Dentistry Commons^™

Interleukin-6 Expression In Disc Derangement Of Human Temporomandibular Joint And Association With Osteoarthrosis, Flavio Camejo, Marina Azevedo, Viviane Ambros, Karina Caporal, Andrea Doetzer, Luis Eduardo Almeida, Marcia Olandoski, Lucia Noronha, Paula C. Trevilatto

School of Dentistry Faculty Research and Publications

The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n = 38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n …

From Solvent-Free Microspheres To Bioactive Gradient Scaffolds, Morta Rasoulianboroujeni, Mostafa Yazdimamaghani, Payam Khoshkenar, Venkata Raveendra Pothineni, Kwang-Min Kim, Teresa A. Murray, Jayakumar Rajadas, David K. Mills, Daryoosh Vashaee, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A solvent-free microsphere sintering technique was developed to fabricate scaffolds with pore size gradient for tissue engineering applications. Poly(D,L-Lactide) microspheres were fabricated through an emulsification method where TiO₂ nanoparticles were employed both as particulate emulsifier in the preparation procedure and as surface modification agent to improve bioactivity of the scaffolds. A fine-tunable pore size gradient was achieved with a pore volume of 30 ± 2.6%. SEM, EDX, XRD and FTIR analyses all confirmed the formation of bone-like apatite at the 14^th day of immersion in Simulated Body Fluid (SBF) implying the ability of our scaffolds to bond to …

Predoctoral Dental Students’ Perceptions Of Dental Implant Training: Effect Of Preclinical Simulation And Clinical Experience, Soni Prasad, Naveen K. Bansal

School of Dentistry Faculty Research and Publications

The aims of this study were to assess 1) differences in perceptions of dental implant training between dental students who received didactic training alone (control group) and those who received didactic plus simulation training (test group); 2) differences in response between students with and without clinical experience in implant dentistry; and 3) the interaction effect of simulation training and clinical experience on students’ satisfaction. A survey was distributed to the control group in 2014 and to the test group in 2015; both groups were at the same U.S. dental school. Data were collected on confidence levels with various implant restorative …

Correlation Between Subjective Nasal Patency And Intranasal Airflow Distribution, Kevin P. Casey, Azadeh A.T, Borojeni, Lisa J. Koenig, John S. Rhee, Guilherme J.M. Garcia

School of Dentistry Faculty Research and Publications

Objectives

(1) Analyze the relationship between intranasal airflow distribution and subjective nasal patency in healthy and nasal airway obstruction (NAO) cohorts using computational fluid dynamics (CFD). (2) Determine whether intranasal airflow distribution is an important objective measure of airflow sensation that should be considered in future NAO virtual surgery planning.

Study Design

Cross-sectional.

Setting

Academic tertiary medical center and academic dental clinic.

Subjects and Methods

Three-dimensional models of nasal anatomy were created based on computed tomography scans of 15 patients with NAO and 15 healthy subjects and used to run CFD simulations of nasal airflow and mucosal cooling. Subjective nasal …

Screening Of Nci-Dtp Library To Identify New Drug Candidates For Borrelia Burgdorferi, Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, R. Edward Watts, Kwang-Min Kim, Mansi B. Parekh, Abhijit Achyut Gurjarpadhye, David Solow-Cordero, Lobat Tayebi, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Lyme disease is the most rapidly growing tick borne zoonotic disease of the Northern Hemisphere and is among the 10 most commonly reported nationally notifiable diseases in the United States.¹ Clinical presentations include erythema migrans, fever, chills, muscle and joint pain.^{2, 3} Though these symptoms tend to fade away even without therapeutic intervention, a significant number of untreated patients develop arthritis and persistent myalgia following exposure to Borrelia burgdorferi.⁴ Furthermore, 10–20% of patients treated for Lyme disease develop symptoms considered typical, or even exaggerated, including muscle, joint pain and generalized fatigue^{5, 6}. This condition is …

