Dentistry Commons^™

Effects Of Oral Contraceptives On The Prevalence Of Alveolar Osteitis After Mandibular Third Molar Surgery: A Retrospective Study, Luis Eduardo Almeida, Sean Pierce, K. Klar, K. Sherman

School of Dentistry Faculty Research and Publications

The objective of this study was to investigate the influence of oral contraceptives on the incidence rate of alveolar osteitis (AO) following the surgical extraction of both impacted mandibular third molars. This retrospective study reviewed the clinical records of patients who presented to the oral surgery clinic of a university school of dentistry for the extraction of impacted mandibular third molars. Using a database search, all patients were categorized by sex, age, occurrence of AO, and whether the females were taking oral contraceptives at the time of surgery. The patient was considered positive for AO if either one or both …

Edge Chipping Resistance And Flexural Strength Of Polymer Infiltrated Ceramic Network And Resin Nanoceramic Restorative Materials, Renos Argyrou, Geoffrey A. Thompson, Seok-Hwan Cho, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

Two novel restorative materials, a polymer infiltrated ceramic network (PICN) and a resin nanoceramic (RNC), for computer-assisted design and computer-assisted manufacturing (CAD-CAM) applications have recently become commercially available. Little independent evidence regarding their mechanical properties exists to facilitate material selection.

Purpose

The purpose of this in vitro study was to measure the edge chipping resistance and flexural strength of the PICN and RNC materials and compare them with 2 commonly used feldspathic ceramic (FC) and leucite reinforced glass-ceramic (LRGC) CAD-CAM materials that share the same clinical indications.

Material and methods

PICN, RNC, FC, and LRGC material specimens …

Mechanical Properties Of Natural Chitosan/Hydroxyapatite/Magnetite Nanocomposites For Tissue Engineering Applications, Fatemeh Heidari, Mehdi Razavi, Mohammad E. Bahrololoom, Reza Bazargan-Lari, Daryoosh Vashaee, Hari Kotturi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Chitosan (CS), hydroxyapatite (HA), and magnetite (Fe₃O₄) have been broadly employed for bone treatment applications. Having a hybrid biomaterial composed of the aforementioned constituents not only accumulates the useful characteristics of each component, but also provides outstanding composite properties. In the present research, mechanical properties of pure CS, CS/HA, CS/HA/magnetite, and CS/magnetite were evaluated by the measurements of bending strength, elastic modulus, compressive strength and hardness values. Moreover, the morphology of the bending fracture surfaces were characterized using a scanning electron microscope (SEM) and an image analyzer. Studies were also conducted to examine the biological response …

Dental Applications Of Natural-Origin Polymers In Hard And Soft Tissue Engineering, Hossein E. Jazayeri, Mina D. Fahmy, Mehdi Razavi, Brett E. Stein, Aatif Nowman, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Clinical advances in the treatment of dentoalveolar defects continue to evolve with the introduction of new innovations in regenerative medicine and tissue bioengineering. Recent developments in tissue engineering are aimed at safely and effectively regenerating a damaged or necrotic area by replenishing its cells and increasing surrounding gene expression. Various techniques have successfully given rise to porous scaffolds being used by clinicians to treat the defect and initiate the repair process. Tissue reconstruction using bioengineered scaffolds is advantageous over traditional autografting, since it prevents the instigation of pain and donor site morbidity while ultimately creating both the environment and machinery …

Evaluation Of An Oral Health Education Session For Early Head Start Home Visitors, Kevin Glatt, Christopher Okunseri, Diane Flanagan, Pippa Simpson, Yumei Cao, Earnestine Willis

School of Dentistry Faculty Research and Publications

Objectives

Home visiting programs promote the education and health of Early Head Start (EHS) children and pregnant women. However, EHS's oral health component is unevenly implemented. We conducted an educational intervention to improve oral health knowledge and motivational interviewing techniques among Wisconsin EHS home visitors.

Methods

A questionnaire assessing oral health-related knowledge and confidence was administered to home visitors before and after an educational session. Changes between pre/post-responses were analyzed with McNemar's test and Wilcoxon Signed Rank test.

Results

After the intervention there were increases in both knowledge and confidence related to oral health communication. Knowledge increases were observed in …

Comparison Of The Transformation Temperatures Of Heat-Activated Nickel-Titanium Orthodontic Archwires By Two Different Techniques, Noor Aminah Obaisi, Maria Therese S. Galang-Boquieren, Carla A. Evans, Tzong Guang Peter Tsay, Grace Viana, David W. Berzins, Spiro Megremis

School of Dentistry Faculty Research and Publications

Objectives

The purpose of this study was to investigate the suitability of the Bend and Free Recovery (BFR) method as a standard test method to determine the transformation temperatures of heat-activated Ni-Ti orthodontic archwires. This was done by determining the transformation temperatures of two brands of heat-activated Ni-Ti orthodontic archwires using the both the BFR method and the standard method of Differential Scanning Calorimetry (DSC). The values obtained from the two methods were compared with each other and to the manufacturer-listed values.

