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Articles 31 - 34 of 34
Full-Text Articles in Virus Diseases
Long-Acting Antiretroviral Nanoformulation Development And Subcellular Trafficking, Dongwei Guo
Long-Acting Antiretroviral Nanoformulation Development And Subcellular Trafficking, Dongwei Guo
Theses & Dissertations
The introduction of nanoformulated antiretroviral therapeutic regimens is a promising alternative to standard once a day oral treatment of HIV infection. Our lab has pioneered this effort and was successful in harnessing mononuclear phagocytes (monocytes, dendritic cells and macrophages) as nanoformulated drug carriers. The approach was developed as Trojan horses for drug transport, delivery and distribution to sites of viral replication in order to facilitate microbial elimination in HIV sanctuaries. However, the remaining challenges for current antiretroviral nanoformulations include to formulate a broad range of hydrophilic short-acting drugs, and to elucidate the mechanism of sequestered nanoparticles in macrophages at the …
Synthesis And Development Of Long-Acting Abacavir Prodrug Nanoformulations, Dhirender Singh
Synthesis And Development Of Long-Acting Abacavir Prodrug Nanoformulations, Dhirender Singh
Theses & Dissertations
Over the past decade, work from our laboratory has demonstrated the potential of targeted nanoformulated antiretroviral therapy (nanoART) to produce sustained high plasma and tissue drug concentrations for weeks following a single intramuscular (IM) administration that can suppress ongoing viral replication and mitigate dose associated viral resistance. While progress has occurred towards developing long-acting nanoformulations for protease and nonnucleoside reverse transcriptase (RT) inhibitors, development of nanoformulations of hydrophilic nucleoside RT inhibitor drugs have remained elusive. Abacavir (ABC); a hydrophilic molecule exhibited limited utilities to develop into long-acting nanoformulation platform. Furthermore, inefficient conversion of ABC to its biological active metabolites; carbovir …
Ccr5 And The Blood Brain Barrier During Hiv-1 Infection And Cell-Cell Communications, Shawna M. Woollard
Ccr5 And The Blood Brain Barrier During Hiv-1 Infection And Cell-Cell Communications, Shawna M. Woollard
Theses & Dissertations
Human Immunodeficiency Virus (HIV-1) infection often results in blood-brain barrier (BBB) dysfunction and central nervous system (CNS) impairment. Since most viral strains that cross the BBB and enter the CNS are macrophage-tropic and use the C-C chemokine receptor type-5 (CCR5) to enter and infect target cells, we hypothesized that CCR5 plays a major role in monocytes-endothelial interactions and HIV-induced BBB dysfunction. Because the cytoskeleton is responsible for cellular morphology and motility, we further hypothesized that HIV-induced monocyte-endothelial interactions and transendothelial migration involve cytoskeletal changes and that CCR5 blockers would also affect these changes. To this end we used two small …
World Of Viruses: The Frozen Horror, Martin Powell, Tom Floyd, Angie Fox, Anisa Angeletti, Peter Angeletti, Judy Diamond, Kristin Watkins, Charles Wood
World Of Viruses: The Frozen Horror, Martin Powell, Tom Floyd, Angie Fox, Anisa Angeletti, Peter Angeletti, Judy Diamond, Kristin Watkins, Charles Wood
Books: College of Public Health
No abstract provided.