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Full-Text Articles in Diseases

Planning A ‘Dancing At The Vatican’ Screening To Celebrate The Global Huntington's Disease Community's Journey, Kenneth P. Serbin Jan 2020

Planning A ‘Dancing At The Vatican’ Screening To Celebrate The Global Huntington's Disease Community's Journey, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


An ‘Electric,’ Inspiring Thanksgiving For The Huntington's Disease Community, Kenneth P. Serbin Nov 2019

An ‘Electric,’ Inspiring Thanksgiving For The Huntington's Disease Community, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


‘Navigating’ The Huntington’S Disease Community Towards Crucial Clinical Trials, Kenneth P. Serbin Nov 2019

‘Navigating’ The Huntington’S Disease Community Towards Crucial Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Are We Failing To Stop Huntington’S Disease By Ignoring 'Natural' Remedies, Alternative Therapies, And Repurposed Drugs?, Kenneth P. Serbin Oct 2019

Are We Failing To Stop Huntington’S Disease By Ignoring 'Natural' Remedies, Alternative Therapies, And Repurposed Drugs?, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


As Range Of Possible Therapies Grows, Chdi Expands Efforts To Defeat Huntington's Disease, Kenneth P. Serbin Oct 2019

As Range Of Possible Therapies Grows, Chdi Expands Efforts To Defeat Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


What If We Could Turn Off The Cause Of Huntington’S Disease?, Kenneth P. Serbin Aug 2019

What If We Could Turn Off The Cause Of Huntington’S Disease?, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Factor-H Partners With Latin American Organizations To Aid Destitute Huntington's Disease Families, Seeks To Expand Support, Kenneth P. Serbin Aug 2019

Factor-H Partners With Latin American Organizations To Aid Destitute Huntington's Disease Families, Seeks To Expand Support, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


‘Dancing At The Vatican,’ About Huntington’S Families' Remarkable Papal Audience, Premieres July 27, Kenneth P. Serbin Jul 2019

‘Dancing At The Vatican,’ About Huntington’S Families' Remarkable Papal Audience, Premieres July 27, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche Restarts Redesigned Phase 3 Huntington’S Disease Trial, Kenneth P. Serbin Jun 2019

Roche Restarts Redesigned Phase 3 Huntington’S Disease Trial, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Are Pre-Existing Conditions Returning, And Obamacare Ending?, Kenneth P. Serbin Jun 2019

Are Pre-Existing Conditions Returning, And Obamacare Ending?, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


My Huntington’S Disease Sister – And A Hero Who Strives For The Unthinkable, Kenneth P. Serbin May 2019

My Huntington’S Disease Sister – And A Hero Who Strives For The Unthinkable, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


‘Let’S Talk About Huntington’S Disease’: 2019 Hd Awareness Month Kicks Off, Kenneth P. Serbin May 2019

‘Let’S Talk About Huntington’S Disease’: 2019 Hd Awareness Month Kicks Off, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Comedian Rod Man’S Heartfelt Speech, Ramona Johnston's Death Remind Us Of Urgent Need To Cure Huntington's Disease, Kenneth P. Serbin Apr 2019

Comedian Rod Man’S Heartfelt Speech, Ramona Johnston's Death Remind Us Of Urgent Need To Cure Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche: Less Frequent Dosing For Phase 3 Huntington's Clinical Trial, Easing Burden On Patients, Kenneth P. Serbin Mar 2019

Roche: Less Frequent Dosing For Phase 3 Huntington's Clinical Trial, Easing Burden On Patients, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche Ramps Up Huntington’S Disease Clinical Trial For Early-To Mid-Stage Patients, Considers Ways To Expand Research, Kenneth P. Serbin Mar 2019

Roche Ramps Up Huntington’S Disease Clinical Trial For Early-To Mid-Stage Patients, Considers Ways To Expand Research, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


‘We Can Now Fear Huntington’S Disease Less’: Reflections On The 14th Therapeutics Conference, Kenneth P. Serbin Mar 2019

‘We Can Now Fear Huntington’S Disease Less’: Reflections On The 14th Therapeutics Conference, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Investigating The Role Of Free Radicals In Huntington's Disease Using Drosophila Melanogaster, Jennifer Libov Mar 2019

Investigating The Role Of Free Radicals In Huntington's Disease Using Drosophila Melanogaster, Jennifer Libov

