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Articles 1 - 7 of 7
Full-Text Articles in Neoplasms
Identification Of Microscopy Cell Images By Using Convolutional Neural Network Application, Ajis Norfatin Farisya
Identification Of Microscopy Cell Images By Using Convolutional Neural Network Application, Ajis Norfatin Farisya
Student Works (2020-2029)
Breast cancer has been the major factor of cancer death and the second main cause of women’s deaths in the world. The false positive results of this cancer cell detection during the screening test leads to false treatment and emotional disturbance of the patients. Thus, breast cancer cell lines (MCF7) is used as the microscopy image samples together with the Human Bone Osteosarcoma Epithelial Cells (U2OS), and Human Hepatocyte as control to study the effectiveness of convolutional neural network (CNN) as a method of image recognition. The objectives of this study are to determine the ability of convolutional neural network …
Synthesis, Cytotoxicity And Apoptosis Studies On Nickel And Zinc Derivatives Of Testosterone-N4-Substituted-Thiosemicarbazones, Mok Piew Heng
Synthesis, Cytotoxicity And Apoptosis Studies On Nickel And Zinc Derivatives Of Testosterone-N4-Substituted-Thiosemicarbazones, Mok Piew Heng
Student Works (2020-2029)
The side effects of cisplatin such as toxicities are mainly due to the lack of selectivity of this chemotherapeutic agent. In order to increase the selectivity of an anticancer agent, hormone molecule that targets a specific receptor may be utilized. This research aimed to prepare cytotoxic Schiff base compounds (and their nickel and zinc complexes) with testosterone and derivatives of thiosemicarbazide, which are potentially selective towards cancerous cells. Three Schiff base ligands (TM, TF, and TP) were made from the conjugation of testosterone with three derivatives of thiosemicarbazide (N4= methyl, fluorophenyl, and ethylphenyl) and their respective nickel (NM, NF, and …
Functional Characterisation Of Cancer-Associated Fibroblasts From Nasopharyngeal Carcinoma, Wee Lin Wong
Functional Characterisation Of Cancer-Associated Fibroblasts From Nasopharyngeal Carcinoma, Wee Lin Wong
Student Works (2020-2029)
Nasopharyngeal carcinoma (NPC) remains a major health issue in Southern China and Southeast Asia where the disease is endemic. Whilst the cure rate for early stage NPC is high, patients often present with late stage diseases and have a 5-year survival rate of less than 50%. NPC patients often suffer from severe treatment side effects because of the location of the tumours that is in proximity to various important organs in the head and neck region. Therefore, alternative therapeutic approaches are needed to improve the treatment outcomes and reduce patient morbidity. Targeted therapies are not in routine use to treat …
Regulation Of Apoptotic Effects Of Erythrocarpine E, A New Cytotoxic Limonoid Extracted From Chisocheton Erythrocarpus., Norliza Shah Jehan Muttiah
Regulation Of Apoptotic Effects Of Erythrocarpine E, A New Cytotoxic Limonoid Extracted From Chisocheton Erythrocarpus., Norliza Shah Jehan Muttiah
Student Works (2010-2019)
The aim of this study is to determine the cytotoxic and apoptotic effects of erythrocarpine E (CEB4), a new limonoid extracted from Chisocheton erythrocarpus. MTT assay, Live/Dead® Viability/Cytotoxicity assay, cell cycle analysis, annexin V analysis, PARP cleavage analysis, DNA fragmentation assay, sandwich ELISA assay and Western blot analysis were performed on five CEB4 treated cancer cell lines; HSC4COX2- and HSC2 (oral), CaSki (cervical), HepG2 (liver), MCF7 (breast) and NHBE (normal human bronchial epithelial cell line). CEB4 treated HSC4COX2-, HSC2, CaSki, HepG2 and MCF7 cells demonstrated a cytotoxic effect and inhibited cell proliferation in a dose and time dependent manner. CEB4 …
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Student Works (2010-2019)
Introduction Oral cancer is a significant health problem worldwide with almost 300,000 new cases are diagnosed each year. Despite the numerous studies done, and even with the best treatment option utilized, more than 50% of patients with oral cancer will experience relapse. In search for better options for prognostication, researches are now focusing on the molecular biology of cancer, for instance in search of reliable tumor markers. Among the markers reported in the literatures, Cyclin D1 is actively studied protein. Cyclin D1 regulates the cell cycle progression by forming a complex with different cyclin dependant kinase. Dysregulation of cyclin D1 …
Oces Sistem Pakar Kanser Ovari, Abd. Rahim Noreen
Oces Sistem Pakar Kanser Ovari, Abd. Rahim Noreen
Student Works (2000-2009)
Sistem Pakar Kanser Ovari atau OCES merupakan projek tahun akhir bagi memenuhi keperluan dalam penganugerahan ljazah Sarjana Muda Sains Komputer. OCES merupakan sistem pakar yang cuba bertindak untuk menggantikan pakar pada bila-bila masa yang diperlukan dengan melakukan diagnosis ke atas pesakit kanser ovari berdasarkan gejala-gejala yang ada pada pesakit. Dalam menjalankan proses diagnosis, satu sesi soal jawab dikendalikan oleh OCES akan dijalankan dan daripada sesi ini, OCES akan mengenalpasti samada pesakit tersebut berpotensi mendapat kanser ovari dan seterusnya membcrikan cadangan tentang kaedah rawatan yang mungkin diperlukan oleh pesakit disamping mampu memberi sedikit sebanyak maklumat mengenai kanser ovari. Dengan wujudnya sistem …
Epstein-Barr Virus Serology In The Diagnosis Of Nasopharyngeal Carcinoma From Sarawak, Madeline Wong Mei Fong
Epstein-Barr Virus Serology In The Diagnosis Of Nasopharyngeal Carcinoma From Sarawak, Madeline Wong Mei Fong
Student Works (2000-2009)
The Epstein-Barr virus (EBV) is closely associated with nasopharyngcal carcinoma (NPC). The role(s) of EBV in NPC remains unclear but antibodies to two EBV proteins namely the viral capsid antigen (VCA) and early antigen (EA), are clinically useful diagnostic markers of NPC. The NPC scenario in Malaysia has been based on studies done on West Malaysian patients but not much has been described for NPC in Sarawak, East Malaysia. In this study, 164 NPC sera from newly histologically confirmed NPC patients were collected from the Radiotherapy Unit of Kuching General Hospital, Sarawak prior to radiotherapy. One hundred and forty seven …