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Articles 31 - 39 of 39
Full-Text Articles in Nervous System Diseases
Altering Endoplasmic Reticulum Stress In A Model Of Blast-Induced Traumatic Brain Injury Controls Cellular Fate And Ameliorates Neuropsychiatric Symptoms, Aric Flint Logsdon, Ryan Coddington Turner, Brandon Peter Lucke-Wold, Matthew James Robson, Zachary James Naser, Kelly Elizabeth Smith, Rae Reiko Matsumoto
Altering Endoplasmic Reticulum Stress In A Model Of Blast-Induced Traumatic Brain Injury Controls Cellular Fate And Ameliorates Neuropsychiatric Symptoms, Aric Flint Logsdon, Ryan Coddington Turner, Brandon Peter Lucke-Wold, Matthew James Robson, Zachary James Naser, Kelly Elizabeth Smith, Rae Reiko Matsumoto
Faculty Publications & Research of the TUC College of Pharmacy
Neuronal injury following blast-induced traumatic brain injury (bTBI) increases the risk for neuropsychiatric disorders, yet the pathophysiology remains poorly understood. Blood-brain-barrier (BBB) disruption, endoplasmic reticulum (ER) stress, and apoptosis have all been implicated in bTBI. Microvessel compromise is a primary effect of bTBI and is postulated to cause subcellular secondary effects such as ER stress. What remains unclear is how these secondary effects progress to personality disorders in humans exposed to head trauma. To investigate this we exposed male rats to a clinically relevant bTBI model we have recently developed. The study examined initial BBB disruption using Evan’s blue (EB), …
Can Healthy Transplanted Tissue Be Used To Restore Motor Function In Patients With Parkinson's Disease?, Aliza Erlbaum
Can Healthy Transplanted Tissue Be Used To Restore Motor Function In Patients With Parkinson's Disease?, Aliza Erlbaum
The Science Journal of the Lander College of Arts and Sciences
Parkinson’s Disease is a condition that disrupts the lives the many people. The disease is characterized by a loss of dopamine producing neurons in the pars compacta of the substantia nigra of the ventral midbrain, and symptoms include a lack of motor control and rigidity in motion. Currently, there are many treatments available to treat patients with Parkinson’s disease. However, each treatment involves many adverse side effects that most wish to avoid. Science is discovering possible innovative, alternative options to treat Parkinson’s disease such as the transplantation of healthy dopaminergic neurons directly into the striatum of the patient. Methods include …
Complex Regional Pain Syndrome: A Review Of Current Treatments, Yosef Lewis
Complex Regional Pain Syndrome: A Review Of Current Treatments, Yosef Lewis
The Science Journal of the Lander College of Arts and Sciences
Complex Regional Pain Syndrome (CRPS) is a syndrome that develops infrequently in patients that experience a minor or severe trauma to a bodily extremity. CRPS has two subtypes; Type-I and II, both are clinically characterized by hyperalgesia. During its acute stage, CRPS hyperalgesia is clinically characterized by edema in the subcutaneous tissues of the epidermis, allodynia, and localized bone resorption. In the later chronic stage, hyperalgesia is aroused by the disregulation of blood flow to the extremity and permanent dystonic and trophic changes to the skin. Because the epidemiology and central causation of CRPS remains unknown until today, health professionals …
Is There An Alternative Way Of Treating Drug Resistant Epilepsy? The Effects Of The Ketogenic Diet In Children With Intractable Epilepsy, Chaya M. Weinberg
Is There An Alternative Way Of Treating Drug Resistant Epilepsy? The Effects Of The Ketogenic Diet In Children With Intractable Epilepsy, Chaya M. Weinberg
The Science Journal of the Lander College of Arts and Sciences
Many children with epilepsy experience seizures that cannot be resolved with medication. Since surgical intervention is not always an option, the ketogenic diet (KD). a high fat, low carbohydrate and protein diet, offers a chance for seizure reduction and in some cases freedom from seizures and medication. Side effects do exist, although none are serious. Efficacy has been proven through many studies. The mechanism of the KD's effectiveness is still unknown, although several hypotheses exist, including the theory that ketone bodies themselves are anticonvulsant, and the hypothesis that glucose restriction stops seizures. Adenosine A1 receptors are also thought to have …
Huntington's Disease And Its Effect On The Brain, Shaina Rivkin-Drizin
Huntington's Disease And Its Effect On The Brain, Shaina Rivkin-Drizin
The Science Journal of the Lander College of Arts and Sciences
Huntington's disease is a neurodegenerative disease that leads to gradual extensive brain damage, especially in the striatum and the cerebral cortex. Initial symptoms are cognitive difficulties, loss of motor contra and sudden mood imbalances. Cognitive function slowly declines into dementia, coupled with behavioral and psychiatric problems. Sufferers die within 20 years due to illness complications: a fall, pneumonia, or heart disease (Walker, 2007). This paper reviews the principle biological cause of the disease, its effect on the brain, diagnosis, and treatment.
