Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (624)
- Pathological Conditions, Signs and Symptoms (450)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (323)
- Public Health (187)
- Cardiovascular Diseases (165)
-
- Emergency Medicine (165)
- Nervous System Diseases (149)
- Diagnosis (132)
- Therapeutics (122)
- Anatomy (119)
- Neoplasms (116)
- Health and Medical Administration (112)
- Chemicals and Drugs (111)
- Neurology (105)
- Medical Sciences (100)
- Life Sciences (95)
- Cardiology (92)
- Mental and Social Health (89)
- Nutritional and Metabolic Diseases (76)
- Psychiatry and Psychology (72)
- Surgery (69)
- Musculoskeletal Diseases (65)
- Community Health and Preventive Medicine (61)
- Bacterial Infections and Mycoses (60)
- Digestive System Diseases (59)
- Social and Behavioral Sciences (58)
- Cell and Developmental Biology (56)
- Female Urogenital Diseases and Pregnancy Complications (56)
- Keyword
-
- Case Reports (50)
- Humans (46)
- COVID-19 (39)
- Female (38)
- Male (30)
-
- Aged (29)
- Treatment Outcome (27)
- Adult (24)
- Neoplasms (23)
- Middle Aged (19)
- Obesity (19)
- Pregnancy (18)
- Case reports (17)
- Diagnosis (17)
- Pain Management (16)
- Biomarkers (14)
- Differential Diagnosis (14)
- New Jersey (14)
- Social Determinants of Health (14)
- Socioeconomic Factors (14)
- Stroke (14)
- Adolescent (12)
- Alzheimer Disease (12)
- Mortality (12)
- Neurodegenerative Diseases (12)
- Quality of Life (12)
- Sepsis (12)
- Animals (11)
- Anxiety (11)
- Diabetes (11)
- Publication Year
- Publication
- Publication Type
- File Type
Articles 901 - 903 of 903
Full-Text Articles in Diseases
Generation And Characterization Of Peptide Fusion Proteins, Brianna L. Probasco
Generation And Characterization Of Peptide Fusion Proteins, Brianna L. Probasco
Graduate School of Biomedical Sciences Theses and Dissertations
Pathogenic Th17 cells drive progression of many autoimmune diseases. Th17 cells develop from naïve T cells in the immune system after antigen-driven stimulation in a specific cytokine environment. Normally, T cells act to fight off infection, but when not properly controlled, they can cause disease. The cytokine interleukin-23 (IL-23) plays an essential role in the expansion of pathogenic Th17 cells. IL-23 is a heterodimeric protein, composed of a p19 alpha chain and a p40 beta chain. The p40 is also part of IL-12 and binds to the IL-12 receptor beta 1 (IL-12Rβ1) subunit. Thus, it follows that the IL-23 receptor …
Notch1 Functions As A Tumor Suppressor In A Model Of K-Ras–Induced Pancreatic Ductal Adenocarcinoma, Linda Hanlon, Jacqueline L Avila, Renée M Demarest, Scott Troutman, Megan Allen, Francesca Ratti, Anil K Rustgi, Ben Z Stanger, Fred Radtke, Volkan Adsay, Fenella Long, Anthony J Capobianco, Joseph L Kissil
Notch1 Functions As A Tumor Suppressor In A Model Of K-Ras–Induced Pancreatic Ductal Adenocarcinoma, Linda Hanlon, Jacqueline L Avila, Renée M Demarest, Scott Troutman, Megan Allen, Francesca Ratti, Anil K Rustgi, Ben Z Stanger, Fred Radtke, Volkan Adsay, Fenella Long, Anthony J Capobianco, Joseph L Kissil
Rowan-Virtua School of Osteopathic Medicine Departmental Research
K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor signaling becomes reactivated in a subset of PDACs, leading to the hypothesis that Notch1 functions as an oncogene in this setting. To determine whether Notch1 is required for K-ras-induced tumorigenesis, we used a mouse model in which an oncogenic allele of K-ras is activated and Notch1 is deleted simultaneously in the pancreas. Unexpectedly, the loss of Notch1 in this model resulted in increased …
Direct Inhibition Of Cdk9 Blocks Hiv-1 Replication Without Preventing T Cell Activation In Primary Human Peripheral Blood Lymphocytes, Dominic Salerno, Muneer G Hasham, Renee Marshall Demarest, Judit Garriga, Alexander Y Tsygankov, Xavier Graña
Direct Inhibition Of Cdk9 Blocks Hiv-1 Replication Without Preventing T Cell Activation In Primary Human Peripheral Blood Lymphocytes, Dominic Salerno, Muneer G Hasham, Renee Marshall Demarest, Judit Garriga, Alexander Y Tsygankov, Xavier Graña
Rowan-Virtua School of Osteopathic Medicine Departmental Research
HIV-1 transcription is essential for the virus replication cycle. HIV-1 Tat is a viral transactivator that strongly stimulates the processivity of RNA polymerase II (RNAPII) via recruitment of the cyclin T1/CDK9 positive transcription elongation factor, which phosphorylates the C-terminal domain (CTD) of RNAPII. Consistently, HIV-1 replication in transformed cells is very sensitive to direct CDK9 inhibition. Thus, CDK9 could be a potential target for anti-HIV-1 therapy. A clearer understanding of the requirements for CDK9 activity in primary human T cells is needed to assess whether the CDK9-dependent step in HIV-1 transcription can be targeted clinically. We have investigated the effects …