Methods

Forty heat-activated Ni-Ti archwires from both Rocky Mountain Orthodontics (RMO) and Opal Orthodontics (Opal) were tested using …

Wearing Complete Dental Prostheses - Effects On Perioral Morphology, Gregor F. Raschke, Philipp Eberl, Geoffrey A. Thompson, Arndt Guentsch, Andre Peisker, Stefan Schultze-Mosgau, Marta Gomez-Dammeier, Gabriel Djedovic, Ulrich M. Rieger, Florian Beuer

School of Dentistry Faculty Research and Publications

Background: To adequately perform rehabilitation of edentulous patients by a complete removable dental prosthesis (CRDP) is from basic interest to dentists to understand the morphologic changes caused by re-establishment of a physiologic jaw relationship. Anthropometric analyses of standardized frontal view and profile photographs may help elucidate such changes. Material and Methods: Photographs of 31 edentulous patients were compared in relaxed lip closure and after insertion of a CRDP in stable occlusion. 2232 anthropometric distances were raised. Eighteen anthropometric indices reflecting the perioral morphology and its integration in the vertical facial harmony were investigated. Results: The intercanthal – mouth width index …

Longterm Quality Of Life After Oncologic Surgery And Microvascular Free Flap Reconstruction In Patients With Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Arndt Guentsch, Korosh Roshanghias, Francy Eichmann, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Background: Quality of life (QoL) has become increasingly important in cancer treatment. It refers to the patient’s perception of the effects of the disease and therapy, and their impact on daily functioning and general feeling of well being. Material and Methods: In this prospective study, a total of 100 patients treated at our institution, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire and the specific EORTC QLQ-H&N35 module. The questionnaires were distributed to the patients between 12 and 60 months postoperatively. Results: Global QoL score was 58.3 and mean score for functioning scale was 76.7. …

Three-Dimensional Bioprinting Materials With Potential Application In Preprosthetic Surgery, Mina D. Fahmy, Hossein E. Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but …

Removable Partial Dentures Vs Overdentures In Children With Ectodermal Dysplasia: Two Case Reports, Georgios Maroulakos, Ioli I. Artopoulou, Matina V. Angelopoulou, Dimitris Emmanouil

School of Dentistry Faculty Research and Publications

Ectodermal dysplasia (ED) represents a disorder group characterised by abnormal development of the ectodermal derivatives. Removable partial dentures (RPD), complete dentures (CD) or overdentures (OD) are most often the treatment of choice for young affected patients. Prosthetic intervention is of utmost importance in the management of ED patients, as it resolves problems associated with functional, aesthetic, and psychological issues, and improves a patient’s quality of life. However, few studies present the principles and guidelines that can assist in the decision-making process of the most appropriate removable prosthesis. The purpose of this study was to suggest a simple treatment decision-making algorithm …

Mentors And Role Models: Two Approaches For Inspiration, Gary L. Stafford

School of Dentistry Faculty Research and Publications

No abstract provided.

Microfluidic Manipulation Of Core/Shell Nanoparticles For Oral Delivery Of Chemotherapeutics: A New Treatment Approach For Colorectal Cancer, Mohammad Mahdi Hasani-Sadrabadi, Shahrouz Taranejoo, Erfan Dashtimoghadam, Ghasem Bahlakeh, Fatemeh Sadat Majedi, Jules John Vandesarl, Mohsen Janmaleki, Fatemeh Sharifi, Arnaud Bertsch, Kerry Hourigan, Lobat Tayebi, Phillippe Renaud, Karl I. Jacob

School of Dentistry Faculty Research and Publications

A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Outcomes Of Primary Endodontic Therapy Provided By Endodontic Specialists Compared With Other Providers, Jacob Burry, Sheila E. Stover, Fredrick Eichmiller, Pradeep Bhagavatula

School of Dentistry Faculty Research and Publications

Introduction

The objective of this study was to compare the outcomes of initial nonsurgical root canal therapy for different tooth types provided by both endodontists and other providers.

