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- Allogenic (1)
- BLT (1)
- Bowman's layer transplantation (1)
- Cornea (1)
- Cultivated limbal stem cell transplantation (CLET) (1)
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- DMAK (1)
- Descemet membrane anterior (1)
- Keratolimbal allograft (KLAL). Limbal stem cell deficiency (LSCD) (1)
- Keratoplasty (1)
- Living-related conjunctival limbal allograft (Ir-CLAL) (1)
- Narrative review (1)
- Nonectatic (1)
- Ocular surface stem cell transplantation (OSST) (1)
- Simple limbal epithelial transplantation (SLET) (1)
- Systemic immunosuppression (1)
Articles 1 - 2 of 2
Full-Text Articles in Tissues
Outcomes Of Allogeneic Ocular Surface Stem Cell Transplantation, Albert Y. Cheung, Natalia Quiroz-Casian, Enrica Sarnicola, Gautam C. Ramanathan, Siddharth Nath, Edward J. Holland
Outcomes Of Allogeneic Ocular Surface Stem Cell Transplantation, Albert Y. Cheung, Natalia Quiroz-Casian, Enrica Sarnicola, Gautam C. Ramanathan, Siddharth Nath, Edward J. Holland
Department of Ophthalmology Faculty Publications
Allogeneic ocular surface stem cell transplantation (OSST) is an established therapeutic approach for limbal stem cell deficiency, utilizing techniques such as keratolimbal allograft (KLAL), living-related conjunctival limbal allograft (lr-CLAL), allogeneic cultivated limbal epithelial transplantation (allo-CLET), and allogeneic simple limbal epithelial transplantation (allo-SLET). This review synthesizes evidence from 35 studies encompassing 1, 268 eyes with at least 24 months of follow-up to evaluate intermediate- and long-term outcomes. Overall, OSST is associated with improvement in visual acuity and restoration of ocular surface stability, although success rates vary widely by technique, ranging from 13% to 87%. Outcomes appear to be influenced by the …
Acellular Bowman Layer And Descemet Membrane Allografts For Non-Ectatic Anterior Corneal Diseases: A Narrative Review Of Emerging Evidence, Hanna Pawlowski, Sanjana Molleti, W. Garrett Hayes, Nadim S. Azar, Albert Y. Cheung, Phillip C. Hoopes, Majid Moshirfar
Acellular Bowman Layer And Descemet Membrane Allografts For Non-Ectatic Anterior Corneal Diseases: A Narrative Review Of Emerging Evidence, Hanna Pawlowski, Sanjana Molleti, W. Garrett Hayes, Nadim S. Azar, Albert Y. Cheung, Phillip C. Hoopes, Majid Moshirfar
Department of Ophthalmology Faculty Publications
Penetrating keratoplasty has long been the standard treatment for many corneal pathologies, but interest has grown in less invasive, tissue-sparing alternatives. Bowman’s layer (BL) and Descemet’s membrane (DM) transplantation are two anterior approaches that use isolated acellular corneal layers to restore structural support and promote epithelial healing, while avoiding many of the limitations of full-thickness grafting. Although both techniques have been described for ectatic disorders, their theoretically low immunogenicity, minimal long-term steroid requirements, and capacity to support reepithelialization make them appropriate options for a range of nonectatic indications. This narrative review describes the application of BL (11 studies) and DM …