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Articles 181 - 210 of 217
Full-Text Articles in Nervous System Diseases
A Challenging Case Of Bilateral Medial Medullary Infarction Resembling Guillain-Barré Syndrome, Alexis Bialousz, Havird Mclean Skalak, Nicholas Carbo, Amanda Westbrook
A Challenging Case Of Bilateral Medial Medullary Infarction Resembling Guillain-Barré Syndrome, Alexis Bialousz, Havird Mclean Skalak, Nicholas Carbo, Amanda Westbrook
South Atlantic Division GME Research Day 2024
No abstract provided.
Incidence Of Syphilis And Neurosyphilis Testing In A Large Sample Of Adults, Amy Mackenzie, Nayda Parisio-Poldiak, Caroline Minton, Barbara Gracious
Incidence Of Syphilis And Neurosyphilis Testing In A Large Sample Of Adults, Amy Mackenzie, Nayda Parisio-Poldiak, Caroline Minton, Barbara Gracious
South Atlantic Division GME Research Day 2024
No abstract provided.
Case Report: Psychiatric And Behavioral Disturbance In Lgi-1 Antibody Encephalitis, Amy Mackenzie, Emytis Tavakoli, Hassan Al-Obaidi, Keera Fishman, Sarah Elmi
Case Report: Psychiatric And Behavioral Disturbance In Lgi-1 Antibody Encephalitis, Amy Mackenzie, Emytis Tavakoli, Hassan Al-Obaidi, Keera Fishman, Sarah Elmi
South Atlantic Division GME Research Day 2024
No abstract provided.
Stroke As A Result Of Caseous Mitral Annular Calcification, Ricardo Estrada-Montes, Sarah Barraza, George Matus, Asha Kurian
Stroke As A Result Of Caseous Mitral Annular Calcification, Ricardo Estrada-Montes, Sarah Barraza, George Matus, Asha Kurian
Central & West Texas GME Research Day 2024
No abstract provided.
Functional Neurologic Disorder (Seizure Type) Leading To Intubation Successfully Treated With Cbt, Hersheth Aggarwal, Kamal Albright
Functional Neurologic Disorder (Seizure Type) Leading To Intubation Successfully Treated With Cbt, Hersheth Aggarwal, Kamal Albright
South Atlantic Division GME Research Day 2024
No abstract provided.
Stroke Chameleon: A Case Of High Grade Glioma, Zachary T. Lowery, Mary M. Carter
Stroke Chameleon: A Case Of High Grade Glioma, Zachary T. Lowery, Mary M. Carter
South Atlantic Division GME Research Day 2024
No abstract provided.
Cerebrovascular Accident Complicating Pulmonary Tb: A Rare Co-Existence, Tesnim Hamdan, Iryna Witt, Nameer Ascandar, Srija Reddy
Cerebrovascular Accident Complicating Pulmonary Tb: A Rare Co-Existence, Tesnim Hamdan, Iryna Witt, Nameer Ascandar, Srija Reddy
West Florida Division GME Research Day 2024
No abstract provided.
