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Articles 1 - 30 of 15523

Full-Text Articles in Diseases

The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell Dec 2024

The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly …


Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang Dec 2024

Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang

Research outputs 2022 to 2026

Background: Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. Methods: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers. Sensitivity analyses for the MR approach …


Highly Toxic Aβ Begets More Aβ, Merc M. Kemeh, Noel Lazo Sep 2024

Highly Toxic Aβ Begets More Aβ, Merc M. Kemeh, Noel Lazo

Chemistry

No abstract provided.


Adaptations And Transformations: Perceptions Of Change In Academic Motivation, Resilience, And Covid-19 Stress, Ella V. Gregorio Jun 2024

Adaptations And Transformations: Perceptions Of Change In Academic Motivation, Resilience, And Covid-19 Stress, Ella V. Gregorio

Dissertations, Theses, and Capstone Projects

Of concern to educators, post-COVID-19 assessments have revealed significant achievement gaps in student performance, as well as significant decreases in adolescent mental health. Less is known about changes in achievement motivation. Here we ask how students perceive their own motivation and whether it changed between “before” the pandemic to the present (Fall 2022 - Spring 2023), about three years after the beginning of the pandemic when many school routines were returning to “normal.” To understand how variance in these perceived changes might be related to pandemic-related stressors, trait resilience, and current mental health, we conducted a large survey study (N …


The Effect Of Dietary Interventions Or Patterns On The Cardiometabolic Health Of Individuals Treated With Androgen Deprivation Therapy For Prostate Cancer: A Systematic Review, Hattie H. Wright, Meegan A. Walker, Suzanne Broadbent, Corey Linton, Jacob J. Keech, Karina T. Rune, Cindy L. Davis, Michelle Morris, Anao Zhang, Robert U. Newton, Skye Marshall Jun 2024

The Effect Of Dietary Interventions Or Patterns On The Cardiometabolic Health Of Individuals Treated With Androgen Deprivation Therapy For Prostate Cancer: A Systematic Review, Hattie H. Wright, Meegan A. Walker, Suzanne Broadbent, Corey Linton, Jacob J. Keech, Karina T. Rune, Cindy L. Davis, Michelle Morris, Anao Zhang, Robert U. Newton, Skye Marshall

Research outputs 2022 to 2026

Prostate cancer survivors treated with androgen deprivation therapy may be at increased risk of cardiovascular disease. Dietary recommendations for the prevention and/or management of cardiovascular disease for these individuals are lacking. This review synthesizes the evidence on the effect of dietary interventions on cardiometabolic biomarkers and cardiovascular disease risk in prostate cancer survivors receiving androgen deprivation therapy. A systematic review was conducted across PubMed, CINAHL, Embase, and Cochrane CENTRAL. Intervention or observational cohort studies evaluating diets, nutrients, or nutraceuticals with or without concurrent exercise interventions on cardiovascular disease, cardiovascular events, or cardiovascular disease biomarkers in those treated with androgen deprivation …


Blunt Cerebrovascular Injury (Bcvi): Universal Cta Neck Screening At Level 2 Trauma Center, Tamine Gogel May 2024

Blunt Cerebrovascular Injury (Bcvi): Universal Cta Neck Screening At Level 2 Trauma Center, Tamine Gogel

Doctor of Nursing Practice Projects

Blunt Cerebrovascular Injury (BCVI) refers to injuries to the vessels supplying blood to the brain, primarily carotid and vertebral arteries, and can result from trauma, resulting in stroke by vessel dissection, thrombus formation, embolization, and hemorrhage. Timely identification is crucial for effective intervention and improved outcomes. This doctoral project proposes the implementation of universal screening using Computed Tomography Angiography (CTA) of the neck during initial workup for blunt force trauma at a Level II ACS-verified trauma center. The primary objective is to mitigate potential delays in diagnosing and treating BCVI, thereby reducing the likelihood of complications. Patients ≥ 15 years …


The Use And Effectiveness Of Diet And Physical Activity As Interventions For Polycystic Ovary Syndrome. A Review., Caroline C. Jones, Jinkyung Park May 2024

The Use And Effectiveness Of Diet And Physical Activity As Interventions For Polycystic Ovary Syndrome. A Review., Caroline C. Jones, Jinkyung Park

The Corinthian

Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that is common among women who are of reproductive age, most commonly in ages between 15 and 44 years of age (Moran et al., 2010). While the exact cause of PCOS is unknown, it is widely believed by many experts that genetic factors including excess levels of insulin and excess androgen are attributing factors (Moran et al., 2010) . Women with PCOS experience several different signs and symptoms including; infrequent or prolonged menstrual periods leading to infertility and the development of cysts (Iatrakis et al., 2006). Some other common symptoms of PCOS …


Atrial Fibrillation, Julianna G. Perritt, Jennifer Goldsberry May 2024

Atrial Fibrillation, Julianna G. Perritt, Jennifer Goldsberry

The Corinthian

Atrial fibrillation, also known as A-Fib or AF, is a cardiovascular abnormality that is characterized by an abnormal heart rhythm or muscle contractions in the atria. These abnormalities are a result of disorganized electrical impulses. AF has various causes including, but not limited to, hypertension (HTN), heart surgery, thyroid disorders, heart defects, and acute alcohol ingestion. Persons with AF are often asymptomatic; however, some patients report heart palpitations, chest tightness, shortness of breath, and lightheadedness. A review of literature was conducted in order to determine the availability of risk factors, patient education, and treatment of AF.


Comparing Bilateral And Unilateral Metal Stabilizers: Incision Complications In Pectus Repair, Seth Saylors, Shawn D. St Peter, Tolulope A. Oyetunji Md Mph, Nelimar Cruz-Centeno, Nitin Nadella May 2024

Comparing Bilateral And Unilateral Metal Stabilizers: Incision Complications In Pectus Repair, Seth Saylors, Shawn D. St Peter, Tolulope A. Oyetunji Md Mph, Nelimar Cruz-Centeno, Nitin Nadella

Research Days

Introduction: The use of metal stabilizers in minimally invasive pectus excavatum repair (MIPER) has been previously associated with multiple postoperative complications. We aimed to identify if bilateral metal stabilizers increase the risk of incision complications when compared to unilateral stabilizers.

Methods: Institutional Review Board approval was obtained. Patients that underwent MIPER with metal stabilizers from 2019 to 2022 and currently had the bar in place, at a single tertiary care pediatric center, were included. A telephone survey evaluated if they had incision-associated symptoms, and if the location was congruent with the stabilizer site. A retrospective chart review was performed to …


Pain Management In Perforated Appendicitis: Transitioning To A Minimal Narcotic Strategy, Seth Saylors, Meredith Elman, Pablo Aguayo, Rebecca M. Rentea, Richard J. Hendrickson, David Juang, Charles L. Snyder, Jason D. Fraser, Tolulope A. Oyetunji Md Mph, Shawn D. St Peter, Nelimar Cruz-Centeno, Charles Marchese May 2024

Pain Management In Perforated Appendicitis: Transitioning To A Minimal Narcotic Strategy, Seth Saylors, Meredith Elman, Pablo Aguayo, Rebecca M. Rentea, Richard J. Hendrickson, David Juang, Charles L. Snyder, Jason D. Fraser, Tolulope A. Oyetunji Md Mph, Shawn D. St Peter, Nelimar Cruz-Centeno, Charles Marchese

Research Days

Introduction: Patient controlled analgesia (PCA) was previously standard for postoperative pain control in children with perforated appendicitis at our institution. We previously reported the equivocal outcome of intravenous (IV) acetaminophen as a pain control adjunct used to transition from PCA to oral narcotics. We have since transitioned to a PCA-free, multi-modal pain control regimen postoperatively in perforated appendicitis. Through observational study, we aim to describe the impact of our new pain control regimen on postoperative narcotic use.

Methods: Children– June 2020 at a single freestanding children’s hospital were reviewed. Details of their hospitalization, including demographic, operative, anesthesia, pain management, and …


Modeling Fast Information And Slow(Er) Disease Spreading: A Geometric Analysis, Iulia Martina Bulai, Mattia Sensi, Sara Sottile May 2024

Modeling Fast Information And Slow(Er) Disease Spreading: A Geometric Analysis, Iulia Martina Bulai, Mattia Sensi, Sara Sottile

Biology and Medicine Through Mathematics Conference

No abstract provided.


