Heterocyclic Compounds Commons^™

Visible Light Kinetics Of N-Heterocyclic Carbenes As Additives For Native Chemical Ligation, Hannah M. Werle, Kaitlyn S. Marley, John P. Morgan

SURF Posters 2026

Spectroscopic data have been obtained demonstrating that N-heterocyclic carbenes are effective catalysts for linking shorter peptides to form longer ones, a reaction known as “native chemical ligation” (NCL).  This reaction is key to the preparation of GLP-1 agonists, such as Zepbound®, Ozempic®, and Wegovy®, which are currently undergoing an explosion in popularity due to their treatment of diabetes, obesity, and cardiac issues.  To assess which catalysts are faster, the kinetics model developed by Raines et al., involving the reaction of N-acetylphenylalanine p-nitrophenylthioester and L-cysteine, is being utilized. This published model allows for easy monitoring of the rate of reaction for …