Methods

By using an insurance company database, 487,476 initial nonsurgical root canal therapy procedures were followed from the time of treatment to the presence of an untoward event indicated by Current Dental Terminology codes for retreatment, apical surgery, or extraction. Population demographics were computed for provider type and tooth location. Kaplan-Meier survival estimates were calculated for 1, 5, and 10 years. Hazard ratios for provider type and tooth location were calculated by …

Is Cell Viability Always Directly Related To Corrosion Resistance Of Stainless Steels?, E. Salahinejad, M. Ghaffari, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

It has been frequently reported that cell viability on stainless steels is improved by increasing their corrosion resistance. The question that arises is whether human cell viability is always directly related to corrosion resistance in these biostable alloys. In this work, the microstructure and in vitro corrosion behavior of a new class of medical-grade stainless steels were correlated with adult human mesenchymal stem cell viability. The samples were produced by a powder metallurgy route, consisting of mechanical alloying and liquid-phase sintering with a sintering aid of a eutectic Mn–Si alloy at 1050 °C for 30 and 60 min, leading to …

Acrylic Resin Guide For Locating The Abutment Screw Access Channel Of Cement-Retained Implant Prostheses, Ayman Ahmed, Georgios Maroulakos, Jorge Garaicoa

School of Dentistry Faculty Research and Publications

Abutment screw loosening represents a common and challenging technical complication of cement-retained implant prostheses. This article describes the fabrication of a simple and accurate poly(methyl methacrylate) guide for identifying the location and angulation of the abutment screw access channel of a cement-retained implant prosthesis with a loosened abutment screw.

Identification Of New Drug Candidates Against Borrelia Burgdorferi Using High-Throughput Screening, Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, David Solow-Cordero, K. M. Kim, A. V. Samineni, Mansi B. Parekh, Lobat Tayebi, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of symptoms, such as muscle and joint pain, psychosocial and cognitive difficulties, and generalized fatigue. This condition is referred to as posttreatment Lyme disease syndrome. While there is no evidence for the presence of viable infectious organisms in individuals with posttreatment Lyme disease syndrome, some researchers found surviving Borrelia burgdorferi population in rodents and primates even after antibiotic treatment. …

Effect Of Toothbrushing On Shade And Surface Roughness Of Extrinsically Stained Pressable Ceramics, Lessly Arlette Garza, Geoffrey A. Thompson, Seok-Hwan Cho, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

The effect of toothbrushing on extrinsically stained pressable ceramic materials is unknown.

Purpose

The purpose of this in vitro study was to investigate the effects of toothbrushing on the shade and surface roughness of extrinsically stained, pressable ceramics.

Material and Methods

Two materials, leucite-based (IPS Empress Esthetic [EE]; Ivoclar Vivadent AG) and lithium disilicate-based ceramic (IPS e.max Press [EP]; Ivoclar Vivadent AG), were studied. For each material, 24 disk-shaped specimens, 10 mm (diameter)×3 mm (height) were fabricated. Three different methods (n=8) of applying extrinsic stains were performed on each material: glazed only (G, control group); stained then …

Adam10 Localization In Temporomandibular Joint Disk With Internal Derangement: An Ex Vivo Immunohistochemical Study, Carla Loreto, Giovanni Paolo Salvatore Chiarenza, Giuseppe Musumeci, Paola Castrogiovanni, Rosa Imbesi, Alessandra Ruggeri, Luis Eduardo Almeida, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved from the archives of the University of Catania. Of these 16 had been removed from females and 9 from males; 11 with anterior disk displacement with reduction (ADDwR) and 14 with anterior disk displacement without reduction (ADDwoR). The sections were dehydrated, embedded in paraffin and cut. Then they were incubated in 0.3% H₂O₂/methanol and half of sections from each sample were incubated …

Surface And Cross-Sectional Characterization Of Titanium-Nitride Coated Nickel–Titanium Endodontic Files, Youssef S. Al Jabbari, Theodoros Koutsoukis, Suliman Al Hadlaq, David W. Berzins, Spiros Zinelis

School of Dentistry Faculty Research and Publications

Background/purpose

Although the effect of experimental surface modifications on various properties (e.g., fatigue, wear) on coated files have been tested in the past, there is no report for the coating quality of commercially available TiN coated files. The aim of this study was to characterize the surface and cross section of TiN coated endodontic files.

Materials and methods

TiN coated nickel–titanium endodontic files (EasyShape) were surface and cross-sectionally analyzed via scanning electron microscopy backscattered electron imaging and energy-dispersive X-ray spectroscopy analysis in spot, area, and line scan modes.

