Dentistry Commons^™

The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider

College of Arts & Sciences Senior Theses

Periodontitis is an irreversible, chronic inflammatory, infectious disease of the oral cavity that affects approximately half of all adults 30 years or older in the USA. The oral cavity is under high immune surveillance because of its constant exposure to microbes in the environment. The primary immune cell responsible for this surveillance is the neutrophil. Pathogens associated with periodontitis possess virulence factors and have evolved strategies to evade neutrophil antimicrobial responses to survive. One such pathogen is Filifactor alocis, whose presence is associated with the progression of periodontitis. F. alocis manipulates several neutrophil antimicrobial functional responses to avoid killing, an …

Molar Macrowear As A Proxy For Age In A Captive Sample Of Papio Hamadryas, Lauren Conrad

Biological Sciences Undergraduate Honors Theses

This study is methods-focused, centering around molar crown macrowear and its performance as a proxy for age in a sample of pedigreed, non-human primates. It analyzes the correlation between age-structured variables and molar wear among both males and females in a captive group of baboons. Here, I examined whether wear is significantly correlated with age-related variables (i.e., generations/cohorts) and whether the structure of the “age” dataset differed across wear categories. Because chronological age is unknown, I used documented pedigrees and parent-offspring relationships to group individuals into possible generations. I then used dental development charts to group individuals into cohorts based …

Impact Of Financial And Demographic Factors On Severity Of Treatment Procedure, Vanessa Gunderson

Theses/Capstones/Creative Projects

Indirect pulp caps (IPCs) and pulpotomies are forms of vital pulp therapy. These procedures are performed on young patients who have deep cavities due to bacterial biofilm damage; however, the two are performed and utilized differently. The less severe of the two procedures is an IPC. This is when decayed dentin is covered with biocompatible material to avoid pulp exposure. The more severe procedure, the pulpotomy, is when the inflamed coronal pulp tissue is removed either partially or fully to save any remaining pulp tissue. In this study, all IPCs and pulpotomies performed by Dr. Ben Reimer throughout ~4.5-years of …

Comparative Study Of Pain Perception With Use Of Vibration And/Or Cold Stimulation Applied During Local Anesthetic Delivery In A Dental Setting: A Systematic Review, Tara Craven, Gage Williams, Brenda S Bohaty

Posters

Delivery of local anesthetic can be one of the most difficult parts of the procedure for pediatric patients undergoing dental treatment and can prevent the child from being able to cooperate for treatment as well as instill anxiety for future visits.1 Several methods can be utilized to help mitigate pain control during the local anesthetic injection including behavior management, vibration, cold sensation, warming the anesthetic, and topical anesthetic.4 These methods are essential to helping the child have a good experience and ultimately be able to tolerate treatment for caries management and a long term positive view of the dentist. One …

Assessment Of Saudi Arabians' Awareness Of Oral Health And Oral Hygiene In A Group Of 200 Dental Clinic Participants, Mahmoud Al Ankily, Mohamed Shamel, Sara Abdel Wahed, Mohamed Mansy

Dentistry

Oral mucosa lesions cause oral sores, discoloration, and anomalies. Oral mucosa genetic and developmental disorders may affect anybody. Oral cavity carcinoma causes 4% of all malignancies worldwide. Early detection of oral cancer improves survival rates. Oral precancerous diseases include color, abnormalities, surface texture, and location that predict malignancy. The goal of this study was to examine the Saudi Arabians' awareness of oral health and oral hygiene. An observational, cross-sectional approach was adopted for the study. Individuals with a probable malignant oral disease who visited an OPD at a dental hospital and had relevant behaviors were recruited in the study. In …

Education, Beliefs, And Health Literacy Of Care Providers On Mouth Care Of Older Adults, Molly Lakin

Honors Program: Senior Projects (Public)

Oral health is important to one’s overall health and quality of life as it can lead to chronic illnesses such as cardiovascular disease, stroke, and neurodegenerative disorders (Haumschild et al. 2021). In long-term care facilities, it is important that dependent older adults are provided mouth care to maintain their oral health and decrease their chances of developing a chronic illness; however, there are barriers affecting the level, quality, and quantity of mouth care being provided in these facilities. A survey was developed to look at the education, beliefs, and health literacy of care providers on providing mouth care in hopes …

Investigating The Influence Of Periodontal Disease On The Association Between Complex Multimorbidity And Health: A Cross-Sectional Study, Hussam M. Alqahtani, Siran M. Koroukian, Kurt C. Stange, Nicholas K. Schiltz, Nabil F. Bissada

Faculty Scholarship

Aims and Objectives: The aim of this study was to evaluate whether periodontal disease (PD) moderates the association between complex multimorbidity (MM) and fair/poor general health in a US representative sample of older individuals. Materials and Methods: This study identified 937 participants who were at least 60 years of age from the 2013-2014 National Health and Nutrition Examination Survey. A multivariable logistic regression model was used to estimate the association between complex MM (including chronic conditions, functional limitations, and geriatric syndromes) and self-reported fair/poor general health. Subsequently, we specified interactions between complex MM and PD to determine whether PD moderates …

Analysis Of Changes In Gingiva-Occlusal Parameters As Perceived By Three Middle-East Populations, Nadine Nachabeh, Tony Daher, Elie Maalouf, Khalil Kharma, Eliane Kaydouh, Carina Mehanna

International Arab Journal of Dentistry

Purpose. This study aims to compare the effect of various smile parameters (buccal corridor, gummy smile, midline to face discrepancy, with and without upper lip filling) on the perception of smile attractiveness by applying the digital modification of images judged by one hundred and eighty laypersons from different Middle East populations.

Materials and Methods. A frontal photo of a woman’s smile is manipulated with Photoshop to modify each smile parameter gradually into 3 grades. The total number of smiles to be assessed is 18. One hundred and eighty participants divided into 3 groups (n=60: 30 men and 30 women): …

The Root Canal Morphology Of Premolars In A Sample Of The Lebanese Population: Clinical Considerations, Marie-José Merhej, Roula El Hachem, Hala Sacre, Pascale Salameh, Nabil Ghosn, Alfred Naaman

International Arab Journal of Dentistry

Objectives: The aim of this study was to investigate the root anatomy of the maxillary and mandibular premolars among a sample of the Lebanese population and to explore their incidence by sex and the symmetry between the left and right sides.

Materials and Methods: This retrospective analysis of 250 cone-beam computed tomography (CBCT) scans consisted of 960 maxillary and 972 mandibular premolars. Roots, canals, and morphology types were recorded. Vertucci’s classification was used to categorize the canal morphologies. Fisher’s exact and chi-square tests were applied (P≤.05).

Results: The majority of maxillary first premolars had two roots (85.3%) with …

An Update Of Additive Manufacturing (3d Printing) Technology In Dentistry, Rami Saleh Al Fodeh, Ahed Al-Wahadni, Baker Otman, Mahmoud Almasri

International Arab Journal of Dentistry

Background: The development of procedures known as additive manufacturing, which aim to produce more complex items with a lower overall material consumption compared to processes known as subtractive manufacturing. In addition, in recent years there has been a significant rise in the quantity of dental materials that are produced via the use of these techniques. As a consequence of this, scientific research has been concentrating more and more on such technologies, particularly in order to shed light on the methodology, indicators, and boundaries of the emerging technology.

Methods: The purpose of this paper is to provide a narrative …

Recent Innovations And Technological Advancements In Dentistry And Medicine, Karthik Rajaram Mohan, Saramma Mathew Fenn, Ravikumar Pethagounder Thangavelu

International Arab Journal of Dentistry

The newer innovations play an important role in the earlier diagnosis of dental caries based on near-infrared transillumination imaging such as Diagnocam and Soprocare intraoral digital cameras, which aid in the diagnosis of dental caries and also differentiate old and newer dental plaques, respectively. Nanoparticles used as carriers for effective and targeted drug therapies in the treatment of rheumatoid arthritis of the temporomandibular joint (TMJ) and candidiasis among chronic denture wearers provided better-increased bioavailability than oral formulations. Artificial intelligence (AI) uses machines to simulate intelligent human behavior. Augmented reality has been presented as a cognitive extension of AI in health …

Compound Odontoma: A Clinical Case Presentation, Georgina El Ghoule, Bassam Salameh, Wassim Al Manhal

International Arab Journal of Dentistry

Odontomas are asymptomatic benign odontogenic tumors, generally discovered fortuitously, or when a tooth failed to erupt. They are mainly composed of enamel and dentin, cement and pulp tissue can also be present in variable amounts. In 2005, the World Health Organization classified two main types of odontoma, an amorphous and irregular mass of calcified dental tissues as complex odontoma and multiple miniature tooth-like structures as compound odontoma. This article is a case presentation of a compound odontoma diagnosed for an eleven year old girl upon a routine radiography, making it a lesion of childhood /adolescence. A retro-alveolar radiography of the …

Clinical Presentation And Differential Diagnosis Of A 10-Year-Old Presenting With Unerupted Maxillary Central Incisor: A Case Report., Dev Patel, Robin Onikul, Amy Burleson, Brenda S Bohaty, Jenna Sparks, Neena Patel, A Naidu

Posters

Delayed eruption of permanent teeth can be caused by numerous factors including nutritional deficiencies, tooth positioning, presence of supernumerary tooth, or presence of a cyst impeding eruption. The keys to identifying the cause of delayed eruption are good clinical and radiographic exam, along with obtaining a complete and accurate history from the patient and parent. This case report details a 10-year-old female presenting to the Children’s Mercy Kansas City Dental Clinic with chief concern for an unerupted upper anterior tooth. The patient’s medical history is noncontributory, and she has no known allergies. This case report will include the patient’s clinical …

Solitary Median Maxillary Incisor And Holoprosencephaly: A Review Of The Literature, Benjamin Olson, Robin Onikul, Amy Burleson, Brenda S. Bohaty, Jenna Sparks, Neena Patel

Posters

A solitary median maxillary incisor (SMMCI) is a rare anomaly that affects approximately 1:50,000 live births. The presence of an SMMCI tooth may be an isolated finding or may be associated with other anomalies such as Holoprosencephaly (HPE). Early recognition of SMMCIS is important given the possibility of other associated findings that may impact pediatric growth and development. The purpose of this clinical case is to report the clinical findings associated with a nine-month-old patient who presented to our clinics with a primary solitary median maxillary incisor and a diagnosis of HPE. This presentation will review the literature regarding the …

Oral Manifestations Of Acute Lymphocytic Leukemia, Angela Yepes Dds, Ms, Mba, Juan Yepes Dds, Md, Mph, Ms, Drph, James E. Jones Dmd, Msd, Edd, Phd

The Journal of the Michigan Dental Association

Leukemia is the most prevalent malignancy of leukocytes and can occur in children and adults. Oral manifestations are part of the complexity of signs and symptoms in patients with leukemia and, in some patients, oral manifestations precede systemic manifestations. Oral signs of leukemia include spontaneous bleeding, gingival enlargement, and whiteness of the oral mucosa. Head and neck lymphadenopathy is common in patients with leukemia. Oral manifestations are the result of the direct invasion of immature cells in the oral cavity tissues or indirectly caused by the replacement of the normal blood cells for immature cells causing anemia, leucopenia, and thrombocytopenia. …

J Mich Dent Assoc May 2023

The Journal of the Michigan Dental Association

In this issue, the reader will find the following original content:

• A case study on recognizing the oral signs of Acute Lymphatic Leukemia
• A special pull-out section to assist clinicians in identifying and treating common oral lesions
• Advice on personal Wellness: "Finding Calm Amidst Chaos."
• State of Michigan C.E. Requirements for License Renewal of Dentists, Hygienists, and Registered Dental Assistants.
• A 10Minute EBD contrasting clinical success of composite restorations vs. glass ionomers.
• Guest commentary "Pretty Good Dentistry."
• News you need, Editorial, and an Advocacy Spotlight.

10-Minute Ebd: Do Posterior Composite Restorations Have Longer-Term Success Than Glass Ionomer?, Eleni E. Langas Dds, Mridula Manoj Dds, Kelsey Carreras-Simons Dds

The Journal of the Michigan Dental Association

This Ten Minute Evidence Based Dentistry Article provides an example of the implementation of the evidence based dentistry search process with trusted search engines, and identification of the best literature through critical appraisal to answer the clinical question on long-term success of posterior resin vs. posterior glass ionomer restorations.

The Human Role In Artificial Intelligence, Christopher J. Smiley Dds

The Journal of the Michigan Dental Association

The success of AI requires human involvement to ensure that it is used safely and effectively. Transparency, collaboration, and standardization are necessary.

Finding Calm Amidst Chaos, Lisa Knowles Dds

The Journal of the Michigan Dental Association

This commentary on mindfulness and wellness provides the practitioner with strategies to achieve peace amidst chaos.

Distal Cantilever Length Comparison In Esthetic Materials For Hybrid Implant Prostheses: An In Vitro Study, Sana Shams Eddin, Elie Jasser, Mohammad Chams Eddin, Carole Abi Ghosn Yared, Joseph Makzoumi, Paul Boulos

International Arab Journal of Dentistry

Objective: the assessment of distal cantilever length in implant supported prothesis (Hybrid prosthesis) by comparing the load to fracture in two different esthetic framework materials (Zirconia and Polyetheretherketone (PEEK)) with two different cantilevers loading distances (10mm, 15mm).

Material and methods: 20 frameworks were fabricated and divided into 4 groups (n=5): according to the material type, Peek, zirconia, and according to the cantilever loading distance (10), or (15) mm and a load-to-fracture test was used until complete fracture of specimens occurs.

Results: The effect of material type and cantilever loading distance were statistically significant for the mean load-to-fracture …

Management Of Pulpal Floor Perforation Using Biodentine™: Case Report, Chaima Bouhajja, Mayada Jemâa, Mohamed Bassem Khattech

International Arab Journal of Dentistry

During endodontic treatment in multi-rooted teeth, furcation perforation refers to an opening in the pulpal floor, leading to a communication with the periodontal ligament space. A three-dimensional hermetic seal, with a biocompatible material, is a key point for the success of pulp floor perforation repair. MTA® has been considered, for a long time, as a gold standard in furcation perforation repair. Besides, BiodentineTM, when used for the same purpose, showed considerable performance and good results. The purpose of this paper was to report the management of an iatrogenic perforation of pulpal floor in the maxillary right first molar, using BiodentineTM.

Ros-Mediated Srms Activation Confers Platinum Resistance In Ovarian Cancer, Yunhan Jiang, Lina Song, Yizhu Lin, Pawel Nowialis, Qiongmei Gao, Tao Li, Bin Li, Xiaobo Mao, Qianqian Song, Chengguo Xing, Guangrong Zheng, Shuang Huang, Lingtao Jin

Faculty, Staff and Student Publications

Ovarian cancer is the leading cause of death among gynecological malignancies. Checkpoint blockade immunotherapy has so far only shown modest efficacy in ovarian cancer and platinum-based chemotherapy remains the front-line treatment. Development of platinum resistance is one of the most important factors contributing to ovarian cancer recurrence and mortality. Through kinome-wide synthetic lethal RNAi screening combined with unbiased datamining of cell line platinum response in CCLE and GDSC databases, here we report that Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites (SRMS), a non-receptor tyrosine kinase, is a novel negative regulator of MKK4-JNK signaling under platinum treatment and …

A Clinical Reference Guide To The Treatment Of Common Oral Lesions, Janet Zalucha Dds, Felipe Nör Dds, Ms, Phd, David Tindle Dds, Ms

The Journal of the Michigan Dental Association

This special MDA Journal pull-out is created as a quick reference for practitioners to assist their patients who present with some of the most common oral pathology manifestations. When encountering these conditions, please consider coordinating care and collaborating with practitioners who have had additional, specialized training in the respective fields. Treatment recommendations for each condition described are included. Note that many of these are considered off-label use of the listed agents. Full prescribing information is beyond the scope of this quick reference guide, so practitioners should thoroughly familiarize themselves with each agent chosen for use.

Oral Prevalence Of Akkermancia Muciniphila Among Pediatric And Adult Orthodontic And Non-Orthodontic Patients, Ching Shen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Akkermansia muciniphila (AM) is one of many highly abundant intestinal microbes that influences homeostasis and metabolic disorders and may also play a role in oral disorders. However, there is little evidence regarding the oral prevalence of this organism. Based upon this lack of evidence, the primary goal of this project is to survey an existing saliva repository to determine the overall prevalence of this organism and any associations with demographic or patient characteristics (age, sex, body mass index, race/ethnicity, orthodontic therapy). Using an approved protocol, a total n = 141 pediatric samples from an existing saliva repository were screened using …

An In-Vitro Analysis Of The Accuracy Of Different Guided Surgery Systems – They Are Not All The Same, Arndt Guentsch, Jennifer Bjork, Reagan Saxe, Shengtong Han, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Objectives

Different static computer-assisted implant surgery (sCAIS) systems are available that are based on different design concepts. The objective was to assess seven different systems in a controlled environment.

Materials and Methods

Each n = 20 implants were placed in identical mandible replicas (total n = 140). The systems utilized either drill-handles (group S and B), drill-body guidance (group Z and C), had the key attached to the drill (group D and V), or combined different design concepts (group N). The achieved final implant position was digitized utilizing cone-beam tomography and compared with the planned position. The angular deviation was …

The Creation Of An Innovative Oral Health Assessment Survey, Purna Patel

Electronic Theses, Projects, and Dissertations

Background Oral health is an important factor to maintain overall health and well-being, such as students’ knowledge, attitude, and practice. Currently, there is a limited amount of research related to oral health awareness in college students.

Objective The purpose of the study was to define the importance of oral health and investigate college students’ understanding related to oral health. Moreover, research shows how students are protecting their oral hygiene.

Results: The outcomes revealed the college student's awareness and understanding of oral health. According to the survey questions, students believe that dental health is a significant aspect of overall health management. …

Differential Effects Of Extracellular Matrix Glycoproteins Fibronectin And Laminin-5 On Dental Pulp Stem Cell Phenotypes And Responsiveness, Hyungbin Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) with the potential to differentiate in a limited number of other tissue types. Some evidence has suggested the modulation of DPSC growth may be mediated, in part, by exogenous extracellular matrix (ECM) glycoproteins, including fibronectin (FN) and laminin-5 (LN5). Although preliminary research suggests that some ECM glycoproteins may work as functional biomaterials to modulate DPSC growth responses, the primary goal of this project is to determine the specific effects of FN and LN5 on DPSC growth and viability.Using an existing DPSC repository, n = 16 DPSC isolates were cultured and …

Dental Pulp Stem Cell Differentiation Potential Of Bmp-2 And Bmp-4, David Li

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Many studies are now evaluating the potential for dental pulp stem cells (DPSC) to assist with more complex and biotechnology applications, such as facilitating and promoting osseointegration following dental implants. However, the effects of factors that may control osseointegration and bone repair using DPSC including bone morphogenic proteins (BMP-2, BMP-4) are not yet well understood.Objective: Based upon this lack of evidence, the primary goal of this project is to evaluate the potential effects of BMPs (alone or in combination with other growth factors) to induce factors associated with osteogenesis. Methods: DPSC isolates from an existing repository (n = 13) …

Chemotherapeutic Drug Resistance Associated With Differential Mirna Expression Of Mir-375 And Mir-27 Among Oral Cancer Cell Lines, Kieran Huni

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: Although progress has been made towards the identification of molecular profiles that influence oral cancer growth and metastasis, recent advances have suggested that non-coding microRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of chemotherapeutic responsiveness. Based upon the paucity of information regarding this phenomenon, this project will determine whether these specific microRNAs are correlated with oral cancer responsiveness to chemotherapies, including Paclitaxel, Cisplatin and Fluorouracil (5FU).Methods: Commercially available and well-characterized oral squamous cell carcinoma cell lines (SCC4, SCC9, SCC15, SCC25 and CAL27) were used for this study. Experimental 96-well assays …

Aesthetic Management Of Peri-Implant Soft Tissue Dehiscence. A Case Report Of A Combined Perio Restorative Approach, Ahmed Hamdy, Dalia M. Ghalwash

Dentistry

This case report designates a combined perio restorative technique in the management of peri-implant 3-dimensional soft tissue defects in an esthetic zone. A staged approach was implemented to treat this case; the first stage was planned to treat the horizontal defect around the implant, in which crown was removed, and coronally advanced flap with connective tissue graft were used to treat the soft tissue defect. At the second stage, a modified coronally advanced flap with connective tissue graft was used to augment the vertical defect, and no vertical releasing incision was made in this stage to maximize the blood supply …