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Articles 1 - 5 of 5
Full-Text Articles in Nervous System
Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed
Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed
NYMC Student Theses and Dissertations
A loss of neurons that synthesize the neuropeptide orexin produces the sleep disorder narcolepsy with cataplexy in humans and other animals. How symptoms of this disorder arise is not well understood, but selectively restoring orexin actions at 5-HT DR neurons rescues key symptoms (cataplexy), suggesting normal orexin signaling is important at these neurons. To better understand how orexin acts on these neurons, our lab identified a set of novel orexin actions that appear mediated by unidentified cation- permeable ion channels. To narrow down the list of possible channels, we used a bioinformatics approach to compare published gene expression profiles of …
Morphometrics In Developmental Neurobiology: Quantitative Analysis Of Growth Cone Motility In Vivo, Anokh Sohal, James Ha, Manuel Zhu, Fayha Lakhani, Lauren Olszewski, Raagav Mohanakrishnan, Tamira Elul
Morphometrics In Developmental Neurobiology: Quantitative Analysis Of Growth Cone Motility In Vivo, Anokh Sohal, James Ha, Manuel Zhu, Fayha Lakhani, Lauren Olszewski, Raagav Mohanakrishnan, Tamira Elul
Faculty Publications & Research of the TUC College of Osteopathic Medicine
In order for the nervous system to function properly, neurons in the brain must establish specific connections during embryonic development. Formation of neuronal circuits involves axons extending from cell bodies and navigating through diverse tissues to reach their targets in the brain. Once axons reach their target tissues, they arborize and make synaptic connections. Axon pathfinding is driven by dynamic motility behaviors expressed by terminal growth cones at the tips of the axons. Here, we applied morphometrics to determine quantitative values for six morphological and motility parameters for growth cones of optic axons navigating through the optic tract of a …
From Squirrels To Cognitive Behavioral Therapy (Cbt): The Modulation Of The Hippocampus, Rachel Ariella Bartfeld
From Squirrels To Cognitive Behavioral Therapy (Cbt): The Modulation Of The Hippocampus, Rachel Ariella Bartfeld
The Science Journal of the Lander College of Arts and Sciences
The legitimacy of psychotherapy can often be thrown into doubt as its mechanisms of action are generally considered hazy and unquantifiable. One way to support the effectiveness of therapy would be to demonstrate the physical effects that this treatment option can have on the brain, just like psychotropic medications that physically alter the brain’s construction leaving no doubt as to the potency of their effects. Beginning with the understanding of therapy as a behavior, this paper first questions the possibility of behavior effecting measurable change on the brain. Examining diverse samples of both animals and humans repeatedly shows that the …
Apoptotic Neurodegeneration In The Developing Human Brain: Possible Role Of General Anesthetics In Its Genesis, And Of L-Carnitine In Its Reversal, Yisroel Yitzchok Rosenfeld
Apoptotic Neurodegeneration In The Developing Human Brain: Possible Role Of General Anesthetics In Its Genesis, And Of L-Carnitine In Its Reversal, Yisroel Yitzchok Rosenfeld
The Science Journal of the Lander College of Arts and Sciences
Recent studies suggest that general anesthetic (GA) agents administered to developing rats, through its mechanism as an NMDA antagonist or a GABAa mimetic, may damage developing neural cells by inducing a higher rate of programmed cell death (apoptosis). Similar heightened degeneration was also apparent in higher primates such as the monkey. This warrants strong concern, as every year thousands of pregnant women and children below 1 year of age undergo a surgical procedure in which GAs are used. A spike in neuroapoptosis may lead to long term cognitive deficiencies lingering into adulthood. Are humans vulnerable to these affects? Different pathways …
The Effects Of Emotional Experiences On Memory Processing, Naomi Berkowitz
The Effects Of Emotional Experiences On Memory Processing, Naomi Berkowitz
The Science Journal of the Lander College of Arts and Sciences
Neural regions, specifically the amygdala, hippocampus, and prefrontal cortex overlap in functions of emotion and memory, indicating a degree of interrelatedness between the two functions. Lesions in medial temporal lobe regions result in an impairment of memory processes specific to emotional stimuli. Additionally, amygdala activity is increased for all valence memory as opposed to neutral. Arousal levels of high and low valence memories affect the pathway for encoding in the brain, and determine the vividness and episodic detail with which a memory will be recorded. The amygdala-hippocampal network is involved in high arousal memory, while a prefrontal cortex-hippocampal network is …