Bacterial Infections and Mycoses Commons^™

Genetic Determinants Involved In Acquisition Of Iron In The Opportunistic Pathogen Mycobacterium Abscessus, Manal F. Farhat

Dissertations, Theses, and Capstone Projects

The opportunistic pathogen Mycobacterium abscessus subsp. abscessus (Mab) has become an emerging public health threat due to the increasing number of Mab-associated chronic pulmonary disease cases. Infection cure rates are only 50% due to the complex resistance of Mab to most antimicrobial drugs and chemotherapy.

Deeper knowledge of Mab biology is needed to illuminate potential candidates for development of improved therapeutics against Mab infections. The ESX-3 type VII protein secretion system of Mab plays an important role in host inflammatory and pathological responses during infection.

In this study, we demonstrate a functional link between the ESX-3 secretion …

Chlamydia Trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion, A. Haines, J. Wesolowski, F. Paumet

Department of Microbiology and Immunology Faculty Papers

Chlamydia trachomatis is the leading cause of sexually transmitted bacterial disease and a global health burden. As an obligate intracellular pathogen, Chlamydia has evolved many strategies to manipulate its host and establish its intracellular niche called the inclusion. C. trachomatis reorganizes the host actin cytoskeleton to form scaffolds around the inclusion and reinforce the growing inclusion membrane. To control the kinetics and formation of actin scaffolds, Chlamydia expresses the effector InaC/CT813, which activates the host GTPase RhoA. Here, we have discovered that InaC stabilizes actin scaffolds through the host actin cross-linking proteins α-actinins 1 and 4. We demonstrate that α-actinins …

Impact Of Enteropathogens On Faltering Growth In A Resource-Limited Setting, Furqan Kabir, Junaid Iqbal, Zehra Jamil, Najeeha Talat Iqbal, Fatima Aziz, Adil Kalam, Sahrish Muneer, Aneeta Hotwani, Sheraz Ahmed, Fayyaz Umrani, Sana Syed, Kamran Sadiq, Syed Asad Ali

Department of Paediatrics and Child Health

Introduction: Environmental enteropathy is an important contributor to childhood malnutrition in the developing world. Chronic exposure to fecal pathogens leads to alteration in intestinal structure and function, resulting in impaired gut immune function, malabsorption, and growth faltering leading to environmental enteropathy.
Methods: A community-based intervention study was carried out on children till 24 months of age in Matiari district, Pakistan. Blood and fecal specimens were collected from the enrolled children aged 3-6 and 9 months. A real-time PCR-based TaqMan array card (TAC) was used to detect enteropathogens.
Results: Giardia, Campylobacter spp., enteroaggregative Escherichia coli (EAEC), Enteropathogenic Escherichia coli (EPEC), …

Case Report Of Extensive Spinal Epidural Abscess, Eric Brown, Marcus Zorovich

Far West Division GME Research Day 2023

No abstract provided.

Acute Appendicitis Secondary To Enterobius Vermicularis: Case Report, Yasmine Hemida, Horeb Cano Gonzalez, Mike K. Liang

Gulf Coast Division GME Research Day 2023

No abstract provided.

A Case Of Embolic Stroke Due To Native Mitral Valve Pasteurella Multocida Infective Endocarditis, Alexia Foy-Crowder, Omar Kandah, Mohamed Faris

South Atlantic Division GME Research Day 2023

No abstract provided.

Mycotic Aortic Abdominal Aneurysm: A Rare Case, Jazmine Duran, Judy Jin, Skyler Westerfeld

Central & West Texas GME Research Day 2023

No abstract provided.

Burkholderia Cepacia Causing Ards In A Patient Without Cystic Fibrosis, Igbayilola Dosunmu, Shahriar Sharif, Samyukta Swaminath, Nashit Mozumder, Diego Marin

East Florida Division GME Research Day 2023

No abstract available.

A Walking Case Of Extensive Klebsiella Pneumoniae Mimicking Lung Cancer, Diem Phuc T. Nguyen, Rebecca L. Cooper, Maria Antonio-Miranda, Patricia Gilford

South Atlantic Division GME Research Day 2023

No abstract provided.

