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University of Nebraska Medical Center
Extracellular Vesicles; Glutaminase; Glutamate; Neurotoxicity; Macrophages; Microglia
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Full-Text Articles in Nervous System Diseases
The Role Of Glutaminase And Extracellular Vesicles In Macrophages And Microglia, Beiqing Wu
The Role Of Glutaminase And Extracellular Vesicles In Macrophages And Microglia, Beiqing Wu
Theses & Dissertations
Glutamate serves as a crucial excitatory neurotransmitter that is essential for the proper functioning of the brain. However, excess levels of glutamate are neurotoxic and contribute to the pathogenesis of various neurodegenerative diseases, inducing HIV-1 associated neurocognitive disorders (HAND). Glutaminase 1 (GLS1) is an important mitochondrial enzyme responsible for producing glutamate from glutamine. GLS1 is upregulated during HAND and released from mitochondria to cytosol and extracellular space. However, why and how GLS1 is released remains unknown. In chapter II, we demonstrated that extracellular vesicles (EVs) carry GLS1 as cargos from cytosol to extracellular space during HIV infection and innate immune …