A Neuroscience-Based Curriculum For Addiction Prevention For Fourth-Grade Students, Paola Andrea Benitez
A Neuroscience-Based Curriculum For Addiction Prevention For Fourth-Grade Students, Paola Andrea Benitez
Social Work Theses - Archive
Substance use is one of the main problems affecting adolescents and young adults. While the consumption of alcohol has decreased, the consumption of marijuana has increased rampantly due to youth's positive perception after being legalized in 24 states with no clear message of the many adverse effects this drug causes. Different approaches to prevention have been used throughout the years: scare-led tactics, socio-emotional learning skills, and neuroscience-based curriculums. Since substance use results from the conjunction of different biopsychosocial factors that lead to this relapsing brain disease, the solution should integrate different preventive solutions as well. Public policy, schools, social workers, …
Non-Coding Rnas Involved In The Molecular Pathology Of Alzheimer’S Disease: A Systematic Review, Reynand Jay Canoy, Jenica Clarisse Sy, Christian Deo Deguit, Caitlin Bridgette Castro, Lyoneil James Dimaapi, Beatrice Gabrielle Panlaqui, Wenzel Perian, Justine Yu, John Mark Velasco, Jesus Emmanuel Sevilleja, Anna Gibson
Non-Coding Rnas Involved In The Molecular Pathology Of Alzheimer’S Disease: A Systematic Review, Reynand Jay Canoy, Jenica Clarisse Sy, Christian Deo Deguit, Caitlin Bridgette Castro, Lyoneil James Dimaapi, Beatrice Gabrielle Panlaqui, Wenzel Perian, Justine Yu, John Mark Velasco, Jesus Emmanuel Sevilleja, Anna Gibson
Ateneo School of Medicine and Public Health Publications
Alzheimer’s disease (AD) is the leading cause of dementia globally, having a pathophysiology that is complex and multifactorial. Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs) in the molecular mechanisms underlying AD. These ncRNAs are involved in critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, and autophagy, which are pivotal in AD development and progression. This systematic review aims to consolidate current scientific knowledge on the role of ncRNAs in AD, making it the first to encompass …
Selecting And Evaluating Key Mds-Updrs Activities Using Wearable Devices For Parkinson's Disease Self-Assessment, Yuting Zhao, Xulong Wang, Xiyang Peng, Ziheng Li, Fengtao Nan, Menghui Zhuo, Jun Qi, Yun Yang, Zhong Zhao, Lida Xu, Po Yang
Selecting And Evaluating Key Mds-Updrs Activities Using Wearable Devices For Parkinson's Disease Self-Assessment, Yuting Zhao, Xulong Wang, Xiyang Peng, Ziheng Li, Fengtao Nan, Menghui Zhuo, Jun Qi, Yun Yang, Zhong Zhao, Lida Xu, Po Yang
Information Technology & Decision Sciences Faculty Publications
Parkinson's disease (PD) is a complex neurodegenerative disease in the elderly. This disease has no cure, but assessing these motor symptoms will help slow down that progression. Inertial sensing-based wearable devices (ISWDs) such as mobile phones and smartwatches have been widely employed to analyse the condition of PD patients. However, most studies purely focused on a single activity or symptom, which may ignore the correlation between activities and complementary characteristics. In this paper, a novel technical pipeline is proposed for fine-grained classification of PD severity grades, which identify the most representative activities. We also propose a multi-activities combination scheme based …
Exploring Drivers Of Sex-Based Disparities In Relapsing Multiple Sclerosis, Stephanie K. Buxhoeveden
Exploring Drivers Of Sex-Based Disparities In Relapsing Multiple Sclerosis, Stephanie K. Buxhoeveden
Theses and Dissertations
Females are three times more susceptible to relapsing multiple sclerosis (MS) and males typically have more severe disease, but the molecular underpinnings of these sex-based disease disparities are unknown and represent a critical knowledge gap.Subject Population: Blood samples from a demographically homogenous group of treatment naïve males and females with relapsing-MS and healthy controls. Research Design: Cross-sectional combinatorial omics pilot study. Instruments: Whole transcriptomic analysis with messenger RNA (mRNA) expression profiling using next generation sequencing (RNA-seq) and micro-RNA (miRNA) expression using NanoString technology. Aim 1) Identify and compare the actively expressed mRNAs in the transcriptome of males and …
A Case Of Parenchymal Hemorrhade Secondary To Dural Venous Sinus Thrombosis, Parnia Forouzan, Jesse Cai, Dewey Le
A Case Of Parenchymal Hemorrhade Secondary To Dural Venous Sinus Thrombosis, Parnia Forouzan, Jesse Cai, Dewey Le
Gulf Coast Division GME Research Symposium 2024
No abstract provided.
