Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Nervous System Diseases
Evaluation Of Immune-Modulating Therapies For Parkinson's Disease, Katherine E. Olson
Evaluation Of Immune-Modulating Therapies For Parkinson's Disease, Katherine E. Olson
Theses & Dissertations
Parkinson’s disease (PD) is the second most common neurodegenerative
disorder, second only to Alzheimer’s disease (AD). It is characterized by a
progressive loss of dopaminergic neurons along the nigrostriatal axis and the
formation of proteinaceous inclusions of alpha-synuclein (α-syn). Secondary to
the loss of dopaminergic neurons is a progression in motor and non-motor
symptoms. Motor symptoms are characterized by slowness in movement,
stiffness and tremor. Non-motor symptoms include depression, constipation,
sleep abnormalities and loss of sense of smell. The cause of disease remains
incompletely understood. However, age, genetics, environment, viral infection,
and interplay between the innate and adaptive immune system …