Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (4)
- Medical Sciences (4)
- Life Sciences (2)
- Nervous System Diseases (2)
- Neurosciences (2)
-
- Amino Acids, Peptides, and Proteins (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biophysics (1)
- Cardiovascular Diseases (1)
- Cardiovascular System (1)
- Cell and Developmental Biology (1)
- Chemicals and Drugs (1)
- Chemistry (1)
- Developmental Biology (1)
- Embryonic Structures (1)
- Immune System Diseases (1)
- Inorganic Chemistry (1)
- Medical Immunology (1)
- Medical Neurobiology (1)
- Molecular and Cellular Neuroscience (1)
- Neuroscience and Neurobiology (1)
- Physical Sciences and Mathematics (1)
- Keyword
-
- TBI (4)
- Cell proliferation (3)
- Epilepsy (3)
- Hippocampus (3)
- Multisensory (3)
-
- Myelin (3)
- Neurogenesis (3)
- Oligodendrocyte (3)
- Peripheral nervous system (3)
- Spinal Cord Injury (3)
- Sulfatide (3)
- Blood-brain barrier (2)
- Brain (2)
- Brain injury (2)
- Brain tumor (2)
- Electrospinning (2)
- Enzyme (2)
- Extracellular matrix (2)
- LRSS (2)
- Lateral geniculate nucleus (2)
- Minocycline (2)
- Nervous System (2)
- Paranode (2)
- Plasticity (2)
- Trauma (2)
- Traumatic Brain Injury (2)
- Vasogenic edema (2)
- Vision (2)
- Achievement (1)
- Acromiohumeral distance (1)
- Publication Year
- Publication
- Publication Type
Articles 61 - 67 of 67
Full-Text Articles in Nervous System
Combinatorial Modulation Of Multiple Signaling Pathways To Gain Therapeutic Response In Breast And Prostate Cell Carcinomas, William Tressel Hawkins Ii
Combinatorial Modulation Of Multiple Signaling Pathways To Gain Therapeutic Response In Breast And Prostate Cell Carcinomas, William Tressel Hawkins Ii
Theses and Dissertations
Our laboratory is primarily interested in novel pharmacological intervention of cell proliferation and survival pathways expressed in various types of cancer. These cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we utilized novel drug combinations with and without radiation to enhance breast & prostate tumor cell death both in vitro and in vivo. Previous studies from our group have shown that UCN-01 and MEK1/2 inhibitors interact to cause tumor cell death in transformed cell lines in vitro. We extended this observation to an in vivo animal model system using the …
The Role Of Sulfatide In Alzheimer's Disease, Charles Britton Beasley Jr.
The Role Of Sulfatide In Alzheimer's Disease, Charles Britton Beasley Jr.
Theses and Dissertations
Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta plaques, neurofibrillary tangles (NFT) and loss of cortical neurons that control memory and cognition. The cause of NFTs and Aβ plaques is not clear, though it is known that they are formed by enzymes which are preferentially sequestered to membrane domains called lipid rafts. Sulfatide (ST) is a glycosphingolipid that is essential for the proper structure and function of lipid rafts. In mice that lack ST, membrane domains that are normally maintained by adhesive contacts and functional lipid rafts are improperly formed and are unstable. In these ST null …
The Influence Of A Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter On Glioma Biology, Jessica Mccready
The Influence Of A Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter On Glioma Biology, Jessica Mccready
Theses and Dissertations
Glioblastomas are an incurable type of brain tumor with a mean survival time of 9-12 months following diagnosis. One of the reasons for this poor prognosis is the ability of tumor cells to invade the surrounding normal brain tissue. Enzymes responsible for this invasive nature include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence glioma biology. This SNP consists of the presence (2G) or absence (1G) of …
Molecular Localization Of Hypoxia Inducible Factor-1-Alpha In Post-Ischemic Myocardium Following In Vivo Prolyl-4 Hydroxylase-2 Gene Silencing, Julia Antoinette Messina
Molecular Localization Of Hypoxia Inducible Factor-1-Alpha In Post-Ischemic Myocardium Following In Vivo Prolyl-4 Hydroxylase-2 Gene Silencing, Julia Antoinette Messina
Theses and Dissertations
Administration of small interfering RNA (siRNA) specific for prolyl-4 hydroxylase-2 (PHD2) results in PHD2 inhibition, Hypoxia Inducible Factor-I (HIF-1) activation, and cardioprotection versus Ischemia Reperfusion (IR). This study observes the effects of siRNA-mediated PHD2 inhibition on the distribution of cardioprotective proteins by immunofluorescence and basic histology. Fifteen mice were divided into 5 groups: PHD2 Control, Non-Targeting scramble (NTS) Control, IR Control, PHD2 IR, and NTS IR. Histologically, tissue damage was reduced dramatically in the PHD2 IR group compared to the NTS IR and IR control groups. From confocal images, total fluorescent pixels and intensities were quantified. The PHD2 IR group …
Identification And Characterization Of The Expression Profile Of Oligodendrocyte-Derived And Associated Proteins Via Unilateral X-Irradation Of The Rat Optic Nerve, Nicholas Greco
Theses and Dissertations
Recent studies examining cell-cell interactions during CNS development and following disease or trauma have highlighted our limited understanding of the in vivo functions of the myelinating cell of the CNS, the oligodendrocyte. With this in mind, our laboratory has developed techniques by which a profile of proteins derived from or regulated by oligodendrocytes can be elucidated. Specifically, we have demonstrated that oligodendrocytes can be selectively eliminated from one optic nerve of a rat by treating the animal with a unilateral exposure of X-irradiation at the time of birth. Consequently, this approach allowed us to experimentally create, within the same animal, …
Status Epilepticus Results In A Duration-Dependent Increased Protein Kinase A Activity In The Rat Pilocarpine Model, James M. Bracey
Status Epilepticus Results In A Duration-Dependent Increased Protein Kinase A Activity In The Rat Pilocarpine Model, James M. Bracey
Theses and Dissertations
This study was conducted to characterize cellular changes occurring during the progression of status epilepticus (SE) that could lead to the maintenance of increased membrane excitability. SE was induced by injection of pilocarpine after which rats were monitored both electrographically and behaviorally. After various lengths of time in SE, specific brain regions were isolated for biochemical study. SE resulted in an early maintenance of PKA activity in both cortical homogenate and crude synaptoplasmic membrane (crude SPM) fractions. At subsequent stages of SE there was a significant increase in PKA activity in both homogenate and crude SPM fractions. Wester blot analysis …
The Effect Of Traumatic Brain Injury On Expression Levels Of Ankyrin-G In The Corpus Callosum And Cerebral Cortex, Andrew S. Vanderveer
The Effect Of Traumatic Brain Injury On Expression Levels Of Ankyrin-G In The Corpus Callosum And Cerebral Cortex, Andrew S. Vanderveer
Theses and Dissertations
The ankyrins comprise a family of proteins serving as components of the membrane cytoskeleton, and participate in a diverse set of associations with multiple binding partners including the cytoplasmic domains of transporters, ion channels, some classes of receptors, and cell adhesion proteins. Moreover, evidence is accumulating that ankyrin participates in defining functionally distinct subcellular regions. The complex functional and structural roles of ankyrins indicate they are likely to play essential roles in the pathology of traumatic axonal injury. The current study examined changes in ankyrin-G expression following a moderate central fluid percussion injury administered to adult rats. At 1d, 3d, …