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Immunohistochemical Analysis Of The Effects Of Streptozotocin-Induced Diabetes On Mouse Testis, Rory E. Field, Brianna R. Demaio, Hannah R. Fioramonti, Makenna M. Landis, Jing Xu
Immunohistochemical Analysis Of The Effects Of Streptozotocin-Induced Diabetes On Mouse Testis, Rory E. Field, Brianna R. Demaio, Hannah R. Fioramonti, Makenna M. Landis, Jing Xu
Montview Journal of Research & Scholarship
Because diabetes mellitus (DM) poses harm to the reproductive systems of humans and mice on both the cellular and histological levels, we sought to understand the effects of streptozotocin-induced (STZ) diabetes mellitus on the spermatogenesis and Anti-Müllerian hormone (AMH) production of mice. The structural integrity of the testes is disrupted due to the high levels of oxidative stress caused by DM, which also hinders spermatogenesis. Advanced glycation end products (AGEs) have been found to induce autophagy in Sertoli cells, and the Sertoli cells of diabetic models have fewer tight junctions between them. This disorganization and decreased integrity of the seminiferous …