Systemic Lupus Erythematosus Presenting As Aseptic Meningitis And Pancytopenia, Julia Collins, Roy Escobar, Vishnu Halthore, Ali Abu-Alya, Tanvir Khosla, Hamza Hansoti, Janita Sidhu, Elia Barraza, Zachary Charif, Azaam Mamoor, Ann Wierman, Venkatachalam Veerappan
Systemic Lupus Erythematosus Presenting As Aseptic Meningitis And Pancytopenia, Julia Collins, Roy Escobar, Vishnu Halthore, Ali Abu-Alya, Tanvir Khosla, Hamza Hansoti, Janita Sidhu, Elia Barraza, Zachary Charif, Azaam Mamoor, Ann Wierman, Venkatachalam Veerappan
Far West Division GME Research Day 2024
No abstract provided.
An Atypical Presentation Of Nms Complicated By Brain Lesion, Sunwoo Lee, Stephanie Tejada, Erkan Batti, Paul Cimoch, Marc Laroque, Mohamad Saad, Donald Kanu, Christopher Ochner
An Atypical Presentation Of Nms Complicated By Brain Lesion, Sunwoo Lee, Stephanie Tejada, Erkan Batti, Paul Cimoch, Marc Laroque, Mohamad Saad, Donald Kanu, Christopher Ochner
East Florida Division GME Research Day 2024
No abstract provided.
Acute Mesenteric Ischemia Secondary To Lupus Vasculitis, Karen Valdez-Cuen, Ammar Mahmood, Mohammad Ridha, Fahad Omar
Acute Mesenteric Ischemia Secondary To Lupus Vasculitis, Karen Valdez-Cuen, Ammar Mahmood, Mohammad Ridha, Fahad Omar
Central & West Texas GME Research Day 2024
No abstract provided.
Menstruation-Induced Migraine And Ocular Symptoms In A Patient With Systemic Lupus Erythematosus, Shafi Muneer
Menstruation-Induced Migraine And Ocular Symptoms In A Patient With Systemic Lupus Erythematosus, Shafi Muneer
East Florida Division GME Research Day 2024
No abstract provided.
In Utero Presentation Of Cri-Du-Chat Syndrome, Sara Hitt, Claire Mccarthy, Reese Groover, Erika Olsen, Anthony Royek
In Utero Presentation Of Cri-Du-Chat Syndrome, Sara Hitt, Claire Mccarthy, Reese Groover, Erika Olsen, Anthony Royek
South Atlantic Division GME Research Day 2024
No abstract provided.
The Influence Of Drd2 Polymorphism Exon 8 C/T (Rs6276) On Manifestations Of Delirium Tremens & Alcohol Withdrawal Seizures, Naomi Schneider
The Influence Of Drd2 Polymorphism Exon 8 C/T (Rs6276) On Manifestations Of Delirium Tremens & Alcohol Withdrawal Seizures, Naomi Schneider
Honors Theses and Capstones
This study explores the correlation between the DRD2 Polymorphism exon 8 C/T (rs6276) and manifestations of delirium tremens (DT). DT is a condition that is clinically diagnosed utilizing two characteristic symptom manifestations: the presence of delirium and severe alcohol withdrawal. It is not entirely understood why DT can occur in some patients, but evidence has suggested that genetic predisposition can play a role. Utilizing the National Institutes of Health (NIH) All of Us Research database and performing a secondary analysis of existing genomic data, this candidate gene association study aims to determine the genotype frequencies within three cohorts: a healthy …
Inhibiting Pi3k/Akt To Enhance Brain Uptake Of Anticancer Agents In Glioblastoma, Louis Rodgers
Inhibiting Pi3k/Akt To Enhance Brain Uptake Of Anticancer Agents In Glioblastoma, Louis Rodgers
Theses and Dissertations--Pharmacy
Glioblastoma (GBM) is the deadliest and most common malignant CNS tumor. Despite advances in understanding its biology and the development of targeted therapies, effective treatment options remain limited. As a result, patient survival rates are dismal, with a 5-year survival rate of only 6.8% and an overall survival of less than two years. This poor outcome is partly due to our inability to treat GBM cells that infiltrate the whole brain. Focal treatments like surgery and radiotherapy alone are insufficient due to these invasive tumor cells. Therefore, chemotherapy following resection and irradiation of the primary tumor is essential to eliminate …
Mycophenolate Associated Progressive Multifocal Leukoencephalopathy In A Woman With Systemic Lupus Erythematosus, Zaur Komachkov, Yacoub Khatab
Mycophenolate Associated Progressive Multifocal Leukoencephalopathy In A Woman With Systemic Lupus Erythematosus, Zaur Komachkov, Yacoub Khatab
Gulf Coast Division GME Research Symposium 2024
No abstract provided.
