Dentistry Commons^™

Immunohistochemical Analysis Of Dentigerous Cysts And Odontogenic Keratocysts Associated With Impacted Third Molars—A Systematic Review, Luis Eduardo Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto

School of Dentistry Faculty Research and Publications

Objective: This systematic review investigates the diagnostic, prognostic, and therapeutic implications of immunohistochemical markers in dentigerous cysts (DCs) and odontogenic keratocysts (OKCs) associated with impacted third molars.

Materials and Methods: A comprehensive search strategy was employed across major databases including MEDLINE/PubMed, EMBASE, and Web of Science, from the inception of the databases to March 2024. Keywords and Medical Subject Heading (MeSH) terms such as “dentigerous cysts”, “odontogenic keratocysts”, “immunohistochemistry”, “Ki-67”, and “p53” were used. The PRISMA 2020 guidelines were followed to ensure methodological rigor. Inclusion criteria encompassed studies on humans and animals providing definitive diagnoses or specific signs and symptoms …

Association Between Periodontal Health Status And Quality Of Life: A Cross-Sectional Study, Kinan M. Al-Bitar, Jeffery M. Garcia, Shengtong Han, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Introduction: Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. The purpose of this study is to determine if the oral health status, specifically the periodontal status, influences oral health–related quality of life.

Materials and methods: Survey data were collected in a US dental school clinical setting in a cross-sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile-49 (OHIP-49). In addition, DMFT index, periodontal status, and health literacy scores (dental and medical health …

Exploring And Describing Current Behavioral And Social Sciences Curricula In Predoctoral Dental Programs, Casey D. Wright, Lance Brendan Young

School of Dentistry Faculty Research and Publications

Purpose

To maintain accreditation status, predoctoral dental programs in the United States and Canada are required to train future dentists in the fundamentals of behavioral sciences. Each program independently determines how to fulfill this task, and little information exists on the consistency of training across programs. The purpose of this study was to identify the range of topics currently taught in predoctoral dental programs in the United States and Canada, who teaches them, and the modes of instruction and assessment.

Methods

Invitations to complete an online survey were emailed to faculty responsible for, or familiar with, the behavioral sciences curricula …

Comparison Of Dmft And Behavior Rating Scores Between Children With Systemic Disease And Healthy Children At The First Dental Visit, Gizem Erbaş Ünverdi, Beste Ozgur, H. Cem Güngör, Paul S. Casamassimo

School of Dentistry Faculty Research and Publications

Purpose: To evaluate and compare oral health and behavior scores at the first dental visit and dental treatment need using general anesthesia/sedation (GA/S) of children with systemic diseases (SD) and healthy children.

Methods: Data were obtained from healthy children (n = 87) and children with SD (n = 79), aged 4 to 6 years, presenting to a hospital dental clinic for a first dental examination. The total number of decayed, missing and filled teeth (dmft), dental behavior score using Frankl Scale, and dental treatment need using GA/S were recorded. Chi-square / Fisher’s exact test and Mann–Whitney U …

Evaluating Surgical Approaches For Hemimandibular Hyperplasia Associated With Osteochondroma: A Systematic Literature Review, Luis Eduardo Almeida, Samuel Zammuto, Diego Fernando Lopez

School of Dentistry Faculty Research and Publications

Background/Objectives: Hemimandibular hyperplasia (HH) associated with osteochondroma presents complex challenges in maxillofacial surgery, including facial asymmetry, occlusal instability, and temporomandibular joint (TMJ) dysfunction. Surgical interventions vary widely in approach and outcomes, underscoring the need for a systematic evaluation of effectiveness. This systematic review assesses the effectiveness of surgical approaches for managing HH associated with osteochondroma, focusing on techniques including condylectomy, orthognathic surgery, distraction osteogenesis, total joint replacement (TJR), and genioplasty. Methods: Following PRISMA 2020 guidelines, a comprehensive search was conducted in PubMed, Scopus, and Web of Science for studies published from 2000 to 2023. Eligibility criteria were based on the …

Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes, Shengtong Han

School of Dentistry Faculty Research and Publications

The genetics of schizophrenia is so complex that it involves both common variants and rare variants. Rare variant association studies of schizophrenia are challenging because statistical methods for rare variant analysis are under-powered due to the rarity of rare variants. The recent Schizophrenia Exome meta-analysis (SCHEMA) consortium, the largest consortium in this field to date, has successfully identified 10 schizophrenia risk genes from ultra-rare variants by burden test, while more risk genes remain to be discovered by more powerful rare variant association test methods. In this study, we use a recently developed Bayesian rare variant association method that is powerful …

Prevalence Of Temporomandibular Disorders (Tmd) In Obesity Patients: A Systematic Review And Meta-Analysis, Giuseppe Minervini, Rocco Franco, Maria Maddalena Marrapodi, Luis Eduardo Almeida, Vincenzo Ronsivalle, Marco Cicciù

School of Dentistry Faculty Research and Publications

Objective

Obesity is a growing epidemic in the world. It increases the risk for severe health conditions, including diabetes, heart disease and stroke. Recent research has found that obesity is associated with an increased risk for temporomandibular disorders (TMDs). The purpose of this literature review with meta-analysis is to analyse the possible association between obesity and temporomandibular disorders.

