Skin and Connective Tissue Diseases Commons^™

Seeing Skin, Seeking Evidence: Lessons From A Dermatology Internship, Isabella Floyd

Health, Human Performance and Recreation Undergraduate Honors Theses

---

Background: Indoor tanning exposes individuals to artificial ultraviolet (UV) radiation through devices such as tanning beds and sunlamps, increasing the risk of skin damage and malignancy. Prior research suggests associations between indoor tanning and melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC), with potential variation based on age of initiation and cumulative exposure.

Purpose: The purpose of this literature review was to examine the association between indoor tanning and skin cancer risk, with a focus on age at first exposure, frequency, and duration of tanning bed use across melanoma, BCC, and SCC outcomes.

Methodology: A structured literature review …

---

An International Review Of Skin Conditions In Incarcerated Persons, Madison Ferris, Rahib K. Islam, Thy N. Huynh, Robert E. Davis, Mirna Becevic, Saurabh Chandra, Ross L. Pearlman, Jeremy J. Jackson, Robert T. Brodell, Shari R. Lipner, Vinayak K. Nahar

Health, Human Performance and Recreation Faculty Publications and Presentations

---

Introduction

Incarceration negatively affects inmates’ skin and overall quality of life. Overcrowded jail cells, poor hygiene, unsanitary conditions, and limited access to quality health care significantly increase the incidence of skin diseases among incarcerated persons (IPs). This review examines these diseases, their causes, and strategies to mitigate them.

Methods

A literature search using Google Scholar and PubMed covered studies from 2002 to 2023, identifying 18 peer-reviewed studies. These studies provided data on IP skin conditions, adherence to treatment, IP living conditions, health care access, and strategies to alleviate skin conditions.

Results

The studies were conducted in Australia, Cameroon, Canada, …

---

Design Of An Fgf-1-Fgf-2 Heterodimer Variant With Enhanced Stability And Cell Proliferation Activity, Nicholas Alan Pohlman

Chemistry & Biochemistry Undergraduate Honors Theses

---

The FGF-1 subfamily, composed of FGF-1 and FGF-2, assists in broad health-related processes such as cell proliferation and angiogenesis respectively.^1,2 The subfamily shows promising signs as a therapeutic, however, the inherent thermal instability leads to a low half-life in vivo.³ To assist in improving the stability, FGF-1 and FGF-2 were connected via a 12-residue glycine linker ultimately producing a heterodimer. This heterodimer was further examined to discover its novel properties. Inspiration for this project was drawn from previous research which performed five mutations on FGF-1 ultimately improving stability in the protein complex. In addition to these five …

---

Visualizing Ischemic Skin Flap Necrosis Through Phasor Analysis Of Autofluorescence Lifetime Images, Hallie Ramser Toomer

Graduate Theses and Dissertations

---

Necrotic skin flaps are difficult to predict and treat due to the lack of quantitative biomarkers. Label-free multiphoton microscopy is well suited for non-invasively monitoring skin metabolism through NAD(P)H and other intrinsic fluorophores, and offers immediate future directions for assessing necrosis in the clinic. The objective of this study was to assess whether phasor FLIM could be used to evaluate skin flap status and treatment efficacy in ex vivo skin sections. Phasor maps revealed differences in growth factor treatment and region, but changes in skin flap autofluorescence at 755nm excitation and 460nm emission were not just related to NAD(P)H. A …

---