Nontyphoidal Salmonella Causing Mycotic Aneurysms And Subsequent Vascular Graft Infection: A Case Report, Bernard Dankyi, Sandi Dunn, Zainab Saeed, Vincent Santi, Aneta Tarasuik Rusek

North Florida Division GME Research Day 2023

No abstract provided.

Surviving The Apprehensive Methicillin-Sensitive Staphylococcus Aureus (Mssa) Bacteremia: A Case Of Bacteremia With An Undetermined Source Of Infection Leading To Suspected Cardioembolic Ischemia And Biochemical Septic Shock, Greisy D. Curbelo Sesin, Eduardo Marino-Urbino, Christopher Fontela, Melanio J. Rodriguez, Jorge A. Diaz, Shivaan C. Oomrigar, Ramon Mendoza Bello, Yoandy Rodriguez Fuentes

East Florida Division GME Research Day 2023

Introduction: This research presents a complex case of a 70-year-old male with acute metabolic encephalopathy and biochemical septic shock, later attributed to cardioembolic ischemia, resulting from Methicillin-Sensitive Staphylococcus Aureus (MSSA) bacteremia with an elusive source of infection.

Case Description: The 70-year-old patient, with a medical history of hypertension and aortic valve stenosis status post-Coronary Artery Bypass Grafting and bioprosthetic valve replacement on dual anti-platelet therapy (clopidogrel and aspirin), was admitted following an unwitnessed fall and a day of vomiting and generalized weakness. Upon arrival, the patient exhibited altered mental status, hypotension, and acidosis. Initial diagnostic workup raised suspicion of biochemical …

Atraumatic Splenic Rupture: An Unaccustomed Complication Of H. Parainfluenzae Endocarditis, Daniel P. High, Jose M. Acosta-Rullan, Danay Herrera, Mauricio Danckers

East Florida Division GME Research Day 2023

No abstract available.

Unique Presentation Of Cerebritis: A Case Report, Wajahat Dawood, Kevin Jiang, Bryan Kharbanda

Gulf Coast Division GME Research Day 2023

No abstract provided.

Intestinal Tuberculosis Presenting As Small Bowel Obstruction, Duyen Quach, Jordan Torres, Kayla Nguyen, Kevin Garnepudi, Wenjing Fang, Mike Liang

Gulf Coast Division GME Research Day 2023

No abstract provided.

Veillonela Discitis: A Rare Presentation And Review Of Literature, Akankcha Alok, Vidya Sagar Kollu, Gautam Kalyatanda

North Florida Division GME Research Day 2023

No abstract provided.

Streptococcus Anginosus Liver Abscess In An Otherwise Healthy 38 Y/O Male: A Case Report, Ryan Hammond, Jiaxin Wen

TriStar Division Research Day 2023

No abstract provided.

Subacute Stroke Like Presentation Likely Due To Disseminated Histoplasmosis In An Immunocompromised Patient, Ashley R. Diaz, Priya Mohan, Utmitha Konda, Alfonso Manotas, Issac Ichoa

East Florida Division GME Research Day 2023

Histoplasmosis capsulatum is an opportunistic fungal infection that is largely asymptomatic and found to have nonspecific signs and symptoms. It predominates in Central and North America, and is one of the leading causes of hospitalization among the fungal family. However, in the right host, such as in this case, a patient with significant immunosuppression can develop serious manifestations as it disseminates outside of the pulmonary system. The challenging element of disseminated histoplasmosis is that despite proper treatment immunocompromised patients will frequently relapse with worsening presentation. There is limited literature on subacute stroke-like presentation in a patient with chronic infection of …

A Rare Case Of Right Atrial Appendage Mass In Patient With Recurrent Methicillin-Resistant Staphylococcus Aureus Bacteremia, Vivek Nadipalli, Ahmed Mahmood, Thomas Alexander

Gulf Coast Division GME Research Day 2023

No abstract provided.

O. Anthropi: An Unusual Cause Of Pneumonia And Bacteremia, Zefr Chao, Anaam Fayyaz, Suresh Antony

Central & West Texas GME Research Day 2023

No abstract provided.

Clostridium Septicum Bacteremia As The Presenting Sign Of Colon Cancer, Andrew Abraham, Sripal Padam

North Florida Division GME Research Day 2023

No abstract provided.

Acute Colonic Perforation With Septic Shock Secondary To Disseminated Histoplasmosis In A Autologous Bone Marrow Transplant Recipient, Harsimrandeep Bhatti, Srijisnu De, Enkhbileg Batbileg, Glen Friedman

Central & West Texas GME Research Day 2023

No abstract provided.

Hairy Cell Leukemia Presenting As Group B Streptococcus Cellulitis And Abscesses, Hannah Berrett, Mattias D'Anna, Ajay Iyer, Zachary Hancock, Meg Laures, Muzaffar Iqbal

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Clonal Diversity, Antibiotic Resistance, And Virulence Factor Prevalence Of Community Associated Staphylococcus Aureus In Southeastern Virginia, Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp

EVMS School of Health Professions Faculty Publications

Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary …

Fever Of Unknown Origin Secondary To Staphylococcus Epidermidis Infective Endocarditis In A Patient With Aicardi Syndrome, Kimberly Sanchez Lopez, Elvis Caraballo Antonio, Gabriel Barciela Perez, Melanio J. Rodriguez, Yeissen Godinez

East Florida Division GME Research Day 2023

INTRODUCTION Aicardi syndrome is a rare neurodevelopmental disorder predominantly affecting females and characterized by agenesis of the corpus callosum, infantile spasms, and distinctive chorioretinal lacunae. We present the case of a 24-year-old female with a known history of Aicardi syndrome who presented with fever of unknown origin, ultimately attributed to Staphylococcus Epidermidis infective endocarditis involving a native valve.

CASE DESCRIPTION A 24-year-old female with a history significant for Aicardi syndrome and epilepsy presented to the emergency department for fever during the past week; her primary care physician sent her for outpatient blood work a few days prior, including blood culture, …

Staph What?: An Uncommon Species Of Staphylococcus Endocarditis In An Atypical Case Of Diabetic Ketoacidosis, Gilberto Rivera-Gonzalez, Habiba Khan, Harsimrandeep Bhatti, Jazmine Duran, Caleb Nieves, Paul Mathew

Central & West Texas GME Research Day 2023

No abstract provided.

Chromobacterium Haemolyticum Infection From Hot Springs Near Yellowstone National Park, Kyle Patterson, Sean Shearen, Ken Chapman, Katie Suleta

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Analysis Of Multi-Drug Resistant Mycobacterium Tuberculosis Using Split Deoxyribozymes, Abryana Fergus

Electronic Theses and Dissertations, 2020-2023

Globally, tuberculosis, a disease caused by the species of Mycobacterium tuberculosis (Mtb) complex, stands as a leading cause of death from a single infectious agent. Even though antituberculous drugs are available, treatment is challenging due to antibiotic resistance associated with point mutations in the bacterial genome. Resistance to the first-line antibiotics – rifampin and isoniazid – results in multidrug-resistant tuberculosis (MDR) requiring a more complicated treatment regimen. Timely and accurate identification of drug-resistant TB cases can help prescribe the most effective treatment and prevent the spread of infection. This research aims to develop an assay to discern multi-drug resistant forms …

Empyema Necessitans Due To Actinomycetes Odontolyticus, Alexandra E. Thomson, Jean Toffrey, Jessica Thomas, Jana Byrd, Chad Martins

South Atlantic Division GME Research Day 2023

No abstract provided.

Why A High Titer Rheumatoid Factor And Joint Pain Should Not Automatically Translate Into A Diagnosis Of Rheumatoid Arthritis, Saba Ashraf, Julio Gonzalez-Paoli

West Florida Division GME Research Day 2023

No abstract provided.

A Case Of Vibrio Vulnificus In Galveston, Kayla Nguyen, Duyen Quach, Chinasa Anokwuru, Connor Hogan, Mike Liang

Gulf Coast Division GME Research Day 2023

No abstract provided.