Normal Pressure Hydrocephalus: How Can It Be Told Apart From Neurodegenerative Diseases Of The Elderly?, Raphael C. Zohn
Normal Pressure Hydrocephalus: How Can It Be Told Apart From Neurodegenerative Diseases Of The Elderly?, Raphael C. Zohn
The Science Journal of the Lander College of Arts and Sciences
Normal pressure hydrocephalus (NPH) affects more of the older population than people recognize. The underestimation of this neurological condition is due in most part to the overlap of its symptoms to other forms of dementia as well as many other geriatric conditions. The objective of this paper was to research and contrast various methods of differentiation in the diagnosis of normal pressure hydrocephalus as well as find pretreatment indicators of successful surgery. Methods included reviewing of articles and studies done to evaluate which symptoms are most commonly presented in normal pressure hydrocephalus and their subtle differences from the symptoms of …
Treatment Options For Parkinson’S Disease, Sara Russ
Treatment Options For Parkinson’S Disease, Sara Russ
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from this article: Parkinson’s disease was first described and named Paralysis Agitans in 1817 by British physician James Parkinson (Lieberman 2004). Later on, it took on its current name after Dr. Parkinson. Parkinson’s disease (PD) is a neurological disorder for which the cause is yet to be discovered. Like many other diseases, PD has numerous facets. Throughout all of its different stages, it presents with motor, as well as nonmotor, symptoms (Simuni et al. 2009). Though estimates of people affected by PD are constantly being made, it is difficult to determine a precise and accurate …
Functional Electrical Stimulation In Spinal Cord Injury Rehabilitation, Meir Hildeshaim
Functional Electrical Stimulation In Spinal Cord Injury Rehabilitation, Meir Hildeshaim
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from the introduction to this article: Spinal cord injury is defined as a “disconnection syndrome” that results in a loss of ability of the spinal cord to communicate ascending and/or descending impulses (Hamid and Hayak 2008). Due to its role as the primary conduit of motor and sensory impulses, spinal cord injury is widely regarded as one of the most catastrophic, survivable injuries a person can suffer. Depending on the severity and placement of the injury, the patient can experience a wide range of disability or death. A mild injury may result in the patient …
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper
NYMC Faculty Publications
Enzymes that generate carbanionic intermediates often catalyze paracatalytic reactions with O2 and other electrophiles not considered “normal” reactants. For example, pyridoxal 5′-phosphate (PLP)—containing pig kidney dopa decarboxylase oxidizes dopamine with molecular O2 to 3,4-dihydroxyphenylacetaldehyde at about 1% of the rate at which it catalyzes nonoxidative dopa decarboxylation. The mutant Y332F enzyme, however, catalyzes stoichiometric conversion of dopa to 3,4-dihydroxyphenylacetaldehyde, suggesting that even minor structural changes may alter or initiate paracatalytic reactions catalyzed by certain enzymes. Carbanions generated by several thiamine diphosphate (ThDP)—dependent enzymes react with different electrophiles, transforming some xenobiotics and endogenous compounds into potentially biologically hazardous products. The detrimental …