Chemical Actions and Uses Commons^™

Structural Basis Of Anthocyanin-Mediated Modulation Of Il-2, Il-17, And Tnf-Α: A Docking And Molecular Dynamics Study, Andrey Bogoyavlenskiy, Adolat Manakbayeva, Timur Kerimov, Igor Yershov, Madina Alexyuk, Pavel Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

Publications and Research

Anthocyanins are naturally occurring flavonoid pigments widely distributed in plants and are recognized for their antioxidant and anti-inflammatory activities. However, the molecular mechanisms underlying their potential immunomodulatory effects remain poorly characterized, particularly regarding their direct interactions with key signaling cytokines. In this study, a set of selected anthocyanins was investigated using a hierarchical computational workflow targeting three major pro-inflammatory cytokines: interleukin-2 (IL-2), interleukin-17 (IL-17), and tumor necrosis factor-α (TNF-α). Molecular docking analyses identified primulin and antirrhinin as the most favorable binders, forming stabilizing hydrogen bonds and hydrophobic interactions within predicted cytokine interaction interfaces. To further assess the stability of these …

Myrtillin As A Promising Immunomodulator: Molecular Modeling And Pharmacokinetic Evaluation, Adolat Manakbayeva, Timur Kerimov, I D. Ershov, E. I. Anarkulova, Pavel Alexyuk, Y Moldakhanov, Ahdrey P. Bogoyavlenskiy, Vyacheslav Dushenkov

Publications and Research

Myrtillin, an anthocyanin found in blueberry fruits, is known for its antioxidant and potentially immunomodulatory properties. In this study, molecular docking was used to evaluate its interactions with a wide panel of immune-related proteins, including pro-inflammatory cytokines (TNF-α, IL-6, IL-17), antiinflammatory mediators (IL-4, IL-10), and signaling pathway proteins (1NFK, p52/RelB). The in silico results were supported by interaction analysis, and an ADMET analysis was conducted to assess the pharmacokinetic and toxicological profile. The findings confirm the promise of Myrtillin as a natural modulator of inflammatory responses.

Healthy People Are Bad For Capitalism, Eri King

Theses and Dissertations

Healthy People are Bad For Capitalism is a four part installation that creates an alternative space for the chemicals, Red 40 and Monosodium Glutamate. Presented as a holistic center that offers healing services and remedies, Center for the Red 40 and MSG Healing explores the homeopathic doctrine of Like Cures Like (what make a human ill also cures them) through the relationship between Traditional Japanese Healing Practices, and Western Capitalism.

Healthy People are Bad For Capitalism presents Red 40 MSG Apothecary, Red 40 Zen MSG Healing Rock Garden, Theta Wave Eternal Flame Meditation and Red 40 MSG …

Under The Gun: Ongoing Assaults On Bahrain’S Health System, Richard Sollom, Holly G. Atkinson

Publications and Research

In February 2011, the Government of Bahrain began targeting health professionals who treated protesters. In April 2012, PHR's Richard Sollom, Deputy Director, and Holly Atkinson, MD, FACP, past President of PHR's Board and volunteer expert, authored a report showing the devastation on Bahrain's health system that have resulted from the Government of Bahrain’s continued assault on doctors, patients, and the healthcare system.