Materials and Methods

Pubmed, Web of Science and Lilacs were systematically searched until 01/03/2000. Articles dealing with TMD and obesity were selected, and numbers that might be useful in the meta-analysis were extracted.

Results

Fifty articles were chosen after using all three …

Gastrointestinal Distress As A Potential Mediator Between Stress And Periodontal Inflammation, Casey D. Wright, Brenda Heaton, Raul I. Garcia, Maureen M. Leonard, Alessio Fasano, Daniel W. Mcneil

School of Dentistry Faculty Research and Publications

Objectives

Periodontal disease is multifactorial in its aetiology, which encompasses biopsychosocial contributors, including psychological stress. Gastrointestinal distress and dysbiosis have been associated with several chronic inflammatory diseases yet have rarely been investigated with respect to oral inflammation. Given the implications of gastrointestinal distress on extraintestinal inflammation, this study aimed to evaluate the potential role of such distress as a mediator between psychological stress and periodontal disease.

Methods

Utilizing a cross-sectional, nationwide sample of 828 adults in the USA generated via Amazon Mechanical Turk, we evaluated data collected from a series of validated self-report psychosocial questionnaires on stress, gut-specific anxiety around …

Detection Of Dental Restorations Using No-Code Artificial Intelligence, Manal Hamdan, Zaid Badr, Jennifer Bjork, Reagan Saxe, Francesca Malensek, Caroline Miller, Rakhi Shah, Shengtong Han, Hossein Mohammad-Rahimi

School of Dentistry Faculty Research and Publications

Objectives

The purpose of this study was to utilize a no-code computer vision platform to develop, train, and evaluate a model specifically designed for segmenting dental restorations on panoramic radiographs.

Methods

One hundred anonymized panoramic radiographs were selected for this study. Accurate labeling of dental restorations was performed by calibrated dental faculty and students, with subsequent final review by an oral radiologist. The radiographs were automatically split within the platform into training (70 %), development (20 %), and testing (10 %) subgroups. The model was trained for 40 epochs using a medium model size. Data augmentation techniques available within the …

Temporomandibular Disorders And Physiotherapy, Luis Eduardo Almeida

School of Dentistry Faculty Research and Publications

No abstract provided.

Patient-Reported Outcomes Following Guided Bone Regeneration: Correlation With Clinical Parameters, Vrisiis Kofina, Morvarid Monfaredzadeh, Swati Y. Rawal, Andrew R. Dentino, Maharaj Singh, Dimitris N. Tatakis

School of Dentistry Faculty Research and Publications

Objectives

Postoperative oral health-related quality of life is procedure-dependent and may vary during early healing. There is scarce evidence on patient-reported outcome measures (PROMs) after extraction and guided bone regeneration (GBR) or on the clinical parameters influencing PROMs. This prospective observational study aimed to evaluate PROMs during the first 2 weeks following extraction and GBR and correlate them with clinical parameters.

Methods

Patients undergoing extraction and GBR (bone graft and resorbable membrane) at a single tooth-bound site were recruited. PROMs (pain, swelling, difficulty of mouth opening, and OHIP-14) were recorded immediately preoperatively, and at 2, 7, and 14 days postoperatively. …

Mandibular Condylar Hyperplasia And Its Correlation With Vascular Endothelial Growth Factor, Luis Eduardo Almeida, Marco Cicciù, Andrea Doetzer, Matthew L. Beck, Gabriele Cervino, Giuseppe Minervini

School of Dentistry Faculty Research and Publications

Background

Condylar hyperplasia (CH) is a rare condition characterised by excessive unilateral growth of the mandibular condyle after cessation of growth on the contralateral side causing facial asymmetry, being more prevalent in the second and third decades.

Objective

The aim of this study was to determine the utility of vascular endothelial growth factor (VEGF-A) as a diagnostic and prognostic factor in condylar hyperplasia, and to determine its potential viability as a therapeutic target.

Methods

This is a case–control study, where 17 mandibular condyles specimens were collected from 17 patients treated for active mandibular condyle hyperplasia and three unaffected human mandibular …

Sports Drinks Effect On Salivary Volume And Ph In Children After Exercise: A Randomized Clinical Study, Matina V. Angelopoulou, Alicia Malak-Santaga, Andreas Agouropoulos, Cesar D. Gonzalez

School of Dentistry Faculty Research and Publications

BACKGROUND: The aim of this study was to examine the sports’ related oral health behavior and the effect of sports drinks on the salivary volume and acidity of 6 to 14 years old children.

METHODS: Sixty-eight children with a median age of 8 years old from Waterford Tennis Association camp participated in the study. Each child was randomly assigned to either the control group that consumed water or the experimental group that consumed a sports drink. Salivary volume and acidity were measured for all groups before exercise, right after exercise and after consuming the rehydrating agent. Salivary volume was measured …

Vaccination Intention And Uptake Within The Black Community In Appalachia, Jamey T. Brumbaugh, Kalo C. Sokoto, Casey D. Wright, Sarah E. Francis, Jaliyah Hubbard, Linda Alexander, Daniel W. Mcneil

School of Dentistry Faculty Research and Publications

Objective:

Black communities have disproportionately experienced adverse health effects from the COVID-19 pandemic while simultaneously having less vaccination access and decreased vaccine utilization. As such, predictors of vaccination uptake within Black communities are a public health imperative. Black Americans from socio-geographic regions associated with health inequities (e.g., Appalachia), including vaccination disparities, represent an intersection of racial, economic, and ethnic social identities. To better understand the preventive health needs of Black communities in Appalachia and elsewhere, this study examined psychosocial predictors of vaccination intention or behavior.

Method:

Adults (n = 336) identifying as Black or African American from West …

An In-Vitro Analysis Of The Accuracy Of Different Guided Surgery Systems – They Are Not All The Same, Arndt Guentsch, Jennifer Bjork, Reagan Saxe, Shengtong Han, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Objectives

Different static computer-assisted implant surgery (sCAIS) systems are available that are based on different design concepts. The objective was to assess seven different systems in a controlled environment.

Materials and Methods

Each n = 20 implants were placed in identical mandible replicas (total n = 140). The systems utilized either drill-handles (group S and B), drill-body guidance (group Z and C), had the key attached to the drill (group D and V), or combined different design concepts (group N). The achieved final implant position was digitized utilizing cone-beam tomography and compared with the planned position. The angular deviation was …

Oral Care Among Older Adults In Assisted Living Facilities, Murad H. Taani, Christopher Okunseri, Kathryn L. Wagner

School of Dentistry Faculty Research and Publications

No abstract provided.

Immunohistochemical Markers Of Temporomandibular Disorders: A Review Of The Literature, Luis Eduardo Almeida, Andrea Doetzer, Matthew L. Beck

School of Dentistry Faculty Research and Publications

Temporomandibular disorders (TMD) are a group of internal derangements encompassing dysfunction, displacement, degeneration of the temporomandibular joints and surroundings muscles of mastication, often accompanied by pain. Relationships between TMD and various chemical biomarkers have been examined throughout the years. This paper aims to gather evidence from the literature regarding other biomarkers and presenting them as one systematic review to investigate the potential links between TMD and different biochemical activity. To identify relevant papers, a comprehensive literature search was carried out in MEDLINE/PubMED, EMBASE, Web of Science and a manual search was performed in the International Journal of Oral and Maxillofacial …

Intra-Marrow Penetrations And Root Coverage Outcomes: A Systematic Review, Vrisiis Kofina, Ving Wang, Alissa V. Fial, Dimitris N. Tatakis

School of Dentistry Faculty Research and Publications

Background

Intra-marrow penetrations (IMPs) have been performed during guided tissue regeneration (GTR) procedures with reported clinical benefits. The aim of this systematic review was to investigate the use and effect of IMPs during root coverage procedures.

Method

A broad search for human and animal studies was performed on PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Registry of Controlled Trials and Web of Science, following a registered review protocol (PROSPERO). All prospective study designs, case series and case reports on gingival recession treatment (follow-up ≥ 6 months) that employed IMPs were included. Root coverage, complete root coverage prevalence, and …

Optimization Of The Modular Reinforced Bone Scaffold For Customized Alveolar Bone Defects, Meisam Omidi, Luis Eduardo Almeida, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A modular reinforced bone scaffold with enhanced mechanical properties has recently been developed by our group. It includes: 1) A load-bearing module: a skeleton which is made of a slowly degradable material, undertaking mechanical necessities of the scaffold, and 2) A bio-reactive module: a porous and biodegradable component undertaking biological necessities of the scaffold. The load-bearing module is placed into the bio-reactive module to reinforce it. This paper is dedicated to optimizing the load-bearing module for a certain customized alveolar bone defect. More specifically, a 3D-printed skeleton, made of polycaprolactone (PCL), is optimized based on the boundary conditions of the …

Edge Chipping Of Translucent Zirconia, Joseph D. Flask, Geoffrey A. Thompson, Maharaj Singh, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

More translucent dental zirconias have been developed by incorporating the cubic phase and reducing the tetragonal phase content that undergoes transformation toughening, leading to reduced mechanical properties. Whether the clinically relevant mechanical property of the edge chipping toughness of the material is also reduced is unclear.

Purpose

The purpose of this in vitro study was to evaluate the edge chipping toughness and translucency of translucent zirconia, 3mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP), and lithium disilicate.

Material and methods

Two translucent zirconia products, Katana and Lava Esthetic; one 3Y-TZP, Lava Plus; and one lithium disilicate, IPS e.max Press …

Oral Manifestations Of Syphilis: A Review Of The Clinical And Histopathologic Characteristics Of A Reemerging Entity With Report Of 19 New Cases, Molly Housley Smith, Richard J. Vargo, Elizabeth Ann Bilodeau, K. Mark Anderson, Anna Trzcinska, Carleigh R. Canterbury, John E. Fantasia, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

Background

Syphilis is a sexually-transmitted infectious disease caused by Treponema pallidum. Cases of primary and secondary syphilis are on the rise in the United States, with a 14.4% increase in new cases noted from 2017 to 2018 and an escalation of 71% between the years 2014 and 2018. Fulfilling its nickname of “the great imitator,” oral manifestations of syphilis may mimic a variety of infectious, neoplastic, or immune-mediated processes, both clinically and histopathologically. This large spectrum of appearances can create a diagnostic challenge to the clinician and/or pathologist, leading to delay in diagnosis or misdiagnosis.

Methods

A database of …

Iatrogenic Acid-Induced Gingival Recession During Crown Cementation: A Case Report, Vrisiis Kofina, H. An, Swati Y. Rawal

School of Dentistry Faculty Research and Publications

Accidental contact of various chemicals in dentistry may cause damage to the gingiva. A male patient presented for a full mouth rehabilitation with ceramic crowns. The patient underwent the steps of ceramic crown preparation uneventfully. At the time of crown delivery, cotton rolls were placed in several vestibular areas for isolation. They were regularly changed during different steps of etching and cementation process, which included the use of Multilink Primer B (Ivoclar Vivadent™). On removal of the cotton roll in the area of upper right canine, the gingival tissues appeared blanched and grayish white. The cotton roll was found to …

Precision And Trueness Of Implant Placement With And Without Static Surgical Guides: An In Vitro Study, Arndt Guentsch, Laxmi Sukhtankar, Hongseok An, Paul Luepke

School of Dentistry Faculty Research and Publications

Statement of problem

Malpositioning of implants is one of the main factors leading to hard- and soft-tissue deficiencies. Whether static computer-guided implant placement increases accuracy and prevents malpositioning is unclear.

Purpose

The purpose of this in vitro study was to determine accuracy defined by trueness and precision (according to International Organization for Standardization 5725) of computer-assisted implant surgery (fully guided and partially guided) in comparison with freehand single implant placement.

Material and methods

Implants (n=20) were placed fully guided (sleeve-bone distance of 2, 4, or 6 mm), partially guided (guide used for pilot drill), or free hand in identical replicas …

P53 And Vegf Expression In Human Temporomandibular Joint Discs With Internal Derangement Correlate With Degeneration, Sergio Castorina, C. Lombardo, Paola Castrogiovanni, Giuseppe Musumeci, E. Barbato, Luis Eduardo Almeida, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

No abstract provided.

Microfluidic-Assisted Fabrication Of Reverse Micelle/Plga Hybrid Microspheres For Sustained Vascular Endothelial Growth Factor Delivery, Meisam Omidi, Luis Eduardo Almeida, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, poly (d, l-lactide-co-glycolide) (PLGA) composite microspheres containing anhydrous reverse micelle (R.M.) dipalmitoylphosphatidylcholine (DPPC) nanoparticles loaded vascular endothelial growth factor (VEGF) were produced using microfluidic platforms. The VEGF-loaded R.M. nanoparticles (VRM) were achieved by initial self-assembly and subsequent lipid inversion of the DPPC vesicles. The fabricated VRMs were encapsulated into the PLGA matrix by flow-focusing geometry microfluidic platforms. The encapsulation efficiency, in vitro release profile, and the bioactivity of the produced composite microspheres were investigated. The release study showed that VEGF was slowly released from the PLGA composite microspheres over 28 days with a reduced initial burst (18 …

A 3-Year Retrospective Study Of Traumatic Dental Injuries To The Primary Dentition, Beste Özgür, Gizem Erbaş Ünverdi, H. Cem Güngör, Dennis J. Mctigue, Paul S. Casamassimo

School of Dentistry Faculty Research and Publications

Background/Aims

Traumatic dental injuries (TDIs) in the primary dentition are a significant public health problem, which has been neglected worldwide. Despite its high prevalence, limited studies address this injury. The aim of this study was to determine the characteristics and treatment modalities of TDIs affecting primary teeth, along with accompanying medical co-morbidities and attendance at follow-up appointments.

Material and Methods

This retrospective analysis included all TDIs affecting primary teeth from January 2014 to January 2017. Data abstraction included demographics, time lapse prior to arrival at hospital, trauma etiology, classification of TDIs, soft tissue and supporting bone injuries, medical co-morbidities, emergency …

Association Of Estrogen Receptor Alpha 1 And Tmj Dysfunction: A Pilot Study, Andrea Doetzer, Luis Eduardo Almeida, Flavio De Alcântara Camejo, Lucia De Noronha, Marcia Olandoski, Paula C. Trevilatto

School of Dentistry Faculty Research and Publications

Objective

Temporomandibular disorder (TMD) is a multifactorial condition and the most common cause of orofacial pain, affecting mostly women, which points to a female hormone predilection. Therefore, the aim of this study was to analyze the association between TMD and estrogen receptor alpha 1 expression in disks of patients with TMD and condyle fracture (CFx).

Study Design

Forty specimens (from 27 patients) included n = 8 CFx, n = 21 anterior disk displacement with reduction (ADDwR), and n = 11 anterior disk displacement without reduction (ADDwoR). Age, area, and intensity of immunostaining were statistically compared between CFx, ADDwR, and ADDwoR …

Osteogenic Differentiation Of Adipose-Derived Mesenchymal Stem Cells Using 3d-Printed Pdlla/ Β-Tcp Nanocomposite Scaffolds, Ashkan Bigham, Amir Hamed Aghajanian, Mehdi Movahedi, Mansoureh Sattary, Mohammad Rafienia, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Designing bone scaffolds containing both organic and inorganic composites simulating the architecture of the bone is the most important principle in bone tissue engineering. The objective of this study was to fabricate a composite scaffold containing poly (D, l)-lactide (PDLLA) and β-tricalcium phosphate (β-TCP) as a platform for osteogenic differentiation of adipose-derived mesenchymal stem cells. In this study, PDLLA/β-TCP scaffolds were fabricated using three-dimensional printing (3D) technology through melt excursion technique. The physicomechanical characteristics, including microstructure, mechanical properties, of the customized scaffolds were investigated. Further, the in vitro biological characteristics of manufactured scaffolds were evaluated in conjugation with buccal fat …

Polymeric Nanoparticles For Nasal Drug Delivery To The Brain: Relevance To Alzheimer's Disease, Navid Rabiee, Sepideh Ahmadi, Ronak Afshari, Samira Khalaji, Mohammad Rabiee, Mojtaba Bagherzadeh, Yousef Fatahi, Rassoul Dinarvand, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin, Thomas J. Webster

School of Dentistry Faculty Research and Publications

Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The blood–brain barrier prevents systemic drugs from accessing the central nervous system and designing a suitable system to overcome this barrier has attracted much attention. The intranasal pathway, given its proximity to the brain, provides a great opportunity for drug delivery. Understanding the physiological characteristics …

Bone Grafting History Affects Soft Tissue Healing Following Implant Placement, Vrisiis Kofina, Mutlu Demirer, Barbaros S. Erdal, Timothy D. Eubank, Vedat O. Yildiz, Dimitris N. Tatakis, Binnaz Leblebicioglu

School of Dentistry Faculty Research and Publications

Background

This study aimed to determine and compare soft tissue healing outcomes following implant placement in grafted (GG) and non-grafted bone (NGG).

Methods

Patients receiving single implant in a tooth-bound maxillary non-molar site were recruited. Clinical healing was documented. Volume and content of wound fluid (WF; at 3, 6, and 9 days) were compared with adjacent gingival crevicular fluid (GCF; at baseline, 1, and 4 months). Buccal flap blood perfusion recovery and changes in bone thickness were recorded. Linear mixed model regression analysis and generalized estimating equations with Bonferroni adjustments were conducted for repeated measures.

Results

Twenty-five patients (49 ± …