A Novel Electrochemical Biosensor Based On Fe3o4 Nanoparticles-Polyvinyl Alcohol Composite For Sensitive Detection Of Glucose, Niuosha Sanaeifar, Mohammad Rabiee, Mojgan Abdolrahim, Mohammadreza Tahriri, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this research, a new electrochemical biosensor was constructed for the glucose detection. Iron oxide nanoparticles (Fe₃O₄) were synthesized through co-precipitation method. Polyvinyl alcohol-Fe₃O₄ nanocomposite was prepared by dispersing synthesized nanoparticles in the polyvinyl alcohol (PVA) solution. Glucose oxidase (GOx) was immobilized on the PVA-Fe₃O₄ nanocomposite via physical adsorption. The mixture of PVA, Fe₃O₄ nanoparticles and GOx was drop cast on a tin (Sn) electrode surface (GOx/PVA-Fe₃O₄/Sn). The Fe₃O₄ nanoparticles were characterized by X-ray diffraction (XRD). Also, Fourier transform infrared …

Porous Magnesium-Based Scaffolds For Tissue Engineering, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R. Boccaccini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments. They are often used to replace and regenerate the damaged bones or to provide structural support …

Oral Melanoma: Relevance To The Dental Team Members, Yeshwant B. Rawal, Thomas B. Dodson, Harbinder S. Bal

School of Dentistry Faculty Research and Publications

Background and Overview

Oral melanomas vary in color and morphology and resemble myriad other reactive, benign, or malignant conditions. The authors describe a case report of a patient with a primary oral melanoma that presented as a nonspecific ulcer, which showed nodal metastasis during resection.

Case Description

A 64-year-old man who was examined by his periodontist to assess implant healing had a reddish-purple ulcer of the maxillary mucosa of 3 to 4 weeks duration. The implant was placed 19 weeks earlier in the mandible. The provisional diagnosis was that this ulcer was a traumatic or inflammatory lesion. The clinician biopsied …

A Current Overview Of Materials And Strategies For Potential Use In Maxillofacial Tissue Regeneration, Hossein E. Jazayeri, Mohammadreza Tahriri, Mehdi Razavi, Kimia Khoshroo, Farahnaz Fahimipour, Erfan Dashtimoghadam, Luis Eduardo Almeida, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Tissue regeneration is rapidly evolving to treat anomalies in the entire human body. The production of biodegradable, customizable scaffolds to achieve this clinical aim is dependent on the interdisciplinary collaboration among clinicians, bioengineers and materials scientists. While bone grafts and varying reconstructive procedures have been traditionally used for maxillofacial defects, the goal of this review is to provide insight on all materials involved in the progressing utilization of the tissue engineering approach to yield successful treatment outcomes for both hard and soft tissues. In vitro and in vivo studies that have demonstrated the restoration of bone and cartilage tissue with …

Development Of 3d Pcl Microsphere/Tio2 Nanotube Composite Scaffolds For Bone Tissue Engineering, Kimia Khoshroo, Tahereh S. Jafarzadeh Kashi, Fathollah Moztarzadeh, Mohammadreza Tahriri, Hossein E. Jazayeri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this research, the three dimensional porous scaffolds made of a polycaprolactone (PCL) microsphere/TiO₂ nanotube (TNT) composite was fabricated and evaluated for potential bone substitute applications. We used a microsphere sintering method to produce three dimensional PCL microsphere/TNT composite scaffolds. The mechanical properties of composite scaffolds were regulated by varying parameters, such as sintering time, microsphere diameter range size and PCL/TNT ratio. The obtained results ascertained that the PCL/TNT (0.5 wt%) scaffold sintered at 60 °C for 90 min had the most optimal mechanical properties and an appropriate pore structure for bone tissue engineering applications. The average pore size …

Complete Mouth Rehabilitation And Gastroesophageal Reflux Disease: Conventional And Contemporary Treatment Approaches, Vasilios Chronopoulos, Georgios Maroulakos, Konstantinos Tsoutis, Panagiota Stathopoulou, William W. Nagy

School of Dentistry Faculty Research and Publications

This report describes the diagnosis and prosthodontic management of 2 patients with a history of chronic gastroesophageal reflux disease and worn dentition. Different treatment approaches were used for oral rehabilitation. Use of conventional and contemporary restorative materials resulted in functional and esthetic prosthodontic rehabilitation with a favorable prognosis.