Piecing Together The Puzzle: Hepatic Abscess In A 16-Year-Old Female, Danielle Statman May 2024

Piecing Together The Puzzle: Hepatic Abscess In A 16-Year-Old Female, Danielle Statman

St. Chris Research Day

No abstract provided.


Implementation Of Lymphedema Education Toolkit For Nurse Coordinators, Heather Gee May 2024

Implementation Of Lymphedema Education Toolkit For Nurse Coordinators, Heather Gee

Master's Projects and Capstones

Problem: Lymphedema is a chronic condition that develops secondary to cancer treatments such as chemotherapy, radiation, and surgical removal of affected lymph nodes. This swelling in patient’s limbs can cause discomfort and limit mobility, however lymphedema is often not detected until later stages, delaying treatment and patient education.

Context: This quality improvement project was conducted at Hospital S Women’s Cancer Center, an outpatient center specializing in advanced treatments for breast and gynecological cancers. This center has a multidisciplinary team focusing on both the medical and surgical aspects of oncology treatment.

Interventions: An evidence-based lymphedema education toolkit was created for nurse …


The Impact Of Health-Related Social Needs On Health Outcomes Among Youth Presenting To A Midwest Pediatric Diabetes Clinic Network, Jasmine Roghair, Emily Dewit, Katelyn Evans, Mitchell Barnes, Heather Feingold, Samantha Jacob, Courtney M. Winterer, Jeffrey D. Colvin, Mark A. Clements, Shilpi Relan, Kelsee Halpin May 2024

The Impact Of Health-Related Social Needs On Health Outcomes Among Youth Presenting To A Midwest Pediatric Diabetes Clinic Network, Jasmine Roghair, Emily Dewit, Katelyn Evans, Mitchell Barnes, Heather Feingold, Samantha Jacob, Courtney M. Winterer, Jeffrey D. Colvin, Mark A. Clements, Shilpi Relan, Kelsee Halpin

Research Days

Screening for health-related social needs (HRSNs) is recommended as part of routine diabetes care given the impact of social factors on health outcomes.

Youth presenting to a tertiary diabetes center will have different diabetes-related health outcomes based on positive or negative HRSNs screenings at routine clinic visits.

Baseline data were collected from patients whose parent/guardian completed a HRSN screen as part of their child’s diabetes clinic intake from 9/1/21 to 8/30/22. The screen is a 6-item questionnaire adapted from the Accountable Health Communities HRSNs Screening Tool to screen for HRSNs in 4 domains (housing, utilities, transportation, and food). Longitudinal data …


Increasing Palliative Care Team Involvement In Pediatric Hematopoietic Stem Cell Transplant Patients, Meagan Vacek, Lisa Tarbell, Melissa List, Erin Hall, Jennifer Linebarger, Kelstan Ellis, Gina Jones, Joel Thompson May 2024

Increasing Palliative Care Team Involvement In Pediatric Hematopoietic Stem Cell Transplant Patients, Meagan Vacek, Lisa Tarbell, Melissa List, Erin Hall, Jennifer Linebarger, Kelstan Ellis, Gina Jones, Joel Thompson

Research Days

Early implementation of palliative care in pediatric oncology is well established but its role in pediatric hematopoietic stem cell transplant (HSCT) patients is yet to be fully determined. Multiple organizations encourage palliative care involvement in HSCT patients. Our aim was to increase palliative care team consults for patients receiving HSCT for our targeted diagnosis. Though we did not achieve this aim, we were able to increase the palliative care team's involvement in the total cohort of patients undergoing HSCT.


