Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (17)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (15)
- Medical Sciences (10)
- Medical Specialties (9)
- Therapeutics (9)
-
- Medical Pharmacology (6)
- Public Health (6)
- Psychiatry and Psychology (5)
- Surgical Procedures, Operative (5)
- Amino Acids, Peptides, and Proteins (4)
- Musculoskeletal Diseases (4)
- Pathological Conditions, Signs and Symptoms (4)
- Mental Disorders (3)
- Neurology (3)
- Pediatrics (3)
- Anatomy (2)
- Behavior and Behavior Mechanisms (2)
- Cardiovascular Diseases (2)
- Cells (2)
- Health Services Administration (2)
- Medical Genetics (2)
- Neoplasms (2)
- Nervous System Diseases (2)
- Organic Chemicals (2)
- Orthopedics (2)
- Skin and Connective Tissue Diseases (2)
- Surgery (2)
- Keyword
-
- Cannabis (2)
- Pain (2)
- Total knee arthroplasty (2)
- Weight loss (2)
- ASK1 (1)
-
- Ace inhibitors (1)
- Adolescentadverse drug reactionarticlecerebral palsychildclinical practicecomplicationdisabilityfemalegoal attainmentGross Motor Function Classification Systemgroups by agehumanincidencemajor clinical studymalemulticenter studyobservational studyphase 4 clinical trialside effectspasticitybotulinum toxin (1)
- Adrenal (1)
- Alcohol (1)
- Allopurinol (1)
- Alpha-2 agonist (1)
- Amygdala (1)
- Analgesia (1)
- Analgesics (1)
- Angiotensin converting enzyme inhibitors (1)
- Anti-epileptic (1)
- Anti-microbial drugs (1)
- Anticoagulation (1)
- Antidepressant (1)
- Antiepileptic drug (1)
- Antioxidant activity (1)
- Antioxidants (1)
- Antiseizure medication (1)
- Arthroplasty (1)
- Assembly methods (1)
- Atopic dermatitis (1)
- Attention deficit hyperactivity disorder (ADHD) (1)
- BlaKPC (1)
- Calcineurin inhibitors (1)
- Calcium (1)
Articles 31 - 31 of 31
Full-Text Articles in Chemical Actions and Uses
Efficacy And Safety Of Abobotulinumtoxina For Upper Limb Spasticity In Children With Cerebral Palsy: A Randomized Repeat-Treatment Study, Mauricio R. Delgado, Ann Tilton, Jorge Carranzo-Del Rio, Nigar Dursun, Marcin Bonikowski, Resa Aydin, Iwona Maciag-Tymecka, Joyce Oleszek, Edward Dabrowski, Anne-Sophie Grandoulier, Philippe Picaut, The Dysport In Pul Study Group
Efficacy And Safety Of Abobotulinumtoxina For Upper Limb Spasticity In Children With Cerebral Palsy: A Randomized Repeat-Treatment Study, Mauricio R. Delgado, Ann Tilton, Jorge Carranzo-Del Rio, Nigar Dursun, Marcin Bonikowski, Resa Aydin, Iwona Maciag-Tymecka, Joyce Oleszek, Edward Dabrowski, Anne-Sophie Grandoulier, Philippe Picaut, The Dysport In Pul Study Group
School of Medicine Faculty Publications
Aim: To assess the efficacy and safety of repeat abobotulinumtoxinA injections in reducing upper limb spasticity in children with cerebral palsy (CP). Method: This was a double-blind, repeat-cycle study (NCT02106351) in children with CP (2–17y). Children were randomized to receive 2U/kg (control), 8U/kg, or 16U/kg abobotulinumtoxinA injections into the target muscle group (wrist or elbow flexors) and additional muscles alongside occupational therapy via a home-exercise therapy program (HETP; minimum five 15min sessions/wk). Children received 8U/kg or 16U/kg plus HETP in cycles 2 to 4. Results: During cycle 1, 210 children (126 males, 84 females; mean age [SD] 9y [4y 5mo], …