Gastroesophageal reflux disease (GERD) is a “condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications." Reflux episodes can be intensified by dietary habits, smoking, physical exercise, and obstructive sleep apnea.Complications of GERD are regurgitation, chest pain, esophagitis, Barrett’s esophagus, esophageal adenocarcinoma, cough, asthma, and dental erosion.GERD is …

Viscoelastic Properties Of Orthodontic Adhesives Used For Lingual Fixed Retainer Bonding, Demetrios P. Papadogiannis, A. Iliadi, T. Gerard Bradley, N. Silikas, George Eliades, T. Eliades

School of Dentistry Faculty Research and Publications

Objective

To evaluate the viscoelastic properties of two experimental BPA-free and one BisGMA-based orthodontic resin composite adhesives for bonding fixed retainers.

Methods

A commercially available BisGMA-based (TXA: Transbond LR) and two bisphenol A-free experimental adhesives (EXA and EXB) were included in the study. The viscoelastic behavior of the adhesives was evaluated under static and dynamic conditions at dry and wet states and at various temperatures (21, 37, 50 °C). The parameters determined were shear modulus (G), Young’s modulus (E) under static testing and storage modulus (G₁), loss tangent (tan δ) and dynamic viscosity (n*) under …

Cranio-Maxillofacial Reconstruction With Microvascular Radialis Flaps—Parameters And Correlations Of Postoperative Pain Management, Gregor F. Raschke, Winfried Meissner, Andre Peisker, Gabriel Djedovic, Ulrich M. Rieger, Arndt Guentsch, Daria Porwit, Marta Gomez-Dammeier, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Objectives

Postoperative pain management is of highest interest for patients undergoing maxillofacial surgery including microvascular reconstructive surgery. Currently, there is a lack of information regarding process and outcome of postoperative pain management after microvascular reconstruction.

Materials and methods

In a prospective clinical study, 31 adults were evaluated on the first postoperative day following microvascular reconstruction with a radial forearm flap using the standardized questionnaire of the Germany-wide project Quality Improvement in Postoperative Pain Management (QUIPS). It enables a standardized assessment of patients’ characteristics, pain parameters, outcome and pain therapy process parameters.

Results

Pain management consisted predominately of premedication with midazolam, …

Evaluation Of A Post-Treatment Follow-Up Program In Patients With Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Arndt Guentsch, Paul Luepke, Korosh Roshanghias, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Objectives

The duration and the frequency of follow-up after treatment of oral squamous cell carcinoma are not standardized in the current literature. The purpose of this study was to evaluate our local standard post-treatment and follow-up protocol.

Materials and methods

Overall, 228 patients treated curatively from 01/2006 to 07/2013 were reviewed. To evaluate the follow-up program, data on the secondary event were used. To determine risk groups, all patients with tumor recurrence were specifically analyzed. Relapse-free rate were estimated by the Kaplan-Meier product limit method. The chi-square test was used to identify independent risk factors for tumor relapse.

Results

In …

Optimizing Anterior Implant Outcome Immediately After Implant Placement And Grafting By Using Patient’S Extracted Teeth: A Case Report, Soni Prasad, Jay Darryl Banez, Despoina Bompolaki, Yvonne Hart

School of Dentistry Faculty Research and Publications

Optimizing anterior implant outcome using patient’s extracted teeth.