A Genomics Driven Induced Pluripotent Stem Cell Model Of Infant Acute Lymphoblastic Leukemia - Early Results, Meagan Vacek, Jacqelyn Nemechek, Irina Pushel, Bradley Thornton, Molly Leyda, Priyanka Prem Kumar, Midhat Farooqi, Jay L. Vivian, Erin M. Guest, John M. Perry May 2024

A Genomics Driven Induced Pluripotent Stem Cell Model Of Infant Acute Lymphoblastic Leukemia - Early Results, Meagan Vacek, Jacqelyn Nemechek, Irina Pushel, Bradley Thornton, Molly Leyda, Priyanka Prem Kumar, Midhat Farooqi, Jay L. Vivian, Erin M. Guest, John M. Perry

Research Days

While the cure rates for pediatric ALL have improved over the decades, infants with ALL (iALL) have not benefitted from these advances and continue to have a devastating prognosis. Unfortunately progress in treatment has also been slowed by inadequate research models. With this project, we address this unmet need by investigating a novel model to understand the cellular and molecular changes that occur during iALL onset and progression.


Diffuse Correlation Spectroscopy Measures Of Cerebral Blood Flow During Graded Hypoxia In Neonatal Piglets, Danielle Shoshany, Shadi Malaeb, Randolph Sinahon, Mert Deniz Polat, Meltem Izzetoglu, Patricia A. Shewokis, Kurtulus Izzetoglu May 2024

Diffuse Correlation Spectroscopy Measures Of Cerebral Blood Flow During Graded Hypoxia In Neonatal Piglets, Danielle Shoshany, Shadi Malaeb, Randolph Sinahon, Mert Deniz Polat, Meltem Izzetoglu, Patricia A. Shewokis, Kurtulus Izzetoglu

St. Chris Research Day

No abstract provided.


Ebv Infection Rates In An Urban Pediatric Population With Oncologic Diagnoses, Daniel Barr, Maxim Yankelevich, Gregory Halligan, Eugenia Kim, Jason White May 2024

Ebv Infection Rates In An Urban Pediatric Population With Oncologic Diagnoses, Daniel Barr, Maxim Yankelevich, Gregory Halligan, Eugenia Kim, Jason White

St. Chris Research Day

No abstract provided.


Effect Of Puberty On Polycystic Ovary Syndrome Presentation, Jaclyn Lo, Erin Finn, Yesenia Garcia-Reyes, Haseeb Rahat, Meredith A. Ware, Nazeen Morelli, Camilo Vivas, Kristen J. Nadeau, Melanie G. Cree May 2024

Effect Of Puberty On Polycystic Ovary Syndrome Presentation, Jaclyn Lo, Erin Finn, Yesenia Garcia-Reyes, Haseeb Rahat, Meredith A. Ware, Nazeen Morelli, Camilo Vivas, Kristen J. Nadeau, Melanie G. Cree

St. Chris Research Day

No abstract provided.


A Phenomenological Study Of Adult Patients With Auto-Immune Disease And Their Exposure To Adverse Childhood Experiences, Milton Louis Gonzalez May 2024

A Phenomenological Study Of Adult Patients With Auto-Immune Disease And Their Exposure To Adverse Childhood Experiences, Milton Louis Gonzalez

Doctoral Dissertations and Projects

This qualitative phenomenological study explored and described the shared experiences of individuals impacted by an autoimmune disease and their exposure to adverse childhood experiences. The theory guiding this study was Vygotsky’s social constructivist theory, utilizing Kaiser Permanente’s Adverse Childhood Experience study as a guide to create awareness amongst physicians and mental health professionals, leading them to a more holistic approach when treating patients affected by an autoimmune disease. This was a qualitative study using Husserl’s transcendental phenomenology (TPh). The data collection methods used in the study included questionnaires, individual interviews, and document analysis. These forms of data were analyzed through …


Assessing The Impact And Cost-Effectiveness Of Covid-19 Testing In Adult Social Care Homes In England, Siyu Chen May 2024

Assessing The Impact And Cost-Effectiveness Of Covid-19 Testing In Adult Social Care Homes In England, Siyu Chen

Biology and Medicine Through Mathematics Conference

No abstract provided.


Dual-Domain Clustering Of Spatiotemporal Infectious Disease Data, Samuel R. Thornton, Erin C.S. Acquesta, Patrick D. Finley, Mansoor A. Haider May 2024

Dual-Domain Clustering Of Spatiotemporal Infectious Disease Data, Samuel R. Thornton, Erin C.S. Acquesta, Patrick D. Finley, Mansoor A. Haider

Biology and Medicine Through Mathematics Conference

No abstract provided.


Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr May 2024

Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr

Biology and Medicine Through Mathematics Conference

No abstract provided.


Variation In Systemic Corticosteroid Prescribing During Asthma-Related Hospitalizations Across Children's Hospitals, Sian Best, Kathryn Kyler, Matt Hall, Jessica L. Bettenhausen, Shelby Chesbro, Nicholas Clark, Adrienne Deporre, Jonathan Ermer, Leah Jones, Jessica Markham, Maria Newmaster, Laura Plencner, Henry T. Puls, Smit Shah, Bridgette Jones, Megan Collins, Elisha Mccoy May 2024

Variation In Systemic Corticosteroid Prescribing During Asthma-Related Hospitalizations Across Children's Hospitals, Sian Best, Kathryn Kyler, Matt Hall, Jessica L. Bettenhausen, Shelby Chesbro, Nicholas Clark, Adrienne Deporre, Jonathan Ermer, Leah Jones, Jessica Markham, Maria Newmaster, Laura Plencner, Henry T. Puls, Smit Shah, Bridgette Jones, Megan Collins, Elisha Mccoy

Research Days

This abstract describes the variability and trends in inpatient systemic corticosteroid prescribing practices for acute asthma exacerbations in children's hospitals, and aims to determine associations between the prescribed steroid and hospitalization outcomes.


Characterizing New Invasive Infections In Children’S Mercy Extracorporeal Membrane Oxygenation And And Continuous Renal Replacement Therapy Patients, Samantha M. Davidson, Jay F. Rilinger, Jenna O. Miller, Caroline Holten, Josh Herigon May 2024

Characterizing New Invasive Infections In Children’S Mercy Extracorporeal Membrane Oxygenation And And Continuous Renal Replacement Therapy Patients, Samantha M. Davidson, Jay F. Rilinger, Jenna O. Miller, Caroline Holten, Josh Herigon

Research Days

This abstract characterizes the patients at Children's Mercy who developed a new serious bacterial infection while on extracorporeal support.


Emotion Regulation Strategies And Perceived Emotional Intelligence: The Effect Of Age., Iwanna Sepiadou May 2024

Emotion Regulation Strategies And Perceived Emotional Intelligence: The Effect Of Age., Iwanna Sepiadou

Adultspan Journal

The aim of this study was to investigate the relationship between perceived emotional intelligence and the reported use of cognitive reappraisal and expressive suppression. We also investigated the possible effects of age on the aforementioned variables. The total sample consisted of 379 people (158 men, 220 women, 1 unreported). Across participants, 273 were young (20-39 years old) and 106 were middle-aged (40-65 years old). We found statistically significant positive correlations between the dimensions of perceived emotional intelligence and the reported use of cognitive reappraisal and negative primarily correlations between the dimensions of perceived emotional intelligence and the reported use of …


A Case Of Incidental Left Ventricular Aneurysm, Sacide S. Ozgur, Yezin Shamoon, Rachel Abboud, Atul Prakash, Fayez Shamoon May 2024

A Case Of Incidental Left Ventricular Aneurysm, Sacide S. Ozgur, Yezin Shamoon, Rachel Abboud, Atul Prakash, Fayez Shamoon

Journal of Community Hospital Internal Medicine Perspectives

Post MI left ventricular aneurysm (LVA) may be incidental, yet it presents potential risks such as heart failure, arrhythmias, thromboembolism. Monitoring and vigilant follow-up are essential to promptly identify LVA in patients with risk factors.


Endocrine Shades Of Silicone Fillers: A Case Of Calcitriol-Mediated Hypercalcemia, Maria Martinez-Cruz, Thayse Lozovoy Madsen-Barbosa, Fidini Antoni, Christopher Haas May 2024

Endocrine Shades Of Silicone Fillers: A Case Of Calcitriol-Mediated Hypercalcemia, Maria Martinez-Cruz, Thayse Lozovoy Madsen-Barbosa, Fidini Antoni, Christopher Haas

Journal of Community Hospital Internal Medicine Perspectives

Background: The inflammatory reaction of foreign body granulomas (FBG) may be so vast that it leads to severe systemic effects. Case Report: A 42-year-old woman was referred to the ED with severe recurrent symptomatic hypercalcemia associated with worsening kidney function. She had presented multiple times with similar complaints. Severe hypercalcemia (13.8 mg/dL) was noted, with appropriately low PTH, elevated PTHrP, low 25-hydroxyvitamin D, and normal 1,25-dihydroxyvitamin D levels. She admitted having significant subcutaneous silicone filler injections in the hips six years prior. Admission workup revealed a normal 25-hydroxyvitamin D, but a marked elevation of 1,25-dihydroxyvitamin D (138 pg/mL). Whole-body PET-CT …


A Rare Case Report Of Hypoketotic Hypoglycemia Induced Seizures Due To Secondary Carnitine Deficiency In A 44-Year-Old Female, Ayrton Bangolo, Nicole Tesoro, Sonia Onyeka, Mary Bangura, Rekha Shrestha, Vignesh K. Nagesh, Roua Alrestom, Joshua Rathod, Eugenio L. Gomez, Youssef Laabidi, Imane Laabidi, Conrad Erikson, Aayat Sheikh, Sharon Maria, Mansi Naria, Erwin J. Tabucanon, Juilee V. Dongre, Auda Auda, Mohammed Jurri, Reshma Radhakrishnan, Hisham Alrefai, Simcha Weissman May 2024

A Rare Case Report Of Hypoketotic Hypoglycemia Induced Seizures Due To Secondary Carnitine Deficiency In A 44-Year-Old Female, Ayrton Bangolo, Nicole Tesoro, Sonia Onyeka, Mary Bangura, Rekha Shrestha, Vignesh K. Nagesh, Roua Alrestom, Joshua Rathod, Eugenio L. Gomez, Youssef Laabidi, Imane Laabidi, Conrad Erikson, Aayat Sheikh, Sharon Maria, Mansi Naria, Erwin J. Tabucanon, Juilee V. Dongre, Auda Auda, Mohammed Jurri, Reshma Radhakrishnan, Hisham Alrefai, Simcha Weissman

Journal of Community Hospital Internal Medicine Perspectives

Carnitine deficiency is a rare metabolic condition that can result in fasting hypoglycemia. Carnitine deficiency could be primary or secondary to other conditions. Among secondary causes, antiepileptics such as valproic acid have been incriminated. Valproic acid is known to deplete carnitine stores and inhibit the process of β-oxidation. Herein we report the case of a 44-year-old female with epilepsy that presented with breakthrough seizures associated with hypoglycemia despite being on appropriate antiepileptic therapy. The patient was later found to have carnitine deficiency. Discontinuation of valproic acid and supplementation with L-carnitine resolved the patient’s hypoglycemia and breakthrough seizures. With this case …


Physicians' Perspective On Percutaneous Left Atrial Appendage Closure In Patients With Atrial Fibrillation And Chronic Kidney Disease In Pakistan, Rubaiqa Khan, Malik Faisal Iftikhar, Naveed Hussain, Waleed Abbasi, Jahanzeb Malik, Waheed Akhtar, Amin Mehmoodi, Muhammad Awais May 2024

Physicians' Perspective On Percutaneous Left Atrial Appendage Closure In Patients With Atrial Fibrillation And Chronic Kidney Disease In Pakistan, Rubaiqa Khan, Malik Faisal Iftikhar, Naveed Hussain, Waleed Abbasi, Jahanzeb Malik, Waheed Akhtar, Amin Mehmoodi, Muhammad Awais

Journal of Community Hospital Internal Medicine Perspectives

This study, conducted in Pakistan, examines the perspectives of 1200 physicians across diverse specialties regarding Left Atrial Appendage Occlusion (LAAO) procedures for atrial fibrillation (AF) patients with chronic kidney disease (CKD). Using a random sampling approach, physicians participated in a survey that assessed their familiarity with LAAO, views on its effectiveness and safety, experience levels, and encountered challenges. The results unveil a spectrum of knowledge levels among physicians, reinforcing the need for tailored medical education and training programs. The majority of patients were between 30 and 49 years old (59.8%). A notable proportion, 33.3%, had limited or no knowledge of …