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Full-Text Articles in Disease Modeling

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump Dec 2023

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump

Electronic Theses and Dissertations

Biomanufactured 3D-organoids show promise for modeling and treating various conditions, particularly insulin-dependent diabetes mellitus (type-1 diabetes). Pancreatic islet organoids serve as sustainable sources of insulin-producing β-cells, potentially restoring insulin regulation in patients and providing a long-term solution for diabetes. Hydrogel droplet printing is an emerging technique in regenerative medicine due to its advantageous tunability and biocompatibility; however, challenges of consistency, quality control, and scalability persist. To address these issues, we developed a novel air-jetting based droplet bioprinting system for the generation of monodispersed alginate micro-droplets. The objective of this project was to incorporate human induced pluripotent stem cells (hiPSCs) into …


Modeling The Effects Of Fentanyl And Narcan On The Opioid Epidemic In Allegheny County Using Mathematics, Lindsay Moskal, Lauren Sines, Rachael Neilan Ph.D. May 2020

Modeling The Effects Of Fentanyl And Narcan On The Opioid Epidemic In Allegheny County Using Mathematics, Lindsay Moskal, Lauren Sines, Rachael Neilan Ph.D.

Undergraduate Research and Scholarship Symposium

Starting in the 1990s, physicians across the United States have increasingly prescribed opioid pain relievers, which has given rise to the current opioid epidemic. As a result, there has been a drastic increase in the number of overdose fatalities. In 2017, the number of opioid overdose deaths peaked and the U.S. declared the crisis as a public health emergency. One state that has contributed significantly to this epidemic is Pennsylvania, which ranks first for the greatest number of overdose deaths and third for the highest death rate. In fact, Allegheny County has witnessed an overdose death rate that is three …


Modeling The Effects Of Fentanyl And Narcan On The Opioid Epidemic In Allegheny County Using Mathematics, Lindsay Moskal, Lauren Sines, Rachael Neilan Ph.D. May 2020

Modeling The Effects Of Fentanyl And Narcan On The Opioid Epidemic In Allegheny County Using Mathematics, Lindsay Moskal, Lauren Sines, Rachael Neilan Ph.D.

Undergraduate Research and Scholarship Symposium

Starting in the 1990s, physicians across the United States have increasingly prescribed opioid pain relievers, which has given rise to the current opioid epidemic. As a result, there has been a drastic increase in the number of overdose fatalities. In 2017, the number of opioid overdose deaths peaked and the U.S. declared the crisis as a public health emergency. One state that has contributed significantly to this epidemic is Pennsylvania, which ranks first for the greatest number of overdose deaths and third for the highest death rate. In fact, Allegheny County has witnessed an overdose death rate that is three …