Honors Program: Senior Projects (Public)

During normal cell metabolism, reactive oxygen species (ROS) are produced as a byproduct of oxidative phosphorylation. ROS are utilized in the cell as a signaling molecule and can be maintained at healthy levels by cellular antioxidants. However, when the cell experiences oxidative stress due to environmental or genetic conditions, levels of ROS can exceed healthy levels and inhibit necessary life functions by damaging biomolecules and cellular structures. This loss of function can lead to physiological decline and neurodegeneration, such as in diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and, potentially, Huntington’s disease. The following experiments use the model genetic organism …


Chdi’S Chief Scientist: ‘Not A Time For The Huntington's Community To Rest Its Laurels', Kenneth P. Serbin Feb 2019

Chdi’S Chief Scientist: ‘Not A Time For The Huntington's Community To Rest Its Laurels', Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Continued Progress, But Also Caution, In The Fight Against Huntington's Disease, Kenneth P. Serbin Feb 2019

Continued Progress, But Also Caution, In The Fight Against Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Hacking Humans, Upgrading Homo Sapiens: The Role Of The Huntington's Disease Community And The Consequences For Life, Kenneth P. Serbin Jan 2019

Hacking Humans, Upgrading Homo Sapiens: The Role Of The Huntington's Disease Community And The Consequences For Life, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


A Friend Of The Huntington’S Community Receives Award For Hd Article In Influential Brazilian Magazine, Kenneth P. Serbin Jan 2019

A Friend Of The Huntington’S Community Receives Award For Hd Article In Influential Brazilian Magazine, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche Announces U.S., Canada Sites For Phase 3 Clinical Trial Of Huntington's Disease Drug, Kenneth P. Serbin Dec 2018

Roche Announces U.S., Canada Sites For Phase 3 Clinical Trial Of Huntington's Disease Drug, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Building Solidarity In Disease Communities’ Quest For Better Care And Treatments: A Conversation With A Young Tennis Award-Winner, Kenneth P. Serbin Dec 2018

Building Solidarity In Disease Communities’ Quest For Better Care And Treatments: A Conversation With A Young Tennis Award-Winner, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Protein Aggregates And Polyglutamine Tracts In Neurodegenerative Disease, John Mack Nov 2018

Protein Aggregates And Polyglutamine Tracts In Neurodegenerative Disease, John Mack

Senior Honors Theses

The incidence of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of these diseases remains poorly understood. One pathway that these neurodegenerative diseases share is the accumulation of pathologic proteins which are not only harmful in their soluble form but may go on to form toxic aggregates. In many cases, a consensus has yet to be reached concerning the mechanism for protein aggregation. Therefore, the exploration of the roles of these proteins and their possible mechanisms, along with potential techniques for …


This Thanksgiving, Appreciating Stable Health And New Plans For Huntington's Disease Advocacy, Kenneth P. Serbin Nov 2018

This Thanksgiving, Appreciating Stable Health And New Plans For Huntington's Disease Advocacy, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche Announces First Sites For Key Huntington’S Disease Observational Study, Kenneth P. Serbin Nov 2018

Roche Announces First Sites For Key Huntington’S Disease Observational Study, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Unpacking Generation Hd1, The Roche Phase 3 Huntington's Disease Clinical Trial, Kenneth P. Serbin Sep 2018

Unpacking Generation Hd1, The Roche Phase 3 Huntington's Disease Clinical Trial, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Roche Phase 3 Clinical Trial For Huntington’S Disease Gene-Slicing Drug To Enroll Volunteers In Early 2019, Kenneth P. Serbin Sep 2018

Roche Phase 3 Clinical Trial For Huntington’S Disease Gene-Slicing Drug To Enroll Volunteers In Early 2019, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


In Harriet’S Tragic Death, The Vulnerability Caused By Huntington's Disease – But Also The Story Of A Beautiful Soul, Kenneth P. Serbin Jul 2018

In Harriet’S Tragic Death, The Vulnerability Caused By Huntington's Disease – But Also The Story Of A Beautiful Soul, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


Free From The Threat Of Huntington’S Disease, Our 'Miracle Baby' Turns 18, Kenneth P. Serbin May 2018

Free From The Threat Of Huntington’S Disease, Our 'Miracle Baby' Turns 18, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.