Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (70)
- Neurology (50)
- Medical Sciences (34)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (23)
- Neurosciences (17)
-
- Geriatrics (13)
- Life Sciences (13)
- Public Health (13)
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10)
- Diagnosis (9)
- Investigative Techniques (9)
- Pathological Conditions, Signs and Symptoms (9)
- Cardiovascular Diseases (8)
- Mental and Social Health (8)
- Psychiatry and Psychology (8)
- Social and Behavioral Sciences (8)
- Pediatrics (7)
- Therapeutics (7)
- Biomedical Informatics (6)
- Chemicals and Drugs (6)
- Neurosurgery (6)
- Psychological Phenomena and Processes (6)
- Bioinformatics (5)
- Health Services Research (5)
- Biochemistry, Biophysics, and Structural Biology (4)
- Genetics and Genomics (4)
- Medical Genetics (4)
- Institution
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (16)
- Rowan-Virtua School of Osteopathic Medicine Departmental Research (13)
- Department of Neurology Faculty Papers (11)
- Faculty, Staff and Students Publications (11)
- Department of Neurosurgery Faculty Papers (6)
-
- Department of Jefferson Headache Center Papers and Presentations (5)
- Farber Institute for Neuroscience Faculty Papers (3)
- Manuscripts, Articles, Book Chapters and Other Papers (3)
- Ambulatory and Primary Care Articles (2)
- Department of Biochemistry and Molecular Biology Faculty Papers (2)
- Department of Medicine Faculty Papers (2)
- Neurology Faculty Publications (2)
- College of Nursing Faculty Papers & Presentations (1)
- College of Population Health Faculty Papers (1)
- Computational Medicine Center Faculty Papers (1)
- Dartmouth Scholarship (1)
- Department of Exercise Science Faculty Papers (1)
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (1)
- Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers (1)
- Department of Physical Therapy Faculty Papers (1)
- Department of Radiology Faculty Papers (1)
- Department of Rehabilitation Medicine Faculty Papers (1)
- Department of Surgery Faculty Papers (1)
- Farber Institute for Neuroscience Staff Papers and Presentations (1)
- NYMC Faculty Publications (1)
- Neurosurgery Faculty Publications (1)
- Pharmacy and Wellness Review (1)
- SKMC Student Presentations and Publications (1)
- Wills Eye Hospital Papers (1)
- Publication Type
Articles 91 - 93 of 93
Full-Text Articles in Nervous System Diseases
Hdqlife: Development And Assessment Of Health-Related Quality Of Life In Huntington Disease (Hd), N E Carlozzi, S G Schilling, J-S Lai, J S Paulsen, E A Hahn, J S Perlmutter, C A Ross, N R Downing, A L Kratz, M K Mccormack, M A Nance, K A Quaid, J C Stout, R C Gershon, R E Ready, J A Miner, S K Barton, S L Perlman, S M Rao, S Frank, I Shoulson, H Marin, M D Geschwind, P Dayalu, S M Goodnight, D Cella
Hdqlife: Development And Assessment Of Health-Related Quality Of Life In Huntington Disease (Hd), N E Carlozzi, S G Schilling, J-S Lai, J S Paulsen, E A Hahn, J S Perlmutter, C A Ross, N R Downing, A L Kratz, M K Mccormack, M A Nance, K A Quaid, J C Stout, R C Gershon, R E Ready, J A Miner, S K Barton, S L Perlman, S M Rao, S Frank, I Shoulson, H Marin, M D Geschwind, P Dayalu, S M Goodnight, D Cella
Rowan-Virtua School of Osteopathic Medicine Departmental Research
PURPOSE: Huntington disease (HD) is a chronic, debilitating genetic disease that affects physical, emotional, cognitive, and social health. Existing patient-reported outcomes (PROs) of health-related quality of life (HRQOL) used in HD are neither comprehensive, nor do they adequately account for clinically meaningful changes in function. While new PROs examining HRQOL (i.e., Neuro-QoL-Quality of Life in Neurological Disorders and PROMIS-Patient-Reported Outcomes Measurement Information System) offer solutions to many of these shortcomings, they do not include HD-specific content, nor have they been validated in HD. HDQLIFE addresses this by validating 12 PROMIS/Neuro-QoL domains in individuals with HD and by using established PROMIS …
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper
NYMC Faculty Publications
Enzymes that generate carbanionic intermediates often catalyze paracatalytic reactions with O2 and other electrophiles not considered “normal” reactants. For example, pyridoxal 5′-phosphate (PLP)—containing pig kidney dopa decarboxylase oxidizes dopamine with molecular O2 to 3,4-dihydroxyphenylacetaldehyde at about 1% of the rate at which it catalyzes nonoxidative dopa decarboxylation. The mutant Y332F enzyme, however, catalyzes stoichiometric conversion of dopa to 3,4-dihydroxyphenylacetaldehyde, suggesting that even minor structural changes may alter or initiate paracatalytic reactions catalyzed by certain enzymes. Carbanions generated by several thiamine diphosphate (ThDP)—dependent enzymes react with different electrophiles, transforming some xenobiotics and endogenous compounds into potentially biologically hazardous products. The detrimental …
Disruption Of The Cbfa2 Gene Causes Necrosis And Hemorrhaging In The Central Nervous System And Blocks Definitive Hematopoiesis., Qing Wang, Terryl Stacy, Michael M Binder, Miguel Marin-Padilla, Arlene H. Sharpe, Nancy A. Speck
Disruption Of The Cbfa2 Gene Causes Necrosis And Hemorrhaging In The Central Nervous System And Blocks Definitive Hematopoiesis., Qing Wang, Terryl Stacy, Michael M Binder, Miguel Marin-Padilla, Arlene H. Sharpe, Nancy A. Speck
Dartmouth Scholarship
The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is preceded by symmetric, bilateral necrosis in these regions. Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption …