Chemical Actions and Uses Commons^™

Theaflavin-3, 3'-Digallate Decreases Human Ovarian Carcinoma Ovcar-3 Cell-Induced Angiogenesis Via Akt And Notch-1 Pathways, Not Via Mapk Pathways, Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen

Biochemistry and Microbiology

Theaflavin-3, 3'-digallate (TF3) is a black tea polyphenol produced from polymerization and oxidization of the green tea ployphenols epicatechin gallate and (-)-epigallocatechin-3-gallate (EGCG) during fermentation of fresh tea leaves. TF3 has been reported to have anticancer properties. However, the effect of TF3 on tumor angiogenesis and the underlying mechanisms are not clear. In the present study, TF3 was verified to inhibit tumor angiogenesis. Compared with EGCG, TF3 was more potent. TF3 inhibited human ovarian carcinoma OVCAR-3 cell-induced angiogenesis in human umbilical vein endothelial cell model and in chick chorioallantoic membrane model. TF3 reduced tumor angiogenesis by downregulating HIF-1α and VEGF. …

Drug Of Choice As A Predictor Of Program Completion In A 12-Week Intensive Outpatient Program And Continuing Care Program, James R. Myers

Theses, Dissertations and Capstones

This study consisted of a one year examination of a twelve week Intensive Outpatient Program (IOP), followed by continuing care treatment, coupled with required attendance to a Twelve Step AA/NA Program. This study detailed the treatment plan available at a local Intensive Outpatient Program in Southern West Virginia. A sample, separating alcoholics from other substance abusers to obtain an estimated completion rate was used.

Tills thesis comprised a one-year history of subjects (6/30/98 -07/01/99). A total of 84 subjects entered into the Intensive Outpatient Program (IOP) within the above time frame. Determination of completion rates was based on a categorical …