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Articles 1 - 3 of 3
Full-Text Articles in Enzymes and Coenzymes
Computationally Assessing The Specificity Of Receptor Tyrosine Kinase Inhibitors, Htoo Say
Computationally Assessing The Specificity Of Receptor Tyrosine Kinase Inhibitors, Htoo Say
Theses/Capstones/Creative Projects
Receptor tyrosine kinases (RTKs) are vital to cell signaling processes such as growth, survival, and differentiation. Dysregulation through mutation or overexpression often contributes to cancer, making RTKs key therapeutic targets for tyrosine kinase inhibitors (TKIs). However, the low specificity of many TKIs leads to off-target effects. This project uses molecular docking to evaluate the binding affinities and selectivity of FDA-approved TKIs across 18 RTK subtypes. The dockings conducted revealed significant variability in binding affinities, with Sorafenib exhibiting strong specificity for EphB2 (-7.6 kcal/mol) and poor compatibility with EphA7 and ErbB4 (-3.0 kcal/mol). These findings underscore the role of specific molecular …
Identification And Characterization Of Butyrate-Producing Species In The Human Gut Microbiome, Grace Maline
Identification And Characterization Of Butyrate-Producing Species In The Human Gut Microbiome, Grace Maline
Theses/Capstones/Creative Projects
Inflammatory Bowel Diseases (IBD) including ulcerative colitis, indeterminate colitis, and Crohn’s disease are increasingly common conditions that places a high physical and financial burden on individuals and global healthcare systems. Though many treatments exist for these conditions, their unpredictable nature and causation make them difficult to manage across the variety of IBD patients. Additionally, many of these treatments come with undesirable side effects or modes of delivery. Therefore, it is worthwhile to explore the use of Short Chain Fatty Acids (SCFAs) such as butyrate whose affects in the human gut include decreased inflammation and decreased risk of colorectal cancer. As …
Remotely Controlled Enzyme Behavior Using Localized Thermal Gradients, Sarah Brown
Remotely Controlled Enzyme Behavior Using Localized Thermal Gradients, Sarah Brown
UNO Student Research and Creative Activity Fair
No existing model describes an identified special case of enzyme behavior when directly stimulated with thermal energy via an RF field.
The ability to remotely influence cellular functions and outcomes is a new approach to targeted medicine. Nano-medicine and biotechnology are the future of medical diagnostics and treatment. The ability to remotely influence cellular functions and outcomes is a new approach to targeted medicine. Direct heating of an enzyme vs bulk heating changes the enzyme activity.
I tested how direct transfer of thermal energy changes rates of enzyme reactions. We created samples of enzymes, attached to ferrous (magnetic) nano-particles, and …