Female Urogenital Diseases and Pregnancy Complications Commons^™

Drug-Induced Nutrient Depletion, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

Characterization Of Bacterial Pathogens Involved In Aerobic Vaginitis: Prevalence, Strain Characterization And Sequelae, Leslie A. Lafferty

Graduate School of Biomedical Sciences Theses and Dissertations

Aerobic vaginitis (AV) is a more recently defined infection that involves aerobic pathogenic bacteria that replace the normal flora of the vaginal tract. It is commonly mistaken for other vaginal infections, such as bacterial vaginosis (BV), because they share many common symptoms. AV leads to complications during pregnancy, such as premature delivery and amnion infection, and is diagnosed by indications that range from vaginal discharge to inflammation. Because this infection is difficult to diagnose differentially from other vaginal infections, it is important to determine what pathogens are involved in AV so that we may have the ability to detect them. …

Maternal Obesity And Incidence Of Depression, Caroline A. Habjan

Renée Crown University Honors Thesis Projects - All

Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound for the …

Identification Of Transcription Factors Gzf3, Rfx1, Orf19.3928 As Being Implicated In Candida-Bacterial Interactions., Joni Watson

Undergraduate Honors Theses

Candida albicans is an opportunistic pathogen that is present in the normal flora in a majority of individuals. One key factor in C. albicans virulence is the ability to change its morphology from yeast to an elongated or hyphal form. The regulation of this morphogenesis relies in part upon quorum sensing (QS) molecules. C. albicans often exists as part of a mixed culture alongside other microbes and is influenced by their presence as well as the presence of QS molecules that they produce. In this study, a library of diploid homozygous transcriptional regulator knockout (TRKO) mutants were screened to identify …

Gestational Diabetes, David D. Monin

Biology Undergraduate

No abstract provided.

Targeted Single Molecule Sequencing Methodology For Ovarian Hyperstimulation Syndrome., Funda Orkunoglu-Suer, Arthur F. Harralson, David Frankfurter, Paul Gindoff, Travis J. O'Brien

Genomics and Precision Medicine Faculty Publications

BACKGROUND: One of the most significant issues surrounding next generation sequencing is the cost and the difficulty assembling short read lengths. Targeted capture enrichment of longer fragments using single molecule sequencing (SMS) is expected to improve both sequence assembly and base-call accuracy but, at present, there are very few examples of successful application of these technologic advances in translational research and clinical testing. We developed a targeted single molecule sequencing (T-SMS) panel for genes implicated in ovarian response to controlled ovarian hyperstimulation (COH) for infertility.

RESULTS: Target enrichment was carried out using droplet-base multiplex polymerase chain reaction (PCR) technology (RainDance®) …

Human Papillomavirus And The Gardasil Vaccine: Medicalization And The Gendering Of Bodies And Bodily Risk, Lauren Camara

Laurier Undergraduate Journal of the Arts

No abstract provided.

Study Of Intuitive Eating Ratings And Self-Efficacy Differences In Women With Polycystic Ovarian Syndrome (Pcos), Meaghan Ormsby Schillinger

Master's Theses and Doctoral Dissertations

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder, which if left untreated can lead to infertility and diabetes.

Objective: To determine whether women with PCOS who practice intuitive eating skills are more confident in sustaining healthy lifestyle changes.

Methods: A web-based survey was completed by 120 women with PCOS. Bivariate associations between the self-efficacy and intuitive eating scales was investigated using scatterplots, Pearson’s correlation coefficient, and a simple linear regression model. Ratings on the intuitive eating scale were dichotomized as high or low and self-efficacy ratings were compared.

Results: Of the 120 responses, 89% of …

The Development Of A Comprehensive Antifungal Susceptibility Testing Assay For Vulvovaginal Candidiasis Therapy, David Hardaker

Graduate School of Biomedical Sciences Theses and Dissertations

Vulvovaginal candidiasis is the most common fungal infection of the female urogenital tract, commonly caused by Candida albicans and C. glabrata. However, treatment can be difficult when caused by non-albicans strains due to resistance to the oral antifungal drug fluconazole. The mechanism through which strains of Candida, particularly C. glabrata, develop resistance to different antifungal classes has not been completely characterized. The ergosterol biosynthesis pathway, an important component of the cell membrane, is the major target of antifungals such as fluconazole, an inhibitor of the ERG 11 gene. Current research shows that an upregulation of specific genes in C. glabrata …

Novel Binding Domains Mediate Binding Of Hpv 16 E6 To Fadd And Procaspase 8, Sandy S. Tungteakkhun

Loma Linda University Electronic Theses, Dissertations & Projects

To evade the host response to infection, viruses have developed means to survive and propagate. HPV 16, a causative agent of cervical cancer and of some cases of oropharyngeal cancers, is one example. We have reported that the early viral protein E6 binds to proteins necessary for propagation of the apoptotic signal following receptor/ligand interactions, such as those mediated by FADD DED and procaspase 8 DED. E6 expression leads to the dose-dependent accelerated degradation of FADD and the protection of E6-expressing cells from Fas-induced apoptosis. Surprisingly, the splice isoforms of E6, E6_large and E6*, affect the stability of procaspase …

Clover Infertility Of Sheep : Continuing Problem, N R. Adams, Keith Croker

Journal of the Department of Agriculture, Western Australia, Series 4

Some varieties of subterranean clover, notably Dinninup, Dwalganup and Yarloop, contain compounds which act like the female sex hormone oestrogen. These plant oestrogens, or "phyto-oestrogens", interfere with the fertility of sheep and depress the percentage of lambs born.

Over the past 10 years our understanding of clover infertility has increased, and we can now gauge the extent of this residual problem. In fact, there is a widespread but low-level incidence of infertility which does not greatly affect individial farms but which has an important impact on the State's sheep production.

Reproductive Wastage Among Merino Ewe Flocks. 2. Non-Clover Areas, T Marshall, B. R. Beetson, R. J. Lightfoot, G. R. Mcmullen

Journal of the Department of Agriculture, Western Australia, Series 4

This research sought to define the reasons for low fertility among Merino ewes in Western Australia.

This first article looks at wastage in Non-Clover areas

Clover Disease : What Do We Know And What Can We Do, T Marshall

Journal of the Department of Agriculture, Western Australia, Series 4

A review of 30 years' study and practical experience of clover disease in Western Australia—and a summary of current recommendations for reducing problems in sheep grazing pastures based on oestrogenic subterranean clover.

Reproductive Wastage In Sheep On Clover Areas, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Western Australia's 67 per cent lambing for 1970 compares poorly with that of other Australian States, and other countries. From the 12.3 million ewes mated in this State's agricultural areas in 1970, only 8.2 million lambs were marked.

This low 77.7 per cent conception rate sparked the present series of reproductive wastage investigations by the Department's Sheep and Wool Branch.

This report describes the first year's results of the project in W.A.'s "clover disease" areas.

Interactions Of Pregnancy And Diabetes, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.

A Measure Of Clover Infertility In Ewes, N Davenport

Journal of the Department of Agriculture, Western Australia, Series 4

SERIOUS impairment of the breeding ability of ewes grazed for prolonged periods on growing pastures containing dominant subterranean clover has been experienced in Western Australia for many years.

The first widespread recognition of the problem coincided with the upsurge of improved pasture establishment based on the Dwalganup variety of subterranean clover in the higher rainfall sections of the wheatbelt and adjacent sheep raising areas to the west and south.

Cervical Incompetence, William C. Gilkey

Henry Ford Hospital Medical Journal

No abstract provided.

Fatal Spontaneous Hematoma Of The Vulva In A Primipara At 36 Weeks Gestation Before Onset Of Labor, Peter H. Mulder

Henry Ford Hospital Medical Journal

No abstract provided.

Toxemia Of Pregnancy, C. Paul Hodgkinson

Henry Ford Hospital Medical Journal

No abstract provided.