Skin and Connective Tissue Diseases Commons^™

Steven-Johnson’S Syndrome/Toxic Epidermal Necrolysis, Lindsey Grant

Nursing Student Class Projects (Formerly MSN)

Steven-Johnson’s Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are both diseases mediated by hypersensitive immune reactions resulting in “full thickness epidermal necrosis” characterized by skin detachment. However, in SJS, there is only 10% skin surface area involvement whereas in TEN, over 30% of the skin becomes detached. TENS has a 50% mortality rate. (East-Innis & Thompson, 2013, p. 590) Why Chosen: SJS/TEN is a rare but extremely fatal disease. Initially, it is often mistaken as a simple allergic reaction to a new medication or environmental exposure because both cause truncal rashes and fevers. However, simple allergic reactions occur within days …

Dermoscopy: An Evidence-Based Approach For The Early Detection Of Melanoma, Angela Armstrong

UNF Graduate Theses and Dissertations

The purpose of this project was to evaluate the effectiveness of a practice-based dermoscopy training program for dermatology healthcare providers in order to improve their technique of performing clinical skin exams for the early detection of melanomas.

The overall incidence of melanoma continues to rise. More than 75% of all skin cancer deaths are from melanoma. Advanced melanoma spreads to lymph nodes and internal organs and can result in death. One American dies from melanoma almost every hour (American Cancer Society [ACS], 2009). Early diagnosis and excision are essential to reduce morbidity and to improve patient survival.

This one-group before-and-after …

The Effect Of Fetal Age On Skin Permeability In Guinea Pigs, Benita Stiles Whitted

Loma Linda University Electronic Theses, Dissertations & Projects

Preliminary investigation has indicated large decreases in fetal skin permeability during the latter half of gestation (Parmley and Seeds, 1970; Treager, 1966). The purpose of this study was to demonstrate the degree of skin permeability in fetal guinea pigs at various gestational stages. The test hypothesis was that these skins would show a significant decrease in permeability to tritiated water when tested at time increments through out the latter half of gestation.

In vitro skin permeability to tritiated water was measured in samples from 22 guinea pig fetuses. Gestational age ranged from 30 to 65 days in increments of five, …