Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (20)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (16)
- Medical Sciences (13)
- Medical Specialties (11)
- Therapeutics (10)
-
- Amino Acids, Peptides, and Proteins (6)
- Medical Pharmacology (6)
- Public Health (6)
- Neoplasms (5)
- Psychiatry and Psychology (5)
- Surgical Procedures, Operative (5)
- Musculoskeletal Diseases (4)
- Pathological Conditions, Signs and Symptoms (4)
- Biological Phenomena, Cell Phenomena, and Immunity (3)
- Mental Disorders (3)
- Neurology (3)
- Oncology (3)
- Pediatrics (3)
- Anatomy (2)
- Behavior and Behavior Mechanisms (2)
- Cardiovascular Diseases (2)
- Cells (2)
- Health Services Administration (2)
- Medical Genetics (2)
- Nervous System Diseases (2)
- Nutritional and Metabolic Diseases (2)
- Organic Chemicals (2)
- Keyword
-
- Cannabis (2)
- Pain (2)
- Total knee arthroplasty (2)
- Tumor microenvironment (2)
- Weight loss (2)
-
- ASK1 (1)
- Ace inhibitors (1)
- Adolescentadverse drug reactionarticlecerebral palsychildclinical practicecomplicationdisabilityfemalegoal attainmentGross Motor Function Classification Systemgroups by agehumanincidencemajor clinical studymalemulticenter studyobservational studyphase 4 clinical trialside effectspasticitybotulinum toxin (1)
- Adrenal (1)
- Alcohol (1)
- Allopurinol (1)
- Alpha-2 agonist (1)
- Amygdala (1)
- Analgesia (1)
- Analgesics (1)
- Angiotensin converting enzyme inhibitors (1)
- Anti-epileptic (1)
- Anti-microbial drugs (1)
- Anticoagulation (1)
- Antidepressant (1)
- Antiepileptic drug (1)
- Antioxidant activity (1)
- Antioxidants (1)
- Antiseizure medication (1)
- Arthroplasty (1)
- Assembly methods (1)
- Atopic dermatitis (1)
- Attention deficit hyperactivity disorder (ADHD) (1)
- BlaKPC (1)
- Calcineurin inhibitors (1)
Articles 31 - 34 of 34
Full-Text Articles in Chemical Actions and Uses
H2s, Sg-1002, Protects Against Myocardial Oxidative Damage And Hypertrophy In Vitro Via Induction Of Cystathionine Β-Synthase And Antioxidant Proteins, Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam
H2s, Sg-1002, Protects Against Myocardial Oxidative Damage And Hypertrophy In Vitro Via Induction Of Cystathionine Β-Synthase And Antioxidant Proteins, Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam
School of Medicine Faculty Publications
Endogenously produced hydrogen sulfide (H2S) is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H2S levels have proven cardioprotective in models of acute myocardial infarction (MI) and heart failure (HF). The present study was undertaken to investigate the effects of a novel H2S prodrug, SG-1002, on stress induced hypertrophic signaling in murine HL-1 cardiac muscle cells. Treatment of HL-1 cells with SG-1002 under serum starvation without or with H2O2 increased the levels of H2S, H2S producing enzyme, and cystathionine β-synthase (CBS), as well as antioxidant protein levels, such as super oxide dismutase1 (SOD1) and catalase, and additionally decreased oxidative …
Pharmacologic And Clinical Considerations Of Nalmefene, A Long Duration Opioid Antagonist, In Opioid Overdose., Amber N. Edinoff, Catherine A. Nix, Tanner D. Reed, Elizabeth M. Bozner, Mark R. Alvarez, Mitchell C. Fuller, Fatimah Anwar, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye
Pharmacologic And Clinical Considerations Of Nalmefene, A Long Duration Opioid Antagonist, In Opioid Overdose., Amber N. Edinoff, Catherine A. Nix, Tanner D. Reed, Elizabeth M. Bozner, Mark R. Alvarez, Mitchell C. Fuller, Fatimah Anwar, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye
School of Medicine Faculty Publications
No abstract provided.
A Comparison Of 4-Year Total Medical Care Costs, Adverse Outcomes, And Opioid/Prescription Analgesic Use For 3 Knee Osteoarthritis Pain Treatments: Intra-Articular Hyaluronic Acid, Intra-Articular Corticosteroids, And Knee Arthroplasty., John Mackowiak, John T Jones, Vinod Dasa
A Comparison Of 4-Year Total Medical Care Costs, Adverse Outcomes, And Opioid/Prescription Analgesic Use For 3 Knee Osteoarthritis Pain Treatments: Intra-Articular Hyaluronic Acid, Intra-Articular Corticosteroids, And Knee Arthroplasty., John Mackowiak, John T Jones, Vinod Dasa
School of Medicine Faculty Publications
To compare the medical costs associated with treatments for knee osteoarthritis (OA): intra-articular corticosteroids (ICS) and intra-articular hyaluronic acid (IHA) primarily, and ICS/IHA vs knee arthroplasty (TKA) secondarily. This was a retrospective analysis of an insurance claims database. Eligible members had diagnosed OA and no claims for ICS, IHA, or TKA during the 6–18-month look-back period. Cohorts of interest over the 4-year observation period were: patients who received ICS only, those who received IHA only, and those who received TKA only. Outcomes assessed included: (1) total allowed medical costs, (2) claims for pre-specified, treatment-related adverse outcomes and costs, and (3) …
Efficacy And Safety Of Abobotulinumtoxina For Upper Limb Spasticity In Children With Cerebral Palsy: A Randomized Repeat-Treatment Study, Mauricio R. Delgado, Ann Tilton, Jorge Carranzo-Del Rio, Nigar Dursun, Marcin Bonikowski, Resa Aydin, Iwona Maciag-Tymecka, Joyce Oleszek, Edward Dabrowski, Anne-Sophie Grandoulier, Philippe Picaut, The Dysport In Pul Study Group
Efficacy And Safety Of Abobotulinumtoxina For Upper Limb Spasticity In Children With Cerebral Palsy: A Randomized Repeat-Treatment Study, Mauricio R. Delgado, Ann Tilton, Jorge Carranzo-Del Rio, Nigar Dursun, Marcin Bonikowski, Resa Aydin, Iwona Maciag-Tymecka, Joyce Oleszek, Edward Dabrowski, Anne-Sophie Grandoulier, Philippe Picaut, The Dysport In Pul Study Group
School of Medicine Faculty Publications
Aim: To assess the efficacy and safety of repeat abobotulinumtoxinA injections in reducing upper limb spasticity in children with cerebral palsy (CP). Method: This was a double-blind, repeat-cycle study (NCT02106351) in children with CP (2–17y). Children were randomized to receive 2U/kg (control), 8U/kg, or 16U/kg abobotulinumtoxinA injections into the target muscle group (wrist or elbow flexors) and additional muscles alongside occupational therapy via a home-exercise therapy program (HETP; minimum five 15min sessions/wk). Children received 8U/kg or 16U/kg plus HETP in cycles 2 to 4. Results: During cycle 1, 210 children (126 males, 84 females; mean age [SD] 9y [4y 5mo], …