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2022

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Articles 481 - 510 of 826

Full-Text Articles in Dentistry

Micro-Computed Tomography Assessment Of Bone Structure In Aging Mice, Junbo Shim, Chihiro Iwaya, Catherine G Ambrose, Akiko Suzuki, Junichi Iwata May 2022

Micro-Computed Tomography Assessment Of Bone Structure In Aging Mice, Junbo Shim, Chihiro Iwaya, Catherine G Ambrose, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long bones, vertebrae, and the palms in aging mice, they have not yet been established for craniofacial bones. In this study, we conducted a morphometric assessment of craniofacial bones, in comparison with long bones, in aging mice. Although age-related changes were observed in the microarchitecture of the femur, tibia, vertebra, and basisphenoid bone, and were more pronounced in females than in males, the microarchitecture of both the interparietal bone …


An Observational Retrospective Study Of Adverse Events And Behavioral Outcomes During Pediatric Dental Sedation, Kawtar Zouaidi, Gregory Olson, Helen H Lee, Elsbeth Kalenderian, Muhammad F Walji May 2022

An Observational Retrospective Study Of Adverse Events And Behavioral Outcomes During Pediatric Dental Sedation, Kawtar Zouaidi, Gregory Olson, Helen H Lee, Elsbeth Kalenderian, Muhammad F Walji

Faculty, Staff and Student Publications

Purpose: The purpose of this study was to examine a university-based dental electronic health records (EHR) database to identify sedation-related adverse events (AEs) and assess patients' behavioral outcomes during routine pediatric dental sedations (PDSs) in a dental school clinic.

Methods: A database was screened for patients younger than 18 years old who had received dental sedation in 2019. The qualifying EHRs were then accessed and sedations were reviewed for AEs, which were categorized using a 12-point classification system and the Tracking and Reporting Outcomes of Procedural Sedation Tool. Patient behaviors were assessed using provider progress notes and categorized as presence/ …


Ada News - 05/09/2022, American Dental Association, Publishing Division May 2022

Ada News - 05/09/2022, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold May 2022

An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold

Honors Theses

Literature reviews and interviews with dentists working in rural Mississippi counties examined the effects of population decline on rural dental care in Mississippi. With the state’s continual population decline, loss of industry follows a loss of people. Through a cascade of effects, this can further reduce underserved areas’ access to dental care. In order to address the issue of rural Mississippi continuing to be underserved, policies need to be implemented that will make rural practice at least enticing if not desirable.


A Rat Experimental Model For Investigation Of The Effect Of Diabetes On Submandibular Salivary Glands Treated With Epidermal Growth Factor, Mahmoud Bakr, Mohamed Shamel, Sara Abdelwahed, Mahmoud Al Ankily May 2022

A Rat Experimental Model For Investigation Of The Effect Of Diabetes On Submandibular Salivary Glands Treated With Epidermal Growth Factor, Mahmoud Bakr, Mohamed Shamel, Sara Abdelwahed, Mahmoud Al Ankily

Dentistry

BACKGROUND: Despite the plethora of research around the negative effects of diabetes on different body organs, this topic still attracts a lot of attention to find potential remedies that could counteract or reverse the damaging effect of diabetes.AIM: In this study, we developed a reliable experimental rat model that can be used for the investigation of the ability of epidermal growth factor (EFG) in restoring the normal architecture of oral tissues after being damaged by diabetes.METHODS: Eighty adult male albino rats (average weight ±220 gm) were used in the current study. Twenty rats served as control and received no treatment. …


Too Much Of A Good Thing: Case Of Fluoride Toxicity, Swet Patel, John Polunin, James Espinosa, Alan Lucerna, Trent Malcolm May 2022

Too Much Of A Good Thing: Case Of Fluoride Toxicity, Swet Patel, John Polunin, James Espinosa, Alan Lucerna, Trent Malcolm

Rowan-Virtua Research Day

Overall, the beneficial role of fluoride for the maintenance of proper dental hygiene has been known for many decades which has been corroborated by a plethora of research. Media and culture have further highlighted how using fluoride supplementation can help with dental cavities. It is clear that just as there are benefits to fluoride usage, there also risks. Further awareness needs to be made that showcases the downfalls of excess fluoride use. Labels need to be placed on fluoride products that emphasizes the dosing. It is imperative that people are educated on the toxicity of fluoride as too much of …


Assessment Of Dental Care In Children With Congenital Heart Disease, Mollie Walton May 2022

Assessment Of Dental Care In Children With Congenital Heart Disease, Mollie Walton

Research Days

Background: The incidence of infective endocarditis (IE) is significantly higher in patients with congenital heart disease (CHD) compared to the general population. Studies have investigated the incidence of IE in adults with CHD to identify the factors that contribute to the development of IE. One such factor is suboptimal oral health. Several studies have shown that children with CHD have higher levels of untreated oral disease as compared to children without CHD.

Objectives/Goal: Identify factors that may affect compliance with routine dental care, including: age, sex, severity of CHD, repair/palliation, and qualification for prophylactic antibiotics.

Methods/Design: A retrospective chart review …


New Dentist News (May 2022), Ada Committee On The New Dentist May 2022

New Dentist News (May 2022), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.


An Exploration Of Low-Income Dental Services In The Tri-Cities, Macie Proffitt May 2022

An Exploration Of Low-Income Dental Services In The Tri-Cities, Macie Proffitt

Undergraduate Honors Theses

Dental care has great importance in the overall health of every individual. Many do not realize the effect oral health plays in their overall health and many areas in the United States do not have access to the dental care needed to obtain proper healthcare standards. In many of these areas, such as the Appalachian region, dental services for low-income citizens are limited. Specifically, in the Northeast Tennessee region, these dental services are severely limited. Washington County and Hawkins County of Northeast Tennessee are specific underserved areas in the Appalachian region. The purpose of this project was to explore the …


Sedation Services Offered At Pediatric Dental Offices In The United States As Reported On Publicly Available Practice Websites, Stefanie Curtis, Jane Witt, Brenda S. Bohaty, Robin Onikul, Amy Burleson, Jenna Sparks, Neena Patel May 2022

Sedation Services Offered At Pediatric Dental Offices In The United States As Reported On Publicly Available Practice Websites, Stefanie Curtis, Jane Witt, Brenda S. Bohaty, Robin Onikul, Amy Burleson, Jenna Sparks, Neena Patel

Posters

Background: As early childhood caries impacts children throughout the United States, restorative dental procedures are often needed. The literature indicates that due to a variety of factors, parents may research their child’s dental condition and try to find options for care that they perceive as least traumatic for their children. These options frequently include sedation and general anesthesia. This background research is typically completed via the internet on public websites. Purpose: The purpose of this investigation was to identify if information regarding specific types of sedation/anesthesia services offered by pediatric dental providers are available on practice websites and to determine …


Suppression Of Microrna 124–3p And Microrna 340–5p Ameliorates Retinoic Acid-Induced Cleft Palate In Mice, Hiroki Yoshioka, Akiko Suzuki, Chihiro Iwaya, Junichi Iwata May 2022

Suppression Of Microrna 124–3p And Microrna 340–5p Ameliorates Retinoic Acid-Induced Cleft Palate In Mice, Hiroki Yoshioka, Akiko Suzuki, Chihiro Iwaya, Junichi Iwata

Faculty, Staff and Student Publications

The etiology of cleft lip with or without cleft palate (CL/P), a common congenital birth defect, is complex, with genetic and epigenetic, as well as environmental, contributing factors. Recent studies suggest that fetal development is affected by maternal conditions through microRNAs (miRNAs), a group of short noncoding RNAs. Here, we show that miR-129-5p and miR-340-5p suppress cell proliferation in both primary mouse embryonic palatal mesenchymal cells and O9-1 cells, a neural crest cell line, through the regulation of Sox5 and Trp53 by miR-129-5p, and the regulation of Chd7, Fign and Tgfbr1 by miR-340-5p. Notably, miR-340-5p, but not miR-129-5p, was upregulated …


Bullied Because Of Their Teeth: Evidence From A Longitudinal Study On The Impact Of Oral Health On Bullying Victimization Among Australian Indigenous Children, Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk May 2022

Bullied Because Of Their Teeth: Evidence From A Longitudinal Study On The Impact Of Oral Health On Bullying Victimization Among Australian Indigenous Children, Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk

Research outputs 2022 to 2026

Making life better for Indigenous peoples is a global priority. Although bullying and oral health have always been a topic of concern, there is limited information regarding the impact of this problem on the general population, with no evidence in this regard among the Australian Indigenous population. Thus, we aimed to quantify the relationship between bullying victimization and oral health problems by remoteness among 766 Australian Indigenous children aged between 10–15-years using data from the LSIC study. Bivariate and multilevel mixed-effect logistic regression analyses were employed. Findings indicated children self-reported bullying more than parents reported their children were being bullied …


Quantification Of Dental Fissures Through Occlusal Topography Analysis, Duru Erkan May 2022

Quantification Of Dental Fissures Through Occlusal Topography Analysis, Duru Erkan

Biological Sciences Undergraduate Honors Theses

Narrow, deep, and elaborate dental fissures are widely believed to increase the predisposition of enamel to develop carious lesions as these surfaces are thought to be ideal for cariogenic bacteria to adhere to. Therefore, dentists prescribe sealants as a preventative measure for patients with such fissures to avoid tooth decay. Yet to date, there is no objective data supporting the notion that fissure morphology actually affects caries susceptibility, nor is there a quantifiable, clinically practical method to characterize fissure patterns expected to increase risk of caries disease.

In this study, three new methods to quantitatively characterize fissure pattern in mandibular …


Oligodontia, Mandibular Hypoplasia And Microglossia In Pediatric Patients: Review Of The Literature And Report Of A Case, Gage Williams, Robin Onikul, Jenna Sparks, Neena Patel, Amy Burleson, Brenda S. Bohaty May 2022

Oligodontia, Mandibular Hypoplasia And Microglossia In Pediatric Patients: Review Of The Literature And Report Of A Case, Gage Williams, Robin Onikul, Jenna Sparks, Neena Patel, Amy Burleson, Brenda S. Bohaty

Posters

Introduction: The combined findings of oligodontia, mandibular hypoplasia and congenital malformation of the tongue (hypoplasia) is relatively rare in children. This presentation discusses the case of a 6-year-old female patient who presented to the dental clinic at The Children’s Mercy Hospital in Kansas City, Missouri for emergent care secondary to gross dental caries. Additional findings at the initial visit were that of oligodontia, microglossia, micrognathia, and mandibular hypoplasia. A review of the medical history indicated that due to the physical anomalies noted at birth, a genetic microarray was completed indicating some variants of unknow clinical significance. As these forms of …


Case Presentation: Pulpal Obliteration In Primary Dentition Of An 8-Year-Old, Differential Diagnosis Dental Dysplasia Type Ii., Tara Craven, Amy Burleson, Brenda S. Bohaty, Jenna Sparks, Neena Patel, Aparna Naidu May 2022

Case Presentation: Pulpal Obliteration In Primary Dentition Of An 8-Year-Old, Differential Diagnosis Dental Dysplasia Type Ii., Tara Craven, Amy Burleson, Brenda S. Bohaty, Jenna Sparks, Neena Patel, Aparna Naidu

Posters

Tooth development anomalies can happen at many stages of cell development and are relatively common. These anomalies can be isolated findings however, they may also indicate minor or major associated syndromes and identification of these findings are essential to providing comprehensive care for patients. Dentin Dysplasia Type II is a rare autosomal dominant disease resulting from a disruption in the apposition stage of cell development. This disease affects the primary teeth and clinical manifestations can include bulbous crowns, cervical constriction, mild discoloration (amber color) and pulp obliteration. Permanent teeth tend to look typical but can demonstrate thistle-tube shaped pulps and/or …


10-Minute Ebd: Charcoal Toothpastes Pose Risks With Few Benefits, Kelly Lemke Dds, Ms May 2022

10-Minute Ebd: Charcoal Toothpastes Pose Risks With Few Benefits, Kelly Lemke Dds, Ms

The Journal of the Michigan Dental Association

The rising popularity of charcoal toothpaste, fueled by social media influencers and claims of teeth-whitening benefits, prompts an investigation into its effectiveness and potential risks. The article explores the evidence through a PICO (Population, Intervention, Comparison, Outcome) question focused on patients seeking whiter teeth. A literature review reveals limited scientific validation for the cosmetic or health benefits of charcoal-containing oral products. The abrasiveness of charcoal toothpaste poses risks, potentially leading to enamel loss, dentin exposure, and hypersensitivity. Lack of fluoride in many charcoal toothpaste formulations raises concerns about caries risk. The article emphasizes the importance of dental providers conducting due …


Periodontal Disease And Covid-19, Zhaozhao Chen Dds, Ms, Phd, Laurie K. Mccauley Dds, Ms, Phd, Purnima S. Kumar Bds, Ms, Phd, Hom-Lay Wang Dds, Ms, Phd May 2022

Periodontal Disease And Covid-19, Zhaozhao Chen Dds, Ms, Phd, Laurie K. Mccauley Dds, Ms, Phd, Purnima S. Kumar Bds, Ms, Phd, Hom-Lay Wang Dds, Ms, Phd

The Journal of the Michigan Dental Association

As the gateway to the respiratory system, the oral cavity can play an essential role in SARS-CoV-2 invasion and transmission. Besides high expression of angiotensin‐converting enzyme 2 (ACE2), the oral cavity can harbor viral particles in saliva, gingival crevicular fluid, and the periodontal pocket. Microbial and inflammatory associations closely link periodontitis and COVID-19. In this review, we summarize the possible oral manifestations of COVID‐19, its association with periodontal diseases, the plausible underlying mechanisms of microbial and inflammatory crosstalk between COVID‐19 and periodontal diseases, and mitigation protocols during periodontal treatment.


Dental Morphology In A Juvenile Mammal From The Late Cretaceous Of South America: Tooth Eruption And Development., Kayla E Newton May 2022

Dental Morphology In A Juvenile Mammal From The Late Cretaceous Of South America: Tooth Eruption And Development., Kayla E Newton

Electronic Theses and Dissertations

Meridiolestids are a diverse and distinct clade of Cretaceous–Miocene South American dryolestoid mammals ranging in size from small shrew-sized insectivores to large dog- sized omnivores. Cronopio dentiacutus from the Cenomanian La Buitrera locality, Rio Negro Province, Argentina (Candeleros Fm.) is the oldest and best known of them, represented by skull material and associated jaws. A juvenile skull as attributed to Cronopio dentiacutus, based on tooth size and morphology, was collected from the type locality. The specimen includes the skull and both articulated lower jaws. The fossil is poorly ossified and partially flattened; CT scanning reveals most of the dentition …


The Impact Of Composition, Core Metal Mass And Phase Transformation Behaviour On The Dynamic Cyclic Fatigue Of Ni-Ti Files At Different Temperatures, Shehabeldin Mohamed Saber Prof.Dr. May 2022

The Impact Of Composition, Core Metal Mass And Phase Transformation Behaviour On The Dynamic Cyclic Fatigue Of Ni-Ti Files At Different Temperatures, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To assess impact of elemental composition, core metal mass and phase transformation behaviour on the dynamic cyclic fatigue resistance of three Ni-Ti rotary files at room and body temperatures. Methods: Twenty instruments of each system were tested for dynamic cyclic fatigue resistance in a simulated root canal with a 90° angle of curvature and a 5-mm radius of curvature at room and body temperature. The core metal mass at the fractured surface of each instrument was calculated by Image J software analysis of SEM images. The energy dispersive X-ray analysis was used to assess file composition. Scanning calorimetry was …


Aggregatibacter Actinomycetemcomitans Exploits And Modulates The Immune Response By Human Neutrophils For Survival In The Anaerobic Environment., Hazel Ozuna May 2022

Aggregatibacter Actinomycetemcomitans Exploits And Modulates The Immune Response By Human Neutrophils For Survival In The Anaerobic Environment., Hazel Ozuna

Electronic Theses and Dissertations

Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative facultative anaerobe and an opportunistic oral pathogen, strongly associated with localized periodontitis and other inflammatory diseases. Periodontitis is a chronic inflammation of the periodontium resulting from the inflammatory response of the host towards the dysbiotic microbial community present at the gingival crevice. The host immune response creates a hostile environment for microorganisms; therefore, it is important for Aa to be able to regulate the necessary genes to survive and thrive in such an environment. Aaexpresses several virulence factors such as a cytolethal distending toxin (Cdt), lipopolysaccharide (LPS) and leukotoxin A (LtxA), …


Dental Students' Perceptions Of Dental Hygienists' Education And Scope Of Practice, Cynthia Metzger May 2022

Dental Students' Perceptions Of Dental Hygienists' Education And Scope Of Practice, Cynthia Metzger

Electronic Theses and Dissertations

Oral health is strongly correlated to systemic health in the United States. Dental professionals play a significant role in addressing the oral health and prevention of disease for populations in the United States. Because many areas in the United States lack access to dental care, the federal government considers dental hygienists part of the solution. It is now paying attention to restrictive dental hygiene scope of practice rules in each state. State dental boards, comprised mainly of dentists, make these rules based on their perception of dental hygienists' lack of education. This study explored fourth-year dental students' perceptions of the …


Peer Review/Ethics: How Can Our Office Be More Inclusive Of Transgender Patients?, Debra Peters Dds May 2022

Peer Review/Ethics: How Can Our Office Be More Inclusive Of Transgender Patients?, Debra Peters Dds

The Journal of the Michigan Dental Association

In this professional ethics article, Dr. Debra Peters of the ADA’s Council on Ethics, Bylaws and Judicial Affairs addresses the need for dental teams to be more inclusive of transgender patients, emphasizing the challenges faced by transgender and gender non-conforming (TGNC) individuals in accessing dental care. The article recommends providing training and resources for dental teams, highlighting the importance of first impressions and effective communication during patient interactions. Practical suggestions include incorporating affirmed name and gender options in registration forms, ensuring appropriate language in interactions, and addressing insurance claim discrepancies. The column promotes creating a respectful environment and cites the …


Covid-19’S Impact On Dental Practice: Managing With Less Support, Christopher J. Smiley Dds May 2022

Covid-19’S Impact On Dental Practice: Managing With Less Support, Christopher J. Smiley Dds

The Journal of the Michigan Dental Association

This editorial explores the impact of COVID-19 on dental practice, focusing on the challenges of managing with reduced support due to workforce shortages. The author shares personal experiences highlighting broader workforce realities, including stress, compensation concerns, and a desire for work-life balance contributing to the "Great Resignation." The dental field, already facing shortages, witnesses increased competition for skilled professionals, with corporate dentistry exacerbating the situation. The editorial discusses potential solutions, such as revising delegation rules, addressing relicensure barriers, and advocating for higher education funding. The lasting changes in dental practice administration and patient care delivery post-COVID-19, including potential shifts in …


Staff Matters: Employees On Military Leave, Jodi Schafer Sphr, Shrm-Scp May 2022

Staff Matters: Employees On Military Leave, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

This Staff Matters column addresses an employer's concern about an employee being deployed for military service and explores options for managing the situation. The response emphasizes the application of the Uniformed Services Employment and Reemployment Rights Act of 1994 (USERRA) and the Family and Medical Leave Act (FMLA). The article highlights that USERRA, applicable to all employers regardless of size, mandates unpaid leave for military service members and outlines re-employment rights. Practical suggestions for coping with the absence, including hiring temporary staff and having a clear policy in the employee handbook, are provided. The column also hints at future articles …


J Mich Dent Assoc May 2022 May 2022

J Mich Dent Assoc May 2022

The Journal of the Michigan Dental Association

Monthly, The Journal of the Michigan Dental Association brings news, information, and feature articles to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this May 2022 issue, the reader will find the following original content:

  • A feature on “Periodontal Disease and COVID-19"
  • A cover feature introducing Dr. Vince Benivegna 2022-23 MDA President
  • A 10-Minute EBD: “Charcoal Toothpastes Pose Risks with Few Benefits”
  • A Professional Ethics article on “How Can Our Office be More Inclusive of Transgender Patients”
  • News you need: an Editorial, a profile on Dr. Jessica Rikert, recipient of the …


Meet New Mda President Vince Benivegna, David Foe Ma May 2022

Meet New Mda President Vince Benivegna, David Foe Ma

The Journal of the Michigan Dental Association

In an interview with the Journal, Dr. Vince Benivegna, incoming Michigan Dental Association (MDA) President, shares insights into his goals, challenges facing Michigan dentists, and the value of organized dentistry. As an oral surgeon and seasoned MDA volunteer, Dr. Benivegna addresses issues such as staffing shortages, dental supplies, and the evolving practice environment. He emphasizes the MDA's role in advocacy, mentorship, and supporting diverse dental professionals. Discussing the opioid crisis, Dr. Benivegna highlights dentistry's contributions while acknowledging the need for ongoing efforts. The interview provides a comprehensive view of leadership, professional growth, and work-life balance in organized dentistry.


Dentistry And The Law: What Is Illegal About Disclosing Fee Schedules?, Dan Schulte Jd May 2022

Dentistry And The Law: What Is Illegal About Disclosing Fee Schedules?, Dan Schulte Jd

The Journal of the Michigan Dental Association

This Dentistry and the Law column addresses the question of disclosing fee schedules by dental plans. The author clarifies that dental plans often withhold fee schedule information, citing potential antitrust violations or illegality. However, the column asserts that this is an excuse rather than a legal constraint. The author explains that disclosing fee schedules does not violate antitrust laws; violations occur through agreements that unreasonably restrain competition. The reluctance of dental plans to disclose fee information is attributed to business objectives, not legal concerns. Dentists are encouraged to request fee schedules to make informed decisions about network participation, with a …


The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, Nicole Stephens May 2022

The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, Nicole Stephens

Dissertations and Theses (Open Access)

Poor oral health is a predictor of cognitive decline in elderly populations and has been shown to precede dementia. As cognitive decline progresses, patients are likely to move from the community into nursing facilities. We hypothesize that severity of dementia and residency type will impact the oral health of patients with dementia. Fifty-two participants of two dementia levels were recruited from the UTHealth Neurocognitive Disorders Center and two Houston-area nursing homes. A standardized oral health assessment, plaque index, and oral bacteria analysis determined participants’ oral health status. Further, data was collected on participants’ medical history, oral hygiene habits, dietary habits, …


Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park May 2022

Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

This thesis presents a study of heritability of maxillary dental arch dimensions in a captive baboon colony. Arch dimensions are important subject because they influence the entirety of the craniofacial and masticatory complex. The goal of this study was to quantify the relative genetic influence on arch dimensions and the nature of this influence at different points along the maxillary arcade. Referencing virtual, three-dimensional dental cast scans, widths were measured at different points between the a) maxillary left and right canines, and b) maxillary left and right first molars (M1). Specifically, measurements were taken at the inner (lingual) gingival margin, …


Comparative Expression Of Exosome-Derived Dental Pulp Stem Cell (Dpsc) Microrna, Matthew Hunsaker May 2022

Comparative Expression Of Exosome-Derived Dental Pulp Stem Cell (Dpsc) Microrna, Matthew Hunsaker

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Dental pulp stem cells (DPSC) are pluripotent stem cells capable of differentiating into several tissue types. Several studies have demonstrated DPSC can be extracted from deciduous and permanent teeth, including third molars (wisdom teeth) - however, much less is known regarding the factors that determine and regulate pluripotency and differentiation responsiveness among these harvested DPSC. Recent evidence has suggested small, non-coding microRNAs mediate (in part) differentiation and self-renewal among some stromal and hematopoetic stem cells, although much remains to be discovered regarding microRNA regulation of DPSC phenotypes. Based upon this information, the overall goal of this study was to …