A Case Of Sore Throat And Dizziness, Victoria Gordon, Anita Datta
A Case Of Sore Throat And Dizziness, Victoria Gordon, Anita Datta
Gulf Coast Division GME Research Symposium 2024
No abstract provided.
Isolated Case Of Alexia Following Cardiac Ablation: A Rare Stroke Presentation, Matthew M. Mason, Nantian Harsell, Bryan Kharbanda
Isolated Case Of Alexia Following Cardiac Ablation: A Rare Stroke Presentation, Matthew M. Mason, Nantian Harsell, Bryan Kharbanda
Gulf Coast Division GME Research Symposium 2024
No abstract provided.
Intracrnial Hemorrhage And Ecg Changes, Negar Niknam, Eric N. Riha, Bushra Bangash, Parshvi Patel, Skantha K. Manjunath, Gnananandh Jayaraman, Ramesh Kesavan, Siva T. Sarva
Intracrnial Hemorrhage And Ecg Changes, Negar Niknam, Eric N. Riha, Bushra Bangash, Parshvi Patel, Skantha K. Manjunath, Gnananandh Jayaraman, Ramesh Kesavan, Siva T. Sarva
Gulf Coast Division GME Research Symposium 2024
No abstract provided.
Emerging Unconventional Therapies For Glioblastoma Multiforme, Danielle Morang
Emerging Unconventional Therapies For Glioblastoma Multiforme, Danielle Morang
Capstone Showcase
Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary malignant brain tumor occurring in adults with a median survival of less than two years. It is a highly invasive tumor characterized by genetic heterogeneity, angiogenesis, and rapid proliferation. Patients undergo a multimodal treatment regimen consisting of surgical resection and chemoradiation therapy, yet GBM tumors almost always recur with a worsening prognosis. The molecular and genetic complexities of GBM pose a significant challenge for developing effective therapeutics. Thus, it is imperative to identify new therapeutic targets and explore novel treatment strategies to improve patients’ overall survival time and quality of …
Examining The Efficacy Of Treatments For Complex Regional Pain Syndrome, Michael Podcasy
Examining The Efficacy Of Treatments For Complex Regional Pain Syndrome, Michael Podcasy
Capstone Showcase
Complex Regional Pain Syndrome (CRPS) is a disease that affects the sensory, motor, sudomotor, vasomotor and trophic systems of patients. The pathophysiology is currently unknown and the diagnostic criteria that is used, the Budapest criteria, has its own shortcomings. This had led to hurdles in the research of the disease and well as a lack of high-quality studies on the efficacy of the many treatments currently being used to treat CRPS today. This poster explores those concepts.
Co-Occurrence Of Autism Spectrum Disorder And Attention-Deficit/Hyperactivity Disorder With Idiopathic Hypersomnia: Data From The Hypersomnia Foundation Registry, Sophie Sevan Mikkelsen
Co-Occurrence Of Autism Spectrum Disorder And Attention-Deficit/Hyperactivity Disorder With Idiopathic Hypersomnia: Data From The Hypersomnia Foundation Registry, Sophie Sevan Mikkelsen
Honors Undergraduate Theses
In recent years, hypersomnia patients and researchers alike have increasingly discussed the possibility of heightened comorbidities, or co-occurrences, of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) with the central disorders of hypersomnolence: idiopathic hypersomnia (IH) and narcolepsy (N). While a few scarce studies have investigated a link between ADHD and N, there has been no research on the co-occurrence of these conditions with IH. This study, using data from the Hypersomnia Foundation’s CoRDS Patient Registry, is the first to identify self-reported rates of ASD and ADHD diagnoses by people with idiopathic hypersomnia. Four chi-square tests were conducted to determine …
Dysbiosis In Parkinson's Disease: A Meta-Analysis Of Gut Microbiota And Its Role In Gastrointestinal Dysfunction And Disease Progression, Ayan M. Siddiqui Mr.
Dysbiosis In Parkinson's Disease: A Meta-Analysis Of Gut Microbiota And Its Role In Gastrointestinal Dysfunction And Disease Progression, Ayan M. Siddiqui Mr.
Honors Undergraduate Theses
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms, including gastrointestinal (GI) dysfunction. Symptoms such as constipation, bloating, and nausea often show early signs before the onset of motor symptoms. Recent research has suggested an essential role of the human gut microbiome and gut dysbiosis, an imbalance in gut microbiota composition, in the pathogenesis of PD. This thesis aims to assess the potential relationship between gut dysbiosis and PD by conducting a meta-analysis, focusing on differences in gut microbiota between PD patients and healthy controls and evaluating their implications for GI dysfunction and PD progression. The …
Characterizing The Cellular Response To Astrovirus Infection In The Central Nervous System, Amy E. Davis
Characterizing The Cellular Response To Astrovirus Infection In The Central Nervous System, Amy E. Davis
Theses and Dissertations (ETD)
Central nervous system (CNS) diseases caused by infectious agents pose significant health challenges, often leading to severe neurological dysfunction with high morbidity and mortality rates. Astroviruses (AstVs), traditionally known for causing gastroenteritis, have recently been identified as neuroinvasive pathogens capable of inducing neurological diseases. This study explores the cellular and molecular mechanisms by which AstV, specifically non-classical VA1 and classical HAstV1 genotypes, induce CNS pathology in human neurons and astrocytes. Utilizing primary human neurons and astrocytes from various brain regions, this research investigates the cytotoxic effects, apoptotic pathways, and inflammatory responses triggered by these viruses. This study reveals that VA1 …
Anatomical And Physiological Characterization Of Striatal Activation Of The Cerebral Cortex, Yuhan Wang
Anatomical And Physiological Characterization Of Striatal Activation Of The Cerebral Cortex, Yuhan Wang
Theses and Dissertations (ETD)
Purpose. The striatum receives excitatory glutamatergic input from nearly all parts of the cerebral cortex, and its output is delivered by direct pathway medium spiny neurons (dMSNs) expressing D1 type dopamine (DA) receptors (D1Rs) and indirect pathway MSNs (iMSNs) expressing D2 DA receptors (D2Rs). Loss of DA results in the imbalance between the activities of dMSNs and iMSNs in Parkinson’s disease (PD), leading to ab-normal interactions between the cerebral cortex and striatum. Thus, understanding the inter-actions between the cortex and striatum is important. The monosynaptic corticostriatal cir-cuit has been extensively studied. In contrast, due to the poly-synaptic nature of the …
Molecular Determinants Of Trp Channel Gating, Briar J. Bell
Molecular Determinants Of Trp Channel Gating, Briar J. Bell
Theses and Dissertations (ETD)
Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This family of proteins is characterized by a generally shared structure: an intracellular N terminus featuring ankyrin repeats, six transmembrane helices including the pore domain, a re-entrant loop and TRP helix, and an intracellular C terminus with varying structure. Each of these regions has been implicated in the regular function of TRPs, while mutations that alter trafficking …