Successful implant treatment in the anterior maxilla is predicated on providing a functional and esthetically acceptable outcome. As well, achieving a predictable ideal emergence profile and soft tissue contour is expected. Placing immediate provisional restorations utilizing the patient’s modified extracted teeth can facilitate initiate facial soft tissue contouring while precluding undue pressure on the surgical site during the early healing phase. This allows for a one stage surgical procedure, fixed provisionalization and ideal tissue contouring.

This clinical report presents the use of a patient’s modified extracted permanent teeth as bonded fixed provisional …

Dental Impressions: The Digital Alternative, Gary L. Stafford

School of Dentistry Faculty Research and Publications

No abstract provided.

Immunohistochemical Analysis Of Il-1 Beta In The Discs Of Patients With Temporomandibular Joint Dysfunction, Luis Eduardo Almeida, Sean Pierce, Joseph Zacharias, William E. Cullinan, Lucia Noronha, Marcia Olandoski, Vinicius Tramontina, Carla Loreto, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

Purpose: Interleukin-1 beta (IL-1β) is a cytokine that participates in the regulation of immune responses and inflammatory reactions. It is hypothesized that IL-1 levels may be elevated in patients suffering from temporomandibular joint dysfunction. The purpose of this study was to determine the association of IL-1β expression with TMD using an immunohistochemical approach to evaluate the joint disc.

Materials and methods: A total of 39 human temporomandibular joint disc samples were collected, with 31 samples in the test group. Nineteen of the test group samples were from discs of patients with anterior disc displacement with reduction, and 12 …

Oral Examination, Alessandro Villa, Michael J. Wells, Drore Eisen, Jeff Burgess, James J. Nordlund, Denis P. Lynch, Gary L. Stafford

School of Dentistry Faculty Research and Publications

The oral cavity is the first component of the digestive tract, which is delimited by the lips anteriorly and the oropharynx posteriorly. The oral cavity functions as a protective barrier and is an essential component for speech and swallowing, mastication, digestion, and taste sensation.

The oral examination comprises a uniform and consistent inspection of the head and neck and an intraoral evaluation of the hard and soft tissues (see the images below) in conjunction with a thorough medical and dental history. The entire mouth should be inspected regardless of the patient’s chief complaint and reasons for the visit. ^{[1 …}

Expression Of Mmp-13 In Human Temporomandibular Joint Disc Derangement And Osteoarthritis, Juliano Henrique Perotto, Flavio Camejo, Andrea Doetzer, Luis Eduardo Almeida, Marina Azevedo, Marcia Olandoski

School of Dentistry Faculty Research and Publications

Objective: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis.

Methods: Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups.

Results: There was no statistically significant difference for the …

The Relationships Between Fluoride Intake Levels And Fluorosis Of Late‐Erupting Permanent Teeth, Pradeep Bhagavatula, Alexandra Curtis, Barbara Broffitt, Karin Weber-Gasparoni, John J. Warren, Steven M. Levy

School of Dentistry Faculty Research and Publications

Objectives

To examine the relationships between fluoride intake levels and fluorosis of late‐erupting permanent teeth.

Methods

The current study used information collected from 437 children in the longitudinal Iowa Fluoride Study. Participants' fluoride intake information was collected using questionnaires from birth to age 10 years. Estimated mean daily fluoride intake was categorized into low, moderate, and high intake tertiles for each age interval (2‐5, 5‐8, and 2‐8 years). Bivariate analyses were performed to study the relationships between self‐reported fluoride intake levels during three age intervals and dental fluorosis.

Results

For canines and second molars, the prevalence of mostly mild fluorosis …

Expression Of Interleukin-1 And Temporomandibular Disorder: Contemporary Review Of The Literature, Adam Sorenson, Kyle Hresko, Seth Butcher, Sean Pierce, Vinícius Augusto Tramontina, Rosalia Leonardi, Carla Loreto, Jose A. Bosio, Luis Eduardo Almeida

School of Dentistry Faculty Research and Publications

Objective: Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1.

Methods: A literature search (2006–2016) to identify eligible studies was completed …

Evaluation Of Glycated Albumin (Ga) And Ga/Hba1c Ratio For Diagnosis Of Diabetes And Glycemic Control: A Comprehensive Review, Sara Yazdanpanah, Mohammad Rabiee, Mohammadreza Tahriri, Mojgan Abdolrahim, Asodollah Rajab, Hossein E. Jazayeri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and non-ketotic hyperosmolar coma. In addition, possible long-term complications include impotence, nerve damage, stroke, chronic kidney failure, cardiovascular disease, foot ulcers, and retinopathy. Historically, universal methods to measure glycemic control for the diagnosis of diabetes included fasting plasma glucose level (FPG), 2-h plasma glucose (2HP), and random plasma glucose. However, these measurements did not provide information about glycemic control over a long period of time. To …

Digital Holographic Microscopy Of Phase Separation In Multicomponent Lipid Membranes, Vahideh Farzam Rad, Ali-Reza Moradi, Ahmad Darudi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Lateral in-homogeneities in lipid compositions cause microdomains formation and change in the physical properties of biological membranes. With the presence of cholesterol and mixed species of lipids, phospholipid membranes segregate into lateral domains of liquid-ordered and liquid-disordered phases. Coupling of two-dimensional intralayer phase separations and interlayer liquid-crystalline ordering in multicomponent membranes has been previously demonstrated. By the use of digital holographic microscopy (DHMicroscopy), we quantitatively analyzed the volumetric dynamical behavior of such membranes. The specimens are lipid mixtures composed of sphingomyelin, cholesterol, and unsaturated phospholipid, 1,2-dioleoyl-sn-glycero-3-phosphocholine. DHMicroscopy in a transmission mode is an effective tool for quantitative visualization of phase …

Impact Of Wisconsin Medicaid Policy Change On Dental Sealant Utilization, Christopher Okunseri, Elaye Okunseri, Raul I. Garcia, Cesar Gonzales, Alexis Vistocky, Aniko Szabo

School of Dentistry Faculty Research and Publications

Background

In September 2006, Wisconsin Medicaid changed its policy to allow nondentists to become certified Medicaid providers and to bill for sealants in public health settings.

Objective

This study examined changes in patterns of dental sealant utilization in first molars of Wisconsin Medicaid enrollees associated with a policy change.

Data Source

The Electronic Data Systems of Medicaid Evaluation and Decision Support for Wisconsin from 2001 to 2009.

Study Design

Retrospective claims data analysis of Wisconsin Dental Medicaid for children aged 6-16 years.

Principal Findings

A total of 479,847 children followed up for 1,441,300 person-years with 64,546 visits were analyzed. The …

Differences In Utilization Of Dental Procedures By Children Enrolled In Wisconsin Medicaid And Delta Dental Insurance Plans, Pradeep Bhagavatula, Qun Xiang, Aniko Szabo, Fredrick Eichmiller, Christopher Okunseri

School of Dentistry Faculty Research and Publications

Background

Few studies have directly compared dental procedures provided in public and private insurance plans for enrollees living in dental health professional shortage areas (DHPSAs). We examined the rates for the different types of dental procedures received by 0–18-year-old children living in DHPSAs and non-DHPSAs who were enrolled in Medicaid and those enrolled under Delta Dental of Wisconsin (DDW) for years 2002 to 2008.

Methods

Medicaid and DDW dental claims data for 2002 to 2008 was analyzed. Enrollees were divided into DDW-DHPSA and non-DHPSA and Medicaid-DHPSA and non-DHPSA groups. Descriptive and multivariable analyses using over-dispersed Poisson regression were performed to …

Development Of Plga-Coated Β-Tcp Scaffolds Containing Vegf For Bone Tissue Engineering, Arash Khojasteh, Farahnaz Fahimipour, Mohamadreza Baghaban Eslaminejad, Mohammad Jafarian, Shahrbanoo Jahangir, Farshid Bastami, Mohammadreza Tahriri, Akbar Karkhaneh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Bone tissue engineering is sought to apply strategies for bone defects healing without limitations and short-comings of using either bone autografts or allografts and xenografts. The aim of this study was to fabricate a thin layer poly(lactic-co-glycolic) acid (PLGA) coated beta-tricalcium phosphate (β-TCP) scaffold with sustained release of vascular endothelial growth factor (VEGF). PLGA coating increased compressive strength of the β-TCP scaffolds significantly. For in vitro evaluations, canine mesenchymal stem cells (cMSCs) and canine endothelial progenitor cells (cEPCs) were isolated and characterized. Cell proliferation and attachment were demonstrated and the rate of cells proliferation on the VEGF released scaffold was …

Short Implants Had Lower Survival Rates In Posterior Jaws Compared To Standard Implants, Gary L. Stafford

School of Dentistry Faculty Research and Publications

Data sources

PubMed/Medline, Embase and Cochrane Library databases supplemented by searches of the journals; Clinical Implant Dentistry and Related Research, Clinical Oral Implants Research, International Journal of Oral and Maxillofacial Implants, International Journal of Oral and Maxillofacial Surgery, Journal of Clinical Periodontology, Journal of Dentistry, Journal of Oral and Maxillofacial Surgery, Journal of Oral Implantology, Journal of Oral Rehabilitation, Journal of Periodontology, Periodontology 2000.

Study selection

Randomised controlled trials (RCTs) and prospective studies with at least ten patients, published in the last ten years that compared short and standard implants and published in English were considered.

Data extraction and …

Efficacy Of The Biomaterials 3 Wt%-Nanostrontium-Hydroxyapatite-Enhanced Calcium Phosphate Cement (Nanosr-Cpc) And Nanosr-Cpc-Incorporated Simvastatin-Loaded Poly(Lactic-Co-Glycolic-Acid) Microspheres In Osteogenesis Improvement, Reza Masaeli, Tahereh S. Jafarzadeh Kashi, Rassoul Dinarvand, Vahid Rakhshan, Hossein Shahoon, Behzad Hooshmand, Fatemeh Mashhadi Abbas, Majid Raz, Alireza Rajabnejad, Hossein Eslami, Kimia Khoshroo, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Aims

The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2) creating a simvastatin-loaded poly(lactic-co-glycolic acid) (SIM-loaded PLGA) microspheres plus CPC composite (SIM-loaded PLGA + nanostrontium-CPC). The third goal was the extensive assessment of multiple in vitro and in vivo characteristics of the above experimental explorative products in vitro and in vivo (animal and surgical studies).

Methods and results pertaining to Sr-HA/CPC

Physical and chemical properties of the prepared Sr-HA/CPC were evaluated. MTT assay and …

Recent Advancements In Regenerative Dentistry: A Review, Pouya Amrollahi, Brinda Shah, Amir Seifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Although human mouth benefits from remarkable mechanical properties, it is very susceptible to traumatic damages, exposure to microbial attacks, and congenital maladies. Since the human dentition plays a crucial role in mastication, phonation and esthetics, finding promising and more efficient strategies to reestablish its functionality in the event of disruption has been important. Dating back to antiquity, conventional dentistry has been offering evacuation, restoration, and replacement of the diseased dental tissue. However, due to the limited ability and short lifespan of traditional restorative solutions, scientists have taken advantage of current advancements in medicine to create better solutions for the oral …

Lubricin In Synovial Fluid Of Mild And Severe Temporomandibular Joint Internal Derangements, Rosalia Leonardi, Rosario E. Perrotta, Luis Eduardo Almeida, Carla Loreto, Giuseppe Musumeci

School of Dentistry Faculty Research and Publications

Background: To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). Material and Methods: A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system. Results: The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage …