfun Güngör, Oya Gökmen
Turkish Journal of Medical Sciences
The merits of prophylactic oophorectomy at the time of hysterectomy have been debated for many years. The most compelling argument for prophylactic removal of the ovaries has always been the prevention of ovarian cancer (2). Prophylactic oophorectomy has advantages and disadvantages. The actual incidence of cancer in retained ovaries is difficult to estimate. The advantages of prophylactic oophorectomy include the prevention of ovarian cancer, the alleviation of symptoms from residual ovary syndrome and the elimination of the need for reoperation for adnexal disease (2). Disadvantages include surgical castration, which results in the need for hormone replacement, and changes in self-image …
Neuronal Differentiation In The Cerebral Cortexof The Rat: A Golgi-Cox Study, Necdet Demi̇r, Ramazan Demi̇r
Neuronal Differentiation In The Cerebral Cortexof The Rat: A Golgi-Cox Study, Necdet Demi̇r, Ramazan Demi̇r
Turkish Journal of Medical Sciences
The development of cerebral cortex neurons has been studied in different stages of pre- and postnatal periods of rats. In order to show the neuronal processes, the Golgi-Cox impregnation technique was used. The first neuronal process development was observed in the cranial and caudal poles of the cerebral cortex during the 15th prenatal day and continued spreading from the lateral regions and poles towards the dorsocentral regions of the hemispheres. The cells which showed the first impregnation in the cerebral cortex, were bipolar cells and their bodies were located in the deep regions of the hemisphere wall. Primitive multipolar cells, …
Amino Acid Neurotransmitter Levels In Thecerebral Cortex Of Mice Receivingimipenem/Cilastatin -Lack Of Excitotoxicity In Thecentral Nervous System, Mete Akisü, Nilgün Kültürsay, Canan Çoker, Çiler Akisü, Meral Baka
Amino Acid Neurotransmitter Levels In Thecerebral Cortex Of Mice Receivingimipenem/Cilastatin -Lack Of Excitotoxicity In Thecentral Nervous System, Mete Akisü, Nilgün Kültürsay, Canan Çoker, Çiler Akisü, Meral Baka
Turkish Journal of Medical Sciences
Imipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhibition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divided into three equal groups and given therapeutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of Imipenem/cilastatine (I/C) or saline solution …
Anatomic And Hrct Demonstration Ofmidline Sternal Foramina, Zühre Aslı Aktan, Recep Savaş
Anatomic And Hrct Demonstration Ofmidline Sternal Foramina, Zühre Aslı Aktan, Recep Savaş
Turkish Journal of Medical Sciences
Midline sternal foramina are uncommon anomalies. Because of this, it is possible to mistakenly identify such a defect as defect as a gunshot wound or sternal disease by CT. In this study the frequency of midline sternal foramina in Turkish adults is investigated by high resolution computed tomography (HRCT) and visual inspection of sternal bones.
A Study On The Interparietal Bone In Man, Ferruh Yücel, Hulusi Eği̇lmez, Zehra Akgün
A Study On The Interparietal Bone In Man, Ferruh Yücel, Hulusi Eği̇lmez, Zehra Akgün
Turkish Journal of Medical Sciences
In the present study a total of 44 dry skulls and 500 skull films from the Sivas region of Turkey were examined to determine whether or not the interparietal bone was present. The incidence of interparietal bones was found to be 2.8 percent (15/544).
Plasma Antioxidant Status And Nitrate Levels Inpatients With Hypertension Andcoronary Heart Disease, Bülent Sözmen, Cahit Kazaz, Dilek Taskiran, Leyla Aslan, Akan Akyol, Eser Yıldırım Sözmen
Plasma Antioxidant Status And Nitrate Levels Inpatients With Hypertension Andcoronary Heart Disease, Bülent Sözmen, Cahit Kazaz, Dilek Taskiran, Leyla Aslan, Akan Akyol, Eser Yıldırım Sözmen
Turkish Journal of Medical Sciences
In this study, we investigated first; the possible involvement of nitric oxide and antioxidant enzyme level in the pathogenesis of essential hypertension and second we investigated serum nitrite-nitrate and antioxidant enzyme activities and lipid profiles (total, HDL and LDL cholesterol, trygliceride) to determine the relationship between these parameters in atherosclerosis. 13 patients with coronary heart disease, 18 patients with essential hypertension and 16 age-matched health subjects were taken into this study. Plasma nitrite, nitrate levels were measured by Griess reaction, erythrocyter superoxide dismutase and catalase activities were determined by the methods of Misra&Fridovich and Aebi, respectively. Serum lipid analysis were …
Determination Of Ph, Fibronectin, Cholesterol,Lactate Dehydrogenase And Sialic Acid In Thedifferentiation Of Nonmalignant Andmalignant Ascites, Hülya Aksoy, Ahmet Kiziltunç, Yilmaz Aksoy, Naciye Kurtul, Ebubekir Bakan
Determination Of Ph, Fibronectin, Cholesterol,Lactate Dehydrogenase And Sialic Acid In Thedifferentiation Of Nonmalignant Andmalignant Ascites, Hülya Aksoy, Ahmet Kiziltunç, Yilmaz Aksoy, Naciye Kurtul, Ebubekir Bakan
Turkish Journal of Medical Sciences
Ascites, being an accumulation of excess fluid within the peritoneal cavity, is most frequently encountered in patients with cirrhosis or certain other diseases such as congestive cardiac failure, peritoneal tuberculosis and some primary or secondary peritoneal tumours. This study included 17 patients (5 females, 12 males) with malignant ascites (MA) and 23 patients (13 females, 10 males) with nonmalignant ascites (NMA). We aimed to determinet the values for total sialic acid (SA), pH, cholesterol, fibronectin, total protein concentrations and lactate dehydrogenase (LDH) activity in ascitic fluid for the differential diagnosis of ascites. While total SA, fibronectin, cholesterol, LDH and total …
Tracheopathia Osteoplastica, Adil Zamani, Ayşe Gül Zamani, Ergün Bikmaz, Oktay İmeci̇k
Tracheopathia Osteoplastica, Adil Zamani, Ayşe Gül Zamani, Ergün Bikmaz, Oktay İmeci̇k
Turkish Journal of Medical Sciences
No abstract provided.
Axillary Cystic Lymphangioma Presenting Inpregnancy, Fazıl Gelal, Kamil Yücel, Erdal Tuğsel, Şefik Güney
Axillary Cystic Lymphangioma Presenting Inpregnancy, Fazıl Gelal, Kamil Yücel, Erdal Tuğsel, Şefik Güney
Turkish Journal of Medical Sciences
No abstract provided.
A Patient With Emaciation, Fever, Massivehepatosplenomegaly And Pancytopenia
A Patient With Emaciation, Fever, Massivehepatosplenomegaly And Pancytopenia
Turkish Journal of Medical Sciences
No abstract provided.
The Frequency Of Chromosomal Abnormalities Inmen With Azoospermia Andoligoasthenoteratozoospermia: A Preliminarystudy, Cüneyt Tüzün, Kubilay Vi̇cdan, Semra Kahraman, Suat Özgür, Ahmet Z. Işik, Kutay Bi̇beroğlu
The Frequency Of Chromosomal Abnormalities Inmen With Azoospermia Andoligoasthenoteratozoospermia: A Preliminarystudy, Cüneyt Tüzün, Kubilay Vi̇cdan, Semra Kahraman, Suat Özgür, Ahmet Z. Işik, Kutay Bi̇beroğlu
Turkish Journal of Medical Sciences
The aim of this study is to investigate the frequency of chromosomal abnormalities in men with severe andrological infertility, In 50 men with azoospermia and severe oligoasthenoteratozoospermia (OAT), who referred for our intracytoplasmic sperm injection program, a cytogenetic study has been prospectively carried out. Peripheral blood lymphocytes were cultured for chromosomal analysis and for each proband 30 metaphases were analyzed by GTG banding technique. Major chromosomal abnormalities were detected in 4 of cases (8%). There were 3 sex-chromosome abnormalities, 46XXY in all 3 cases, and one autosomal chromosomal abnormality 46 XY, t (1;7) (P32;Q32). Although the sample size is small, …