Fabrication Of Nanocrystalline Austenitic Stainless Steel With Superior Strength And Ductility Via Binder Assisted Extrusion Method, L. Heidari, M. J. Hadianfard, A. R. Khalifeh, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Biomedical austenitic stainless steel (ASTM F2581) has been processed by the powder metallurgy technology using binder assisted extrusion method and aside a sintering aid. The resultant microstructure was examined by optical microscopy, field emission scanning electron microscopy, transmission electron microscopy and x-ray diffraction methods. The optical microscopy images indicate that using the binder and sintering aid considerably decreases the porosities of the sintered samples. The x-ray diffraction and transmission electron microscopy images reveal that the microstructure of the sintered alloy consists of austenite in nanocrystalline form and amorphous phases. The mechanical properties were measured through compressive tests. The mean yield …

Spect/Ct Correlation In The Diagnosis Of Unilateral Condilar Hyperplasia, Diego Fernando López, Valentina Borrás Ríos Borrás, Juan Manuel Muñoz, Rodrigo Cardenas-Perilla, Luis Eduardo Almeida

School of Dentistry Faculty Research and Publications

Objective:

To evaluate the correlation between metabolic bone activity measured by single photon emission computed tomography (SPECT) and the anatomic condylar characteristics acquired by computed tomography (CT), in patients with unilateral condylar hyperplasia (UCH).

Method and Materials/Patients:

Observational, descriptive study in a group of 71 patients with clinical diagnosis of UCH and indication of SPECT/CT. Bone SPECT images obtained in a gamma-camera GE Infina and processed in a station Xeleris 3 with the program Volumetrix MI Evolution for bone. CT images acquired in a PET/CT Biograph mcT20 equipment (Siemens) processed in a station Osirix V 7.5.1 (Pixmeo, Bomex, Switzerland).

Results: …

Inventing Dental Continuing Education: History Of The Dental Forum -- Milwaukee, Kenneth J. Waliszewski

School of Dentistry Faculty Research and Publications

Life-long learning is an ancient concept. The young are unaware of it. A beginning practitioner, often blinded by ego, ignores its value. The seasoned veteran, haunted by challenges, wonders how it passed him by. History can and does often teach us lessons. In 1787, Benjamin Franklin stood up to address the American Constitutional Convention and urged his fellow patriots to sign the document. At the age of 81, he was the oldest person in the group. He acknowledged having opened his mind to contrarian viewpoints from his younger colleagues. Franklin spoke these words: “If you are convinced that you know …

Simultaneous Selective Enrichment Of Methylparaben, Propylparaben, And Butylparaben From Cosmetics Samples Based On Syringe-To-Syringe Magnetic Fluid Phase Microextraction, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Present work is the preparation of novel magnetic nanofluids based on deep eutectic solvent and used for the rapid microextraction of methylparaben (MP), propylparaben (PP), and butylparaben (BP) from cosmetics samples using syringe-to-syringe dispersive magnetic nanofluid microextraction procedure (SS-DMNF-ME). The optimization of the extraction of MP, PP, and BP was performed through central composite design (CCD). The optimum extraction conditions were assessed by optimizing pH, nanofluid volume, NaCl concentration, cycle number, and methanol volume. pH 8.0, 200 μL of magnetic nanofluid, 6% w/v of NaCl, eight cycles of injection/back injection, and 80 μL of methanol were the optimum extraction conditions, …

The Use Of Mineral Trioxide Aggregate In The Treatment Of Horizontal Root Fractures: A Case Presentation And Literature Update, Elif Ballikaya, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Root fracture is a rarely seen traumatic injury in permanent dentition. It has a prevalence of 0.5-7 %. Tooth survival is significantly affected by the type of healing and the location of the root fracture. Additionally, the patient’s age, stage of root development, mobility and dislocation of the coronal fragment, and diastasis between fragments following this kind of injury are among the important factors. In this case presentation, the management with MTA plug and 6-year follow-up of a horizontal root fracture was reported. A literature update regarding the use of MTA in the management of horizontal root fractures was also …

Concurrent Application Of Conductive Biopolymeric Chitosan/ Polyvinyl Alcohol/ Mwcnts Nanofibers, Intracellular Signaling Manipulating Molecules And Electrical Stimulation For More Effective Cardiac Tissue Engineering, Ali Abedi, Behnaz Bakhshandeh, Ali Babaie, Javad Mohammadnejad, Sadaf Vahdat, Reza Mombeiny, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Fabrication of appropriate electro-conductive scaffold, application of small molecules (SMs), electrical stimulation (ES), and stem cells are steps forward in cardiac tissue engineering. Herein, for the first time, all mentioned factors have been taken into account concurrently regarding the differentiation of unrestricted somatic stem cells (USSCs) into cardiac cells. To accomplish this goal, electrospun composite scaffolds made of chitosan (CS) and polyvinyl alcohol (PVA) with multi-wall carbon nanotubes (MWCNTs; ranged from 0 to 2.5% w/w) were fabricated. After analyzing mechanical, electrical, and biological properties, the best MWCNTs portion was selected. Of note, the addition of 2%w/w MWCNTs to the CS/PVA …

Zirconia Restorations: An American Dental Association Clinical Evaluators Panel Survey, Nathaniel C. Lawson, Kevin Frazier, Ana K. Bedran-Russo, Sharukh Khajotia, Jacob Park, Olivia Urquhart

School of Dentistry Faculty Research and Publications

Background

Zirconia is a relatively new dental material used for indirect dental restorations. Little is known about how dental practitioners are using this material in their practice.

Methods

A survey on zirconia restorations was developed and administered electronically through e-mail communications to the American Dental Association Clinical Evaluators (ACE) Panel on August 31, 2020. Reminders were sent to nonrespondents, and the survey closed 2 weeks after the launch date.

Results

When using zirconia for a restoration, respondents choose it to restore natural teeth (99%) more often than implants (76%). Almost all respondents (98%) use it for posterior crowns, whereas approximately …

Bioresorbable Composite Polymeric Materials For Tissue Engineering Applications, Sakineh Hajebi, Saeed Mohammadi Nasr, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

This review covers the development of bioresorbable polymeric composites for applications in tissue engineering. Various commercially available bioresorbable polymers are described, with emphasis on recent bioresorbable composites based on natural and synthetic polymers. Bioresorbable polymers contain hydrolyzable bonds, which are subjected to chemical degradation via either reactive hydrolysis or enzyme-catalyzed active hydrolysis. For synthetic polymers, chemical hydrolysis is the most important mode of degradation. The degradation rate can be controlled by varying the molecular weight and crystallinity. Examples of bioresorbable polymers are: polyurethane, poly(D,L)lactide, poly(lactic-co-glycolic) acid, poly(α-hydroxy acids), cross-linked polyester hydrogels, poly(orthoesters), polyanhydrides and polyethylene glycol.

A 3d Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity For Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification And In Vitro Studies, Ashkan Bigham, Amir Hamed Aghajanian, Mehdi Movahedi, Mansoureh Sattary, Mohammad Rafienia, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This is a comprehensive study reporting the fabrication of highly porous Gehlenite scaffold (Ca₂Al₂SiO₇)—both with and without surface modification—for the first time. The sintering temperature of Gehlenite scaffolds was optimized. Next, the optimized Gehlenite scaffold was coated by polycaprolactone (PCL)-Forsterite (Mg₂SiO₄) nanocomposite to improve the scaffold’s brittleness and biological properties. 1375 °C was found to be the optimized sintering temperature by which the Gehlenite scaffold was consolidated. Different PCL and Forsterite concentrations were separately applied on the optimized scaffold to yield a complete nanocomposite coating without clogging the macroporous structure. …

Recent Developments In Targeting Genes And Pathways By Rnai-Based Approaches In Colorectal Cancer, Asiyeh Jebelli, Behzad Baradaran, Jafar Mosafer, Amir Baghbanzadeh, Ahad Mokhtarzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A wide spectrum of genetic and epigenetic variations together with environmental factors has made colorectal cancer (CRC), which involves the colon and rectum, a challenging and heterogeneous cancer. CRC cannot be effectively overcome by common conventional therapies including surgery, chemotherapy, targeted therapy, and hormone replacement which highlights the need for a rational design of novel anticancer therapy. Accumulating evidence indicates that RNA interference (RNAi) could be an important avenue to generate great therapeutic efficacy for CRC by targeting genes that are responsible for the viability, cell cycle, proliferation, apoptosis, differentiation, metastasis, and invasion of CRC cells. In this review, we …

Macro-And Micromechanical Modelling Of Ha-Elastin Scaffold Fabricated Using Freeze Drying Technique, Matin Mohammadzadeh Rad, Saeed Saber-Samandari, Mojtaba Sadighi, Lobat Tayebi, Mohammad Mohammadi Aghdam, Amirsalar Khandan

School of Dentistry Faculty Research and Publications

No abstract provided.

Inhibition Of Candida Albicans And Mixed Salivary Bacterial Biofilms On Antimicrobial Loaded Phosphated Poly(Methyl Methacrylate), Andrew R. Dentino, Dong Hwa Lee, Kelley Dentino, Arndt Guentsch, Mohammadreza Tahriri

School of Dentistry Faculty Research and Publications

Biofilms play a crucial role in the development of Candida-associated denture stomatitis. Inhibition of microbial adhesion to poly(methyl methacrylate) (PMMA) and phosphate containing PMMA has been examined in this work. C. albicans and mixed salivary microbial biofilms were compared on naked and salivary pre-conditioned PMMA surfaces in the presence or absence of antimicrobials (Cetylpyridinium chloride [CPC], KSL-W, Histatin 5 [His 5]). Polymers with varying amounts of phosphate (0–25%) were tested using four C. albicans oral isolates as well as mixed salivary bacteria and 24 h biofilms were assessed for metabolic activity and confirmed using Live/Dead staining and confocal microscopy. …

In Vitro Study Of Surface Alterations To Polyetheretherketone And Titanium And Their Effect Upon Human Gingival Fibroblasts, Maryam Gheisarifar, Geoffrey A. Thompson, Carl Drago, Fahimeh Tabatabaei, Morteza Rasoulianboroujeni

School of Dentistry Faculty Research and Publications

Statement of problem

Soft-tissue attachment to different surfaces may play a pivotal role in the long-term success of dental implants. However, studies on the issue, especially on newer materials, are sparse.

Purpose

The purpose of this in vitro study was to evaluate the viability and adhesion of human gingival fibroblasts (HGFs) on different implant abutment materials with specific surface modifications.

Material and methods

One hundred and fifty specimens in 6 experimental groups were evaluated: smooth-machined titanium alloy (Ti), laser-modified titanium (TiL), smooth-machined polyetheretherketone (PEEK) (P), laser-modified PEEK (PL), plasma-treated PEEK (PP), laser- and plasma-treated PEEK (PLP). Machined Ti was considered …

A Dynamic Mechanical Method To Assess Bulk Viscoelastic Behavior Of The Dentin Extracellular Matrix, Yvette Alania, Mariana Cavalcante Dos Reis, Joo-Won Nam, Rasika S. Phansalkar, James Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To develop a protocol for assessment of the bulk viscoelastic behavior of dentin extracellular matrix (ECM), and to assess relationships between induced collagen cross-linking and viscoelasticity of the dentin ECM.

Methods

Dentin ECM was treated with agents to induce exogenous collagen cross-linking: proanthocyanidins (PACs) from Vitis vinifera – VVe, PACs from Pinus massoniana - PMe, glutaraldehyde – (GA), or kept untreated (control). A dynamic mechanical strain sweep method was carried out in a 3-point bending submersion clamp at treatment; after protein destabilization with 4 M urea and after 7-day, 6-month, and 12-month incubation in simulated body fluid. Tan δ, …

Serum Levels Of Vitamin C And Vitamin D In A Cohort Of Critically Ill Covid-19 Patients Of A North American Community Hospital Intensive Care Unit In May 2020: A Pilot Study, Cristian Arvinte, Maharaj Singh, Paul E. Marik

School of Dentistry Faculty Research and Publications

Background

The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of vitamin C and vitamin D as a risk-assessment tool, and therapeutic option, in COVID-19.

Objective

The objective of this pilot study was to measure serum vitamin C and vitamin D levels in a cohort of patients with critical COVID-19 illness in our community hospital ICU, correlate with other illness risk factors (age, BMI, HgbA1c, smoking status), generate hypotheses, and …

Graphite/Gold Nanoparticles Electrode For Direct Protein Attachment: Characterization And Gas Sensing Application, Javad Shabani Shayeh, Yahya Sefidbakht, Meisam Omidi, Fatemeh Yazdian, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this work, graphite/gold nanoparticles (G/AuNPs) were synthesized through a facile chemical method, and its potential application for direct protein attachment for electrochemical detection of carbon monoxide (CO) was investigated. The preparation of G/AuNPs electrodes was optimized by synthesizing the nanoparticles in different concentration of HAuCl₄.3H₂O at various temperatures. The G/AuNPs electrode was subsequently modified by four types of mercaptopropionic acid, including 1-mercaptopropionic, 3-mercaptopropionic, 6-mercaptopropionic, and 11-mercaptopropionic acid, to achieve the best structure for protein attachment. Visible absorption and electrochemical studies showed that 3-mercaptopropionic acid possesses the best performance regarding the electrical conductivity between electrode and …

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …

Dental Sealants And Restorative Treatment For First Molars Among Medicaid Enrollees, Christopher Okunseri, Brian D. Hodgson, Elaye Okunseri, Raul Garcia, Alexis D. Visotcky, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objectives

To assess the association between dental sealant placement and subsequent restorative treatment of permanent first molars over time.

Methods

We analysed Wisconsin Medicaid claims data from 2001 to 2009 for children aged 6-16 years. Children entered the study cohort at age 6 and were censored if Medicaid eligibility was lost for >31 days. A fixed effects analysis via a Cox proportional hazards model, stratified by individual, was used to estimate the time-averaged and time-dependent effects of sealant placement on dental treatment defined as any restorative, endodontic or surgical procedure.

Results

A total of 185,262 children with permanent first molars …

Epidemiology Of Male Breast Cancer, Santhi Konduri, Maharaj Singh, George Bobustuc, Richard Rovin, Amin Kassam

School of Dentistry Faculty Research and Publications

Background

Due to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose of this study was to determine survival and risk factors for male breast cancer in a large U.S. population.

Methods

In this study, 19,795 male patients with breast cancer were identified from the National Cancer Database (2004–2014). Patient demographics, tumor characteristics and treatments were analyzed by using descriptive statistics. We used multivariate Cox regression and Kaplan Meier analysis.

Results

Over 10 years, the incidence of male breast cancer increased from 7.2% to 10.3%, while mortality decreased from 11% to 3.8%. Socioeconomic factors predicting …

Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to the level of absolute configuration and determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via a biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led to the isolation of PAC oligomers that represent the main bioactive principles of C. verum: two A-type tetrameric PACs, epicatechin-(2β→O→7,4β→8)-epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin (1) and parameritannin A1 (2), together with a trimer, cinnamtannin B1 (3). Structure …

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …

Drug-Delivery Ca-Mg Silicate Scaffolds Encapsulated In Plga, A. Jadidi, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca₇MgSi₄O₁₆) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility …

Synergistic Effects Of Conductive Pva/Pedot Electrospun Scaffolds And Electrical Stimulation For More Effective Neural Tissue Engineering, Ali Babaie, Behnaz Bakhshandeh, Ali Abedi, Javad Mohammadnejad, Iman Shabani, Abdolreza Ardeshirylajimi, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering. In this research, electrospun conductive PVA (Polyvinyl alcohol)/PEDOT(poly(3,4-ethylenedioxythiophene)) scaffolds were fabricated in different compositions. Conductivity of electrospinning solutions and electrospun scaffolds were measured. Morphology and topography, mechanical properties and water contact angle of scaffolds were analyzed. Chemistry of scaffolds were studied using FTIR analysis, while biocompatibility and cellular interactions with scaffolds were tested using MTT assay and cellular attachment and spreading testing. Our results show improvements in PEDOT-containing scaffolds, in terms of physiochemical properties, and cell viability compared to …

A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Abstract

Objective

The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates.

Materials and Methods

Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with …

Molar-Incisor Hypomineralization Studies, Azza Tagelsir Ahmed, Brian D. Hodgson, E. Angeles Martinez-Mier

School of Dentistry Faculty Research and Publications

The problem of demarcated hypomineralization defects of the permanent first molars (molar-incisor hypomineralization [MIH]) has been an emerging issue for oral health professionals around the globe. Yet, the first set of US-based epidemiologic data on MIH took as long as 2 decades from the time when MIH was first described by Weerheijm and colleagues.¹ In response to the June JADA article titled “Prevalence of Molar-Incisor Hypomineralization and Other Enamel Defects and Associated Sociodemographic Determinants in Indiana,” (Tagelsir Ahmed A, Soto-Rojas AE, Dean JA, Eckert GJ, Martinez-Mier EA, JADA. 2020;151[7]: 491-501), we attempt to highlight some of the challenges encountered …

Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This study evaluates the use of nanotubes (NTs) as a matrix for local drug delivery modified by a biodegradable polymeric coating on medical-grade nitinol (NiTi alloy) surfaces. For this purpose, NiTi was anodized within parameters that promote the formation of NTs, ultrasonicated, annealed and impregnated with vancomycin hydrochloride. To improve bioperformance, poly(lactic-co-glycolic acid) (PLGA) was also deposited on the drug-loaded NTs. The samples were characterized in terms of structure, wettability, drug delivery, corrosion and cytocompatibility. Scanning electron microscopy and water contact angle measurements signify the formation of open-top homogeneous NTs of 600– 700 nm in length and ~30 nm in …

Nano-Hydroxyapatite And Nano-Hydroxyapatite/Zinc Oxide Scaffold For Bone Tissue Engineering Application, Fatemeh Heidari, Reza Bazargan-Lari, Mehdi Razavi, Farahnaz Fahimipour, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol‐gel and precipitation methods respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher …

A Tri-Component Knee Plug For The 3rd Generation Of Autologous Chondrocyte Implantation, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite and β-tricalcium phosphate to accommodate the bony parts underneath the knee cartilage. It is a cylinder with a diameter of 20 mm and height of 7.5 mm, with a slight dome shape on top. The plug also comprises a Cartilage Portion (component 2) which is a …

Removal Of Water Binding Proteins From Dentin Increases The Adhesion Strength Of Low-Hydrophilicity Dental Resins, Ana Paula Farina, Doglas Cecchin, Cristina M. P. Vidal, Ariene A. Leme-Kraus, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To investigate the role of proteoglycans (PGs) on the physical properties of the dentin matrix and the bond strength of methacrylate resins with varying hydrophilicities.

Methods

Dentin were obtained from crowns of human molars. Enzymatic removal of PGs followed a standard protocol using 1 mg/mL trypsin (Try) for 24 h. Controls were incubated in ammonium bicarbonate buffer. Removal of PGs was assessed by visualization of glycosaminoglycan chains (GAGs) in dentin under transmission electron microscopy (TEM). The dentin matrix swelling ratio was estimated using fully demineralized dentin. Dentin wettability was assessed on wet, dry and re-wetted dentin surfaces through water …

Sublingual Emphysema Following Alveoloplasty: A Case Report, Austin Dodge, Katelyn Kreh, Vrisiis Kofina, Swati Y. Rawal

School of Dentistry Faculty Research and Publications

Various cases of introduction of air into soft tissues have been reported in the dental literature. Here, we report a rare case of localized sublingual emphysema after alveoloplasty. There was no facial involvement. The patient responded to treatment and recovered uneventfully.