Results

Surface imaging revealed parallel oblong regions with higher mean atomic …

Surface And Cross-Sectional Characterization Of Titanium-Nitride Coated Nickel–Titanium Endodontic Files, Youssef S. Al Jabbari, Theodoros Koutsoukis, Suliman Al Hadlaq, David W. Berzins, Spiros Zinelis

School of Dentistry Faculty Research and Publications

Background/purpose

Although the effect of experimental surface modifications on various properties (e.g., fatigue, wear) on coated files have been tested in the past, there is no report for the coating quality of commercially available TiN coated files. The aim of this study was to characterize the surface and cross section of TiN coated endodontic files.

Materials and methods

TiN coated nickel–titanium endodontic files (EasyShape) were surface and cross-sectionally analyzed via scanning electron microscopy backscattered electron imaging and energy-dispersive X-ray spectroscopy analysis in spot, area, and line scan modes.

Results

Surface imaging revealed parallel oblong regions with higher mean atomic contrast, …

Timing Of Fluoride Intake And Dental Fluorosis On Late-Erupting Permanent Teeth, Pradeep Bhagavatula, Steven M. Levy, Barbara Broffitt, Karin Weber-Gasparoni, John J. Warren

School of Dentistry Faculty Research and Publications

Objective: Very few studies have examined the relationship between timing of fluoride intake and development of dental fluorosis on late-erupting permanent teeth using period-specific fluoride intake information. This study examined this relationship using longitudinal fluoride intake information from the Iowa Fluoride Study.

Methods: Participants’ fluoride exposure and intake (birth to 10 years of age) from water, beverages, selected food products, dietary fluoride supplements, and fluoride toothpaste was collected using questionnaires sent to parents at 3- and 4- month intervals from birth to 48 months of age and every 6 months thereafter. Three trained and calibrated examiners used the Fluorosis Risk …

Assessment Formats In Dental Medicine: An Overview, Susanne Gerhard-Szep, Arndt Guentsch, Peter Pospiech, Andreas Söhnel, Petra Scheuzel, Tugba Zahn

School of Dentistry Faculty Research and Publications

Aim: At the annual meeting of German dentists in Frankfurt am Main in 2013, the Working Group for the Advancement of Dental Education (AKWLZ) initiated an interdisciplinary working group to address assessments in dental education. This paper presents an overview of the current work being done by this working group, some of whose members are also actively involved in the German Association for Medical Education's (GMA) working group for dental education. The aim is to present a summary of the current state of research on this topic for all those who participate in the design, administration and evaluation of university-specific …

The Isolated Orbital Floor Fracture From A Transconjunctival Or Subciliary Perspective-A Standardized Anthropometric Evaluation, Gregor F. Raschke, Gabriel Djedovic, Andre Peisker, Rene Wohlrath, Ulrich M. Rieger, Arndt Guentsch, Marta Gomez-Dammeier, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Background: The influence of orbital fractures and their repair on the rate of deformities of the lower eyelid is an ongoing source of discussion in the literature. Most of the present studies include isolated blow-out as well as combined orbital fractures. Material and Methods: We present a retrospective evaluation of a series of 100 patients after isolated blow-out fracture repair using reference anthropometric data on standardized photographs. Analysis included eye fissure width and height, lid sulcus height, upper lid height, upper and lower iris coverage, position of cornea to palpebra inferior, canthal tilt, scleral show, ectropion and entropion. It was …

Treatment Of A Periodontic-Endodontic Lesion In A Patient With Aggressive Periodontitis, Mina D. Fahmy, Paul G. Luepke, Mohamed Ibrahim, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Case Description: This case report describes the successful management of a left mandibular first molar with a combined periodontic-endodontic lesion in a 35-year-old Caucasian woman with aggressive periodontitis using a concerted approach including endodontic treatment, periodontal therapy, and a periodontal regenerative procedure using an enamel matrix derivate. In spite of anticipated poor prognosis, the tooth lesion healed. This case report also discusses the rationale behind different treatment interventions. Practical Implication. Periodontic-endodontic lesions can be successfully treated if dental professionals follow a concerted treatment protocol that integrates endodontic and periodontic specialties. General dentists can be the gatekeepers in managing …

Do The Mechanical And Chemical Properties Of InvisalignTm Appliances Change After Use? A Retrieval Analysis, T. Gerard Bradley, Lauren Teske, George Eliades, Spiros Zinelis, Theodore Eliades

School of Dentistry Faculty Research and Publications

Aim: To investigate the mechanical and chemical alterations of Invisalign appliances after intraoral aging.

Materials and methods: Samples of Invisalign appliances (Align Technology, San Jose, California, USA) were collected following routine treatment for a mean period of 44±15 days (group INV), whereas unused aligners of the same brand were used as reference (group REF). A small sample from the central incisors region was cut from each appliance and the buccal surface was analysed by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy (n = 5). Then the appliances were cut (n = 25) and embedded in acrylic resin, ground/polished …

Clinical Practice Guidelines For Recall And Maintenance Of Patients With Tooth-Borne And Implant-Borne Dental Restorations, Avinash S. Bidra, Diane M. Daubert, Lily T. Garcia, Timothy F. Kosinski, Conrad A. Nenn, John A. Olsen, Jeffrey A. Platt, Susan S. Wingrove, Nancy Deal Chandler, Donald A. Curtis

School of Dentistry Faculty Research and Publications

Purpose

To provide guidelines for patient recall regimen, professional maintenance regimen, and at-home maintenance regimen for patients with tooth-borne and implant-borne removable and fixed restorations.

Materials and Methods

The American College of Prosthodontists (ACP) convened a scientific panel of experts appointed by the ACP, American Dental Association (ADA), Academy of General Dentistry (AGD), and American Dental Hygienists Association (ADHA) who critically evaluated and debated recently published findings from two systematic reviews on this topic. The major outcomes and consequences considered during formulation of the clinical practice guidelines (CPGs) were risk for failure of tooth- and implant-borne restorations. The panel conducted …

Travel Distances By Wisconsin Medicaid Enrollees Who Visit Emergency Departments For Dental Care, Christopher Okunseri, Rabeea Vanevenhoven, Thomas Chelius, Kirsten M.M. Beyer, Elaye Okunseri, William K. Lobb, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objectives: Prior studies document increased numbers of nontraumatic dental condition (NTDC) visits to U.S. emergency departments (EDs). However, the influence of travel distance on ED use for NTDCs, particularly for Medicaid enrollees has hitherto received little attention. The authors examined the effect of travel distance on Wisconsin Medicaid enrollees’ NTDC visits to EDs after adjustment for covariates.

Methods: NTDC-related visits claims data for Wisconsin Medicaid (2001-2009) was analyzed. For each enrollee, travel distance to the nearest of 130 EDs in Wisconsin was determined. The number of NTDC visits per person-year was aggregated by ZIP+4 of residence. Negative binomial regression adjusting …

A Systematic Review Of Recall Regimen And Maintenance Regimen Of Patients With Dental Restorations. Part 1: Tooth-Borne Restorations, Avinash S. Bidra, Diane M. Daubert, Lily T. Garcia, Marissa F. Gauthier, Timothy F. Kosinski, Conrad A. Nenn, John A. Olsen, Jeffrey A. Platt, Susan S. Wingrove, Nancy Deal Chandler, Donald A. Curtis

School of Dentistry Faculty Research and Publications

Purpose

To evaluate the current scientific evidence on patient recall and maintenance of dental restorations on natural teeth, standardize patient care regimens, and improve maintenance of oral health. An additional purpose was to examine areas of deficiency in the current scientific literature and provide recommendations for future studies.

Materials and Methods

An electronic search for articles in the English language literature from the past 15 years was performed independently by multiple investigators using a systematic search process. After application of predetermined inclusion and exclusion criteria, the final list of articles was reviewed in depth to meet the objectives of this …

A Systematic Review Of Recall Regimen And Maintenance Regimen Of Patients With Dental Restorations. Part 2: Implant-Borne Restorations, Avinash S. Bidra, Diane M. Daubert, Lily T. Garcia, Marissa F. Gauthier, Timothy F. Kosinski, Conrad A. Nenn, John A. Olsen, Jeffrey A. Platt, Susan S. Wingrove, Nancy Deal Chandler, Donald A. Curtis

School of Dentistry Faculty Research and Publications

Purpose

To evaluate the current scientific evidence on patient recall and maintenance of implant-supported restorations, to standardize patient care regimens and improve maintenance of oral health. An additional purpose was to examine areas of deficiency in the current scientific literature and provide recommendations for future studies.

Materials and Methods

An electronic search for articles in the English language literature from the past 10 years was performed independently by multiple investigators using a systematic search process. After application of predetermined inclusion and exclusion criteria, the final list of articles was reviewed to meet the objectives of this review.

Results

The initial …

Transdermal Delivery Of Functional Collagen Via Polyvinylpyrrolidone Microneedles, Wenchao Sun, Mohammed Inayathullah, Martin A. C. Manoukian, Andrey V. Malkovskiy, Sathish Manickam, M. Peter Marinkovich, Alfred T. Lane, Lobat Tayebi, Alexander M. Seifalian, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence …